Quick Reference Handbook for Surgical Pathologists

Description:

This book contains a compilation of high-yield, at-a-glance summaries in quick reference format for various topics that are frequently encountered by pathologists in the daily practice or on the boards. The focus is not organ-based histologic criteria, but rather everything else that goes into pathologic diagnoses but is difficult to keep committed to memory. The emphasis is on immunohistochemistry, special stains, grading systems, molecular markers, tumor syndromes, and helpful clinical references. Also included are morphologic summaries that encompass high-yield material cutting across all organ systems, such as an illustrated guide for microorganisms, tumor differentials, and an illustrated glossary of pathologic descriptors. The book has a unique format in that the information is presented primarily in tables and diagrams accompanied by brief and to-the-point explanatory text. The guiding principle was to boil the information down to the essentials but with just enough commentary to be accessible to a newcomer to pathology and to serve as a quick reference to a practicing pathologist.   In the 7 years since its initial publication, there have been considerable advances in surgical pathology, particularly immunohistochemical stains, molecular diagnostics, and histologic grading schemes.  In the second edition, the content has been thoroughly updated to incorporate these developments, while retaining the overall scope and concise format of the first edition. In addition, the reader will find summaries for many new topics as well as multiple new cartoon illustrations and diagrams. 

Table of Contents – At a Glance:

Chapter 1: Immunostains: Introduction

Applications of Immunohistochemistry (IHC) in Anatomic Pathology

Markers of Differentiation at a Glance

Location, Location, Location! Primer on Location of Antigens

Primer on Cytokeratins

CK7 and CK20 Expression Profile Diagram

CK7 and CK20 Expression Profiles

Expression of EMA, CEA, and Vimentin in Carcinomas

Primer on Markers of Muscle Differentiation

Primer on Markers of Neuroendocrine (NE) Differentiation

Primer on Markers of Melanocytic Differentiation

Primer on Markers of Neuroglial Differentiation

Primer on Markers of Vascular Differentiation

Primer on Assessment of Invasion

Primer on Proliferation Markers and p53

Differential Diagnosis of Undifferentiated Malignant Neoplasms (Carcinoma Versus Melanoma Versus Ly

Carcinoma of Unknown Primary (CUP): Summary of Key Markers Used to Identify the Site of Origin

Key Multipurpose Markers for the Site of Origin in Carcinomas: Diagram

Differential Diagnosis of Small Round Blue Cell Tumors (SRBCT)

Differential Diagnosis of Spindle-Cell Tumors

Differential Diagnosis of Neuroendocrine (NE) and Neuroectodermal Neoplasms

Chapter 2: Immunostains: Solid Tumors

Breast

Breast: Differentials

Prostate and Bladder

Prostate and Bladder: Differentials

Kidney

Kidney: Differentials

Adrenal

Testis

Thyroid, Parathyroid, and Sinonasal Tract

Salivary Glands

Pancreas

Tubular Gastrointestinal Tract

Immunohistochemical Testing of DNA Mismatch Repair (MMR) Proteins

Liver

Lung

Lung: Common Differentials

Mesothelioma and Thymic Epithelial Neoplasms

Soft Tissue

Soft Tissue – 2

Central Nervous System

CNS: Differentials

Gynecologic Tract

Gynecologic Tract: Differentials

Gynecologic Tract: Differentials – 2

Skin

Skin – 2

Chapter 3: Immunostains: Hematopoietic System

Stages of Lymphocyte Differentiation and Corresponding Lymphomas

Normal Stages of B-Cell Development, Immunostains, and Corresponding Lymphomas

Reactive Hyperplasia versus Follicular Lymphoma

B-Cell Lymphomas

Plasma Cell-Rich and Plasmablastic Neoplasms

Immunoprofiles of Selected Hematopoietic Disorders

Histiocytic and Dendritic Cell Lesions

Chapter 4: Predictive Markers

Semiquantitative Assessment of Predictive Markers by IHC

Predictive Biomarkers and Targeted Therapies: Solid Tumors (Selected Examples)

Predictive Biomarkers and Targeted Therapies: Hematopoietic System (Selected Examples)

Chapter 5: Immunostains: Antibody Index – Solid Tumors

Common Multipurpose Immunostains at a Glance

Immunostains Where Antibody Clone Matters, Sometimes a Lot

Alphabetical Antibody Index: Solid Tumors

Chapter 6: Immunostains: Antibody Index – Hematopoietic System

Chapter 7: Special Stains

Quick Primer on Mucins

Special Stains at a Glance

Special Stains at a Glance: Microorganisms

Alphabetical Index of Special Stains

Chapter 8: Grading (and Classification) Systems Quick Reference: Solid Tumors

Breast

Genitourinary Tract: Prostate

Genitourinary Tract: Kidney and Bladder

Head and Neck

Pancreas and Biliary Tree

Esophagus

Liver Biopsy

Neuroendocrine Neoplasms

Neuroblastoma

Sarcoma Grading (Not for the Faint of Heart!)

Central Nervous System

Central Nervous System: 2

Gynecologic Tract

Gynecologic Tract: 2

Transplant Pathology

Transplant Pathology: 2

The Good the Bad and the Ugly: Prognostic Features in Neoplasms with Difficult-to-Predict Behav

The Good the Bad and the Ugly: 2

The Good the Bad and the Ugly: 3

Chapter 9: Grading (and Classification) Quick Reference: Hematopoietic System

Myeloid Neoplasms

Diagnostic Approach to AML

Chapter 10: Tumor Genetics and Cytogenetics: Solid Tumors

General Principles

Multipurpose Alterations at a Glance

Cytogenetic and Genetic Alterations in Solid Tumors: Quick Reference

Chapter 11: Tumor Genetics and Cytogenetics: Hematopoietic System

Chapter 12: Tumor Syndromes

Tumor Syndromes: Introduction

At-a-glance Summaries of Tumor Syndromes

IHC as a Surrogate for Germline Testing in Hereditary Cancer Syndromes

“Slide to Syndrome”

Lynch Syndrome/HNPCC

Chapter 13: Quick Clinical References for Pathologists

Metastases “From → To”: At-a-Glance Summary

Metastases “To ← From”: At-a-glance Summary

Serologic Tumor Markers: Common Associations

Paraneoplastic Syndromes

Chapter 14: Potpourri of Quick Morphologic References

Tumor Differentials 101

There’s a Fungus Among Us! Quick Reference for Histologic Identification of Fungi

There’s a Fungus Among Us! Quick Reference for Histologic Identification of Fungi – 2

There’s a Fungus Among Us! Quick Reference for Histologic Identification of Fungi – 3

Quick Reference for Histological Identification of Viruses

Tumor Viruses: Quick Reference for Tumor/Viral Associations

Quick Electron Microscopy Reference for Tumors and Select Non-tumor Diagnoses

Chapter 15: Quick Size References

Chapter 16: It Looks Like What? An Illustrated Glossary of Histopathologic Descriptors

Part 1. Solid Tumors

Part 2 Hematopoietic System

References

Chapter 1. Immunostains: Introduction

Chapter 2. Immunostains: Solid Tumors

Chapter 3. Immunostains: Hematopoietic System

Chapter 4. Predictive Markers

Chapter 5. Immunostains: Antibody Index – Solid Tumors

Chapter 6. Immunostains: Antibody Index – Hematopoietic System

Chapter 7. Special Stains

Chapter 8. Grading (and Classification) Quick Reference: Solid Tumors

Chapter 9. Grading (and Classification) Quick Reference: Hematopoietic System

Chapter 10. Tumor Genetics and Cytogenetics: Solid Tumors

Chapter 11. Tumor Genetics and Cytogenetics: Hematopoietic System

Chapter 12. Tumor Syndromes

Chapter 13. Quick Clinical References for Pathologists

Chapter 14. Potpourri of Quick Morphologic References

Chapter 15. Quick Size References

Chapter 16. It Looks Like WHAT? An Illustrated Glossary of Histopathologic Descriptors

Subject Index

Outer