Neurodegenerative Diseases: Clinical Aspects, Molecular Genetics and Biomarkers

Description:

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Table of Contents:

1. Genetics and Epigenetics in the Neurodegenerative Disorders of the Central Nervous System

2. Diagnosis of Alzheimer’s Disease Typical and Atypical Forms

3. Genetic Complexity of Early-Onset Alzheimer’s Disease

4. Genetic Risk Factors for Complex Forms of Alzheimer’s Disease

5. Role of Cerebrovascular Disease in Cognition

6. Risk Factors and Prevention in Alzheimer’s Disease and Dementia

7. Diagnosis of Frontotemporal Dementia

8. Autosomal Dominant Frontotemporal Lobar Degeneration: From Genotype to Phenotype

9. Genetic Risk Factors for Sporadic Frontotemporal Dementia

10. Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models

11. Fluid Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia

12. Biomarkers for Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Imaging

13. Genotypic and Phenotypic Heterogeneity in Amyotrophic Lateral Sclerosis

14. Lewy Body Dementia

15. Rare Dementias

16. Neurodevelopmental and Neurodegenerative Alterations in the Pathophysiology of Schizophrenia: Focus on Neuro-Immuno-Inflammation

17. Parkinson’s Disease: Contemporary Concepts and Clinical Management

18. Neurodegeneration and Multiple Sclerosis