Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
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Editura: Springer
Limba: Engleza
Nr. pagini: 405
Coperta: Hardcover
Dimensiuni: 16.08 x 2.06 x 23.85 cm
An aparitie: 29-02-20
Description:
This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
Table of contents:
Perspective for Part I
Pages 3-5
Yamagishi, Hiroyuki
The Alveolar Stem Cell Niche of the Mammalian Lung
Pages 7-12
Hogan, Brigid L. M.
Lung Development and Notch Signaling
Pages 13-23
Morimoto, Mitsuru
Specialized Smooth Muscle Cell Progenitors in Pulmonary Hypertension
Pages 25-30
Saddouk, Fatima Zahra (et al.)
Diverse Pharmacology of Prostacyclin Mimetics: Implications for Pulmonary Hypertension
Pages 31-61
Clapp, Lucie H. (et al.)
Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension
Pages 63-70
Ranchoux, Benoît (et al.)
Extracellular Vesicles, MicroRNAs, and Pulmonary Hypertension
Pages 71-77
Chen, Tianji (et al.)
Roles of Tbx4 in the Lung Mesenchyme for Airway and Vascular Development
Pages 79-81
Uchida, Keiko (et al.)
A lacZ Reporter Transgenic Mouse Line Revealing the Development of Pulmonary Artery
Pages 83-85
Ishizaki, Reina (et al.)
Roles of Stem Cell Antigen-1 in the Pulmonary Endothelium
Pages 87-89
Maeda, Jun (et al.)
Morphological Characterization of Pulmonary Microvascular Disease in Bronchopulmonary Dysplasia Caused by Hyperoxia in Newborn Mice
Pages 91-93
Nakanishi, Hidehiko (et al.)
Involvement of CXCR4 and Stem Cells in a Rat Model of Pulmonary Arterial Hypertension
Pages 95-96
Zhang, Tingting (et al.)
Ca2+ Signal Through Inositol Trisphosphate Receptors for Cardiovascular Development and Pathophysiology of Pulmonary Arterial Hypertension
Pages 97-99
Shibata, Akimichi (et al.)
Perspective for Part II
Pages 103-108
Pathophysiology of Pulmonary Circulation in Congenital Heart Disease
Pages 109-123
Hashimoto, Megumi (et al.)
Development of Novel Therapies for Pulmonary Hypertension by Clinical Application of Basic Research
Pages 125-129
Satoh, Kimio (et al.)
Using Patient-Specific Induced Pluripotent Stem Cells to Understand and Treat Pulmonary Arterial Hypertension
Perspective for Part III
Pages 223-225
Nakanishi, Toshio
The Ductus Arteriosus, a Vascular Outsider, in Relation to the Pulmonary Circulation
Pages 227-233
Gittenberger-de Groot, Adriana C. (et al.)
Molecular, Genetic, and Pharmacological Modulation of the Ductus Arteriosus: KATP Channels as Novel Drug Targets
Pages 235-242
Shelton, Elaine L. (et al.)
New Mediators in the Biology of the Ductus Arteriosus: Lessons from the Chicken Embryo
Pages 243-249
Sterren, Saskia (et al.)
Constriction of the Ductus Arteriosus with KATP Channel Inhibitors
Pages 251-257
Momma, Kazuo (et al.)
New Insights on How to Treat Patent Ductus Arteriosus
Pages 259-264
Yokoyama, Utako (et al.)
Antenatal Administration of Betamethasone Contributes to Intimal Thickening of the Ductus Arteriosus
Pages 265-266
Kemmotsu, Takahiro (et al.)
Prostaglandin E-EP4-Mediated Fibulin-1 Up-regulation Plays a Role in Intimal Thickening of the Ductus Arteriosus
Pages 267-268
Ito, Satoko (et al.)
Transcriptional Profiles in the Chicken Ductus Arteriosus During Hatching
Pages 269-271
Shinjo, Satoko (et al.)
Inhibition of Cyclooxygenase Contracts Chicken Ductus Arteriosus
Pages 273-274
Akaike, Toru (et al.)
Prostaglandin E2 Receptor EP4 Inhibition Constricts the Rat Ductus Arteriosus
Pages 275-276
Sakuma, Toshiki (et al.)
Dilatation of the Ductus Arteriosus by Diazoxide in Fetal and Neonatal Rats
Pages 277-279
Toyoshima, Katsuaki (et al.)
The Effect of Long-term Administration of Prostaglandin E1 on Morphological Changes in Ductus Arteriosus
Pages 281-283
Iwaki, Ryuma (et al.)
Significance of SGK1 as a Protein Kinase Transcriptionally Regulated by ALK1 Signaling in Vascular Endothelial Cells
Pages 285-287
Nakagawa, Osamu (et al.)
| An aparitie | 29-02-20 |
| Autor | Toshio Nakanishi; H. Scott Baldwin; Jeffrey R. Fineman; Hiroyuki Yamagishi |
| Dimensiuni | 16.08 x 2.06 x 23.85 cm |
| Editura | Springer |
| Format | Hardcover |
| ISBN | 9789811511844 |
| Limba | Engleza |
| Nr pag | 405 |
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