Management of Advanced Prostate Cancer

Description:

This textbook summarizes the state of the art in the management of locally advanced and metastatic prostate cancer with the aim of providing the knowledge required for optimal treatment decision making in individual cases. Readers will find comprehensive coverage of the latest developments in surgery, radiotherapy, androgen deprivation therapy (ADT), chemotherapy, and immunotherapy. The role of the hormonal therapies abiraterone and enzalutamide and docetaxel-based chemotherapy in castration-resistant prostate cancer and hormone-sensitive metastatic disease is carefully evaluated. Among the other therapies discussed are LHRH agonists and antagonists, cabazitaxel, radium-223, and various novel agents still under clinical trials. The section on surgical approaches addresses, among other topics, the use of robot-assisted radical prostatectomy, pelvic lymphadenectomy, and the benefits of adjuvant and neoadjuvant therapy. The current role of external beam radiotherapy, alone or in combination with ADT and brachytherapy, for locally advanced disease is reviewed. Management of Advanced Prostate Cancer will be a valuable resource for practitioners at all levels of expertise.

Table of contents:

Part I. Surgery for Advanced Prostate Cancer

1. Natural History of High-Risk Prostate Cancer

2. Identifying the Best Candidate for Radical Prostatectomy in High-Risk Prostate Cancer

3. Neoadjuvant Therapy Prior to Radical Prostatectomy

4. Robot-Assisted Radical Prostatectomy for High-Risk Prostate Cancer

5. Pelvic Lymphadenectomy for High-Risk Prostate Cancer

6. Adjuvant Therapy in Locally Advanced Prostate Cancer

7. Role of Radical Prostatectomy in the Management of Metastatic Prostate Cancer

Part II. Radiotherapy for Advanced Prostate Cancer

8. The Roles of Radiotherapy, Androgen Deprivation Therapy, and Their Combination for Locally Advanced Prostate Cancer

9. External Beam Radiotherapy for Advanced Prostate Cancer: Dose, Technique, and Fractionation

10. Radiotherapy for Prostate Cancer Patients with Pelvic Lymph Node Metastasis

11. Emerging Role of Radiotherapy in Stage IV Prostate Cancer

12. Adjuvant and Salvage Radiation Therapy for Prostate Cancer After Radical Prostatectomy

Part III. Androgen Deprivation Therapy for Advanced Prostate Cancer

13. Immediate vs. Delayed ADT for Recurrent Prostate Cancer

14. Intermittent Versus Continuous ADT for Advanced Prostate Cancer

15. LHRH Agonist and Antagonist for Prostate Cancer

16. Abiraterone or Enzalutamide in Chemotherapy-Naïve Metastatic CRPC

17. Abiraterone or Enzalutamide in CRPC After Chemotherapy

18. Clinical Results of Secondary Hormonal Treatment

19. Side Effects and Management of ADT for Prostate Cancer

Part IV. Systemic Chemotherapy, Immunotherapy and Palliative Care for Advanced Prostate Cancer

20. Systemic Chemotherapy for Metastatic Hormone-Sensitive Prostate Cancer

21. Systemic Chemotherapy in Metastatic Castration-Resistant Prostate Cancer

22. Radiopharmaceutical Therapy in Metastatic CRPC

23. Immunotherapy for CRPC

24. Clinical Trials in CRPC

25. Palliative Care for Metastatic Symptomatic CRPC