Lippincott Illustrated Reviews: Immunology

 

Description:

Lippincott® Illustrated Reviews: Immunology, 3rd Edition, offers an engaging, vividly illustrated presentation and all of the popular learning features of the Lippincott® Illustrated Review series to reinforce essential immunology concepts and connect basic science to real-life clinical situations. Like other titles in this series, this dynamic resource follows an intuitive outline organization and boasts a wealth of vibrant illustrations and study aids that clarify complex information and ensure retention.   Whether used as a review text for a short immunology course or paired with Lippincott® Illustrated Reviews: Microbiology for a combined microbiology/immunology course, this revised and updated edition familiarizes readers with the latest practices in immunology and emphasizes clinical application to deliver unparalleled preparation for exams and clinical practice. 

 

 

Table of Contents:

 

Video 1: B-Cell Activation

Video 2: Cytotoxic T-Cell Killing

Video 3: Isotype Switch

Video 4: T-Cell Activation

Video 5: VDJ Light and Heavy

Video 6: Type 1 Hypersensitivity

Video 7: Type III Hypersensitivity

Unit I: Sense of Being: The Concept of Self and Self/Nonself Recognition

Chapter 1: The Need for Self-Recognition

I. OVERVIEW

II. THE IMMUNOLOGIC CONCEPT OF SELF

A. Recognizing self

B. Recognizing the absence of self

C. Recognizing nonself

III. IMMUNOLOGIC MEMORY

IV. DEFENSE MECHANISMS

Study Questions

Chapter 2: Antigens and Receptors

I. OVERVIEW

II. ANTIGENS

A. Epitopes: The basic recognition unit

B. Immunogens

C. Haptens

D. Tolerogens

E. Immunogenicity

III. RECEPTORS

A. Preformed receptors

B. Somatically generated receptors

Study Questions

Unit II: The Innate Immune System

Chapter 3: Barriers to Infection

I. OVERVIEW

II. PHYSICAL BARRIERS

A. Skin

B. Mucous membranes

C. Respiratory tract

D. Urinary tract

III. CHEMICAL AND ENVIRONMENTAL BARRIERS

A. pH

B. Microcidal action of secreted molecules

IV. BIOLOGIC BARRIERS: COMMENSAL MICROBES

Study Questions

Chapter 4: Cells of the Innate Immune System

I. OVERVIEW

II. AGRANULAR LEUKOCYTES

A. Lymphoid lineage cells

B. Monocytic lineage cells

III. GRANULAR LEUKOCYTES

A. Neutrophils

B. Basophils and mast cells

C. Eosinophils

Study Questions

Chapter 5: Innate Immune Function

I. OVERVIEW

II. RECOGNITION

A. Pathogen-associated molecular patterns

B. Pattern recognition receptors

C. Markers of abnormal self

III. SOLUBLE DEFENSE MECHANISMS

A. Type I interferons

B. Microcidal molecules

C. Complement

D. Cytokines and chemokines

IV. CELLULAR DEFENSE MECHANISMS

A. Phagocytosis

B. Natural killer cell responses

V. INFLAMMATION

Study Questions

Unit III: The Adaptive Immune System

Chapter 6: Molecules of Adaptive Immunity

I. OVERVIEW

II. IMMUNOGLOBULINS

A. Basic structure

B. Isotypes

III. CLASSICAL PATHWAY OF COMPLEMENT ACTIVATION

A. Activation of C1

B. Production of C3 convertase

C. Production of C5 convertase

IV. MAJOR HISTOCOMPATIBILITY MOLECULES

A. MHC class I molecules

B. MHC class II molecules

V. T CELL RECEPTORS

A. Basic structure

B. Variable and constant regions

VI. MOLECULES OF CELLULAR INTERACTION

A. Cytokines

B. Chemokines

C. Adhesion molecules

D. Cluster of differentiation molecules

E. Signal transduction molecules

Study Questions

Chapter 7: Cells and Organs

I. OVERVIEW

II. LYMPHOCYTES

A. Thymus-derived cells

B. Bone marrow–derived cells

C. Natural killer cells

III. LYMPHOID TISSUES AND ORGANS

A. Primary organs

B. Secondary lymphoid tissues and organs

C. Lymphatic circulatory system

Study Questions

Chapter 8: Generation of Immune Diversity: Lymphocyte Antigen Receptors

I. OVERVIEW

II. PROPERTIES OF LYMPHOCYTE ANTIGEN RECEPTORS

III. DNA REARRANGEMENT

IV. T CELL RECEPTORS

A. Gene clusters encoding T cell receptors

B. Variable regions: Rearrangement of V, D, and J genes

C. Uniting variable and constant regions

D. Random combinations of light and heavy chains

V. B CELL RECEPTORS

A. Gene clusters encoding B cell receptors

B. Light chains

C. Heavy chains

D. Heavy and light chain combinations

E. Isotype switch: Mechanism

F. Isotype switch: Consequence

G. Somatic hypermutation

Study Questions

Chapter 9: Lymphocyte Development

I. OVERVIEW

II. T CELL LINEAGE

A. Thymus structure

B. αβ T cell development

C. γδ T cell development

D. NKT cell origin

III. B CELL LINEAGE

A. Bone marrow

B. B cell development

C. B-1 and B-2 B cells

Study Questions

Chapter 10: Lymphocyte Activation

I. OVERVIEW

II. ANTIGEN PRESENTATION

A. Presentation by MHC class II

B. Presentation by MHC class I

III. T CELL ACTIVATION

A. Immunologic synapse

B. T cell–signal transduction

C. CD41 T cell maturation

D. CD8+ T cell maturation

E. Control of T cell responses and memory T cell generation

IV. B CELL ACTIVATION

A. T-independent activation

B. T-dependent activation

C. Plasma cells and memory B cells

Study Questions

Chapter 11: Lymphocyte Effector Functions

I. OVERVIEW

II. HUMORAL IMMUNITY

A. Antigen–antibody reactions

B. Agglutination

C. Neutralization

D. Opsonization

E. Antibody-dependent cell-mediated cytotoxicity

F. Complement activation

G. Immediate hypersensitivity

III. CELL-MEDIATED IMMUNITY

A. Delayed (-type) hypersensitivity: Role of CD41 T cells

B. Cytotoxic T lymphocytes: Role of CD8+ T cells

IV. IMMUNOLOGIC MEMORY

Study Questions

Chapter 12: Regulation of Adaptive Responses

I. OVERVIEW

II. TOLERANCE

A. Mechanisms of immunologic nonresponsiveness

B. Regulatory T cells

C. The role of coinhibitors in immune regulation

III. REGULATION OF THE ADAPTIVE IMMUNE RESPONSE BY TH-CELL SUBSETS

IV. REGULATORY CYTOKINES

Study Questions

Unit IV: Clinical Aspects of Immunity

Chapter 13: The Well Patient: How Innate and Adaptive Immune Responses Maintain Health

I. OVERVIEW

II. CELLULAR RECIRCULATION AND HOMING

A. Cell adhesion molecules

B. Proinflammatory cytokines

C. Extravasation

III. RESPONSES TO INFECTIOUS AGENTS

A. Humoral responses

B. Cell-mediated responses

C. Effective responses to pathogens

D. Microbial evasion of immune responses

IV. INFLAMMATION

V. MUCOSAL IMMUNITY

A. Epithelial layer

B. Lamina propria

C. Mechanisms of mucosal immunity

VI. VACCINATION

A. Characteristics of vaccines

B. Types of vaccines

C. Adjuvants

Study Questions

Chapter 14: Hypersensitivity Reactions

I. OVERVIEW

II. TYPE I HYPERSENSITIVITY

A. Localized reactions

B. Systemic reactions

III. TYPE II HYPERSENSITIVITY

A. Interaction of antibody with cells

B. Interaction of antibody with the extracellular matrix

C. Antibody-mediated disruption of cellular function

IV. TYPE III HYPERSENSITIVITY

A. Localized reactions

B. Systemic reactions

V. TYPE IV HYPERSENSITIVITY

A. Contact dermatitis

B. Delayed (-type) hypersensitivity

C. T cell–mediated cytotoxicity

Study Questions

Chapter 15: Immune Deficiency

I. OVERVIEW

II. PRIMARY (CONGENITAL) IMMUNE DEFICIENCIES

A. Defects in stem cells

B. Defects in T cells

C. Defects in B cells

D. Defects in phagocytes and natural killer cells

E. Defects in the complement system

III. SECONDARY (ACQUIRED) IMMUNE DEFICIENCIES

A. Physiologic sequelae

B. Therapeutic treatment

C. Infection

D. Cancer

IV. TREATMENT OF IMMUNE DEFICIENCIES

A. Passive supplementation

B. Bone marrow transplantation

C. Genetic engineering

Study Questions

Chapter 16: Autoimmunity

I. OVERVIEW

II. SELF-TOLERANCE

A. Central tolerance

B. Peripheral tolerance

III. LOSS OF SELF-TOLERANCE

A. Molecular mimicry

B. Epitope spreading

C. Loss of suppression

D. Sequestered antigens

E. Neoantigens

IV. AUTOIMMUNE DISEASES

A. Humoral-associated autoimmune diseases

B. Cell-mediated autoimmune diseases

V. HLA ASSOCIATION WITH AUTOIMMUNE DISEASES

Study Questions

Chapter 17: Transplantation

I. OVERVIEW

II. GENETIC BASIS OF TRANSPLANTATION

A. Histocompatibility genes and antigens

B. Types of grafts

C. The laws of transplantation

III. TISSUE REJECTION

A. Types of rejection

B. Immune responses involved in rejection

C. Therapeutic intervention

IV. TISSUE-SPECIFIC CONSIDERATIONS

A. Transfusion

B. Bone marrow

C. Immune-privileged sites

V. TISSUE SOURCES

A. Human tissues and organs

B. Nonhuman (xeno-) tissues and organs

Study Questions

Chapter 18: Immune Pharmacotherapy

I. OVERVIEW

II. MEASURES THAT ENHANCE THE IMMUNE RESPONSE

A. Adjuvant therapy

B. Cytokine therapy

C. Antibody replacement therapy

III. MEASURES THAT DIMINISH THE IMMUNE RESPONSE

A. Anti-inflammatory agents

B. Immunosuppressive measures

IV. THERAPIES USED TO ALTER THE IMMUNE RESPONSE

A. Preemptive measures

B. Modification of ongoing disease

Study Questions

Chapter 19: Tumor Immunity

I. OVERVIEW

II. CANCER

A. Terminology and definitions

B. Malignant transformation

C. Tumors of the immune system

D. Oncogenes and cell growth

E. Tumor antigens

III. IMMUNE SURVEILLANCE

A. Innate

B. Adaptive

IV. IMMUNE EVASION

A. Evasion strategies by the tumor

B. Tumor immune evasion due to manipulated functions of immune cells

V. CANCER IMMUNOTHERAPY

A. Use of monoclonal antibodies to target tumor cells

B. Immunomodulatory molecules to increase an individual’s inherent antitumor immune response

C. Adoptive T cell transfer

D. Cancer vaccines

E. Alternative approaches to use the immune system to kill tumor cells

Study Questions

Chapter 20: Measurement of Immune Function

I. OVERVIEW

II. EPITOPE DETECTION BY ANTIBODIES

A. Particulate antigens

B. Soluble antigens

III. EPITOPE QUANTITATION BY ANTIBODIES

A. Radioimmunoassay

B. Enzyme-linked immunosorbent assay

C. Fluorescent immunosorbent assay

IV. EPITOPE DETECTION IN AND ON CELLS

A. Immunofluorescence

B. Flow cytometry

V. ASSESSMENT OF IMMUNE FUNCTION

A. Phagocyte function

B. Proliferation

C. Cytotoxic T-lymphocyte assay

VI. ASSESSMENT OF HYPERSENSITIVITY

A. Allergy skin testing (type I hypersensitivity)

B. Testing for types II and III hypersensitivity

C. Contact dermatitis and delayed (-type) hypersensitivity (type IV)

Study Questions

Review Questions

Glossary

Index

 

An aparitie	9 Mar. 2021
Autor	Dr. Thao Doan, Dr. Susan M. Viselli Ph.D., Dr. Fabio Lievano MD, Dr. Michelle Swanson-Mungerson PhD
Dimensiuni	27.7 x 1.9 x 21.5 cm
Editura	LWW
Format	Paperback
ISBN	9781975172602
Limba	Engleza
Nr pag	400