Kidney Transplantation in Sensitized Patients

Description:

This book presents state of the art knowledge on all aspects of kidney transplantation in recipients in whom desensitization strategies are necessary in order to overcome immunologic barriers such as anti-human leukocyte antigen (HLA) donor-specific antibody and ABO blood group incompatibility. Readers will find detailed, up-to-date information on the various immunomodulating therapies that may be employed in these circumstances and the outcomes that may be expected. Full guidance is provided on preoperative evaluation and management and post-transplantation care. In addition, the pathology of antibody-mediated rejection and acute cellular rejection in this context is discussed. For most patients with end-stage renal disease, kidney transplantation offers significant benefits compared with dialysis, but especially sensitization to HLAs remains a major clinical obstacle to success. Kidney Transplantation in Sensitized Patients will assist in achieving optimal results in individual patients. It will be an important resource for everyone involved in the care of kidney transplant recipients.

Table of Contents:

1. Introduction to Kidney Transplantation in sensitized patients

2. Preoperative Evaluation of Sensitized Patients

3. Preoperative Management (Desensitization)

4. Induction and Maintenance Immunosuppressants in Sensitized Renal Allograft Recipients

5. Postoperative Management

6. Complication from Desensitization

7. Treatment of Rejection in Desensitized KT Patients

8. Pathology of the Allograft Kidney

9. Postoperative Results