Kidney Transplantation, Bioengineering, and Regeneration, Kidney Transplantation in the Regenerative Medicine Era

Description:

Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement.

In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney.

• Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair
• Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation
• Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research
• Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function

·  Introduction

·  Part I: Kidney Transplantation

·  Section I: Epidemiology of Kidney Disease and Transplantation

·  Chapter 1. Epidemiology of End-Stage Renal Failure: The Burden of Kidney Diseases to Global Health

·  Chapter 2. Transplant Programs Worldwide and the Spanish Miracle

·  Section II: Donor Selection and Allocation

·  Chapter 3. The Deceased Kidney Donor

·  Chapter 4. The Living Donor

·  Chapter 5. Criteria for Kidney Allocation in the United States

·  Chapter 6. Strategies to Increase the Donor Pool

·  Section III: Kidney Preservation and Transplant Procedures

·  Chapter 7. Kidney Preservation

·  Chapter 8. Ex-vivo Normothermic Perfusion in Renal Transplantation

·  Chapter 9. Kidney Transplant Recipient Surgery

·  Chapter 10. Robotic-Assisted Kidney Transplantation

·  Chapter 11. Orthotopic Kidney Transplantation

·  Chapter 12. Kidney Transplantation Combined With Other Organs

·  Chapter 13. Pediatric Renal Transplantation

·  Section IV: Kidney Recipient: Before and Peritransplant

·  Chapter 14. Indications for Renal Transplantation: Evaluation of Transplant Candidates

·  Abstract

·  Chapter 15. Early Postoperative ICU Care of the Kidney Transplant Recipient

·  Chapter 16. Approaches to Minimize Delayed Graft Function in Renal Transplantation

·  Section V: Transplantation Immunology and Immunomodulation

·  Chapter 17. Histocompatibility Testing in the Transplant Setting

·  Chapter 18. The Immune Response to the Allograft

·  Chapter 19. Induction Immunosuppression in Kidney Transplantation

·  Chapter 20. Maintenance Immunosuppression in Kidney Transplantation

·  Chapter 21. Novel Drugs in Kidney Transplantation

·  Chapter 22. Hematopoietic Stem Cell Transplantation for Induction of Allograft Tolerance

·  Chapter 23. Regulatory T Cell Therapy in Transplantation

·  Chapter 24. Mesenchymal Stromal Cells to Improve Solid Organ Transplant Outcome:

·  Chapter 25. Renal Transplantation Across HLA and ABO Barriers

·  Section VI: Graft Monitoring Tools

·  Chapter 26. Pathology of the Renal Allograft

·  Chapter 27. Imaging-Based Monitoring of the Renal Graft

·  Chapter 28. Immune Monitoring in Kidney Transplantation

·  Chapter 29. Renal Function Measurements

·  Chapter 30. Pharmacokinetics and Genomics of Immunosuppressive Drugs

·  Chapter 31. Gene Expression Technology Applied to Kidney Transplantation

·  Section VII: Early Posttransplant Immune Events

·  Chapter 32. Acute Cellular Rejection

·  Chapter 33. Acute Antibody-Mediated Rejection

·  Section VIII: Early and Late Complications

·  Chapter 34. Vascular Complications in Renal Transplantation

·  Chapter 35. Infections in Kidney Transplant Recipients

·  Chapter 36. Metabolic Disorders Following Kidney Transplantation

·  Chapter 37. Cancer After Kidney Transplantation

·  Chapter 38. Cardiovascular Disease and Renal Transplantation

·  Chapter 39. Graft and Patient Survival

·  Chapter 40. Urological Complications of the Renal Graft

·  Chapter 41. Impact of De Novo Donor-specific Alloantibody in Primary Renal Allografts

·  Chapter 42. De Novo and Recurrence of Renal Disease

·  Section X: Transplant Issues in Specific Patient Groups

·  Chapter 43. Kidney Transplantation in the Elderly

·  Chapter 44. Dual Kidney Transplantation

·  Chapter 45. Kidney Transplantation in the Diabetic Patient

·  Chapter 46. Kidney Transplantation in the Hepatitis C Infected Recipient

·  Chapter 47. Pregnancy After Kidney Transplantation

·  Chapter 48. Nutrition of the Kidney Transplant Recipients

·  Section XI: Ethics and Costs

·  Chapter 49. Kidney Transplantation in Developing Countries

·  Chapter 50. Health-Related Quality of Life Outcomes After Kidney Transplantation

·  Chapter 51. Costs of Kidney Transplantation

·  Section XII: Unmet Needs

·  Chapter 52. Kidney Transplantation: Have the Promises Been Kept and Needs Met

·  Chapter 53. Innovations in Kidney Transplant Research

·  Part II: Kidney Bioengineering and Regeneration

·  Section I: Introduction

·  Chapter 54. Converging Organ Transplantation Towards Regenerative Medicine

·  Chapter 55. A Systems Engineering Approach to Restoring Kidney Structure and Function

·  Abstract

·  Section II: Kidney Development

·  Chapter 56. Kidney Development in the Mammal

·  Chapter 57. Renal Branching Morphogenesis

·  Section III: Bioengineering

·  Chapter 58. Principles of Stem Cell Biology Applied to the Kidney

·  Chapter 59. Extracellular Matrix Biology Applied to the Kidney

·  Chapter 60. Interplay Between Growth Factor Receptors, Small GTPases, and Mechanical Stress in the Maintenance of Kidney Glomerular Homeostasis

·  Chapter 61. Bioengineering Approach to Immunomodulation

·  Chapter 62. Principles of Organ Bioengineering

·  Chapter 63. Recellularization of Kidney Scaffold With Stem Cells

·  Section IV: Bioreactors and Biomaterials

·  Chapter 64. Bioreactors for Cell Culture Systems and Organ Bioengineering

·  Chapter 65. Synthetic Biomaterial for Regenerative Medicine Applications

·  Chapter 66. Immune Responses to Biomaterials Used in Renal Engineering

·  Section V: Regeneration

·  Chapter 67. Regeneration of Kidney From Human Reprogrammed Stem Cells

·  Chapter 68. Bioprinting Complex 3D Tissue and Organs

·  Chapter 69. Principles of Kidney Regeneration

·  Chapter 70. Markers of Repair and Regeneration in the Marginal Kidney

·  Chapter 71. Nephron Repair in Mammals and Fish

·  Chapter 72. Imaging of Glomerular Regeneration

·  Chapter 73. Reversibility of Renal Fibrosis

·  Chapter 74. Pharmacological Induction of Kidney Regeneration

·  Chapter 75. Developmental Approaches to Kidney Regeneration

·  Section VI: Adult Cells for Regeneration

·  Chapter 76. Nephron Progenitors

·  Chapter 77. Urine Progenitor Cells for Potential Application in Renal Tissue Repair

·  Chapter 78. Endothelial Progenitor Cells in Kidney Disease

·  Section VII: Cell Therapy For Renal Tissue Repair

·  Chapter 79. Mesenchymal Stromal Cells for Acute Renal Injury

·  Chapter 80. Amniotic Fluid Cells: Kidney Injury and Regeneration

·  Chapter 81. Renal Cells From Spermatogonial Germline Stem Cells for Protection Against Kidney Injury

·  Chapter 82. Kidney-on-a-Chip: Technologies for Studying Pharmacological and Therapeutic Approaches to Kidney Repair

·  Chapter 83. Renal Replacement Devices

·  Chapter 84. Xenotransplantation and Kidney Regenerative Technology

·  Chapter 85. Embryonic Organoid Transplantation

·  Chapter 86. Lineage Reprogramming Toward Kidney Regeneration

·  Chapter 87. Regenerating Kidney Structure and Function: An Industry Perspective