Intrahepatic Cholangiocarcinoma: Diagnosis and Management

This book provides a comprehensive review of the epidemiology, molecular pathogenesis, diagnosis and treatment of intrahepatic cholangiocarcinoma (ICC).  It brings together an impressive group of international experts in cholangiocarcinoma research and clinical care.  The book was organized and written to aid the clinician’s understanding of emerging research in cholangiocarcinoma and its application to the clinical care of patients with ICC. Each chapter details the scientific evidence to support clinical decisions that are needed to care for these complex patients.  Focused chapters detail the epidemiology, diagnostic evaluation, as well as staging and prognosis of this disease. In addition to dedicated chapters on surgical management of ICC, a broad emphasis on locoregional therapies, including percutaneous ablation and transarterial therapies, is included. An up-to-date overview of the molecular pathogenesis and pathological assessment of ICC is detailed prior to chapters focusing on systemic chemotherapy and emerging novel therapy options.

Intrahepatic Cholangiocarcinoma is not only an invaluable resource for many as they seek to provide the best multidisciplinary cancer care to patients with ICC, but also an opportunity to identify new avenues of scientific discovery that lead to significant advances in the diagnosis and management of ICC.

Table of Contents:

Epidemiology and Risk Factors

Pages 1-10

Katkhuda, Riham (et al.)

Clinical Presentation and Diagnosis

Pages 11-20

Abbasi, Arezou (et al.)

Staging and Prognosis

Pages 21-51

Rekman, Janelle F. (et al.)

Imaging

Pages 53-66

Khoshpouri, Pegah (et al.)

Surgical Treatment

Pages 67-83

Margonis, Georgios Antonios (et al.)

Management of the Nodal Basin

Pages 85-94

Guglielmi, Alfredo (et al.)

Pathologic Assessment

Pages 95-105

Swanson, Benjamin J.

Systemic Therapy

Pages 107-121

Jin, Ning (et al.)

Percutaneous Ablation

Pages 123-134

Qian, Guojun (et al.)

Transarterial Therapies

Pages 135-150

Shamimi-Noori, Susan (et al.)

Radiotherapy

Pages 151-165

Keane, Florence K. (et al.)

Molecular Pathogenesis: From Inflammation and Cholestasis to a Microenvironment-Driven Tumor

Pages 167-182

Milani, Eleonora (et al.)

Clinical Trials and Novel/Emerging Treatment

Pages 183-208

Mizrahi, Jonathan D. (et al.)