Hypoparathyroidism

• First textbook to be devoted entirely to hypoparathyroidism
• Provides essential, up-to-date information on the pathology, diagnosis, and treatment of hypoparathyroidism 
• Covers a wide range of hypoparathyroid disorders Discusses novel replacement therapy with PTH 1-34 and 1-84 
• Includes a chapter on surgical hypoparathyroidism

About this book

Hypoparathyroidism, a condition in which insufficient parathyroid hormone (PTH) is produced to maintain normocalcemia is associated with a variety of acute and chronic symptoms and complications due to hypocalcemia. Replacement therapy utilizing PTH has long been awaited, and this book is new and very timely as it coincides with the  publication of results on the role of the PTH molecule in the pharmacological management of this disorder. This advance is sparking renewed interest in hypoparathyroidism, which is attributable to neck surgery in most cases and to inherited disorders in a minority.

Hypoparathyroidism has been written by acknowledged experts in the field and provides essential, up-to-date information on the pathology, diagnosis, and treatment of the condition. It opens by addressing in detail the anatomy and physiology of the parathyroids and describing the epidemiology and clinical presentation of hypoparathyroidism. The full range of hypoparathyroid disorders are then discussed, including the various genetic forms, postoperative hypoparathyroidism, and other forms of acquired hypoparathyroidism. Individual chapters focus on refractory disease, the impact of the condition on bone, and the management of acute hypocalcemia. Both conventional treatment for hypoparathyroidism and the novel replacement therapy with PTH  peptides are then thoroughly examined. Pseudohypoparathyroidism is also extensively discussed, with information on the various forms, differential diagnosis, and genetic testing. This book will be of interest to all endocrinologists, and also to surgeons and internal medicine physicians.

Table of contents (38 chapters)

·         The History: From Ivar Sandström to the Sequence of Parathyroid Hormone

Mannstadt, Michael (et al.)

Pages 3-10

·         Embryology of the Parathyroid Glands

Manley, Nancy R.

Pages 11-18

·         PTH and PTH-Related Peptides

Isaia, Giancarlo (et al.)

Pages 19-24

·         PTH Assays and Their Clinical Significance

D’Amour, Pierre

Pages 25-32

·         Control of Parathyroid Hormone Secretion by Extracellular Ca

Brown, Edward M.

Pages 33-48

·         Phosphate Control of PTH Secretion

Messa, Piergiorgio

Pages 49-59

·         Role of Magnesium in Parathyroid Physiology

Steen, Oren (et al.)

Pages 61-67

·         The PTH/Vitamin D/FGF23 Axis

Goltzman, David (et al.)

Pages 69-79

·         The PTH Receptorsome and Transduction Pathways

Gardella, Thomas J.

Pages 81-87

·         G Protein Gsα and

Bastepe, Murat

Pages 89-98

·         Parathyroid Hormone Actions on Bone and Kidney

Pajevic, Paola Divieti (et al.)

Pages 99-109

·         PTH and PTHrP: Nonclassical Targets

Cianferotti, Luisella

Pages 111-126

·         In Vitro Cellular Models of Parathyroid Cells

Gomez, Ana Rita (et al.)

Pages 127-135

·         Epidemiology of Hypoparathyroidism

Clarke, Bart L.

Pages 139-154

·         Clinical Presentation of Hypoparathyroidism

Wheeler, Amber L. (et al.)

Pages 155-165

·         Familial Isolated Hypoparathyroidism

Hendy, Geoffrey N. (et al.)

Pages 167-175

·         Autoimmune Hypoparathyroidism

Kemp, E. Helen (et al.)

Pages 177-188

·         DiGeorge Syndrome

Tarsitano, Marina (et al.)

Pages 189-197

·         Hypoparathyroidism, Deafness, and Renal Anomaly Syndrome

Nesbit, M. Andrew

Pages 199-213

·         Hypoparathyroidism, Dwarfism, Medullary Stenosis of Long Bones, and Eye Abnormalities (Kenny-Caffey Syndrome) and Hypoparathyroidism, Retardation, and Dysmorphism (Sanjad-Sakati) Syndrome

Hershkovitz, Eli (et al.)

Pages 215-224

·         Hypoparathyroidism in Mitochondrial Disorders

Orsucci, Daniele (et al.)

Pages 225-230

·         Postoperative Hypoparathyroidism

Tonelli, Francesco (et al.)

Pages 231-247

·         Hypoparathyroidism During Pregnancy, Lactation, and Fetal/Neonatal Development

Kovacs, Christopher S.

Pages 249-269

·         Rare Causes of Acquired Hypoparathyroidism

Wémeau, Jean-Louis

Pages 271-278

·         Refractory Hypoparathyroidism

Masi, Laura

Pages 279-286

·         Bone Histomorphometry in Hypoparathyroidism

Dempster, David W.

Pages 287-296

·         Management of Acute Hypocalcemia

Cooper, Mark Stuart (et al.)

Pages 297-301

·         Conventional Treatment of Chronic Hypoparathyroidism

Rejnmark, Lars

Pages 303-312

·         Follow-up in Chronic Hypoparathyroidism

Mannstadt, Michael (et al.)

Pages 313-318

·         Treatment of Hypoparathyroidism with Parathyroid Hormone 1–34

Winer, Karen K. (et al.)

Pages 319-331

·         Replacement Therapy with PTH(1–84)

Rubin, Mishaela R. (et al.)

Pages 333-342

·         Classification of Pseudohypoparathyroidism and Differential Diagnosis

Mantovani, Giovanna (et al.)

Pages 345-354

·         Pseudohypoparathyroidism Type 1a, Pseudopseudohypoparathyroidism, and Albright Hereditary Osteodystrophy

Weinstein, Lee S.

Pages 355-362

·         Pseudohypoparathyroidism Type Ib (PHP-Ib): PTH-Resistant Hypocalcemia and Hyperphosphatemia Due to Abnormal

Jüppner, Harald

Pages 363-372

·         Genetic Testing in Pseudohypoparathyroidism

Linglart, Agnès (et al.)

Pages 373-388

·         Blomstrand’s Chondrodysplasia

Giusti, Francesca (et al.)

Pages 389-395

·         Hypoparathyroidism During Magnesium Deficiency or Excess

Rizzoli, René

Pages 397-403

·         Advocacy and Hypoparathyroidism in the Twenty-First Century

Sanders, James E. (et al.)

Pages 407-414