Harrison’s Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)

Description:

 

MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine—Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforce the text material and provide a robust platform for further study and research.

 

Table of Contents:

PART 1 The Profession of Medicine

1 The Practice of Medicine

2 Promoting Good Health

3 Decision-Making in Clinical Medicine

4 Screening and Prevention of Disease

5 Health Care Systems in Developed Countries

6 The Safety and Quality of Health Care

7 Racial and Ethnic Disparities in Health Care

8 Ethical Issues in Clinical Medicine

9 Palliative and End-of-Life Care

PART 2 Cardinal Manifestations and Presentation of Diseases

SECTION 1 Pain

10 Pain: Pathophysiology and Management

11 Chest Discomfort

12 Abdominal Pain

13 Headache

14 Back and Neck Pain

SECTION 2 Alterations in Body Temperature

15 Fever

16 Fever and Rash

17 Fever of Unknown Origin

SECTION 3 Nervous System Dysfunction

18 Syncope

19 Dizziness and Vertigo

20 Fatigue

21 Neurologic Causes of Weakness and Paralysis

22 Numbness, Tingling, and Sensory Loss

23 Gait Disorders, Imbalance, and Falls

24 Confusion and Delirium

25 Dementia

26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes, and Other Cerebral Disorders

27 Sleep Disorders

SECTION 4 Disorders of Eyes, Ears, Nose, and Throat

28 Disorders of the Eye

29 Disorders of Smell and Taste

30 Disorders of Hearing

31 Sore Throat, Earache, and Upper Respiratory Symptoms

32 Oral Manifestations of Disease

SECTION 5 Alterations in Circulatory and Respiratory Functions

33 Dyspnea

34 Cough

35 Hemoptysis

36 Hypoxia and Cyanosis

37 Edema

38 Approach to the Patient with a Heart Murmur

39 Palpitations

SECTION 6 Alterations in Gastrointestinal Function

40 Dysphagia

41 Nausea, Vomiting, and Indigestion

42 Diarrhea and Constipation

43 Unintentional Weight Loss

44 Gastrointestinal Bleeding

45 Jaundice

46 Abdominal Swelling and Ascites

SECTION 7 Alterations in Renal and Urinary Tract Function

47 Dysuria, Bladder Pain, and the Interstitial Cystitis/Bladder Pain Syndrome

48 Azotemia and Urinary Abnormalities

49 Fluid and Electrolyte Disturbances

50 Hypercalcemia and Hypocalcemia

51 Acidosis and Alkalosis

SECTION 8 Alterations in the Skin

52 Approach to the Patient with a Skin Disorder

53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders

54 Skin Manifestations of Internal Disease

55 Immunologically Mediated Skin Diseases

56 Cutaneous Drug Reactions

57 Photosensitivity and Other Reactions to Light

SECTION 9 Hematologic Alterations

58 Interpreting Peripheral Blood Smears

59 Anemia and Polycythemia

60 Disorders of Granulocytes and Monocytes

61 Bleeding and Thrombosis

62 Enlargement of Lymph Nodes and Spleen

PART 3 Pharmacology

63 Principles of Clinical Pharmacology

64 Pharmacogenomics

PART 4 Oncology and Hematology

SECTION 1 Neoplastic Disorders

65 Approach to the Patient with Cancer

66 Prevention and Early Detection of Cancer

67 Cancer Genetics

68 Cancer Cell Biology

69 Principles of Cancer Treatment

70 Infections in Patients with Cancer

71 Oncologic Emergencies

72 Cancer of the Skin

73 Head and Neck Cancer

74 Neoplasms of the Lung

75 Breast Cancer

76 Upper Gastrointestinal Tract Cancers

77 Lower Gastrointestinal Cancers

78 Tumors of the Liver and Biliary Tree

79 Pancreatic Cancer

80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas

81 Renal Cell Carcinoma

82 Cancer of the Bladder and Urinary Tract

83 Benign and Malignant Diseases of the Prostate

84 Testicular Cancer

85 Gynecologic Malignancies

86 Primary and Metastatic Tumors of the Nervous System

87 Soft Tissue and Bone Sarcomas and Bone Metastases

88 Carcinoma of Unknown Primary

89 Paraneoplastic Syndromes: Endocrinologic/Hematologic

90 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis

91 Late Consequences of Cancer and Its Treatment

SECTION 2 Hematopoietic Disorders

92 Hematopoietic Stem Cells

93 Iron Deficiency and Other Hypoproliferative Anemias

94 Disorders of Hemoglobin

95 Megaloblastic Anemias

96 Hemolytic Anemias

97 Anemia Due to Acute Blood Loss

98 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia

99 Polycythemia Vera and Other Myeloproliferative Neoplasms

100 Acute Myeloid Leukemia

101 Chronic Myeloid Leukemia

102 Acute Lymphoid Leukemia

103 Chronic Lymphocytic Leukemia

104 Non-Hodgkin’s Lymphoma

105 Hodgkin’s Lymphoma

106 Less Common Hematologic Malignancies

107 Plasma Cell Disorders

108 Amyloidosis

109 Transfusion Biology and Therapy

110 Hematopoietic Cell Transplantation

SECTION 3 Disorders of Hemostasis

111 Disorders of Platelets and Vessel Wall

112 Coagulation Disorders

113 Arterial and Venous Thrombosis

114 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

PART 5 Infectious Diseases

SECTION 1 Basic Considerations in Infectious Diseases

115 Approach to the Patient with an Infectious Disease

116 Molecular Mechanisms of Microbial Pathogenesis

117 Approach to the Acutely Ill Infected Febrile Patient

118 Immunization Principles and Vaccine Use

119 Health Recommendations for International Travel

120 Climate Change and Infectious Disease

SECTION 2 Clinical Syndromes: Community-Acquired Infections

121 Pneumonia

122 Lung Abscess

123 Infective Endocarditis

124 Infections of the Skin, Muscles, and Soft Tissues

125 Infectious Arthritis

126 Osteomyelitis

127 Intraabdominal Infections and Abscesses

128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning

129 Clostridium difficile Infection, Including Pseudomembranous Colitis

130 Urinary Tract Infections, Pyelonephritis, and Prostatitis

131 Sexually Transmitted Infections: Overview and Clinical Approach

132 Encephalitis

133 Acute Meningitis

134 Chronic and Recurrent Meningitis

135 Brain Abscess and Empyema

136 Infectious Complications of Bites

SECTION 3 Clinical Syndromes: Health Care–Associated Infections

137 Infections Acquired in Health Care Facilities

138 Infections in Transplant Recipients

SECTION 4 Therapy for Bacterial Diseases

139 Treatment and Prophylaxis of Bacterial Infections

140 Bacterial Resistance to Antimicrobial Agents

SECTION 5 Diseases Caused by Gram-Positive Bacteria

141 Pneumococcal Infections

142 Staphylococcal Infections

143 Streptococcal Infections

144 Enterococcal Infections

145 Diphtheria and Other Corynebacterial Infections

146 Listeria monocytogenes Infections

147 Tetanus

148 Botulism

149 Gas Gangrene and Other Clostridial Infections

SECTION 6 Diseases Caused by Gram-Negative Bacteria

150 Meningococcal Infections

151 Gonococcal Infections

152 Haemophilus and Moraxella Infections

153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria

154 Legionella Infections

155 Pertussis and Other Bordetella Infections

156 Diseases Caused by Gram-Negative Enteric Bacilli

157 Acinetobacter Infections

158 Helicobacter pylori Infections

159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species

160 Salmonellosis

161 Shigellosis

162 Infections Due to Campylobacter and Related Organisms

163 Cholera and Other Vibrioses

164 Brucellosis

165 Tularemia

166 Plague and Other Yersinia Infections

167 Bartonella Infections, Including Cat-Scratch Disease

168 Donovanosis

SECTION 7 Miscellaneous Bacterial Infections

169 Nocardiosis

170 Actinomycosis

171 Whipple’s Disease

172 Infections Due to Mixed Anaerobic Organisms

SECTION 8 Mycobacterial Diseases

173 Tuberculosis

174 Leprosy

175 Nontuberculous Mycobacterial Infections

176 Antimycobacterial Agents

SECTION 9 Spirochetal Diseases

177 Syphilis

178 Endemic Treponematoses

179 Leptospirosis

180 Relapsing Fever

181 Lyme Borreliosis

SECTION 10 Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae

182 Rickettsial Diseases

183 Infections Due to Mycoplasmas

184 Chlamydial Infections

SECTION 11 Viral Diseases: General Considerations

185 Medical Virology

186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs

SECTION 12 Infections Due to DNA Viruses

187 Herpes Simplex Virus Infections

188 Varicella-Zoster Virus Infections

189 Epstein-Barr Virus Infections, Including Infectious Mononucleosis

190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8

191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections

192 Parvovirus Infections

193 Human Papillomavirus Infections

SECTION 13 Infections Due to DNA and RNA Respiratory Viruses

194 Common Viral Respiratory Infections

195 Influenza

SECTION 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

196 The Human Retroviruses

197 Human Immunodeficiency Virus Disease: AIDS and Related Disorders

SECTION 15 Infections Due to RNA Viruses

198 Viral Gastroenteritis

199 Enterovirus, Parechovirus, and Reovirus Infections

200 Measles (Rubeola)

201 Rubella (German Measles)

202 Mumps

203 Rabies and Other Rhabdovirus Infections

204 Arthropod-Borne and Rodent-Borne Virus Infections

205 Ebolavirus and Marburgvirus Infections

SECTION 16 Fungal Infections

206 Diagnosis and Treatment of Fungal Infections

207 Histoplasmosis

208 Coccidioidomycosis

209 Blastomycosis

210 Cryptococcosis

211 Candidiasis

212 Aspergillosis

213 Mucormycosis

214 Superficial Mycoses and Less Common Systemic Mycoses

215 Pneumocystis Infections

SECTION 17 Protozoal and Helminthic Infections: General Considerations

216 Introduction to Parasitic Infections

217 Agents Used to Treat Parasitic Infections

SECTION 18 Protozoal Infections

218 Amebiasis and Infection with Free-Living Amebae

219 Malaria

220 Babesiosis

221 Leishmaniasis

222 Chagas Disease and African Trypanosomiasis

223 Toxoplasma Infections

224 Protozoal Intestinal Infections and Trichomoniasis

SECTION 19 Helminthic Infections

225 Introduction to Helminthic Infections

226 Trichinellosis and Other Tissue Nematode Infections

227 Intestinal Nematode Infections

228 Filarial and Related Infections

229 Schistosomiasis and Other Trematode Infections

230 Cestode Infections

PART 6 Disorders of the Cardiovascular System

SECTION 1 Introduction to Cardiovascular Disorders

231 Approach to the Patient with Possible Cardiovascular Disease

232 Basic Biology of the Cardiovascular System

233 Epidemiology of Cardiovascular Disease

SECTION 2 Diagnosis of Cardiovascular Disorders

234 Physical Examination of the Cardiovascular System

235 Electrocardiography

236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging

237 Diagnostic Cardiac Catheterization and Coronary Angiography

SECTION 3 Disorders of Rhythm

238 Principles of Electrophysiology

239 The Bradyarrhythmias: Disorders of the Sinoatrial Node

240 The Bradyarrhythmias: Disorders of the Atrioventricular Node

241 Approach to Supraventricular Tachyarrhythmias

242 Physiologic and Nonphysiologic Sinus Tachycardia

243 Focal Atrial Tachycardia

244 Paroxysmal Supraventricular Tachycardias

245 Common Atrial Flutter, Macroreentrant, and Multifocal Atrial Tachycardias

246 Atrial Fibrillation

247 Approach to Ventricular Arrhythmias

248 Premature Ventricular Beats, Non-Sustained Ventricular Tachycardia, and Idioventricular Rhythm

249 Sustained Ventricular Tachycardia

250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation

251 Electrical Storm and Incessant VT

SECTION 4 Disorders of the Heart

252 Heart Failure: Pathophysiology and Diagnosis

253 Heart Failure: Management

254 Cardiomyopathy and Myocarditis

255 Cardiac Transplantation and Prolonged Assisted Circulation

256 Aortic Valve Disease

257 Aortic Regurgitation

258 Mitral Stenosis

259 Mitral Regurgitation

260 Mitral Valve Prolapse

261 Tricuspid Valve Disease

262 Pulmonic Valve Disease

263 Multiple and Mixed Valvular Heart Disease

264 Congenital Heart Disease in the Adult

265 Pericardial Disease

266 Atrial Myxoma and Other Cardiac Tumors

SECTION 5 Coronary and Peripheral Vascular Disease

267 Ischemic Heart Disease

268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)

269 ST-Segment Elevation Myocardial Infarction

270 Percutaneous Coronary Interventions and Other Interventional Procedures

271 Hypertensive Vascular Disease

272 Renovascular Disease

273 Deep Venous Thrombosis and Pulmonary Thromboembolism

274 Diseases of the Aorta

275 Arterial Diseases of the Extremities

276 Chronic Venous Disease and Lymphedema

277 Pulmonary Hypertension

PART 7 Disorders of the Respiratory System

SECTION 1 Diagnosis of Respiratory Disorders

278 Approach to the Patient with Disease of the Respiratory System

279 Disturbances of Respiratory Function

280 Diagnostic Procedures in Respiratory Disease

SECTION 2 Diseases of the Respiratory System

281 Asthma

282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia

283 Occupational and Environmental Lung Disease

284 Bronchiectasis

285 Cystic Fibrosis

286 Chronic Obstructive Pulmonary Disease

287 Interstitial Lung Disease

288 Disorders of the Pleura

289 Disorders of the Mediastinum

290 Disorders of Ventilation

291 Sleep Apnea

292 Lung Transplantation

PART 8 Critical Care Medicine

SECTION 1 Respiratory Critical Care

293 Approach to the Patient with Critical Illness

294 Acute Respiratory Distress Syndrome

295 Mechanical Ventilatory Support

SECTION 2 Shock and Cardiac Arrest

296 Approach to the Patient with Shock

297 Sepsis and Septic Shock

298 Cardiogenic Shock and Pulmonary Edema

299 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death

SECTION 3 Neurologic Critical Care

300 Coma

301 Severe Acute Encephalopathies and Critical Care Weakness

302 Subarachnoid Hemorrhage

PART 9 Disorders of the Kidney and Urinary Tract

303 Cellular and Molecular Biology of the Kidney

304 Acute Kidney Injury

305 Chronic Kidney Disease

306 Dialysis in the Treatment of Renal Failure

307 Transplantation in the Treatment of Renal Failure

308 Glomerular Diseases

309 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development

310 Tubulointerstitial Diseases of the Kidney

311 Vascular Injury to the Kidney

312 Nephrolithiasis

313 Urinary Tract Obstruction

PART 10 Disorders of the Gastrointestinal System

SECTION 1 Disorders of the Alimentary Tract

314 Approach to the Patient with Gastrointestinal Disease

315 Gastrointestinal Endoscopy

316 Diseases of the Esophagus

317 Peptic Ulcer Disease and Related Disorders

318 Disorders of Absorption

319 Inflammatory Bowel Disease

320 Irritable Bowel Syndrome

321 Diverticular Disease and Common Anorectal Disorders

322 Mesenteric Vascular Insufficiency

323 Acute Intestinal Obstruction

324 Acute Appendicitis and Peritonitis

SECTION 2 Nutrition

325 Nutrient Requirements and Dietary Assessment

326 Vitamin and Trace Mineral Deficiency and Excess

327 Malnutrition and Nutritional Assessment

328 Enteral and Parenteral Nutrition

SECTION 3 Liver and Biliary Tract Disease

329 Approach to the Patient with Liver Disease

330 Evaluation of Liver Function

331 The Hyperbilirubinemias

332 Acute Viral Hepatitis

333 Toxic and Drug-Induced Hepatitis

334 Chronic Hepatitis

335 Alcoholic Liver Disease

336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis

337 Cirrhosis and Its Complications

338 Liver Transplantation

339 Diseases of the Gallbladder and Bile Ducts

SECTION 4 Disorders of the Pancreas

340 Approach to the Patient with Pancreatic Disease

341 Acute and Chronic Pancreatitis

PART 11 Immune-Mediated, Inflammatory, and Rheumatologic Disorders

SECTION 1 The Immune System in Health and Disease

342 Introduction to the Immune System

343 The Major Histocompatibility Complex

344 Primary Immune Deficiency Diseases

SECTION 2 Disorders of Immune-Mediated Injury

345 Urticaria, Angioedema, and Allergic Rhinitis

346 Anaphylaxis

347 Mastocytosis

348 Autoimmunity and Autoimmune Diseases

349 Systemic Lupus Erythematosus

350 Antiphospholipid Syndrome

351 Rheumatoid Arthritis

352 Acute Rheumatic Fever

353 Systemic Sclerosis (Scleroderma) and Related Disorders

354 Sjögren’s Syndrome

355 The Spondyloarthritides

356 The Vasculitis Syndromes

357 Behçet’s Syndrome

358 Inflammatory Myopathies

359 Relapsing Polychondritis

360 Sarcoidosis

361 IgG4-Related Disease

362 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases

SECTION 3 Disorders of the Joints and Adjacent Tissues

363 Approach to Articular and Musculoskeletal Disorders

364 Osteoarthritis

365 Gout and Other Crystal-Associated Arthropathies

366 Fibromyalgia

367 Arthritis Associated with Systemic Disease, and Other Arthritides

368 Periarticular Disorders of the Extremities

PART 12 Endocrinology and Metabolism

SECTION 1 Endocrinology

369 Approach to the Patient with Endocrine Disorders

370 Mechanisms of Hormone Action

371 Physiology of Anterior Pituitary Hormones

372 Hypopituitarism

373 Pituitary Tumor Syndromes

374 Disorders of the Neurohypophysis

375 Thyroid Gland Physiology and Testing

376 Hypothyroidism

377 Hyperthyroidism

378 Thyroid Nodular Disease and Thyroid Cancer

379 Disorders of the Adrenal Cortex

380 Pheochromocytoma

381 Multiple Endocrine Neoplasia

382 Autoimmune Polyendocrine Syndromes

SECTION 2 Sex- and Gender-Based Medicine

383 Disorders of Sex Development

384 Disorders of the Testes and Male Reproductive System

385 Disorders of the Female Reproductive System

386 Menstrual Disorders and Pelvic Pain

387 Hirsutism

388 Menopause and Postmenopausal Hormone Therapy

389 Infertility and Contraception

390 Sexual Dysfunction

391 Women’s Health

392 Men’s Health

393 Lesbian, Gay, Bisexual, and Transgender (LGBT) Health

SECTION 3 Obesity, Diabetes Mellitus, and Metabolic Syndrome

394 Pathobiology of Obesity

395 Evaluation and Management of Obesity

396 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology

397 Diabetes Mellitus: Management and Therapies

398 Diabetes Mellitus: Complications

399 Hypoglycemia

400 Disorders of Lipoprotein Metabolism

401 The Metabolic Syndrome

SECTION 4 Disorders of Bone and Mineral Metabolism

402 Bone and Mineral Metabolism in Health and Disease

403 Disorders of the Parathyroid Gland and Calcium Homeostasis

404 Osteoporosis

405 Paget’s Disease and Other Dysplasias of Bone

SECTION 5 Disorders of Intermediary Metabolism

406 Heritable Disorders of Connective Tissue

407 Hemochromatosis

408 Wilson’s Disease

409 The Porphyrias

410 Disorders of Purine and Pyrimidine Metabolism

411 Lysosomal Storage Diseases

412 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism

413 Inherited Disorders of Amino Acid Metabolism in Adults

414 Inherited Defects of Membrane Transport

PART 13 Neurologic Disorders

SECTION 1 Diagnosis of Neurologic Disorders

415 Approach to the Patient with Neurologic Disease

416 Neuroimaging in Neurologic Disorders

417 Pathobiology of Neurologic Diseases

SECTION 2 Diseases of the Central Nervous System

418 Seizures and Epilepsy

419 Cerebrovascular Diseases

420 Ischemic Stroke

421 Intracranial Hemorrhage

422 Migraine and Other Primary Headache Disorders

423 Alzheimer’s Disease

424 Frontotemporal Dementia

425 Vascular Dementia

426 Dementia with Lewy Bodies

427 Parkinson’s Disease

428 Tremor, Chorea, and Other Movement Disorders

429 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

430 Prion Diseases

431 Ataxic Disorders

432 Disorders of the Autonomic Nervous System

433 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders

434 Diseases of the Spinal Cord

435 Concussion and Other Traumatic Brain Injuries

436 Multiple Sclerosis

437 Neuromyelitis Optica

SECTION 3 Nerve and Muscle Disorders

438 Peripheral Neuropathy

439 Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies

440 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction

441 Muscular Dystrophies and Other Muscle Diseases

SECTION 4 Chronic Fatigue Syndrome

442 Chronic Fatigue Syndrome

SECTION 5 Psychiatric and Addiction Disorders

443 Biology of Psychiatric Disorders

444 Psychiatric Disorders

445 Alcohol and Alcohol Use Disorders

446 Opioid-Related Disorders

447 Cocaine and Other Commonly Used Drugs

448 Nicotine Addiction

PART 14 Poisoning, Drug Overdose, and Envenomation

449 Heavy Metal Poisoning

450 Poisoning and Drug Overdose

451 Disorders Caused by Venomous Snakebites and Marine Animal Exposures

452 Ectoparasite Infestations and Arthropod Injuries

PART 15 Disorders Associated with Environmental Exposures

453 Altitude Illness

454 Hypothermia and Peripheral Cold Injuries

455 Heat-Related Illnesses

PART 16 Genes, the Environment, and Disease

456 Principles of Human Genetics

457 The Practice of Genetics in Clinical Medicine

458 Gene and Cell Based Therapy in Clinical Medicine

459 The Human Microbiome

PART 17 Global Medicine

460 Global Issues in Medicine

461 Worldwide Changes in Patterns of Infectious Disease

462 Primary Care and Global Health

PART 18 Aging

463 The Biology of Aging

464 Clinical Problems Associated with the Aging Process

PART 19 Consultative Medicine

465 Approach to Medical Consultation

466 Medical Disorders During Pregnancy

467 Medical Evaluation of the Surgical Patient

PART 20 Frontiers

468 Behavioral Economics and Health

469 Complementary, Alternative, and Integrative Health Approaches

470 Telomere Disease

471 The Role of Epigenetics in Disease and Treatment

472 Mitochondrial DNA and Heritable Traits and Diseases

473 Applications of Stem Cell Biology in Clinical Medicine

474 Microbial Genomics and Infectious Disease

475 The Role of Circadian Biology in Health and Disease

476 Network Medicine: Systems Biology in Health and Disease

477 Emerging Neurotherapeutic Technologies

Index

 

 

An aparitie	2018
Autor	J. Larry Jameson, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, Dan L. Longo and Joseph Loscalzo
Dimensiuni	22.6 x 10.9 x 28.4 cm
Editura	McGraw-Hill Education
Format	Hardback
ISBN	9781259644030
Limba	Engleza
Nr pag	4048