- More than 400 chapters authored by a veritable "Who’s Who" of modern medicine
- A practical, templated organization with an emphasis on up-to-date, evidence-based references
- New chapters on Population Health, Effects of Climate Change on Health, Bradycardias, Transgender Medicine, Whipple Disease, COVID-19 Virology and Pathobiology, COVID-19 Epidemiology/Clinical Manifestations/Diagnosis/Community Prevention, COVID-19 Treatment and Vaccination, Polyomaviruses, and more
- Thousands of algorithms, figures, and tables that make its information readily accessible
- Over 100 supplementary videos, heart sounds, and key references
- Available in print and on a variety of electronic devices
- Continuously updated by Lee Goldman, MD
- An digital version is included with purchase. The digital allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
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1 Approach to Medicine, the Patient, and the Medical Profession 2 Bioethics in the Practice of Medicine 3 Palliative Care 4 Disparities in Health and Health Care 5 Global Health 6 History and Physical Examination 7 Approach to the Patient with Abnormal Vital Signs 8 Statistical Interpretation of Data for Clinical Decisions 9 Measuring Health and Health Care 10 Quality, Safety, and Value 11 Comprehensive Chronic Disease Management 11 Population Health 12 The Periodic Health Examination 13 Diet and Nutrition 14 Physical Activity 15 Immunization 16 Principles of Occupational and Environmental Medicine 17 Effects of Climate Change on Health 18 Radiation Injury 19 Bioterrorism 20 Chronic Poisoning: Trace Metals and Others 21 Adolescent Medicine 22 Epidemiology of Aging 23 Geriatric Assessment 24 Common Clinical Sequelae of Aging 25 Principles of Drug Therapy 26 Pain 27 Delirium in the Older Patient 27 Biology of Addiction 28 Immunomodulatory Drugs 29 Biologic Agents and Signaling Inhibitors 30 Complementary, Alternative, and Integrative Medicine 31 Principles of Genetics 32 Clinical Genomics – Genome Structure and Variation 33 Applications of Molecular Technologies to Clinical Medicine 34 Regenerative Medicine, Cell, and Gene Therapies 35 Innate and Adaptive Immunity 36 Tissue Injury and Repair 37 Complement System in Disease 38 Transplantation Immunology 39 Approach to the Patient with Possible Cardiovascular Disease 40 Epidemiology of Cardiovascular Disease 41 The Adaptive Immunse System 41 Cardiac and Circulatory Function 42 Mechanisms of Inflammation and Tissue Repair 42 Electrocardiography 43 Echocardiography 44 Noninvasive Cardiac Imaging 45 Heart Failure: Epidemiology, Pathobiology, and Diagnosis 46 Heart Failure: Treatment, Prevention, and Prognosis 47 Diseases of the Myocardium and Endocardium 48 Principles of Electrophysiology 49 Approach to the Patient with Suspected Arrhythmia 50 Catheterization and Angiography 50 Cardiac Arrest and Life-Threatening Arrhythmias 51 Bradycardias 52 Supraventricular Tachycardias 53 Ventricular Arrhythmias 54 Electrophysiologic Procedures and Surgery 55 Congenital Heart Disease in Adults 56 Chronic Ischemic Heart Disease 57 Acute Coronary Syndrome: Unstable Angina and Non-ST Elevation Myocardial Infarction 58 ST Elevation Acute Myocardial Infarction and Complications of Myocardial Infarction 59 Interventional and Surgical Treatment of Coronary Artery Disease 60 Valvular Heart Disease 61 Infective Endocarditis 62 Pericardial Diseases 63 Diseases of the Aorta 64 Arterial Hypertension 65 Atherosclerotic Peripheral Arterial Disease 66 Other Peripheral Arterial Diseases 67 Thrombotic Disorders: Hypercoagulable States 68 Venous Thrombosis and Embolism 69 Pulmonary Hypertension 70 Antithrombotic and Antiplatelet Therapy 71 Approach to the Patient with Respiratory Disease 72 Imaging in Pulmonary Disease 73 Respiratory Testing and Function 74 Disorders of Ventilatory Control 75 Asthma 76 Chronic Obstructive Pulmonary Disease 77 Cystic Fibrosis 78 Bronchiectasis, Atelectasis, Cysts, and Localized Lung Disorders 79 Alveolar Filling Disorders 80 Interstitial Lung Disease 81 Occupational Lung Disease 82 Physical and Chemical Injuries of the Lung 83 Sarcoidosis 84 Acute Bronchitis and Tracheitis 85 Overview of Pneumonia 86 Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum 87 Interventional and Surgical Approaches to Lung Disease 88 Approach to the Patient in a Critical Care Setting 89 Respiratory Monitoring in Critical Care 90 Acute Respiratory Failure 91 Mechanical Ventilation 92 Approach to the Patient with Shock 93 Cardiogenic Shock 94 Shock Syndromes Related to Sepsis 95 Disorders Due to Heat and Cold 96 Acute Poisoning 97 Medical Aspects of Trauma and Burns 98 Envenomation, Bites, and Stings 99 Rhabdomyolysis 100 Approach to the Patient with Renal Disease 101 Structure and Function of the Kidneys 102 Disorders of Sodium and Water Homeostasis 103 Potassium Disorders 104 Acid-Base Disorders 105 Disorders of Magnesium and Phosphorus 106 Acute Kidney Injury 107 Glomerular Disorders and Nephrotic Syndromes 108 Tubulointerstitial Diseases 109 Diabetes and the Kidney 110 Vascular Disorders of the Kidney 111 Nephrolithiasis 112 Cystic Kidney Diseases 113 Hereditary and Developmental Abnormalities of the Urinary Tract 114 Benign Prostatic Hyperplasia and Prostatitis 115 Urinary Incontinence 116 Chronic Kidney Disease 117 Treatment of Irreversible Renal Failure 118 Approach to the Patient with Gastrointestinal Disease 119 Diagnostic Imaging Procedures in Gastroenterology 120 Gastrointestinal Endoscopy 121 Gastrointestinal Hemorrhage 122 Disorders of Gastrointestinal Motility 123 Functional Gastrointestinal Disorders: Irritable Bowel and Upper GI Syndromes 124 Diseases of the Esophagus 125 Acid Peptic Disease 126 Approach to the Patient with Diarrhea and Malabsorption 127 Inflammatory Bowel Disease 128 Anatomic and Inflammatory Diseases of the Intestines and Peritoneum 129 Vascular Gastrointestinal Diseases 130 Pancreatitis 131 Diseases of the Rectum and Anus 132 Approach to the Patient with Liver Disease 133 Approach to the Patient with Jaundice or Abnormal Liver Tests 134 Acute Viral Hepatitis 135 Chronic Viral and Autoimmune Hepatitis 136 Toxin- and Drug-Induced Liver Disease 137 Bacterial, Parasitic, Fungal, and Granulomatous Liver Diseases 138 Alcoholic and Nonalcoholic Steatohepatitis 139 Cirrhosis and Its Sequelae 140 Hepatic Failure and Liver Transplantation 141 Diseases of the Gallbladder and Bile Ducts 142 Hematopoiesis and Hematopoietic Growth Factors 143 The Peripheral Blood Smear 144 Approach to the Anemias 145 Microcytic and Hypochromic Anemias 146 Autoimmune and Intravascular Hemolytic Anemias 147 Hemolytic Anemias: Red Cell Membrane and Metabolic Defects 148 The Thalassemias 149 Sickle Cell Disease and Other Hemoglobinopathies 150 Megaloblastic Anemias 151 Aplastic Anemia and Related Bone Marrow Failure States 152 Polycythemia Vera, Essential Thrombocythemia, and Primary Myelobfibrosis 153 Leukocytosis and Leukopenia 154 Approach to the Patient with Lymphadenopathy and Splenomegaly 155 Histiocytoses 156 Eosinophilic Syndromes 157 Approach to the Patient with Bleeding and Thrombosis 158 Thrombocytopenia 159 Von Willebrand Disease and Abnormalities of Platelet and Vascular Function 160 Coagulation Factor Deficiencies 161 Disseminated Intravascular Coagulation, Liver Failure, and Vitamin K Deficiency 162 Transfusion Medicine 163 Hematopoietic Stem Cell Transplantation 164 Approach to the Patient with Cancer 165 Epidemiology of Cancer 166 Cancer Biology and Genetics 167 Myelodysplastic Syndromes 168 The Acute Leukemias 169 The Chronic Lymphocytic Leukemia 170 Chronic Myeloid Leukemias 171 Non-Hodgkin Lymphomas 172 Hodgkin Lymphoma 173 Plasma Cell Disorders 174 Amyloidosis 175 Tumors of the Central Nervous System 176 Head and Neck Cancer 177 Lung Cancer and Other Pulmonary Neoplasms 178 Neoplasms of the Esophagus and Stomach 179 Neoplasms of the Small and Large Intestine 180 Pancreatic Cancer 181 Liver and Biliary Tract Tumors 182 Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis 183 Breast Cancer and Benign Breast Disorders 184 Gynecologic Cancers 185 Testicular Cancer 186 Prostate Cancer 187 Bone Tumors, Sarcomas, and Other Soft Tissue Neoplasms 188 Melanoma and Nonmelanoma Skin Cancers 189 Approach to Inborn Errors of Metabolism 190 Disorders of Lipid Metabolism 191 Glycogen Storage Diseases 192 Lysosomal Storage Diseases 193 Homocystinuria and Hyperhomocysteinemia 194 The Porphyrias 195 Wilson Disease 196 Iron Overload (Hemochromatosis) 197 Protein-Energy Malnutrition 198 Malnutrition: Assessment and Support 199 Vitamins, Trace Minerals, and Other Micronutrients 200 Eating Disorders 200 Nutrition’s Interface with Health and Disease 201 Obesity 202 Approach to the Patient with Endocrine Disease 203 Principles of Endocrinology 204 Neuroendocrinology and the Neuroendocrine System 205 Anterior Pituitary 206 Posterior Pituitary 207 Thyroid 208 Adrenal Cortex 209 Adrenal Medulla, Catecholamines, and Pheochromocytoma 210 Diabetes Mellitus 211 Hypoglycemia and Pancreatic Islet Cell Disorders 212 Polyglandular Disorders 213 Neuroendocrine Tumors 214 Sexual Development, Identity, and Gender Medicine 215 Transgender Medicine 216 The Testis and Male Hypogonadism, Infertility, and Sexual Function 217 Ovaries and Pubertal Development 218 Reproductive Endocrinology and Infertility 219 Approach to Women’s Health 220 Contraception 221 Common Medical Problems in Pregnancy 222 Menopause 223 Intimate Partner Violence 224 Approach to the Patient with Metabolic Bone Disease 225 Osteoporosis 226 Osteomalacia and Rickets 227 Parathyroid Glands, Hypercalcemia, and Hypocalcemia 228 Paget Disease of Bone 229 Osteonecrosis, Osteosclerosis/Hyperostosis, and Other Bone Disorders 230 Approach to the Patient with Allergic or Immunologic Disease 231 Primary Immunodeficiency Diseases 232 Urticaria and Angioedema 233 Systemic Anaphylaxis, Food Allergy, and Insect Sting Allergy 234 Drug Allergy 235 Mastocytosis 236 Approach to the Patient with Rheumatic Disease 237 Laboratory Testing in the Rheumatic Diseases 238 Imaging Studies in the Rheumatic Diseases 239 Inherited Diseases of Connective Tissue 240 The Systemic Autoinflammatory Diseases 241 Osteoarthritis 242 Bursitis, Tendinitis, Periarticular Disorders, and Sports Medicine 243 Rheumatoid Arthritis 244 The Spondyloarthropathies 245 Systemic Lupus Erythematosus 246 Systemic Sclerosis (Scleroderma) 247 Sjögren Syndrome 248 Inflammatory Myopathies 249 The Systemic Vasculitides 250 Giant Cell Arteritis and Polymyalgia Rheumatica 251 Infections of Bursae, Joints, and Bones 252 Crystal Deposition Diseases 253 Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Pain 254 Systemic Diseases in Which Arthritis Is a Feature 255 Surgical Treatment of Joint Diseases 256 Introduction to Microbial Disease: Pathophysiology and Diagnostics 257 The Human Microbiome 258 Principles of Anti-Infective Therapy 259 Approach to Fever or Suspected Infection in the Normal Host 260 Approach to Fever and Suspected Infection in the Compromised Host 261 Prevention and Control of Health Care–Associated Infections 262 Approach to the Patient with Suspected Enteric Infection 263 Approach to the Patient with Urinary Tract Infection 264 Approach to the Patient with a Sexually Transmitted Infection 265 Approach to the Patient before and after Travel 266 Antibacterial Chemotherapy 267 Staphylococcal Infections 268 Streptococcus Pneumoniae Infections 269 Nonpneumococcal Streptococcal Infections and Rheumatic Fever 270 Enterococcal Infections 271 Clostridial and Clostridioides Infections 272 Gram Positive Rod Infections 273 Diseases Caused by Non–Spore-Forming Anaerobic Bacteria 274 Erysipelothrix Infections 274 Neisseria Meningitidis Infections 274 Anthrax 274 Listeriosis 275 Neisseria Gonorrhoeae Infections 276 Chancroid and Cutaneous Ulcers 277 Haemophilus and Moraxella Infections 278 Cholera and Other Vibrio Infections 279 Campylobacter Infections 280 Escherichia Coli Enteric Infections 281 Other Enterobacteriaceae including Multidrug Resistant Strains 282 Pseudomonas and Related Gram-Negative Bacillary Infections 283 Acinetobacter and Stenotrophomonas Infections 284 Salmonella Infections (including enteric fever) 285 Shigellosis 286 Brucellosis 287 Tularemia and Other Francisella Infections 288 Plague and Other Yersinia Infections 289 Whooping Cough and Other Bordetella Infections 290 Legionella Infections 291 Bartonella Infections 291 Granuloma Inguinale (Donovanosis) 292 Granuloma Inguinale (Donovanosis) 293 Mycoplasma Infections 294 Diseases Caused by Chlamydiae 295 Syphilis and Nonsyphilitic Treponematoses 296 Lyme Disease 297 Relapsing Fever and Other Borrelia Infections 298 Leptospirosis 298 Nonsyphilitic Treponematoses 299 Tuberculosis 300 The Nontuberculous Mycobacteria 301 Leprosy (Hansen Disease) 302 Rickettsial Infections 303 Zoonoses 304 Actinomycosis 305 Whipple Disease 306 Nocardiosis 307 Systemic Antifungal Agents 308 Endemic Fungi 309 Cryptococcosis 310 Candidiasis 311 Aspergillosis 312 Mucormycosis 313 Pneumocystis Pneumonia 314 Mycetoma and Dematiaceous Fungal Infections 315 Antiparasitic Therapy 316 Malaria 317 African Sleeping Sickness 318 Chagas Disease 319 Leishmaniasis 320 Toxoplasmosis 321 Cryptosporidiosis 322 Giardiasis 323 Amebiasis 324 Babesiosis and Other Protozoan Diseases 325 Cestodes 326 Trematode Infections 327 Nematode Infections 328 Antiviral Therapy (Non-HIV) 329 The Common Cold 330 Respiratory Syncytial Virus 331 Parainfluenza Viral Disease 332 Influenza 333 Adenovirus Diseases 334 Pre-2019 Coronaviruses 335 Covid-19 Virology and Pathobiology 336 Covid-19 Epidemiology/Clinical Manifestations/Diagnosis/Community Prevention 337 COVID-19 Treatment, Vaccination, and Prognosis 338 Measles 339 Rubella (German Measles) 340 Mumps 341 Polyomaviruses 342 Parvovirus 343 Smallpox, Monkeypox, and Other Poxvirus Infections 344 Papillomavirus 345 Herpes Simplex Virus Infections 346 Varicella-Zoster Virus (Chickenpox, Shingles) 347 Cytomegalovirus 348 Epstein-Barr Virus Infection 349 Enteroviruses 350 Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses 351 Viral Hemorrhagic Fevers 351 Arboviruses Affecting the Central Nervous System 352 Arboviruses Causing Fever, Rash, and Neurologic Syndromes 353 EPIDEMIOLOGY AND DIAGNOSIS OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND ACQUIRED IMMUNODEFICIENCY SYNDROME 354 Pathobiology of HIV Infection 355 Acute Clinical Manifestation and Diagnosis of HIV 356 Prevention of HIV Infection 357 Antiretroviral Therapy of HIV/AIDS 358 Microbial Complications of HIV/AIDS 359 Systemic Manifestations of HIV/AIDS 359 Immune Reconstitution Inflammatory Syndrome in HIV/AIDS 360 Retroviruses Other Than HIV 361 Delirium and Changes in Mental Status 362 Psychiatric Disorders in Medical Practice 363 Nicotine and Tobacco Use 364 Alcohol Use Disorders 365 Drug Abuse Disorders 366 Approach to the Patient with Neurologic Disease 367 Headaches and Other Head Pain 368 Traumatic Brain Injury and Spinal Cord Injury 369 Mechanical and Other Lesions of the Spine, Nerve Roots, and Spinal Cord 370 Regional Cerebral Dysfunction: Higher Mental Functions 371 Alzheimer and Other Dementias 372 The Epilepsies 373 Coma, Vegetative State, and Brain Death 374 Sleep Disorders 375 Approach to Cerebrovascular Diseases 376 Ischemic Cerebrovascular Disease 377 Hemorrhagic Cerebrovascular Disease 378 Prion Diseases 378 Parkinsonism 379 Other Movement Disorders 380 Multiple Sclerosis and Demyelinating Conditions 381 Meningitis: Bacterial, Viral, and Other 382 Brain Abscess and Parameningeal Infections 383 Encephalitis 384 Nutritional and Alcohol-Related Neurologic Disorders 385 Congenital, Developmental, and Neurocutaneous Disorders 386 Autonomic Disorders 387 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases 388 Peripheral Neuropathies 389 Muscle Diseases 390 Disorders of Neuromuscular Transmission 391 Diseases of the Visual System 392 Neuro-Ophthalmology 393 Diseases of the Mouth and Salivary Glands 394 Approach to the Patient with Nose, Sinus, and Ear Disorders 395 Smell and Taste 396 Hearing and Equilibrium 397 Throat Disorders 398 Principles of Medical Consultation 399 Preoperative Evaluation 400 Overview of Anesthesia 401 Postoperative Care and Complications 402 Medical Consultation in Psychiatry 403 Approach to Skin Diseases 404 Principles of Therapy of Skin Diseases 405 Eczema, Photodermatoses, Papulosquamous (including Fungal) Diseases, and Figurate Erythemas 406 Macular, Papular, Vesiculobullous, and Pustular Diseases 407 Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases 408 Infections, Pigmentation Disorders, Regional Dermatology, and Distinctive Lesions in Black Skin 409 Diseases of Hair and Nails Reference Intervals and Laboratory Values
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