Breast MRI for High-risk Screening

Description:

This book offers a comprehensive overview of the use of breast MRI for screening high-risk women, including those with familial-genetic hereditary predisposition and previous chest radiation therapy, typically lymphoma survivors. It discusses the historical background of studies and research that provided the body of evidence in favor of MRI screening of these women. Technical and clinical topics are treated in dedicated chapters, including models for individualized risk estimation, radiogenomics of breast cancer in high-risk women, computer-aided detection/diagnosis and machine learning systems applied to breast MRI, and psycho-oncology issues. Alternatives to breast MRI screening such as pharmaco-prevention and prophylactic mastectomy are also discussed, taking into account the public debate on the “Angelina Jolie” effect. The high breast cancer risk model is proposed as a paradigm for personalized medicine. This book will be of interest to radiologists, surgeons, oncologists and to all professionals devoted to female healthcare.

Table of Contents:

1. From NMR to Clinical Breast MRI

2. The Mantra about Low Specificity of Breast MRI

3. Hereditary Breast Cancer: BRCA and Other Susceptibility Genes

4. MRI Protocols for Breast Cancer Screening

5. Gadolinium-Based Contrast Agents for Breast MRI and Uncertainties About Brain Gadolinium Retention

6. Applying the MRI BI-RADS in a High-Risk Population

7. CAD and Machine Learning for Breast MRI

8. Radiogenomics and Phenotype Presentation of Breast Cancer with a Special Focus on High-Risk Women

9. Primary Studies on Breast MRI Screening of High-Risk Women

10. Genetic/Familial High-Risk Screening: MRI Alone?

11. Systematic Reviews, Meta-Analyses, and Cost-Effective Analyses on Breast MRI Screening of High-Risk Women

12. Radioprotection Issues for Women with Hereditary Predisposition for Breast Cancer

13. Impact of MRI Screening on High-Risk Patient Outcome

14. The Special Case of Previous Chest Radiation Therapy

15. Electronic Data Capture Systems for Breast Cancer Research

16. Guidelines and Recommendations on High-Risk Breast Cancer Screening All Over the World: Agreements and Differences

17. A Soft Option for Primary Prevention: Drugs and Agents

18. Surgical Options for Primary Prevention: Prophylactic Mastectomy and Oophorectomy

19. Psychological Aspects of High Risk of Breast Cancer

20. Calculating, Using and Improving Individual Breast Cancer Risk Estimates

21. MRI for Screening Women with a Personal History of Breast Cancer

22. Breast MRI Screening for the Intermediate Risk: An Open Issue

23. Hypotheses for the Future