Atlas of Liver Pathology: A Pattern-Based Approach

Description:

Part of the new Pattern-Based Approach series, designed to teach pathology in a way that reflects actual sign-out, this new visually-oriented guidebook presents real-life cases and practical diagnostic tips. Disease processes are organized into ‘patterns’ of injury—the method by which pathologists approach their work—and self-assessment quizzes are provided for each chapter to give you experience with high-yield, board-style teaching topics.

 

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Table of Contents:

 

1 BASIC PATTERNS IN LIVER PATHOLOGY

Introduction

Acute Hepatitis Versus Chronic Hepatitis Versus Acute-on-Chronic Hepatitis

Acute Liver Failure

Almost-Normal Liver

Resolving Hepatitis Pattern

Cytoplasmic Changes

Bland Lobular Necrosis

Fatty Liver

Hepatitic Pattern of Injury

Giant Cell Hepatitis

Granulomas

Bland Lobular Cholestasis

Biliary Obstruction

Ductopenia

Chronic Biliary/Cholestatic Injury

Vascular Disease

Combined Patterns

Cryptogenic Cirrhosis

Hepatocellular Tumors

Near Misses

2 ACUTE AND CHRONIC VIRAL HEPATITIS

General Considerations

Determining Etiology

Acute Versus Chronic Hepatitis

Grading Hepatitis

Staging Hepatitis

Specific Hepatotropic Viruses

General Histology Patterns

Hepatitis A

Hepatitis B

Hepatitis D Infection

Hepatitis C

Fibrosing Cholestatic Hepatitis B And C

Hepatitis E Viral Infection

Nonhepatotropic Viruses

Epstein–Barr Virus (EBV)

Cytomegalovirus (CMV)

Adenovirus, Herpes Simplex Virus (HSV), and Varicella Zoster Virus (VZV)

Near Misses

3 NONVIRAL INFECTIONS OF THE LIVER

Introduction

Parasitic Infections

Echinococcosis

Schistosomiasis

Tick-Borne Diseases

Bacterial Infections

Syphilis

Whipple Disease

Actinomycosis

Liver Abscesses

Malaria

Near Misses

4 GRANULOMAS AND GRANULOMATOUS DISEASE

Overview

Approach to Diagnosis

Types of Granulomas

Fibrin Ring Granuloma

Fibrotic Granuloma

Foreign Body Granuloma

Lipogranuloma

Mineral Oil Granuloma

Necrotizing Granuloma

Specific Granulomatous Diseases

Mycobacterium Tuberculosis

Bacillus Calmette–Guerin and Other Mycobacterium Infections

Mycobacterium Leprae

Fungal Infections

Parasites

Sarcoidosis

Common Variable Immunodeficiency (CVID)

Crohn Disease

Drug Reactions

Granulomas and Neoplasms

Other Causes

Near Misses

5 DRUG-INDUCED LIVER INJURY

Overview

General Approach

Inflammatory Patterns of Injury

Idiosyncratic Drug Reactions

Resolving Pattern of Hepatitis

Direct Toxins

Allergic Type Drug Reactions

Other Patterns of Injury

Isolated Hyperammonemia

Hypervitaminosis A

Glycogen Pseudo–Ground Glass Changes

Other Drug-Induced Smooth Endoplasmic Reticulum Proliferations

Glycogenic Hepatopathy

Macrovesicular Steatosis

Microvesicular Steatosis

Phospholipidiosis

Ductopenic Pattern

Vascular Changes Associated with Dili

Medications Associated with Fibrosis

Near Misses

6 FATTY LIVER DISEASE

Introduction

Nonalcohol Fatty Liver Disease (NAFLD)

All About the Fat

How Do You Go from Steatosis to Steatohepatitis?

Balloon Cells

Lobular Inflammation

Portal Inflammation

Other Findings in Fatty Liver Disease

Formal Grading and Staging

Determining Etiology

Alcohol Liver Disease

Drug Reactions Causing Fatty Liver Disease

Other Rare Causes of Macrovesicular Steatosis

Microvesicular Steatosis

Near Misses

7 AUTOIMMUNE HEPATITIS

Clinical Findings

Laboratory Findings

Histological Findings

Overview of Histological Findings

Interface Activity

Portal Tract Inflammation

Lobular Changes

Fulminant Liver Failure

Cryptogenic Cirrhosis and “Burned Out Autoimmune Hepatitis”

Autoimmune Hepatitis in Men

Immunohistochemical Findings

Fibrosis Staging

Pediatric Autoimmune Hepatitis

Overlap Syndromes

Aih–Pbc: Overlap Between Autoimmune Hepatitis and Primary Biliary Cirrhosis

Aih–Psc: Overlap Between Autoimmune Hepatitis and Primary Sclerosing Cholangitis

Near Misses

8 CHOLESTATIC AND BILIARY TRACT DISEASE

Introduction

Bland Lobular Cholestasis Pattern

Biliary Cirrhosis Pattern

Biliary Obstruction Pattern

Special Stains

Diseases that can Mimic Biliary Obstruction

Ascending Cholangitis

Primary Sclerosing Cholangitis

Small Duct Primary Sclerosing Cholangitis

Primary Biliary Cirrhosis

A New Name?

Clinical and Laboratory Findings

Histology Findings

Idiopathic Ductopenia

Igg4 Sclerosing Disease

Igg4 Immunohistochemistry

Sclerosing Cholangitis Associated with Type 2 Autoimmune Pancreatitis

Segmental Cholangiectasia

Pediatric Cholestatic Liver Disease

Overview

Biliary Atresia

Neonatal Giant Cell Hepatitis

Paucity of Intrahepatic Bile Ducts

Bile Salt Deficiency Diseases

Serum Findings

Histological Findings

Inherited Defects in Bilirubin Metabolism

Cystic Biliary Diseases and Bile Duct  Malformations

Congenital Hepatic Fibrosis/Autosomal Recessive Polycystic Kidney And Liver Disease

Caroli Syndrome/Caroli Disease

Autosomal Dominant Polycystic Kidney and Liver Disease

Solitary Bile Duct Cysts

Near Misses

9 VASCULAR DISEASE

General Histologial Patterns

Patterns of Injury With Portal Vein Disease

Acute Portal Vein Disease

Chronic Portal Vein Disease

Patterns of Injury With Hepatic Artery Disease

Sinusoidalinusoidal Disease

Veno-Occlusive Disease

Sickle Cell Disease

Vascular Outflow Disease

Congenital/Genetic Abnormalities

Hereditary Hemorrhagic Telangiectasia

Hereditary Lymphedema

Nodular Regenerative Hyperplasia

Peliosis Hepatitis

Segmental Atrophy and Nodular Elastosis

Tumors Associated With Vascular Disease

Near Misses

10 SYSTEMIC DISEASES INVOLVING THE LIVER

Amyloid

Lect2 Amyloid

Light Chain Deposition Disease

WaldenströM Macroglobulinaemia

Diabetes Mellitus

Fatty Liver Disease

Glycogenic Hepatopathy

Diabetic Hepatosclerosis

Other Endocrine Diseases

Hypopituitary Disease

Thyroid Disease

Inflammatory Conditions

Celiac Disease

Common Variable Immunodeficiency

Crohn Disease

Systemic Autoimmune Disease

Liver Disease in Pregnancy

Hyperemesis Gravidarum

Intrahepatic Cholestasis of Pregnancy

Preeclampsia, Eclampsia, and Hellp Syndrome

Acute Fatty Liver of Pregnancy

Hematopathology-Related Diseases

Langerhans Histiocytosis

Rosai Dorfman Disease

Mast Cell Disease

Other Systemic Dieases

Cystic Fibrosis

Hypertension, Systemic

Sepsis

Hemophagocytic Syndrome

Near Misses

11 TRANSPLANT PATHOLOGY

Donor Liver Evaluation

Preservation Changes

Acute Cellular Rejection

Grading Acute Cellular Rejection

Atypical Patterns of Acute Cellular Rejection

Idiopathic Posttransplant Hepatitis

Antibody-Mediated Rejection

Chronic Rejection

Vascular Problems

Hepatic Artery Insufficiency

Small-For-Size Graft

Piggyback Grafts and Congestive Hepatopathy

Other Findings

Opportunistic Viral Infections

Recurrent Disease

Glycogenic Hepatopathy

Drug Reaction

Posttransplant Lymhoproliferative Disorder

Graft Versus Host Disease

Engraftment Syndrome

Near Misses

12 GENETIC DISEASES

Genetic Diseases of the Liver, Overview

Alpha-1-Antitrypsin Deficiency

Afibrinogenemia/Hypofibrinogenemia

Wilson Disease

Copper Stains

Quantitative Copper

Other Rare Copper Overload Diseases

Hemochromatosis

Histological Findings

Genetic Versus Secondary Causes of Iron Overload

Acquired/Secondary Iron Overload

Iron in Donor Liver Biopsies

Determining Iron Levels in the Liver

Iron-Grading Systems

Quantitative Measurement of Hepatic Iron Concentrations

Liver Biopsies in Individuals With Known Hfe Mutations

Other Rare Genetic Causes of Hemochromatosis

Ferroportin Disease and Ferroportin-Associated Hemochromatosis

Neonatal Hemochromatosis

African Iron Overload Disease

Glycogen Storage Diseases

Urea Cycle Defects

Mucopolysaccharidosis

Disorders of Lipid Metabolism

Inborn Errors of Amino Acid Metabolism

Prader–Willi Disease

Erythropoietic Protoporhyria

Disorders of Mitochondria

Telomere Shortening Syndrome

Near Misses

13 PEDIATRIC BENIGN AND MALIGNANT TUMORS

Hepatoblastoma

Histological Types

Hepatoblastoma Staging

Hepatoblastoma Versus Hepatocellular Carcinoma

Calcifying Nested Stromal–Epithelial Tumor

Infantile Hemangioma

Vascular Malformation

Mesenchymal Hamartoma

Embryonal Sarcoma

Rhabdoid Tumors

Rhabdomyosarcoma (Also Called Embryonal Rhabdomyosarcoma)

Near Misses

14 HEPATOCELLULAR TUMORS

Focal Fatty Nodule

Focal Nodular Hyperplasia

Hepatic Adenoma

Hepatic Adenoma–Like Nodules in Cirrhotic Livers

Histological Findings, Overview

Atypical Hepatic Adenomas

Hepatic Adenoma Subtypes

Special High-Risk Subtypes of Hepatic Adenomas

Malignant Transformation

Near Misses

15 MALIGNANT HEPATOCELLULAR TUMORS AND PRECUSORS

Macroregenerative Nodule

Dysplastic Nodule

Hepatocellular Carcinoma

How to Make the Diagnosis of Hepatocellular Carcinoma

Evaluating the Reticulin Stain

Growth Patterns

Other Findings

Angiolymphatic Invasion

Grading Hepatocellular Carcinoma

Immunohistochemical Patterns

Background Liver

Changes After Chemoembolization Therapy

Histological Subtypes

Provisional Subtypes of Hepatocellular Carcinoma

Near Misses

16 BILIARY TUMORS

Benign Biliary Lesions

Reactive Bile Ductular Proliferations

Bile Duct Hamartoma

Bile Duct Adenoma

Biliary Adenofibroma

Immunostains

Risk for Malignant Transformation

Simple Cysts Including Biliary, Mesothelial, and Foregut

Mucinous Cystic Neoplasm

Mucinous Cystic Neoplasm without Ovarian Stroma

Intraductal Papillary Biliary Neoplasm

Cholangiocarcinoma

Grading Cholangiocarcinomas

Immunostains

Near Misses

17 ADULT BENIGN AND MALIGNANT MESENCHYMAL TUMORS

Segmental Atrophy and Nodular Elastosis

Inflammatory Pseudotumor

Hemangioma

Cavernous Hemangioma

Capillary Hemangioma

Anastomosing Hemangioma

Epitheliod Hemangioendothelioma

Angiosarcoma

Angiomyolipoma

Solitar Fibrous Tumor

Near Misses

APPENDIX A

CHAPTER 1. Multiple Choice Questions

CHAPTER 2. Multiple Choice Questions

CHAPTER 3. Multiple Choice Questions

CHAPTER 4. Multiple Choice Questions

CHAPTER 5. Multiple Choice Questions

CHAPTER 6. Multiple Choice Questions

CHAPTER 7. Multiple Choice Questions

CHAPTER 8. Multiple Choice Questions

CHAPTER 9. Multiple Choice Questions

CHAPTER 10. Multiple Choice Questions

CHAPTER 11. Multiple Choice Questions

CHAPTER 12. Multiple Choice Questions

CHAPTER 13. Multiple Choice Questions

CHAPTER 14. Multiple Choice Questions

CHAPTER 15. Multiple Choice Questions

CHAPTER 16. Multiple Choice Questions

CHAPTER 17. Multiple Choice Questions

 

An aparitie	29 Mar. 2019
Autor	Michael Torbenson
Dimensiuni	15.27 x 2.29 x 22.86 cm
Editura	LWW
Format	Hardcover
ISBN	9781496396976
Limba	Engleza
Nr pag	448
Versiune digitala	DA