A Case-Based Guide to Neuromuscular Pathology

Description:

This book provides a practical guide to the field of neuromuscular pathology including muscle, peripheral nerve, and skin biopsies with biopsy interpretation. Divided into three parts, the book begins with introductory chapters that review muscle, nerve, and skin biopsy indications and procedures, normal muscle and nerve histology, and common muscle and nerve pathology. The 28 myopathy case chapters in Part 2 and 11 neuropathy case chapters in Part 3 illustrate the clinical and pathological features of many neuromuscular diseases, demonstrate the indications and utilities of biopsies, discuss clinical and pathological differential diagnosis, update the individual disease management, and summarize pertinent clinical and pathology pearls for each case.  A Case-Based Guide to Neuromuscular Pathology will function as an indispensable reference for neurologists and pathologists looking to understand the utility of muscle, nerve, and skin biopsies. This book will also aid neurology residents, neuromuscular fellows and neuropathology fellows in preparing for questions related to the muscle and nerve pathology in their in-service and board exams. 

Table of Contents:

Part I. Introduction to Neuromuscular Pathology Evaluation

1. Skeletal Muscle Biopsy Evaluation

2. Peripheral Nerve Biopsy Evaluation

3. Skin Biopsy with Cutaneous Nerve Fiber Evaluation

Part II. Myopathy Cases

4. A 20-Year-Old Man with Acute Multi-organ Failure and Rhabdomyolysis

5. A 45-Year-Old Woman with Proximal Limb Weakness and Skin Peeling on Fingertips

6. A 75-Year-Old Man with Slowly Progressive Leg and Hand Weakness

7. A 53-Year-Old Woman with Proximal Limb Weakness and Marked CK Elevation

8. A 61-Year-Old Woman with Progressive Distal Limb and Deltoid Muscle Weakness

9. A 63-Year-Old Woman with Debilitating Muscle Pain

10. A 33-Year-Old Woman with Pain and Swelling in the Right Calf and Persistent Fever

11. A 28-Year-Old Woman with Proximal Limb Weakness and Scapular Winging

12. A 52-Year-Old Man with Proximal Limb Weakness and Hand Stiffness

13. A 51-Year-Old Woman with Long-Standing Exercise Intolerance

14. A 37-Year-Old Woman with Leg Weakness and CK Elevation

15. A 25-Year-Old Woman with Droopy Eyelids and Double Vision

16. A 58-Year-Old Man with Hypercapnic Respiratory Failure

17. A 65-Year-Old Man with Asymmetrical Leg Weakness and Foot Tingling

18. A 40-Year-Old Man with Muscle Pain and Fatigue

19. A 42-Year-Old Woman with Progressive Limb Weakness and Breathing Difficulty

20. A 49-Year-Old Man with Limb Weakness and Painful Skin Lesions

21. A 54-Year-Old Man with Progressive Lower Limb Weakness and CK Elevation

22. A 63-Year-Old Man with Progressive Limb Weakness and Slurred Speech

23. A 6-Year-Old Girl with Muscle Pain and Swelling in the Thighs

24. A 4-Year-Old Boy with Progressive Weakness, Difficulty Walking and Running, and Increased Falls

25. A 2-Year-Old Girl with Hypotonia Since Birth and Delayed Motor and Speech Development

26. An 8-year-old boy with delayed motor milestones and proximal leg muscle weakness

27. A 6-Year-Old-Boy with Proximal Leg Muscle Weakness and Facial Weakness

28. A 6-Week-Old Boy with Neonatal Hypotonia and Feeding and Respiratory Difficulties

29. A 6-Year-Old Boy with Respiratory and Feeding Difficulties at Birth, Delayed Gross Motor Milestones, and Facial and Proximal Lower Limb Weakness

30. A 12-Year-Old Girl with a 2-Year History of Progressive Limb Weakness and Difficulties with Exercise

31. A 3-Month-Old Boy with Generalized Hypotonia, Weakness, Pneumonia and Respiratory Failure

Part III. Neuropathy Cases

32. A 59-Year-Old Woman with Subacute Lower Limb Weakness and Painful Paresthesia

33. A 63-Year-Old Man with Nausea, Vomiting, Orthostatic Dizziness, and Distal Limb Paresthesia

34. A 47-year-old woman with progressive numbness and weakness in the limbs

35. A 65-Year-Old Woman with Acute Limb Weakness and Worsening of Paresthesia

36. A 34-Year-Old Man with Right Hand and Left Foot Numbness

37. A 64-Year-Old Woman with Progressive Pain, Numbness and Weakness in the Right Lower Limb

38. A 68-Year-Old Man with Progressive Lower Limb Numbness and Weakness and Urinary Incontinence

39. A 53-Year-Old Woman with Pain, Burning, Tingling, and Numbness in the Distal Limbs

40. A 40-Year-Old Woman with Patchy Painful Paresthesia

41. A 39-Year-Old Woman with Intermittent Bilateral Foot and Leg Pain since Childhood

42. A 35-Year-Old Man with Pain and Numbness in the Left Lateral Thigh

Back Matter