Bone Marrow Pathology

Discover a comprehensive and up-to-date reference resource for bone marrow pathology, complete with an extensive list of references

The diagnosis and treatment of bone marrow pathologies is one of the most critical areas of medical research and care. For years, Bone Marrow Pathology has served as the essential reference and teaching tool in the field of haematology, with an authoritative treatment of the subject written by acknowledged leaders in the field. Now fully updated to reflect urgent new changes to the theory and practice of haematology, it promises to serve a new generation of practitioners.

In the book, the characteristics and function of normal bone marrow are extensively discussed. Bone marrow pathology, including both aspirate films and trephine biopsy sections, is examined in a clinical context. The content is augmented by discussion of the peripheral blood findings and supplementary bone marrow tests. Readers of the sixth edition of Bone Marrow Pathology will also find:

Lavish illustrations with high-quality images of bone marrow and other associated images

Incorporation of new classifications including the WHO and International Consensus classifications, as well as new and expanded research areas

Emphasis on practical tools including differential diagnosis and common problems and pitfalls

A practical, integrated approach to diagnosis

Perfect for trainee and consultant haematologists and haematopathologists, Bone Marrow Pathology will also prove itself invaluable for cytogeneticists, molecular geneticists and anyone working in immunophenotyping.

Table of Contents:

ONE THE NORMAL BONE MARROW: EXAMINING AND REPORTING BONE MARROW SPECIMENS

The distribution of haemopoietic marrow

The organization of the bone marrow

Cellularity

Haemopoietic and mesenchymal cells

Lymphopoiesis

Storage and erythroblast iron

The cellular composition of bone marrow

Interpretation of bone marrow aspirates and trephine biopsies

Artefacts

References

TWO SPECIAL TECHNIQUES APPLICABLE TO BONE MARROW DIAGNOSIS

Cytochemical and histochemical stains

Immunophenotyping

Cytogenetic analysis

Molecular genetic analysis

Ultrastructural examination

Bone marrow culture for assessment of haemopoietic progenitor cell numbers

Bone marrow culture for microorganisms

References

THREE INFECTION AND REACTIVE CHANGES

Infection

Bone marrow granulomas

Reactive lymphoid infiltrates

Plasmacytosis and cytological abnormalities in plasma cells

Mast cells

Histiocytosis

Haemophagocytic syndromes

Iron overload

HIV infection and the acquired immune deficiency syndrome

Blood vessels and vascular lesions

Bone marrow necrosis

Gelatinous transformation

Amyloid deposition

Bone marrow fibrosis

References

FOUR ACUTE MYELOID LEUKAEMIA, MIXED PHENOTYPE ACUTE LEUKAEMIA, THE MYELODYSPLASTIC NEOPLASMS/SYNDROMES AND HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS

Acute myeloid leukaemia

Acute leukaemia of mixed or ambiguous lineage

The myelodysplastic neoplasms/syndromes

The WHO and International Consensus classifications of the myelodysplastic syndromes

Problems and pitfalls in the diagnosis of myelodysplastic syndromes

Clonal cytopenia of undetermined significance and idiopathic cytopenia of unknown significance

Histiocytic and dendritic cell neoplasms

References

FIVE MYELOPROLIFERATIVE AND MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS AND RELATED CONDITIONS

Myeloproliferative neoplasms

Myelodysplastic/myeloproliferative neoplasms

References

SIX LYMPHOPROLIFERATIVE DISORDERS

Bone marrow infiltration in lymphoproliferative disorders

B‐lineage lymphomas and leukaemias

Lymphoproliferative disorders of T lineage and natural killer (NK) lineage

References

SEVEN PLASMA CELL NEOPLASMS AND RELATED CONDITIONS

Plasma cell neoplasm

Lymphoplasmacytic neoplasms

Other syndromes associated with secretion of a paraprotein

References

EIGHT DISORDERS OF ERYTHROPOIESIS, GRANULOPOIESIS AND THROMBOPOIESIS

Disorders of red cells

Disorders of leucocytes

Disorders of platelets

References

NINE MISCELLANEOUS DISORDERS

Non‐metastatic effects of cancer

Bone marrow dysplasia with polyclonal haemopoiesis

The bone marrow in connective tissue and autoimmune disorders

Congenital immune deficiency syndromes

Autoimmune lymphoproliferative syndrome

The haematological effects of anti‐cancer and immunosuppressive chemotherapy

The haematological effects of other drugs and chemicals

The effect of irradiation on the bone marrow

The haematological effects of alcohol

Aplastic anaemia

Other causes of bone marrow aplasia and hypoplasia

Pearson syndrome and other mitochondrial cytopathies

Other constitutional abnormalities associated with abnormal haemopoiesis

Paroxysmal nocturnal haemoglobinuria

Bone marrow and other haemopoietic stem cell transplantation

Graft‐versus‐host disease (including the effects of donor‐lymphocyte infusion)

The effects of haemopoietic growth factors and other cytokines

Protein‐calorie malnutrition and calorie deficiency

Storage diseases and storage cells in the bone marrow

Sinus histiocytosis with massive lymphadenopathy (Rosai–Dorfman disease)

Gout

Deposition of foreign substances

Vascular and intravascular lesions [184,255]

References

TEN METASTATIC AND NON‐HAEMOPOIETIC TUMOURS

Haematological, histopathological and genetic features of metastatic tumours

The role of bone marrow examination in the staging of solid tumours

The role of bone marrow examination in identifying the tissue of origin of metastases and markers of relevance to prognosis or treatment

Problems and pitfalls in identification of tumour infiltration of bone marrow

References

ELEVEN DISEASES OF BONE

Problems and pitfalls in assessment of bone

References

APPENDIX

Technical methods applicable to trephine biopsy specimens

Methods

Adaptation of methods in a resource‐poor setting

Further reading

INDEX

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