The Neuroscience of Spinal Cord Injury

Features:

Diagnosis and Treatment of Spinal Cord Injury:

• Covers both the diagnosis and treatment of spinal cord injury
• Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
• Features chapters on epidemiology and pain
• Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury
• Discusses pain reduction, drug delivery, and rehabilitation

Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury:

• Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology
• Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
• Features chapters on signaling and hormonal events
• Includes plasticity and gene expression
• Examines health and stress behaviors after spinal cord injury

Table Of Contents:

Diagnosis and Treatment of Spinal Cord Injury:
I. Setting The Scene: Introductory Chapters
1. Outcomes of traumatic spinal cord injury in low-resource setting
Avital Yohann, Laura Purcell and Anthony Charles
2. Spine injuries associated with spinal cord injury
Salomón Flórez Jiménez, Etienne Bourassa-Moreau, Jean-Marc Mac-Thiong and Gilles Maurais
3. Body, action and space representations in people affected by spinal cord injuries
Michele Scandola
4. Methods for treating pain and painful syndromes in spinal cord injury: medications, therapies, interventions, and neuromodulation
James J. Bresnahan

II. Clinical Features Of Spinal Injury
5. Factors Contributing To Pressure Injuries In Traumatic Spinal Cord Injury
Gabrielle Gour-Provencal and Jehane Dagher
6. Venous thromboembolismin spinal cord injury
Rodrigo Lanna de Almeida
7. Osteoporosis-related fractures: what they are and how they occur following spinal cord injury
Ana Paula Champs
8. Brain atrophy and white matter in compression injury to the spinal cord
Angela Bernabeu-Sanz and Eduardo Fernández-Jover
9. Spasticity in spinal cord injury
Ramiro Palazón-García
10. Falls among individuals living with spinal cord injury
L. Rice
11. Infections and spinal cord injury: Covid 19 and beyond
E. López-Dolado
12. Treating sleep problems in spinal cord injury
David J. Berlowitz and Marnie Graco

III. Diagnosis and Evaluation
13. Biomarkers in spinal cord injury
Tania Cristina Leite de Sampaio e Spohr
14. Quality of life tools for spinal cord injured people
Sebastian Salvador-De La Barrera, Ibone Gimenez-Jimenez, Manuel Astray-Lopaz, Antonio Rodriguez-Sotillo, M. Elena Ferreiro-Velasco and Antonio Montoto-Marqués Sr.
15. S100 in spinal cord injury
George Alexiou
16. Balance measures and assessments in spinal cord injury: a narrative
Kristin Musselman and Jean-Francois Lemay

IV. Treatments: Experimental and Clinical
17. Surgical management of acute spinal cord injury in emergency departments
Federico Fusini, Angela Coniglio, Alessandro Rava, Salvatore Risitano, Alessandro Massè and Massimo Girardo
18. Spinal cord epidural stimulation for autonomic nervous system control
April Herrity
19. Treating spinal cord injury with implanted spinal cord stimulators
Hengze You, Y.-P. Zheng and Monzurul Alam
20. Bowel dysfunction in spinal cord injury
M. Elena Ferreiro-Velasco, Antonio Montoto-Marqués Sr., Maria Eugenia Díaz-Recarey, Renato Vilas-Boas, Sebastian Salvador-De La Barrera and Antonio Rodriguez-Sotillo
21. Management of lower urinary tract dysfunction
Noritoshi Sekido
22. Bed and mattress for preventing pressure injuries after spinal cord injury
Annie Levasseur
23. Nerve and tendon transfers in tetraplegia: a new narrative
Federico Fusini, Paolo Titolo, Stefano Artiaco, Bruno Battiston, Salvatore Risitano and Alessandro Massè
24. Gemini-supported spinal cord transplantation for the treatment of chronic spinal paralysis
Sergio Canavero
25. Chondroitinase ABC I as a novel candidate for reducing damage in spinal cord injury
Khosrow Khalifeh
26. Phenol neurolysis for the management of spasticity in people with spinal cord injury
Radha Korupolu and Lavina Jethani
27. Anti-repulsive guidance molecule-a antibody (RGMa) treatment in spinal cord injury
Toshihide Yamashita
28. Mitochondrial biogenesis for the treatment of spinal cord injury
R. G. Schnellmann, Epiphani Simmons, Natalie Scholpa and Joshua Crossman
29. Exploring the exogenous and endogenous effects of melatonin on spinal cord injury
Yonggeun Hong, Dewan Sumsuzzman and Kanghui Park
30. High-intensity interval training in spinal cord injury
Byron Lai, Jereme Wilroy, and Gordon Fisher
31. Stem cells and chronic spinal cord injury: overview
J. D. Ciacci
32. Gene therapy in spinal cord injury
Simon O'Carroll and Connor Clemett
33. Curcumin usage inflammation and spinal cord injury
K.-T. Kim
34. Use of (-)-epigallocatechin-3-gallate on spinal cord injury
ali reza Khalatbary
35. Vitamin D supplementation for active individuals with spinal cord injury
Kelly Pritchett, Brianna Rice and Sophia Berg
36. Corticospinal tract regeneration after spinal cord injury: implications for treatment and recovery
P. Lu
37. Trophic factors in patients with spinal cord injury
J. Quintanar

V. Rehabilitation in Spinal Injury
38. Spinal cord injury: Multiple Family Group (MFG) education and support
DENNIS g. Dyck, Crystal Lederhos Smith and Bruce Becker
39. Spinal cord injury rehabilitation: linking service delivery and community integration
Linda Barclay and Gillean Hilton
40. Rehabilitation in spinal cord injury: Exercise and testing for cardiorespiratory endurance and musculoskeletal fitness
Kerri A. Morgan, Kelly L. Taylor, and Susan Tucker
41. Community based activity-based therapy for spinal cord injuries rehabilitation
Natalia Padula and Camila Quel De Oliveira
42. Rehabilitation and the Self-Management App: spinal cord injury
Ben Mortenson, Gurkaran Singh, Megan MacGillivray, Ethan Simpson and Bonita Sawatzky
43. Biomaterials and spinal cord injury and rehabilitation: a new narrative
Filippo Rossi, Giuseppe Perale and Elisa Lacroce
44. Support in spinal cord injury: a focus on robotics
Angel Gil-Agudo and Guillermo Asín-Prieto

VI. Resources
45. Research and Resources
Rajkumar Rajendram

Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury:
I. Setting The Scene and Introductory Chapters
1. Causes of spinal injury: motor vehicle accidents and beyond
Joji Inamasu
2. MRI findings in spinal cord injury during acute and chronic phases
Syed Ather Enam, Kiran Aftab, Namrah Aziz, Batool Mujtaba, Asma Akbar Ladak and Fatima Mubarak
3. Exercise programs in spinal cord injury
Jeongmin Lee, Dong-il Kim and J. Jeon
4. Use of anodal transcranial direct current stimulation: features, facets and applications to incomplete spinal cord injury
Amanda Vitória Lacerda de Araujo
5. Neuromodulation and restoration of motor responses after severe spinal cord injury
G. Taccola
6. Rehabilitation and wheelchair users after spinal cord injury: an overview
Marcelo Riberto, Ligia Jia Lin Wu and Daniel Rubio de Souza

II. Cellular and Molecular Aspects of Spinal Injury
7. Gene expression, bone loss and spinal cord injury
A. Zamarioli
8. Sperm DNA fragmentation and its relevance to men with spinal cord injury
S. Johnston
9. Cytokines and spinal cord injury
Jesús Amo-Aparicio and Clara Penas
10. Interleukin-10, vascular pathology in traumatic cervical Spinal cord injury
Michael G. Fehlings
11. Protein Degradome in Spinal Cord Injury
S. Bsat, Hani Chanbour, Ali Amine, Charbel Moussalem, Mohamad Nabih El Housheimy, Sarah Kawtharani, Adham Halaoui, Firas H. Kobaissy, Safwan Alomari and Ibrahim Omeis
12. Proteomics of Pressure Ulcers in Spinal cord injury
M. Barderas
13. Innate immune responses of glia and inflammatory cells in spinal cord injury
Stella Elkabes, Lun Li, Cigdem Acioglu and Robert Heary
14. The role of oxidative stress in spinal cord injury animal models: a focus on nuclear factor erythroid-2 related factor 2
Fernando da Silva Fiorin, Caroline Cunha do Espírito-Santo and L.F.F. Royes
15. Novel agent ONO-2506 suppresses astrocytic activation and attenuates post-spinal cord injury pain
Hiroyuki Ishiguro and Takashi Kaito
16. Histology, neural tissue loss and compression-induced spinal cord injury
Jaroslav Pavel
17. Remodeling mitochondrial transport and cellular energetics in axonal regeneration and spinal cord injury
Ning Huang and Zu-Hang Sheng
18. Neurotrophins and their Role in Axonal Outgrowth Following Spinal Cord Injury
Darren Svirskis, Anusha Dravid and Simon O'Carroll
19. The neuroscience of transient receptor potential vanilloid type 4 (TRPV4) and spinal cord injury
I. Han and Hemant Kumar
20. Autoantibodies in spinal cord injury
Daniel Garcia-Ovejero, Lukas Grassner, Eduardo Molina-Holgado and Angel Arevalo-Martin
21. Calpain role in the pathophysiology of spasticity after spinal cord injury
Frédéric Brocard
22. Targeting mTOR Signaling to Promote Autophagy for Functional Recovery after Spinal Cord Injury
Nadia Al-Sammarraie and Swapan K. Ray
23. Tertiary damage: Hippocampal and brain changes after spinal cord injury
Florencia Labombarda

III. Physiological and Metabolic Effects
24. Hormonal events and spinal cord injury: a focus on vasopressin and natriuretic peptide
Charles Hubscher
25. Linking sensorimotor plasticity, the motor cortex and spinal cord injury
R. Nardone
26. Bone mass and spinal cord injury: risk of fracture
Ifaz T. Haider, Narina Simonian, Thomas Schnitzer and W. Brent Edwards
27. Functional and morphological re-organization of the brain following spinal cord injury : Insights from MRI
Maria M. D'Souza, Jeanne D'Souza, Prabhjot Kaur and Pawan Kumar
28. Cardiometabolic changes and upper extremity exercise as an augmentative strategy in spinal cord injury
Benjamin Scoblionko, Patricia Orme, James Pendleton, Roger Liu and James J. Bresnahan
29. Electrophysiological outcome measures in spinal cord injury: a new narrative
Radha Korupolu, Argyrios Stampas, Sudha Tallavajhula and Lumy Sawaki
30. Features and Physiology of Spinal Stretch Reflex Pathways in People with Chronic Spinal Cord Injury
Aiko K. Thompson and Thomas Sinkjær
31. Metabolic syndrome iin spinal cord injury: impact on health
Arcangelo Barbonetti, Chiara Castellini, Sandro Francavilla, Felice Francavilla and Settmio D’Andrea
32. Body composition and spinal cord injury
Katherine Jane Desneves, Nicole Kiss, Robin Daly and Leigh Ward
33. Energy requirements and spinal cord injury
Katherine Jane Desneves, Nicole Kiss, Robin Daly and Leigh Ward
34. Virtual walking and spinal cord injury neuropathic pain
Elizabeth Richardson and Zina Trost
35. Cervical spinal cord injury and thermoregulatory processes: a new narrative
Ibrahim Omeis
36. Spinal cord injury and the gut microbiota
Phillip G. Popovich and Kristina A. Kigerl

IV. Behavioural and Psychological Effects
37. Risk factors and predictors of depression after spinal cord injury: emphasis on the inflammatory process
Caroline Cunha do Espírito-Santo, Fernando da Silva Fiorin and L.F.F. Royes
38. Spirituality, hope, and resilience in the recovery and adaptation process following spinal cord injury
Kate Jones and Grahame Simpson
39. Wellness intervention for spinal cord injuries
Stephanie L. Silveira, Emma Richardson and Robert W. Motl
40. Sexual satisfaction and spinal cord injury
Seçil Taylan
41. Depressive symptoms in rehabilitation, spinal cord injury
Swati Mehta
42. Self-Harm behaviors in Patients with Spinal Cord Injuries: From Nonadherence to Suicide
Maggi Budd, Herb Ames and John Bradley