Sjogren's Syndrome: A Clinical Handbook

Description:

Written by leaders in the field and edited by Dr. Frederick Vivino, this concise, practical resource provides best practices for the diagnosis and treatment of Sjogren’s Syndrome. It offers a concise overview of this complex autoimmune disease, including information on specific clinical settings, childhood Sjogren’s, extra-oral and extra-ocular manifestations, vaccine safety, complementary and alternative medicine, and much more.

Provides concise, clinically focused content with an emphasis on diagnosis and treatment.

Includes Sjogren's Syndrome Foundation Practice Guidelines and the most recent ACR-EULAR classification criteria.

Consolidates today's available information and experience in this important area into one convenient resource.

Table of Contents:

Chapter 1. Sjögren's syndrome: Past, present, and future

Perspective

Brief review of the past—as “we only stand on the shoulders of past giants”

Questions for the present

Looking forward to to the future

Conclusions

Chapter 2. Diagnosis and evaluation of Sjögren's syndrome

Challenge of diagnosis

Clinical presentations

Approach to diagnosis in the clinical setting

Objective assessment of dry eyes

Objective assessment of salivary gland involvement

Proof of autoimmunity

Evolution of the classification criteria

Practical diagnosis

Differential diagnosis

Further evaluation

Conclusions

Chapter 3. Oral manifestations and management in Sjögren's syndrome

Importance of saliva

Major complications and management

Salivary gland swelling

Salivary gland obstruction

Infections

Mucosal lesions

Conclusions

Chapter 4. Diagnosis and management of Sjögren's syndrome related dry eye

Introduction

Diagnosis

Treatment of dry eye and meibomian gland dysfunction

Special considerations

Conclusions

Chapter 5. Approach to children with Sjögren’s syndrome

Introduction

Clinical manifestations

Evaluation

Management

Conclusions

Chapter 6. Extraglandular abnormalities in Sjögren's syndrome

Fatigue and fever

Musculoskeletal manifestations

Pulmonary manifestations

Renal manifestations

Gastrointestinal manifestations

Hematologic abnormalities

Dermatologic manifestations

Conclusions

Chapter 7. Vasculitis in Sjögren's syndrome

Definition and classification

Clinical manifestations

Treatment

Conclusions

Chapter 8. Lymphoproliferative disease in Sjögren's syndrome

Introduction

Epidemiology

Lymphoma in secondary Sjögren's syndrome

Lymphoma subtypes

Multiple myeloma

Risk factors and prediction models

Pathology and pathogenesis

Clinical presentation

Imaging

Diagnostic evaluation

Lymphoma staging

Treatment of lymphoma

Prognosis

Screening protocol for lymphoma

Conclusions

Chapter 9. Sjögren's syndrome: Peripheral and autonomic nervous system involvement

Epidemiology

Clinical presentation

Diagnostic evaluation

Lessons from clinicopathologic studies

Management and prognosis

Conclusions

Chapter 10. Diagnosis and management of central nervous system Sjögren's syndrome

Prevalence

Pathophysiology

Major clinical syndromes

Neurodiagnostic studies

Treatment

Conclusions

Chapter 11. Treatment of Sjögren's syndrome internal organ manifestations and constitutional symptoms

Constitutional symptoms

Rheumatologic manifestations

Respiratory manifestations

Management of gastrointestinal manifestations

Management of renal manifestations

Conclusions

Chapter 12. Integrative rheumatology: Complementary and alternative medicine for the management of Sjögren's syndrome

Introduction

Dietary modifications

Nutritional supplements

Acupuncture

Guided imagery

Psychodynamic group therapy

Cognitive behavior therapy

Sleep disorders

Nonpharmacologic therapies for management of fibromyalgia

Conclusions

Chapter 13. Perioperative management of patients with Sjögren's syndrome

Perioperative management specific to Sjögren's syndrome

Managing sicca preoperatively

Managing extraglandular manifestations

Postoperative care

Risk of infection after surgery

Management of immunosuppression

Conventional disease-modifying antirheumatic drugs

Biologic and targeted therapies

Glucocorticoids

Key messages for immunosuppression

Conclusions

Chapter 14. Utility and safety of vaccines in Sjögren's syndrome

Vaccination: general considerations

Chapter 15. The cost of Sjögren's syndrome and the value of patient resources and support in management

Introduction

Burden of illness

Disability

Stress and Sjögren's syndrome

Support and availability of resources linked to better health

The Sjögren's Foundation: creating a community of support

Conclusions

Index