Description: Offering today’s most authoritative, comprehensive coverage of sleep disorders, Kryger’s Principles and Practice of Sleep Medicine, 7th Edition, is a must-have resource for sleep medicine specialists, fellows, trainees, and technicians, as well as pulmonologists, neurologists, and other clinicians who see patients with sleep-related issues. It provides a solid understanding of underlying basic science as well as complete coverage of emerging advances in management and treatment for a widely diverse patient population. Evidence-based content, hundreds of full-color illustrations, and a wealth of additional resources online help you make well-informed clinical decisions and offer your patients the best possible care.
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1 History of Sleep Physiology and Medicine 2 Normal Human Sleep: An Overview 3 Normal Aging 4 Daytime Sleepiness and Alertness 5 Sleep Deprivation 6 Introduction/Defining sleep Introduction 7 Neural Control of Sleep in Mammals 8 REM Sleep control and function 9 Deep-Brain Imaging of Brain Neurons and Glia during Sleep 10 Evolution of mammalian sleep 11 Sleep in Non-mammalian Vertebrates 12 Introduction: Genetics and Genomics of Sleep 13 Genetics and Genomics of Circadian Clocks 14 Genetics and Genomic Basis of Sleep in Simple Model Organisms 15 Genetics and Genomic Basis of Sleep in Rodents 16 Genetics and Genomic Basis of Sleep in Healthy Humans 17 Genetics and Genomic Basis of Sleep Disorders in Humans 18 Introduction to Physiology in Sleep 19 What Neuroimaging Reveals About the Brain Areas Generating, Maintaining and Regulating Sleep 20 Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation 21 Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders 22 Respiratory Physiology: Central Neural Control of Respiratory Neurons and Motoneurons during Sleep 23 Respiratory Physiology: Understanding the Control of Ventilation 24 Physiology of the Upper and Lower Airways 25 Respiratory Physiology: Sleep at High Altitudes 26 Sleep and Host Defense 27 Endocrine Physiology in Relation to Sleep and Sleep Disturbances 28 Thermoregulation in Sleep and Hibernation 29 Memory Processing in Relation to Sleep 30 Sensory and Motor Processing during Sleep and Wakefulness 31 Local and Use Dependent Aspects of Sleep 32 Pathophysiology of Sleep-Wake Disturbances after Traumatic Brain Injury 33 Introduction 34 Master Circadian Clock and Master Circadian Rhythm 35 Anatomy of the Mammalian Circadian System 36 Physiology of the Mammalian Circadian System 37 Human Circadian Timing System and Sleep-Wake Regulation 38 Sleep Homeostasis and Models of Sleep Regulation 39 Circadian Rhythms in Sleepiness, Alertness, and Performance 40 Central and Peripheral Circadian Clocks 41 Circadian Dysregulation and Cardiometabolic and Immune Health 42 Circadian Dysregulation in Brain Aging and Neuropsychiatric Health 43 Circadian Disorders of the Sleep-Wake Cycle Introduction 44 Introduction 45 Adenosine 46 Role of catecholamines in sleep-wake control in health and disease 47 Cholinergics 47 GABA 48 Histamine 49 Hypocretin/orexin 50 Serotonin and sleep 51 Melatonin 52 Opioids 53 Drugs That Disturb Sleep and Wakefulness 54 Introduction 55 Why We Dream 56 Dream Content: Quantitative Findings 57 EEG Correlates of Sucessful Dream Recall 58 The Neurobiology of Dreaming 59 Lucid Dreaming 60 What is the Function of Nightmares? 61 Dreams and Nightmares in Posttraumatic Stress Disorder 62 Incorporation of Waking Experiences into Dreams 63 Emotion, Motivation, and Reward in Relation to Dreaming 64 Dreaming during Pregnancy 65 Approach to the Patient with Disordered Sleep 66 Cardinal Manifestations of Sleep Disorders 67 Physical Examination of the Sleep Medicine Patient 68 Use of Clinical Tools and Tests in Sleep Medicine 69 Classification of Sleep Disorders 70 Epidemiology of Sleep Disorders 71 Sleep Medicine, Public Policy, and Public Health 72 Introduction Introduction 73 Sleep Forensics: Criminal Culpability for Sleep-Related Violence 74 Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them 75 Legal Aspects of Fatigue- and Safety-Sensitive Professions 76 Sleep Medicine Clinical Practice and Compliance - United States 77 Sleep Medicine Clinical Practice and Compliance - Europe 78 Introduction 79 Performance Deficits During Sleep Loss and Their Operational Consequences 80 Sleep and Sleep Disorders in Operational Settings 81 Shift Work, Shift-Work Disorder, Jet Lag, and Jet lag Disorder 82 Fatigue Countermeasures 83 Sleep, Sleepiness, and Performance Prediction Modeling 84 Fatigue Risk Management Systems 85 Safety Cases and Assessing Alternative Means of Regulatory Compliance in Fatigue Risk Management 86 Fatigue Proofing 87 Sleep and Athletic Performance 88 Assessment of the Occupational Sleep Medicine Field 89 Advances in Insomnia Pathophysiology and Treatment: An Introduction 90 Insomnia: Epidemiology, Risk Factors, & Health Disparities 91 Etiology and Pathophysiology of Insomnia 92 Pediatric Insomnia and its Developmental Trajectories 93 Insomnia Diagnosis, Assessment and Evaluation 94 Insomnia with Short Sleep Duration and Multidimensional Sleep Health 95 Behavioral Treatment I - Therapeutic Approaches and Implementation 96 Behavioral Treatment II - Efficacy, Effectiveness and Dissemination 97 Behavioral Treatment III - Digital and Telehealth Approaches 98 Pharmacological Treatment I - Therapeutic Approaches and Implementation 99 Pharmacological Treatment II - Efficacy, Effectiveness and Contraindications 100 SEQUENCED AND COMBINED PSYCHOLOGICAL AND PHARMACOLOGICAL TREATMENTS FOR INSOMNIA 101 Introduction Introduction 102 Parkinsonism 103 Sleep-Wake Disturbances and Stroke 104 Sleep and Neuromuscular Diseases 105 Alzheimer Disease and Other Dementias 106 Epilepsy 107 Sleep and Headache 108 Sleep Disorders after Traumatic Brain Injury 109 Autoimmune disorders (autoimmune encephalitides and MS) 110 Central Disorders of Hypersomnolence Introduction 111 Narcolepsy: Pathophysiology and Genetic Predisposition 112 Narcolepsy: Diagnosis and Management 113 Idiopathic Hypersomnia 114 Kleine-Levin Syndrome 115 Parasomnias-Overview and Approach 116 Disorders of Arousal 117 Sleep-Related Eating Disorder 118 REM Sleep Behavior Disorder 119 Nightmares and Dream Disturbances 120 Other Parasomnias 121 Restless Legs Syndrome and Periodic Limb Movements During Sleep 122 Movement Disorders in Sleep (other than PLMS) 123 Introduction 124 Central Sleep Apnea: Definitions, Pathophysiology, Genetics, and Epidemiology 125 Central Sleep Apnea: Diagnosis and Management 126 Anatomy and Physiology of Upper Airway Obstruction 127 Snoring and Pathologic Upper Airway Resistance Syndromes 128 Obstructive Sleep Apnea: Heritable Phenotypes and Genetics 129 Deep Phenotyping Across Diagnostic and Therapeutic Continuum of OSA 130 Clinical and Physiologic Heterogeneity of Obstructive Sleep Apnea 131 Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management 132 Positive Airway Pressure Treatment for Obstructive Sleep Apnea 133 Pharmacological Treatments for Sleep Apnea Syndromes 134 Alternative strategies to management of Sleep Disordered Breathing 135 Brain Health in Sleep Apnea 136 Obstructive Sleep Apnea and Metabolic Disorders 137 Overlap Syndromes of Sleep and Breathing Disorders 138 Obesity-Hypoventilation Syndrome 139 Obstructive Sleep Apnea, Obesity, and Bariatric Surgery 140 Advanced modes of positive pressure therapy for sleep-disordered breathing 141 Sleep and Breathing at High Altitude 142 Evolution of sleep disordered breathing across the adult years 143 Introduction 144 Sleep-Related Cardiac Risk 145 Cardiac Arrythmogenesis During Sleep: Mechanisms, Diagnosis, and Therapy 146 Cardiovascular Effects of Sleep-Related Breathing Disorders 147 Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea 148 Coronary Artery Disease and Obstructive Sleep Apnea 149 Heart Failure 150 Stroke/TIA and SDB 151 Insomnia and CVD 152 Introduction Introduction 153 Sleep and Cancer across the Lifespan 154 Fibromyalgia and Chronic Fatigue Syndromes 155 Endocrine Disorders 156 Pain and Sleep 157 Sleep in Chronic Kidney Disease 158 Sleep in the Critically Ill Patient 159 Peri-operative Sleep Medicine 160 Sleep and GI 160 Sleep in Chronic Respiratory Failure 161 Introduction 162 Stress and Sleep 162 Emotion and Sleep Introduction 163 Anxiety Disorders 164 Mood Disorders 165 Schizophrenia and Sleep 166 Substance Abuse 167 Dentistry and Otorhinolaryngology in Sleep Medicine: below the brain and above the larynx 168 Oronasopharyngeal growth & Skeletal Malformations 169 Sleep Bruxism: Definition, Prevalence, Etiology and Mechanisms 170 Sleep Bruxism: Diagnostic Considerations 171 Management of sleep bruxism: psychological, dental, and medical approaches in adults 172 Orofacial Pain/TMD in Relation to Sleep Bruxsim and Breathing Disorders 173 Oral Appliances for Sleep-Disordered Breathing 174 Anesthesia in Upper Airway Surgery 175 Upper airway surgery to treat SBD 176 Pharmacotherapy, Complementary, and Alternative Medicine for Sleep Bruxism 177 Overview 178 SLEEP-RELATED BREATHING DISORDERS IN CHILDREN 179 Neuromuscular disorders: Muscular Dystrophy, Spinal Muscular Atrophy, Mitochondrial Disorders, Myasthenia Gravis, Spina Bifida/Chiari Malformation, Cerebral Palsy, Myotonic Dystrophy, Seizure Disorders 180 Transitional Care for Adolescents with Narcolepsy and other central disorders of hypersomnolence 181 Congenital Heart Disease 182 SLEEP IN INTERSEX AND TRANSGENDER INDIVIDUALS 183 Introduction Introduction 184 Sex Effects and Differences in Circadian Rhythms and Sleep 184 Syndromes Associated with Developmental Delays: Down syndrome, Marfan's syndrome, Other 185 The Menstrual Cycle, Sleep and Circadian Rhythms 186 Sleep and Sleep Disorders Associated with Pregnancy 187 Sleep Disordered Breathing during Pregnancy 188 Postpartum Period and Early Parenthood 189 Sleep and Menopause 190 Introduction 191 Psychiatric and Medical Comorbidities and Effects of Medications in Older Adults 192 Introduction 192 Obstructive Sleep Apnea in Older Adults 193 Insomnia in Older Adults 194 Circadian Rhythms in Older Adults 195 Sleep in Long-Term Care Settings 196 Section Introduction: Polysomnography and beyond 197 Sleep stage scoring 198 CNS Arousals & Cyclic Alternating Patterns 199 Neurologic Monitoring Techniques 200 Monitoring Techniques for Evaluating Suspected Sleep-Disordered Breathing 201 Sleep Telemedicine and Remote PAP Adherence Monitoring 202 Cardiopulmonary Coupling 203 Pulse Wave Analysis 204 Recording and Scoring Sleep-related Movements 205 Home Sleep Testing for Sleep Related Breathing Disorders 206 Consumer sleep tracking: ANSI/CTA performance standards 206 Consumer Sleep 207 Evaluating Sleepiness and Fatigue 208 THE ASSESSMENT OF INSOMNIA 209 Surveys, Sampling, and Polling Methods for Sleep and Public Health 210 Techniques for Clinical Assessment of Circadian Rhythm Disorders 211 Actigraphy Methods and Technical Issues 212 Imaging 213 Sleep and Covid
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