Paul's Fundamental Immunology

Selected as a Doody's Core Title for 2022!

Defining the field of immunology for nearly 40 years, Paul's Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015 and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It's an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.

• Reflects the latest advances in the field, including current insights on immune system function, both basic and translational.
• Contains 51 chapters written by leaders in all subfields of immunology.
• Provides extensive coverage of molecular biology that explains the dynamics underlying immune disorders and their treatment
• Includes 11 all-new chapters covering invertebrate and plant immunity, eosinophils, innate lymphoid cells, gamma/delta T cells, NKT and MAIT cells, immunometabolism, systems immunology, maternal-fetal immunology and more.
• Contains abundant full-color illustrations and tables that provide essential information at a glance.
• Features annual updates from the authors to the VST version, keeping you current with changes in this dynamic field.

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Table of Contents:

Cover image

Title

Copyright

Dedication

Contributors

Foreword

Preface

Contents

Section I. Introduction to Immunology

1 Overview of the Immune System

2 History of Immunology

Section II. Evolution of the Immune System

3 The Insect Immune System

4 Evolution of the Vertebrate and Lower Deuterostome Immune System

5 The Plant Immune System

Section III. Cellular Pathways and Processes in Immunity

6 Immunometabolism

7 Regulated Cell Death in the Immune System

8 Lymphoid Tissues and Organs

9 Type I Cytokines, Interferons, and Their Receptors

10 Tumor Necrosis Factor Superfamily of Cytokines and Receptors

11 Chemokines and Chemokine Receptors

Section IV. Innate Immunity

12 Pattern Recognition Receptors and the IL-1 Family

13 The Complement System

14 Neutrophils

15 Macrophages

16 Mast Cells and Basophils

17 Eosinophils

18 The Biology of Natural Killer Cells and Innate Lymphoid Cells

Section V. Adaptive Immunity

19 The Major Histocompatibility Complex

20 Classical Antigen Processing and Presentation

21 Immunoglobulins: Structure and Function

22 Immunoglobulins: Molecular Genetics

23 T Cell Antigen Receptors and Antigen Recognition

24 Antigen Receptor Signaling

25 B Cell Development in Mice

26 B Cell Responses

27 T Cell Development in the Thymus

28 CD4+ Helper T Cells: Differentiation, Flexibility, and Heterogeneity

29 Regulatory T Cells

30 CD8+ T Cell Memory

31 Cytotoxic Effector Functions

Section VI. Integrative Immunology

32 Immunologic Tolerance

33 Fc Receptors and Their Role in Immune Regulation and Inflammation

34 Dendritic cells

35 Gamma Delta T Cells

36 CD1-Restricted T Cells

37 Mucosal-Associated Invariant T Cells and Other MR1-Reactive T Cells

38 The Mucosal Immune System

39 Introduction to Neuroimmunology

40 Vaccines

41 Maternal-Fetal Immunology

Section VII. Immune Responses to Pathogens

42 Response to Parasites

43 Immune Responses to Bacteria

44 Response to Viruses

45 Immunology of HIV Infection

Section VIII. Immunological Disease States and Immunodeficiency

46 Autoimmunity and Autoimmune Diseases

47 Immunologic Mechanisms of Allergic Disorders

48 Transplantation Immunology

49 Cancer Immunology and Immunotherapy

50 Inborn Errors of Immunity

Index