Oxford Textbook of Endocrinology and Diabetes 3e

Oxford Textbook of Endocrinology and Diabetes 3e

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Cod produs/ISBN: 9780198870197

Disponibilitate: La comanda in aproximativ 4 saptamani

Limba: Engleza

Nr. pagini: 1300

Coperta: Hardcover


An aparitie: 10 Mar 2022



Now in its third edition, the Oxford Textbook of Endocrinology and Diabetes is an up-to-date, objective and comprehensive text that covers the full scope of endocrinology and diabetes. It contains wide ranging and pragmatic advice on diagnosis and clear guidelines for recommended management, while also covering the scientific principles that underlie the medical practice in this important field. The book has been re-organised into 15 overarching sections, with new sections on Endocrinology of Pregnancy and Management of the Transgender Patient included. All other sections have been extensively updated and restructured. Each chapter is written by an internationally acknowledged expert, relates basic science to evidence based guidelines and clinical management, and where appropriate offers an outline of the controversies in the subject. The textbook has an international focus and deals with subject matter applicable across the globe. The new edition has over 800 images complementing the extensive text and information provided. The book is a 'one-stop' text for trainees and consultants in Endocrinology and Diabetes, residents, those preparing for sub-specialty exams and other professionals allied to the area who need to gain an understanding of the field. It acts as both a point of reference for the experienced consultant as well as a trusted training resource. Purchase of the print work also includes full access to the online edition of the textbook for the life of the edition.


Table of Contents:


Section 1 Principles of Basic and Clinical Endocrinology

1.1 Endocrine Practice Fundamentals

1.2 Hormones and Receptors: Fundamental Considerations

1.3 Molecular Aspects of Hormone Regulation

1.4 Endocrinology and Evolution: Lessons from Comparative Endocrinology

1.5 Hormones Across the Lifespan

1.6 Pituitary Assessment Strategy

1.7 Endocrine Autoimmunity

1.8 Common Features of Endocrine Tumours

1.9 Genetic Aspects of Endocrine Disease

1.10 Environmental Influences on Endocrine Disease

1.11 Endocrinology, Sleep, and Circadian Rhythms

1.12 Principles of Hormone Replacement

1.13 Prevention in Endocrinology

Section 2 Pituitary and Hypothalamic Diseases

2.1 Functional Anatomy of the Hypothalamus and Pituitary

2.2 The Neurohypophysis

2.3 Aetiology, Pathogenesis, and Management of Disease of the Pituitary

2.3.1 Development of the Pituitary and Genetic Forms of Hypopituitarism

2.3.2 Molecular Pathogenesis of Pituitary Tumours

2.3.3 Histopathology of Pituitary Tumours

2.3.4 Imaging of the Pituitary

2.3.5 Hypopituitarism: Replacement of Adrenal, Thyroid, and Gonadal Axes

2.3.6 Adult Growth Hormone Deficiency

2.3.7 Surgery of Pituitary Tumours

2.3.8 Pituitary Radiotherapy

2.3.9 Prolactinomas and Hyperprolactinaemia (Including Macroprolactinaemia)

2.3.10 Acromegaly

2.3.11 Clinically Non-Functioning Pituitary Tumours and Gonadotropinomas

2.3.12 Thyrotropinomas

2.3.13 Pituitary Carcinoma

2.3.14 Pituitary Incidentalomas

2.4 Aetiology, Pathogenesis, and Management of Diseases of the Hypothalamus

2.4.1 Hypothalamic Dysfunction (Hypothalamic Syndromes)

2.4.2 Craniopharyngiomas

2.4.3 Perisellar Tumours Including Cysts, Hamartomas, and Vascular Tumours

2.4.4 Lymphocytic Hypophysitis and other Inflammatory Conditions of the Pituitary

2.5 Pineal Physiology and Pathophysiology, Including Pineal Tumours

Section 3 Thyroid Disease

3.1 Evaluation of the Thyroid Patient

3.1.1 The History and Iconography Relating to the Thyroid Gland

3.1.2 Biosynthesis, Transport, Metabolism, and Actions of Thyroid Hormones

3.1.3 Clinical Assessment of the Thyroid Patient

3.1.4 Thyroid Function Tests and the Effects of Drugs

3.1.5 Non-Thyroidal Illness (NTI)

3.1.6 Thyroid Imaging: Nuclear Medicine Techniques

3.1.7 Thyroid Imaging: Non-Isotopic Techniques

3.1.8 Epidemiology of Thyroid Disease and Swelling

3.2 Aetiology of Thyroid Disorders

3.2.1 The Complex Genetics of Thyroid Disease

3.2.2 Environmental Factors

3.2.3 Iodine Deficiency Disorders

3.2.4 Radiation-Induced Thyroid Disease

3.2.5 Autoimmune Thyroid Disease

3.2.6 Thyroiditis

3.3 Thyrotoxicosis and Related Disorders

3.3.1 Clinical Assessment and Systemic Manifestations of Thyrotoxicosis

3.3.2 Thyrotoxic Periodic Paralysis

3.3.3 Thyrotoxic Storm

3.3.4 Subclinical Hyperthyroidism

3.3.5 Causes and Laboratory Investigations of Thyrotoxicosis

3.3.6 Antithyroid Drugs for Thyrotoxicosis

3.3.7 Radioiodine Treatment of Hyperthyroidism

3.3.8 Surgery for Thyrotoxicosis

3.3.9 Management of Graves’ Hyperthyroidism

3.3.10 Graves’ Orbitopathy and Dermopathy

3.3.11 Management of Toxic Multinodular Goitre and Toxic Adenoma

3.3.12 Management of Thyrotoxicosis Without Hyperthyroidism

3.4 Hypothyroidism

3.4.1 Clinical Assessment and Systemic Manifestations of Hypothyroidism

3.4.2 Causes and Laboratory Investigation of Hypothyroidism

3.4.3 Myxoedema Coma

3.4.4 Subclinical Hypothyroidism

3.4.5 Syndromes of Resistance to Thyroid Hormone

3.4.6 Treatment of Hypothyroidism

3.5 Thyroid Lumps

3.5.1 Pathogenesis of Non-Toxic Goitre

3.5.2 Management of Non-Toxic Multinodular Goitre

3.5.3 Management of the Single Thyroid Nodule

3.5.4 Pathogenesis of Thyroid Cancer

3.5.5 Pathology of Thyroid Cancer

3.5.6 Papillary, Follicular, and Anaplastic Thyroid Carcinoma and Lymphoma

3.5.7 Medullary Thyroid Carcinoma

Section 4 Parathyroid, Calcium and Bone Metabolism Disorders

4.1 Parathyroid Anatomy, Hormone Synthesis, Secretion, Action, and Receptors

4.2 Hypercalcaemia

4.3 Primary Hyperparathyroidism

4.4 Familial Hypocalciuric Hypercalcaemia Types 1–3 and Neonatal Severe Primary Hyperparathyroidism

4.5 Hypocalcaemic Disorders, Hypoparathyroidism, and Pseudohypoparathyroidism

4.6 Bones and the Kidney—The Practical Conundrum: Distinguishing Between Osteoporosis and the Bone Diseases that Accompany Chronic Renal Failure

4.7 Hypercalcaemic and Hypocalcaemic Syndromes in Children

4.8 Osteoporosis

4.9 Thyroid Disorders and Bone Disease

4.10 Paget’s Disease of Bone

4.11 Rickets and Osteomalacia (Acquired and Heritable Forms)

4.12 Glucocorticoid-Induced Osteoporosis

Section 5 Adrenal Diseases

5.1 Adrenal Imaging

5.2 Adrenal Surgery

5.3 Adrenal Incidentaloma

5.4 Adrenocortical Cancer

5.5 Phaeochromocytoma and Paraganglioma

5.5.1 Genetics of Phaeochromocytomas, Paragangliomas, and Neuroblastoma

5.5.2 Management of Phaeochromocytoma and Paraganglioma

5.6 Primary Aldosteronism

5.6.1 Genetics of Primary Aldosteronism and Other Steroid-Related Causes of Endocrine Hypertension

5.6.2 Management of Primary Aldosteronism

5.7 Cushing’s Syndrome

5.8 Adrenal Insufficiency

5.8.1 Genetics of Adrenal Insufficiency

5.8.2 Management of Adrenal Insufficiency

5.9 Congenital Adrenal Hyperplasia

5.9.1 Genetics of Congenital Adrenal Hyperplasia

5.9.2 Modern Management of Congenital Adrenal Hyperplasia and Prospects for the Future

Section 6 Neuroendocrine Tumours and Inherited Endocrine Tumour Syndromes

6.1 Overview and Pathophysiology of Neuroendocrine Neoplasms

6.2 Neuroendocrine Tumour Markers

6.3 Carcinoid Syndrome

6.4 Lung Neuroendocrine Tumours

6.5 Non-Functioning Pancreatic Neuroendocrine Tumours

6.6 Gastrinoma

6.7 Insulinoma and Hypoglycaemia

6.8 Glucagonoma

6.9 Vasointestinal Polypeptide Secreting Tumours

6.10 Somatostatinoma

6.11 Imaging Neuroendocrine Tumours of the Gastrointestinal Tract/Gastroenteropancreatic Neuroendocrine Tumours (GEP-NET)

6.11.1 Multiple Endocrine Neoplasia Type 1

6.11.2 Multiple Endocrine Neoplasia Type 2a and 2b

6.12 Familial Syndromes and Genetic Causes of Paraganglioma and Phaeochromocytoma

6.13 Carney’s Complex

6.14 Molecular and Clinical Characteristics of the McCune–Albright Syndrome

6.15 Cowden Syndrome

Section 7 Disorders of Growth, and Development and Transition

7.1 Growth and Its Disorders

7.1.1 Recognizing Normal and Disordered Growth

7.1.2 Disorders of the GH-IGF Axis

7.1.3 Short Stature in Children Born Small for Gestational Age

7.1.4 Growth Disorders with No Defined Aetiology

7.1.5 Tall Stature

7.2 Sex Development

7.2.1 Sex Determination and Differentiation: Physiology Leading to Male and Female Development

7.2.2 Disorders of Sex Development (DSD) in the Newborn

7.3 Pubertal Disorders

7.3.1 Recognizing Normal and Disordered Pubertal Development

7.3.2 Pubertal Delay and Hypogonadism

7.3.3 Precocious Puberty: Diagnosis and Management

7.4 Transition in Endocrinology

Section 8 Female Reproductive Endocrine Disorders

8.1 Normal Female Endocrinology and Ovarian Disorders

8.1.1 Neuroendocrinology of Reproduction: The Role of Hypothalamus and Pituitary

8.1.2 Ovarian and Uterine Development from Fetal Life to Puberty

8.1.3 Menstrual Cycle and Ovulation

8.2 Evaluation of the Female Patient with Suspected Reproductive Endocrine Disorders

8.2.1 Clinical Evaluation of Patients with Suspected Reproductive Endocrine Disorders

8.2.2 Laboratory Evaluation

8.3 Female Reproductive Endocrinology

8.3.1 Disorders of Gonadotropin Secretion

8.3.2 Hyperprolactinaemia

8.3.3 Premenstrual Syndrome

8.4 Polycystic Ovary Syndrome and Other Androgen Excess Disorders

8.4.1 Polycystic Ovary Syndrome: Definitions, Phenotypes, Prevalence, and Genetics

8.4.2 Polycystic Ovary Syndrome: Reproductive Aspects

8.4.3 Polycystic Ovary Syndrome: Metabolic Aspects

8.4.4 Polycystic Ovary Syndrome: Hirsutism

8.5 Female Hypogonadism in Pre- and Post-Menopause

8.5.1 Female Hypogonadism: Premature Ovarian Insufficiency

8.5.2 Female Hypogonadism: Endocrinology of the Menopause and Hormone Replacement Therapy

8.6 Female Infertility

8.6.1 Female Infertility and Assisted Reproduction

8.6.2 Female Infertility: Fertility Preservation

8.7 Hormonal Contraception

8.7.1 Hormonal Contraception

8.8 Exogenous Factors and Female Reproductive Health

8.8.1 Exogenous Factors and Female Reproductive Health: Common Extragonadal Endocrinopathies Affecting Reproduction

8.8.2 Exogenous Factors and Female Reproductive Health: Nutrition and Reproduction

8.8.3 Exogenous Factors and Female Reproductive Health: Environment and Reproduction

Section 9 Endocrine Disorders of Pregnancy

9.1 General Considerations Relating to Thyroid Disease in Pregnancy

9.2 Management of Thyroid Disorders Before Assisted and Spontaneous Pregnancies

9.3 Thyroid Disease During Pregnancy

9.4 Management of Thyroid Disorders After Pregnancy

9.5 Thyroid Disorders in Newborns

9.6 Pituitary Tumours in Pregnancy

9.7 Other Disorders of the Pituitary and Hypothalamus in Pregnancy

9.8 Adrenal Disease in Pregnancy

9.9 Endocrine Bone Disease in Pregnancy

9.10 Imaging of Endocrine Disorders in Pregnancy

Section 10 Male Reproductive Endocrine Disorders

10.1 Normal Male Reproductive Endocrinology

10.1.1 Endocrine and Local Regulation of Testicular Hormone and Sperm Production

10.1.2 Sex Steroid Actions in the Male

10.2 Evaluation of the Male Patient with Suspected Hypogonadism and/or Infertility

10.2.1 Clinical Evaluation

10.2.2 Endocrine Evaluation

10.2.3 Diagnostic Semen Analysis

10.3 Klinefelter’s Syndrome

10.4 Male Adult Hypogonadism

10.4.1 Aetiology

10.4.2 Types of Treatment

10.4.3 Induction of Spermatogenesis by Gonadotrophin Treatment

10.4.4 Benefits of Testosterone Treatment

10.4.5 Risks of Testosterone Treatment

10.5 Management of Idiopathic Male Infertility

10.6 Hypothalamo–Pituitary–Testicular Axis Function in Systemic Diseases and Effects of Medications

10.7 Management of Male Sexual Dysfunction

10.8 Hormonal Male Contraception

10.9 Management of Gynaecomastia

10.10 Exogenous Factors and Male Reproductive Health

10.10.1 Environmental Influences on Male Reproductive Health

Section 11 Management of the Transgender Patient

11.1 Introduction to Transgender and Gender Diverse People

11.2 Endocrine Treatment of Transgender Youth

11.3 Hormone Therapy in Transgender Women

11.4 Hormone Therapy in Transgender Men

11.5 Fertility Options for Transgender Persons

Section 12 Endocrine Responses to Systemic Diseases or Substance Misuse

12.1 Endocrinology of Systemic Disease

12.1.1 The Endocrine Response to Stress

12.1.2 Endocrinology in the Critically Ill

12.1.3 Hormones and the Kidney

12.1.4 The Endocrinology of Liver Disease

12.1.5 Endocrine Abnormalities in HIV Infection

12.1.6 The Endocrinology of Anorexia Nervosa

12.2 Endocrine Complications of Substance Misuse

12.2.1 Endocrinology and Alcohol

12.2.2 Use and Abuse of Performance-Enhancing Hormones in Sport

12.2.3 Effect of Opioids on Adrenal and Reproductive Endocrinology

Section 13 Endocrinology of Cancer

13.1 Endocrine Disorders Caused by Cancer or its Treatment

13.1.1 Metastatic Disease in Endocrine Organs

13.1.2 Paraneoplastic Endocrine Syndromes

13.1.3 Long-Term Endocrine Sequelae of Cancer Therapy

13.1.4 Endocrine Complications of Biological Cancer Therapies

13.2 Hormonal Therapy for Breast and Prostatic Cancers

13.2.1 The Breast: Lactation and Breast Cancer as an Endocrine Disease

13.2.2 Endocrine Treatment of Breast Cancer

13.2.3 Hormonal Therapy for Prostate Cancer: Molecular Basis of Efficacy and Therapeutic Bypass

Section 14 Obesity, Dyslipidaemia and other Metabolic Disorders

14.1 Obesity

14.1.1 The Physiology of Bodyweight Regulation

14.1.2 Obesity as a Public Health Problem

14.1.3 Medical Complications of Obesity

14.1.4 Dietary and Medical Management of Obesity

14.1.5 Metabolic Surgery

14.1.6 Assessment of Obesity in Children

14.1.7 Management of Obesity in Children and Young People

14.1.8 Planning Obesity Care Pathways

14.2 Lipoprotein Metabolism and Dyslipidaemia

14.2.1 Lipoprotein Metabolism

14.2.2 Genetic Forms of Dyslipidaemia

14.3 Other Metabolic Disorders

14.3.1 Hyperinsulinaemic Hypoglycaemia

14.3.2 Autoimmune Hypoglycaemia

14.3.3 Disorders of Carbohydrate Metabolism

14.3.4 Haemochromatosis and Other Inherited Diseases of Iron Metabolism

14.3.5 The Porphyrias

Section 15 Diabetes Mellitus

15.1 Introduction to Diabetes Mellitus

15.1.1 Physiology of Glucose Homeostasis

15.1.2 Classification and Diagnosis of Diabetes Mellitus

15.2 Type 1 Diabetes

15.2.1 Epidemiology and Public Health

15.2.2 Presentation and Natural History of Type 1 Diabetes

15.2.3 Pathogenesis

15.3 Type 2 Diabetes

15.3.1 Epidemiology and Public Health

15.3.2 Presentation and Natural History of Type 2 Diabetes

15.3.3 Pathogenesis

15.4 Non Type 1, Non Type 2 Diabetes

15.4.1 Diagnosis of Non Type 1, Non Type 2 Forms of Diabetes

15.5 Principles of Management of Diabetes

15.5.1 Structured Education

15.5.2 Glucose Monitoring and Sensing

15.5.3 Insulins and Insulin Delivery Devices

15.5.4 Non-Insulin Glucose-Lowering Agents

15.5.5 Hypoglycaemia in the Treatment of Diabetes Mellitus

15.6 Evidence-Based Management of Type 1 Diabetes

15.6.1 Strategies for the Management of Type 1 Diabetes

15.6.2 Psychological and Behavioural Aspects of Type 1 Diabetes Management

15.6.3 Immunotherapy for Type 1 Diabetes

15.6.4 Transplantation (Islet and Solid Organ)

15.7 Evidence-based Prevention and Management of Type 2 Diabetes

15.7.1 Strategies for the Management of Type 2 Diabetes

15.7.2 Psychological and Behavioural Aspects of Type 2 Diabetes Management

15.7.3 Type 2 Diabetes in Different Ethnic Groups

15.7.4 Prevention of Type 2 Diabetes

15.8 Emerging Approaches to Restoring Euglycaemia in Diabetes

15.8.1 Regenerative Medicine for Diabetes

15.8.2 “Closed Loop” Insulin Delivery

15.9 Emergency and Hospital Management of Diabetes

15.9.1 Hyperglycaemic Emergencies

15.9.2 Management of the Inpatient with Diabetes Mellitus

15.9.3 Care of Diabetes in ICU and Perisurgery

15.10 Specialized Management of Other forms of Diabetes

15.10.1 Monogenic Forms of Diabetes Resulting from Beta-Cell Dysfunction

15.10.2 Lipodystrophies and Severe Insulin Resistance Syndromes

15.10.3 Diabetes Secondary to Pancreatic Disease

15.10.4 Diabetes Secondary to Endocrine Disorders

15.10.5 Diabetes in Pregnancy

15.11 Psychiatry and Diabetes

15.11.1 Type 1 Diabetes and Psychiatry

15.11.2 Type 2 Diabetes and Psychiatry

15.12 Microvascular Complications of Diabetes

15.12.1 Pathogenesis of Microvascular Complications

15.12.2 Retinopathy

15.12.3 Diabetic Nephropathy

15.12.4 Diabetic Neuropathy

15.13 Macrovascular Disease in Diabetes

15.13.1 Mechanisms of Macrovascular Disease in Diabetes

15.13.2 Macrovascular Disease in Type 2 Diabetes

15.13.3 Macrovascular Disease in Type 1 Diabetes

15.13.4 Diabetic Dyslipidaemia

15.13.5 Hypertension in Diabetes Mellitus

15.14 The Diabetic Foot

15.14.1 Modern Management of Diabetes-Related Foot Disease

15.15 Delivery of Diabetes Care

15.15.1 Diabetes Service Organization

15.15.2 Health Economics of Diabetes Care and Prevention



An aparitie 10 Mar 2022
Autor John Wass, Wiebke Arlt, Robert Semple
Editura Oxford University Press
Format Hardcover
ISBN 9780198870197
Limba Engleza
Nr pag 1300

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