Neuroprotection in Critical Care and Perioperative Medicine

Description:

Neuroprotection is becoming an increasingly recognized and important part of critical care and perioperative medicine. As human beings survive increasingly severe life-threatening injuries and complex surgical interventions, it has become clear that neurologic injury and dysfunction is a primary driver of long-term outcome and disability. Neuroprotection is currently under-recognized as the primary objective in promoting recovery from life-threatening injuries, illnesses, and procedures. To address this knowledge gap, Neuroprotection in Critical Care and Perioperative Medicine provides a concise review of the current state of the art of clinical care and research. Within the context of critical care, the specific topics covered will include the primary forms of brain injury on which neuroprotection research and intervention has traditionally focused, such as traumatic brain injury, cardiac arrest, acute ischemic stroke, and intracranial hemorrhage, as well as CNS injuries related to sepsis and acute respiratory distress syndrome, mechanical circulatory support, and premature birth. Within the context of perioperative care, the specific topics covered will include anesthetic and perioperative strategies to reduce brain injury from cardiac surgery, aortic surgery and endovascular repair, carotid endarterectomy, vascular and endovascular neurosurgery, and other major surgical procedures.

Table of Contents:

Part I Protection Strategies

1 Physiologic Modulators of Neural Injury After Brain and Spinal Cord Injury

2 Pharmacologic Neuroprotection

Part II Clinimetrics of Neuroprotection

3 Imaging Assessment of Brain Injury

4 Tissue Biomarkers and Neuroprotection

5 Neurophysiologic Monitoring and Neuroprotection

6 Neurological and Functional Outcomes Assessment

7 Assessment of Postoperative Cognitive Decline

Part III Neuroprotection in Critical Care

8 Neuroprotection for Traumatic Brain Injury

9 Neuroprotection for Cardiac Arrest

10 Neuroprotection for Acute Ischemic Stroke

11 Neuroprotection for Intracerebral Hemorrhage

12 Neuroprotection for Mechanical Circulatory Support

13 Neuroprotection in Sepsis and Acute Respiratory Distress Syndrome

14 Neuroprotection for Premature Birth and Neonatal Brain Injury

15 Neuroprotection for Spinal Cord Injury

Part IV Peri-Operative Neuroprotection

16 Neuroprotection for Valvular and Coronary Artery Bypass Grafting Surgery

17 Neuroprotection for Aortic Surgery and Stenting

18 Neuroprotection for Carotid Endarterectomy and Carotid Artery Stenting

19 Neuroprotection for Vascular and Endovascular Neurosurgery

20 Neuroprotection for Spine Surgery

21 Neuroprotection for General, Orthopedic, Peripheral Vascular, and ENT Surgery

Index