Medical Microbiology, 9th Edition

Description:

The foremost text in this complex and fast-changing field, Medical Microbiology, 9th Edition, provides concise, up-to-date, and understandable explanations of key concepts in medical microbiology, immunology, and the microbes that cause human disease. Clear, engaging coverage of basic principles, immunology, laboratory diagnosis, bacteriology, virology, mycology, and parasitology help you master the essentials of microbiology―effectively preparing you for your coursework, exams, and beyond.

Features significant new information on the human microbiome and its influence on the immune and other body systems, and new developments in microbial diagnosis, treatment, diseases, and pathogens.

Updates every chapter with state-of-the-art information and current literature citations.

Summarizes detailed information in tabular format rather than in lengthy text.

Provides review questions at the end of each chapter that correlate basic science with clinical practice.

Features clinical cases that illustrate the epidemiology, diagnosis, and treatment of infectious diseases.

Introduces microbe chapters with summaries and trigger words for easy review.

Highlights the text with clear, colorful figures, clinical photographs, and images that help you visualize the clinical presentation of infections.

Offers additional study features online, including 200 self-assessment questions, microscopic images of the microbes, videos, and a new integrating chapter that provides hyperlinks between the microbes, the organ systems that they affect, and their diseases.

 

Table of Contents:

 

Section 1. Introduction

1. Introduction to Medical Microbiology

Historical Perspective

Viruses

Bacteria

Fungi

Parasites

Immunology

Diagnostic Microbiology

Microbiology and Immunology in the Clinic

Summary

2. Human Microbiome in Health and Disease

Human Microbiome Project

Core Microbiome

Evolution of the Microbiome and Normal Flora

Role of the Microbiome in Disease

Diagnostics and Therapeutics

Probiotics

Perspective

3. Sterilization, Disinfection, and Antisepsis

Sterilization

Disinfection

Antisepsis

Mechanisms of Action

Section 2. General Principles of Laboratory Diagnosis

4. Microscopy and In Vitro Culture

Microscopy

In Vitro Culture

5. Molecular Diagnosis

Nonamplified Nucleic Acid Probes

Nucleic Acid Analysis

Protein Analysis

6. Serologic Diagnosis

Antibodies

Methods of Detection

Immunoassays for Cell-Associated Antigen (Immunohistology)

Immunoassays for Antibody and Soluble Antigen

Serology

Section 3. Basic Concepts in the Immune Response

7. Elements of Host Protective Responses

Soluble Activators and Stimulators of Innate and Immune Functions

Cells of the Immune Response

8. Innate Host Responses

Barriers to Infection

Soluble Components of Innate Responses

Cellular Components of Innate Responses

Activation of Innate Cellular Responses

Normal Flora–Associated Responses

Inflammation

Bridge to Antigen-Specific Immune Responses

9. Antigen-Specific Immune Responses

Immunogens, Antigens, and Epitopes

T Cells

Cell-Surface Receptors of T Cells

Development of T Cells

Initiation of T-Cell Responses

Activation of CD4 T Cells and Their Response to Antigen

CD8 T Cells

INNATE T Cells

B Cells and Humoral Immunity

B cells

Immunoglobulin Types and Structures

Immunogenetics

Antibody Response

10. Immune Responses to Infectious Agents

Antibacterial Responses

Antiviral Responses

Specific Immune Responses to Fungi

Specific Immune Responses to Parasites

Other Immune Responses

Immunopathogenesis

Autoimmune Responses

Immunodeficiency

11. Antimicrobial Vaccines

Types of Immunizations

Immunization Programs

Section 4. Bacteriology

12. Bacterial Classification, Structure, and Replication

Differences between Eukaryotes and Prokaryotes

Bacterial Classification

Bacterial Structure

Structure and Biosynthesis of the Major Components of the Bacterial Cell Wall

Cell Division

Spores

13. Bacterial Metabolism and Genetics

Bacterial Metabolism

Human Bacterial Metabolism

Bacterial Genes and Expression

Bacterial Genetics

14. Mechanisms of Bacterial Pathogenesis

Entry into the Human Body

Colonization, Adhesion, and Invasion

Pathogenic Actions of Bacteria

Immunopathogenesis

Mechanisms for Escaping Host Defenses

Summary

15. Role of Bacteria in Disease

16. Laboratory Diagnosis of Bacterial Diseases

Specimen Collection, Transport, and Processing

Bacterial Detection and Identification

Antimicrobial Susceptibility Tests

17. Antibacterial Agents

Inhibition of Cell Wall Synthesis

Inhibition of Protein Synthesis

Inhibition of Nucleic Acid Synthesis

Other Antibiotics

18. Staphylococcus and Related Gram-Positive Cocci

Physiology and Structure

Pathogenesis and Immunity

Epidemiology

Clinical Diseases

Laboratory Diagnosis

Treatment, Prevention, and Control

19. Streptococcus and Enterococcus

Streptococcus pyogenes

Streptococcus agalactiae

Other β-Hemolytic Streptococci

Viridans Streptococci

Streptococcus pneumoniae

Enterococcus

20. Bacillus

Bacillus anthracis

Bacillus cereus

21. Listeria and Related Gram-Positive Bacteria

Listeria monocytogenes

Erysipelothrix rhusiopathiae

Corynebacterium diphtheriae

22. Mycobacterium and Related Acid-Fast Bacteria

• Physiology and Structure of Mycobacteria

• Mycobacterium Tuberculosis

• Other Slow-Growing Mycobacteria

• Rapidly Growing Mycobacteria

• Nocardia

• Other Weakly Acid-Fast Bacteria

23. Neisseria and Related Genera

Neisseria gonorrhoeae and Neisseria meningitidis

Other Neisseria Species

24. Haemophilus and Related Bacteria

Haemophilus

25. Enterobacteriaceae

General Properties

Escherichia coli

Salmonella

Shigella

Yersinia

Other Enterobacteriaceae

Other General Properties

26. Vibrio and Related Bacteria

Vibrio

Aeromonas

27. Pseudomonas and Related Bacteria

Pseudomonas

Burkholderia

Stenotrophomonas maltophilia

Acinetobacter

Moraxella

28. Campylobacter and Helicobacter

Campylobacter

Helicobacter

29. Miscellaneous Gram-Negative Rods

Bartonella

Bordetella

Other Bordetella Species

Brucella

Cardiobacterium

Francisella

Legionella

Streptobacillus

30. Clostridium

Clostridium difficile

Clostridium perfringens

Clostridium tetani

Clostridium botulinum

Other Clostridial Species

31. Non–Spore-Forming Anaerobic Bacteria

Anaerobic Gram-Positive Cocci

Answers

Anaerobic Gram-Positive Rods

Anaerobic Gram-Negative Cocci

Anaerobic Gram-Negative Rods

32. Treponema, Borrelia, and Leptospira

Treponema

Borrelia

Leptospira

33. Mycoplasma

Physiology and Structure

Pathogenesis and Immunity

Answers

Epidemiology

Clinical Diseases

Laboratory Diagnosis

Treatment, Prevention, and Control

34. Rickettsia, Ehrlichia, and Related Bacteria

Rickettsiaceae

Anaplasmataceae

Coxiellaceae

35. Chlamydia

Physiology and Structure

Section 5. Virology

36. Viral Classification, Structure, and Replication

Classification

Virion Structure

Viral Replication

Viral Genetics

Viral Vectors for Therapy

37. Mechanisms of Viral Pathogenesis

Basic Steps in Viral Disease

Infection of the Target Tissue

Viral Pathogenesis

Viral Disease

Epidemiology

Control of Viral Spread

38. Role of Viruses in Disease

Viral Diseases

Chronic and Potentially Oncogenic Infections

Infections in Immunocompromised Patients

Congenital, Neonatal, and Perinatal Infections

39. Laboratory Diagnosis of Viral Diseases

Specimen Collection

Cytology

Electron Microscopy

Viral Isolation and Growth

Detection of Viral Genetic Material

Detection of Viral Proteins

Viral Serology

40. Antiviral Agents and Infection Control

Targets for Antiviral Drugs

Nucleoside Analogs

Nonnucleoside Polymerase Inhibitors

Protease Inhibitors

Antiinfluenza Drugs

Immunomodulators

Infection Control

41. Papillomaviruses and Polyomaviruses

Human Papillomaviruses

Polyomaviridae

42. Adenoviruses

Structure and Replication

Pathogenesis and Immunity

Epidemiology

Clinical Syndromes

Laboratory Diagnosis

Treatment, Prevention, and Control

Therapeutic Adenoviruses

43. Human Herpesviruses

Structure of Herpesviruses

Herpesvirus Replication

Herpes Simplex Virus

Varicella-Zoster Virus

Epstein-Barr Virus

Cytomegalovirus

Human Herpesviruses 6 and 7

Other Human Herpesviruses

44. Poxviruses

Structure and Replication

Pathogenesis and Immunity

Epidemiology

Clinical Syndromes

45. Parvoviruses

Structure and Replication

Pathogenesis and Immunity

Epidemiology

Clinical Syndromes

Laboratory Diagnosis

Treatment, Prevention, and Control

46. Picornaviruses

Structure

Replication

Enteroviruses

Rhinoviruses

47. Coronaviruses and Noroviruses

Coronaviruses

Noroviruses

48. Paramyxoviruses

Structure and Replication

Measles Virus

Parainfluenza Viruses

Mumps Virus

Respiratory Syncytial Virus

Human Metapneumovirus

Nipah and Hendra Viruses

49. Orthomyxoviruses

Structure and Replication

Pathogenesis and Immunity

Epidemiology

Clinical Syndromes

Laboratory Diagnosis

Treatment, Prevention, and Control

50. Rhabdoviruses, Filoviruses, and Bornaviruses

Rhabdoviruses

Filoviruses

Borna Disease Virus

51. Reoviruses

Structure

Replication

Rotaviruses

Orthoreoviruses (Mammalian Reoviruses)

Coltiviruses and Orbiviruses

52. Togaviruses and Flaviviruses

Alphaviruses and Flaviviruses

Rubella Virus

53. Bunyaviridae and Arenaviridae

Bunyaviridae

Arenaviruses

54. Retroviruses

Classification

Structure

Replication

Human Immunodeficiency Virus

Human T-Cell Lymphotropic Virus and Other Oncogenic Retroviruses

Endogenous Retroviruses

55. Hepatitis Viruses

Hepatitis A Virus

Hepatitis B Virus

Hepatitis C and G Viruses

Hepatitis G Virus

Hepatitis D Virus

Hepatitis E Virus

56. Prion Diseases

Structure and Physiology

Pathogenesis

Epidemiology

Clinical Syndromes

Laboratory Diagnosis

Treatment, Prevention, and Control

Section 6. Mycology

57. Fungal Classification, Structure, and Replication

The Importance of Fungi

Fungal Taxonomy, Structure, and Replication

Ascomycota (Ascomycetes)

Basidiomycota (Basidiomycetes)

Glomerulomycota (Mucormycetes, formerly Zygomycetes)

Microspora (Microsporidia)

Classification of Human Mycoses

Summary

58. Pathogenesis of Fungal Disease

Primary Fungal Pathogens

Opportunistic Pathogens

59. Role of Fungi in Disease

60. Laboratory Diagnosis of Fungal Disease

Clinical Recognition of Fungal Infections

Conventional Laboratory Diagnosis

Immunologic, Molecular, and Biochemical Markers for Direct Detection of Invasive Fungal Infections

61. Antifungal Agents

Systemically Active Antifungal Agents

Topical Antifungal Agents

Investigational Antifungal Agents

Combinations of Antifungal Agents in the Treatment of Mycoses

Mechanisms of Resistance to Antifungal Agents

62. Superficial and Cutaneous Mycoses

Superficial Mycoses

Cutaneous Mycoses

63. Subcutaneous Mycoses

Lymphocutaneous Sporotrichosis

Chromoblastomycosis

Eumycotic Mycetoma

Subcutaneous Entomophthoromycosis

Subcutaneous Phaeohyphomycosis

64. Systemic Mycoses Caused by Dimorphic Fungi

Blastomycosis

Coccidioidomycosis

Emergomycosis and Adiaspiromycosis

Histoplasmosis

Paracoccidioidomycosis

Talaromycosis (Penicilliosis) marneffei

65. Opportunistic Mycoses

Candidiasis

Opportunistic Mycoses Caused by Cryptococcus Neoformans and Other Noncandidal Yeastlike Fungi

Microsporidia

Aspergillosis

Mucormycosis

Mycoses Caused by Other Hyaline Molds

Phaeohyphomycosis

Pneumocystosis

66. Fungal and Fungal-Like Infections of Unusual or Uncertain Etiology

Adiaspiromycosis

Chlorellosis

Lacaziosis (Lobomycosis)

Protothecosis

Pythiosis Insidiosi

Lagenidiosis

Rhinosporidiosis

Section 7. Parasitology

67. Parasitic Classification, Structure, and Replication

Importance of Parasites

Classification and Structure

Physiology and Replication

Summary

68. Pathogenesis of Parasitic Diseases

Exposure and Entry

Adherence and Replication

Cell and Tissue Damage

Disruption, Evasion, and Inactivation of Host Defenses

69. Role of Parasites in Disease

70. Laboratory Diagnosis of Parasitic Disease

Parasite Life Cycle as an Aid in Diagnosis

General Diagnostic Considerations

Parasitic Infections of the Intestinal and Urogenital Tracts

Parasitic Infections of Blood and Tissue

Alternatives to Microscopy

71. Antiparasitic Agents

Targets for Antiparasite Drug Action

Drug Resistance

Antiparasitic Agents

72. Intestinal and Urogenital Protozoa

Amebae (Amoebozoa)

Ciliates (Metamonada [Formerly Flagellates] and Ciliophora)

Sporozoa (Apicomplexa)

73. Blood and Tissue Protozoa

Plasmodium Species

Babesia Species

Toxoplasma gondii

Sarcocystis lindemanni

Free-Living Amebae

Leishmania

Trypanosomes

74. Nematodes

Enterobius vermicularis

Ascaris lumbricoides

Toxocara and Baylisascaris

Trichuris trichiura

Hookworms

Strongyloides stercoralis

Trichinella spiralis

Wuchereria bancrofti and Brugia malayi

Loa loa

Mansonella Species

Onchocerca volvulus

Dirofilaria immitis

Dracunculus medinensis

75. Trematodes

Fasciolopsis buski

Fasciola hepatica

Clonorchis sinensis

Paragonimus westermani

Schistosomes

76. Cestodes

Taenia solium

Cysticercosis

Taenia saginata

Diphyllobothrium latum

Sparganosis

Echinococcus granulosus

Echinococcus multilocularis

Hymenolepis nana

Hymenolepis diminuta

Dipylidium caninum

77. Arthropods

Myriapoda

Crustacea

Pentastomida

Chelicerata (Arachnida)

Hexapoda (Insecta)

Answers

Index

 

An aparitie	2020
Autor	Patrick R. Murray & Ken S. Rosenthal & Michael A. Pfaller
Dimensiuni	21.6 x 27.6 cm
Editura	Elsevier
Format	Book
ISBN	9780323673228
Limba	Engleza
Nr pag	872