Integrated Physiology and Pathophysiology

 

Description:

Edited by physiology instructors who are also active clinicians, Integrated Physiology and Pathophysiology is a one-stop guide to key information you need for early clinical and medical training and practice. This unique, integrated textbook unites these two essential disciplines and focuses on the most relevant aspects for clinical application. A concise, review-like format, tables and diagrams, spaced repetition for effective learning, and self-assessment features help you gain and retain a firm understanding of basic physiology and pathophysiology. Integrated Physiology and Pathophysiology works equally well as a great starting point in your studies and as a review for boards.

Shares the knowledge and expertise of an outstanding editorial team consisting of two practicing clinicians who also teach physiology and pathophysiology at Harvard Medical School, plus a top Harvard medical student.

Provides an integrated approach to physiology and pathophysiology in a concise, bulleted format. Chapters are short and focus on clinically relevant, foundational concepts in clear, simple language.

Employs focused repetition of key points, helping you quickly recall core concepts such as pressure-flow-resistance relationships, ion gradients and action potentials, and mass balance. You’ll revisit these concepts in a variety of meaningful clinical contexts in different chapters; this "spaced learning" method of reinforcement promotes deeper and more flexible understanding and application.

Includes Fast Facts boxes that emphasize take-home messages or definitions.

Contains Integration boxes that link physiology and pathophysiology to pharmacology, genetics, and other related sciences.

Presents clinical cases and with signs and symptoms, history, and laboratory data that bring pathophysiology to life.

Features end-of-chapter board-type questions, complete with clear explanations of the answers, to help prepare you for standardized exams.

 

Table of Contents:

 

Section I. Foundations

1.  General principles of physiology

Foundations of homeostasis

Transport processes in life

Cell membrane structure and transport functions

Types of membrane transport

Signal transduction

Cell-cell communication

Homeostasis

An electromechanical example of homeostasis

Pathophysiology

Case Study 1.1.  Introduction to diagnosis

Section II. Neurophysiology

2.  An overview of nerve cell physiology and electrophysiology

Introduction

Nerve cell structure and function

Pathophysiology of neurons, glia, and electrical conduction

Summary

Review questions

Answers to review questions

3.  Central nervous system

Introduction

Structure and function: The brain

Structure and function: The spinal cord

Central nervous system pathophysiology

Summary

Review questions

Answers to review questions

4.  Peripheral nervous system and autonomic nervous system

Introduction

Peripheral nervous system structure

Autonomic nervous system structure

Autonomic nervous system function

Autonomic nervous system pathophysiology

Summary

Review questions

Answers to review questions

5.  The neuromuscular junction and skeletal muscle

Introduction

System structure

System function

Pathophysiology

Summary

Review questions

Answers to review questions

6.  Smooth muscle

Introduction

System structure

System function

Pathophysiology

Summary

Review questions

Answers to review questions

Case Study 6.1.  Musculoskeletal physiology

Presentation

Discussion

Treatment and subsequent course

Section III. Circulatory Physiology

7.  Blood and hemostasis

Introduction

System structure

System function

Pathophysiology

Summary

Review questions

Answers to review questions

8.  The lymphatic system and the immune system

Introduction

Lymphatic system structure

Lymphatic system function

Lymphatic system pathophysiology

Introduction

Innate versus adaptive immunity

Immune system structure

Immune system function

Immune system pathophysiology

Summary

Review questions

Answers to review questions

Case Study 8.1.  Blood and lymph

Intracellular pathogen response: Virus

Recovery... or is it?

Extracellular pathogen response: Bacteria

Communication among immune cells: Initiation of the adaptive response

Recovery

Section IV. Cardiovascular Physiology

9.  The vasculature

Introduction

System structure

System function

Pathophysiology

Summary

Review questions

Answers to review questions

10.  The heart as a pump

Introduction

System structure

System function

Pathophysiology: Heart failure

Summary

Review questions

Answers to review questions

11.  Cardiac electrophysiology

Introduction

System structure

System function

Pathophysiology

Summary

Review question

Answer to review question

12.  Exercise physiology

Introduction

System function

Pathophysiology

Summary

Review questions

Answers to review questions

Case Study 12.1.  Cardiac physiology

Presentation: History

Discussion

Presentation: Physical examination and laboratory values

Discussion

Treatment and subsequent course

Discussion

Section V. Pulmonary Physiology

13.  The mechanics of breathing

Introduction

System structure: The thorax

System function: The bellows

Pathophysiology: Disorders of pulmonary mechanics

Aging: Altered lung mechanics

Summary

Review questions

Answers to review questions

14.  Gas exchange in the lung

Introduction

System structure: The distal respiratory tree and pulmonary circulation

System function: Oxygenation and the clearance of carbon dioxide

Pathophysiology

Summary

Review questions

Answers to review questions

15.  Gas transport

Introduction

System structure: Oxygen reservoirs and hemoglobin

System function: Oxygen and carbon dioxide transport

Pathophysiology

Summary

Review questions

Answers to review questions

16.  The regulation of breathing

Core concepts (Figs. 16.1 and 16.2)

System structure and function

Pathophysiology: Abnormal patterns of breathing

Summary

Review questions

Answers to review questions

Case Study 16.1.  Pulmonary physiology

Presentation: History

Discussion

Presentation: Physical examination and laboratory values

Discussion

Treatment and subsequent course

Discussion

Section VI. Renal Physiology

17.  Renal structure and function

Introduction

System structure: The kidney

System function: The kidney

Pathophysiology

Summary

Review questions

Answers to review questions

18.  Tubular transport

Introduction

System structure: Functional anatomy of the kidney tubule

System function: Reabsorption and secretion

Pathophysiology of the kidney tubule

Summary

Review questions

Answers to review questions

19.  The regulation of blood pressure and extracellular fluid volume

Introduction

System structure: Body fluid compartments

System function: Blood pressure homeostasis

Pathophysiology

Summary

Review questions

Answers to review questions

20.  Osmoregulation

Introduction

System structure: Body fluid compartments

System function: Homeostasis of sodium concentration

Pathophysiology: Disorders of serum osmolality and their sequelae

Summary

Review questions

Answers to review questions

21.  The regulation of potassium balance

Introduction

System structure: The distribution of potassium

System function: Potassium homeostasis

Pathophysiology: Disorders of plasma [K+] regulation

Hyperkalemia

Hypokalemia

Summary

Review questions

Answers to review questions

22.  Acid-base homeostasis

Introduction

System structure: Components of the pH regulatory apparatus and the distribution of body acid

System function: The variation and control of pH

Pathophysiology: Acidosis and alkalosis

Summary

Review questions

Answers to review questions

23.  Micturition

Introduction

System structure: Anatomy of the urinary system

System function: The transport of urine and its neural control

Pathophysiology: Urinary incontinence

Summary

Review questions

Answers to review questions

Case Study 23.1.  Renal physiology

Presentation: History and physical examination

Discussion

Presentation: Laboratory tests and imaging

Discussion

Course

Discussion

Section VII. Gastrointestinal Physiology

24.  Nutrition, digestion, and absorption

Introduction

System structure

The oral cavity

System function

Pathophysiology

Summary

Review questions

Answers to review questions

25.  Control of gastrointestinal motility and secretion

Introduction

System structure

System function

Pathophysiology

Summary

Review questions

Answers to review questions

26.  Hepatic physiology

Introduction

System structure

System function

Pathophysiology

Summary

Review questions

Answers to review questions

27.  The gastrointestinal immune system

Introduction

Enteric immune system structure

System function

System pathophysiology

Summary

Review questions

Answers to review questions

Case Study 27.1.  Gastrointestinal physiology

Presentation: History and physical examination

Discussion

Presentation: Laboratory tests and biopsy

Discussion

Course

Discussion

Section VIII. Endocrine Physiology

28.  The endocrine pancreas: Fed and fasted metabolic states

Introduction

System structure: The islets of langerhans

System function: The regulation of plasma glucose concentration

Pathophysiology: Dysregulation of the plasma glucose level

Summary

Review questions

Answers to review questions

29.  The pituitary gland

Introduction

System structure

System function

Pathophysiology

Summary

Review questions

Answers to review questions

30.  The thyroid gland

Introduction

System structure

System function

Pathophysiology: Thyroid hormone excess and deficiency

Summary

Review questions

Answers to review questions

31.  The adrenal gland

Introduction

System structure: Adrenal anatomy and embryology

System function: The adrenal cortex

Pathophysiology: Diseases of cortical over- and underproduction

System function: The adrenal medulla

Pathophysiology: Medullary dysfunction

Summary

Review questions

Answers to review questions

32.  Calcium regulation: Parathyroid physiology

Introduction

System structure: The parathyroid glands and the distribution of calcium and phosphorus

System function: Parathyroid hormone and vitamin D

Pathophysiology

Summary

Review questions

Answers to review questions

33.  Calcium regulation: Bone physiology

Introduction

System structure

System function

Pathophysiology

Summary

Review questions

Answers

34.  The female reproductive system

Introduction

System structure

System function

Pathophysiology

Summary

Review questions

Answers to review questions

35.  Pregnancy and parturition

The organs of pregnancy

System function: Pregnancy

Summary

Review questions

Answers to review questions

36.  The male reproductive system

Introduction

System structure

System function

Pathophysiology

Summary

Review questions

Answers to review questions

Case Study 36.1.  Endocrine physiology

Presentation: History and physical examination

Discussion

Presentation: Laboratory tests

Discussion

Treatment

Discussion

Appendix 1

Appendix 2

Appendix 3

Appendix 4

Appendix 5

Index

 

An aparitie	08/12/2021
Autor	Julian L Seifter, David E Sloane, Elisa Walsh
Dimensiuni	21.59 x 27.64 cm
Editura	Elsevier
Format	Paperback
ISBN	9780323597326
Limba	Engleza
Nr pag	544