Diagnostic Atlas of Renal Pathology

Description:

For today’s nephrologist who is tasked with diagnosing a wide range of renal pathologic entities, Diagnostic Atlas of Renal Pathology is a must-have reference for everyday use. The updated 4th Edition offers an in-depth examination of pathophysiology, clinical presentations, and the latest evidence-based practices. Hundreds of pertinent macro- and/or microscopic images are presented in a user-friendly manner intended specifically for renal pathology.

Offers templated, detailed discussions on key characteristic pathologic findings and prognostic, pathogenetic, and etiologic information for each disorder.

Features numerous tables and sidebars with key points and differential diagnoses.

Covers major new advances in the classification and diagnosis of select tubular cystic diseases, new advances in classification of fibrillary processes and C3 related diseases, new insights in monoclonal protein-related diseases, ongoing work in lupus, and advances in IgA nephropathy as well as transplantation.

Contains more than 700 high-quality representative images of light, immunofluorescence, and electron microscopy, including new colorized electron microscopy images, with correlations to clinical presentation and pathogenesis.

Features new animations that clearly depict the progression of membranous nephropathy, membranoproliferative GN, and crescentic GN.

Includes schematic representations of glomerular diseases, which are particularly useful for illustrating difficult concepts.

Table of Contents:

1.  Approach to diagnosis of the kidney biopsy

2.  Normal growth and maturation

3.  Glomerular diseases

Primary glomerular diseases

Glomerular diseases that cause nephrotic syndrome: Nonimmune complex

Glomerular diseases that cause nephrotic/nephritic syndrome: Complement-related

Glomerular diseases that cause nephrotic syndrome because of deposits

Glomerular diseases that cause hematuria or nephritic syndrome: Immune complex

Secondary glomerular diseases

Diseases associated with nephrotic syndrome

Diseases associated with nephritic syndrome or rapidly progressive glomerulonephritis: Immune-mediated

Diseases associated with the nephritic syndrome or rapidly progressive glomerulonephritis: Pauci-immune- or nonimmune-mediated

Diseases with abnormal collagen/basement membranes

Glomerular involvement with bacterial infections

4.  Vascular diseases

Diabetic nephropathy

Thrombotic microangiopathy/thrombotic thrombocytopenic purpura

Scleroderma (systemic sclerosis)

Antiphospholipid antibody disease

Preeclampsia and eclampsia

Fibromuscular dysplasia

Arterionephrosclerosis

Accelerated/severe hypertension

Atheroemboli

5.  Tubulointerstitial diseases

Introduction

Infections of the kidney

Acute pyelonephritis

Chronic pyelonephritis and reflux nephropathy

Xanthogranulomatous pyelonephritis

Malakoplakia

Acute tubulointerstitial nephritis—viral infection

Acute tubulointerstitial nephritis—drug-related

Tubulointerstitial nephritis with uveitis

Anti-tubular basement membrane antibody nephritis

Idiopathic hypocomplementemic tubulointerstitial nephritis

IgG4-related tubulointerstitial nephritis

Interstitial nephritis of sjögren syndrome

Sarcoidosis

Acute kidney injury/acute tubular injury

Warfarin-induced acute kidney injury/anticoagulant-related nephropathy

Heavy metal nephropathy (lead and cadmium nephropathy)

Analgesic nephropathy and papillary necrosis

Monoclonal gammopathy of renal significance

Light chain cast nephropathy and tubulopathy

Tubular crystallopathies

Drug-induced crystallopathies

Lithium nephropathy

Aristolochic acid nephropathy

6.  Endemic nephropathies

Introduction

Aristolochic acid nephropathy (chinese herb nephropathy, balkan endemic nephropathy)

Other endemic fibrosing nephropathies

7.  Chronic kidney disease

Introduction

Age-related sclerosis

Glomerular versus tubulointerstitial versus vascular disease

Segmental glomerulosclerosis: Primary versus secondary

8.  Renal transplantation

Introduction

Evaluation of donor kidneys

Classification of rejection

Antibody-mediated rejection

Chronic active antibody-mediated rejection and transplant glomerulopathy

Acute T cell–mediated rejection

Chronic active T cell–mediated rejection

Interstitial fibrosis/tubular atrophy

Molecular profiling of rejection

Calcineurin inhibitor nephrotoxicity

mTOR inhibitor toxicity

De novo and recurrent thrombotic microangiopathy in allografts

Posttransplant lymphoproliferative disease

Viral infections

Recurrent renal disease

9.  Cystic diseases of the kidney

Introduction

Autosomal dominant polycystic kidney disease

Autosomal recessive polycystic kidney disease

Nephronophthisis

Autosomal dominant tubulointerstitial kidney disease

Medullary sponge kidney

Acquired cystic disease

Cystic renal dysplasia

10.  Renal neoplasia

Introduction

Renal neoplasms

Nephroblastoma (wilms tumor)

Renal angiomyolipoma

Urothelial (transitional cell) carcinoma of the renal pelvis

Index