Basic Immunology, Functions and Disorders of the Immune System, 6th Edition

Description:

Meticulously reviewed and updated for today’s medical students, Basic Immunology, 6th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases—all designed to help students master this complex topic in the most efficient, effective manner possible.

• Emphasizes clinical aspects of immunology, including disease pathogenesis, the development of novel therapies based on basic science, and an appendix of clinical cases for real-world application.
• Provides top-notch instruction from experienced teachers, course directors, and lecturers led by well-known editor and author Dr. Abul Abbas.
• Features a highly readable writing style and practical organization, now with fully revised content and updated images to reflect recent important advances in today’s understanding of the immune system.
• Presents information in a format and style that maximizes usefulness to students and teachers studying medicine, allied health fields, and biology.
• Contains numerous features designed to help students understand key immunologic concepts: high-quality illustrations, practical tables, chapter outlines, bolded key points, and focus questions in every chapter for self-assessment and review.
• Evolve Instructor site with a downloadable image bank is available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com

·  1. Introduction to the Immune System: Nomenclature, General Properties, and Components

·  Innate and Adaptive Immunity

·  Types of Adaptive Immunity

·  Properties of Adaptive Immune Responses

·  Cells of the Adaptive Immune System

·  Tissues of the Immune System

·  Summary

·  2. Innate Immunity: The Early Defense Against Infections

·  General Features and Specificity of Innate Immune Responses

·  Cellular Receptors for Microbes and Damaged Cells

·  Components of Innate Immunity

·  Innate Immune Reactions

·  Role of Innate Immunity in Stimulating Adaptive Immune Responses

·  Summary

·  3. Antigen Capture and Presentation to Lymphocytes: What Lymphocytes See

·  Antigens Recognized by T Lymphocytes

·  Capture of Protein Antigens by Antigen-Presenting Cells

·  Structure and Function of Major Histocompatibility Complex Molecules

·  Processing and Presentation of Protein Antigens

·  Functions of Antigen-Presenting Cells in Addition to Antigen Display

·  Antigen Recognition by B Cells and Other Lymphocytes

·  Summary

·  4. Antigen Recognition in the Adaptive Immune System: Structure of Lymphocyte Antigen Receptors and Development of Immune Repertoires

·  Antigen Receptors of Lymphocytes

·  Development of B and T Lymphocytes

·  Summary

·  5. T Cell–Mediated Immunity: Activation of T Lymphocytes

·  Phases of T Cell Responses

·  Antigen Recognition and Costimulation

·  Biochemical Pathways of T Cell Activation

·  Functional Responses of T Lymphocytes to Antigen and Costimulation

·  Migration of T Lymphocytes in Cell-Mediated Immune Reactions

·  Summary

·  6. Effector Mechanisms of T Cell–Mediated Immunity: Functions of T Cells in Host Defense

·  Types of T Cell–Mediated Immune Reactions

·  Development and Functions of CD4+ Effector T Lymphocytes

·  Differentiation and Functions of CD8+ Cytotoxic T Lymphocytes

·  Resistance of Pathogenic Microbes to Cell-Mediated Immunity

·  Summary

·  7. Humoral Immune Responses: Activation of B Lymphocytes and Production of Antibodies

·  Phases and Types of Humoral Immune Responses

·  Stimulation of B Lymphocytes by Antigen

·  Functions of Helper T Lymphocytes in Humoral Immune Responses

·  Antibody Responses to T-Independent Antigens

·  Regulation of Humoral Immune Responses: Antibody Feedback

·  Summary

·  8. Effector Mechanisms of Humoral Immunity: Elimination of Extracellular Microbes and Toxins

·  Properties of Antibodies that Determine Effector Function

·  Neutralization of Microbes and Microbial Toxins

·  Opsonization and Phagocytosis

·  Antibody-Dependent Cellular Cytotoxicity

·  Immunoglobulin E– and Eosinophil/Mast Cell–Mediated Reactions

·  The Complement System

·  Functions of Antibodies at Special Anatomic Sites

·  Evasion of Humoral Immunity by Microbes

·  Vaccination

·  Summary

·  9. Immunologic Tolerance and Autoimmunity: Self–Nonself Discrimination in the Immune System and Its Failure

·  Immunologic Tolerance: General Priniciples and Significance

·  Central T Lymphocyte Tolerance

·  Peripheral T Lymphocyte Tolerance

·  B Lymphocyte Tolerance

·  Tolerance to Commensal Microbes and Fetal Antigens

·  Autoimmunity

·  Summary

·  10. Immunology of Tumors and Transplantation: Immune Responses to Cancer Cells and Normal Foreign Cells

·  Immune Responses Against Tumors

·  Immune Responses Against Transplants

·  Summary

·  11. Hypersensitivity: Disorders Caused by Immune Responses

·  Types of Hypersensitivity Reactions

·  Immediate Hypersensitivity

·  Diseases Caused by Antibodies Specific for Cell and Tissue Antigens

·  Diseases Caused By Antigen-Antibody Complexes

·  Diseases Caused by T Lymphocytes

·  Neuroimmunology: Interactions Between the Immune and Nervous Systems

·  Summary

·  12. Congenital and Acquired Immunodeficiencies: Diseases Caused by Defective Immunity

·  Congenital (Primary) Immunodeficiencies

·  Acquired (Secondary) Immunodeficiencies

·  Acquired Immunodeficiency Syndrome

·  Summary