Allergies and Hypersensitivity Disease in Animals

Description:

Learn to treat allergic diseases in animals using the latest protocols, procedures, and studies! Allergies and Hypersensitivity Disease in Animals provides an all-in-one review of allergic diseases in dogs, cats, horses, and livestock species. Addressing this growing problem, the book covers key topics such as signs of allergies and hypersensitivity disease, the route by which antigens enter the body, the major mediators of allergies, allergic reactions including anaphylaxis and atopic and contact dermatitis, and diagnosis and treatment. Written by noted veterinary author Ian R. Tizard, this evidence-based reference includes an enhanced eBook with print purchase, with access to a fully searchable version of the text available on a variety of devices. It’s a must-have for every veterinary practice!

Table of contents:

Section 1. Basic Science

1.  The immune system and the defense of the body

Innate immunity

Adaptive immunity

Suggested reading

2.  Type 2 immune responses

Dendritic cells

Helper T cells

Regulatory T cells

Innate lymphoid cells

Type 2 responses

B cell responses

Immunoglobulin E

Suggested reading

3.  Mast cells

Life history

Structure

Location

Receptors

Secretory granules

Degranulation

Non-IgE-mediated degranulation

Late-phase responses

Suggested reading

4.  Eosinophils and basophils

Eosinophils

Basophils

Suggested reading

5.  The mediators of inflammation and allergy

Inflammatory mediators

Cytokines

Suggested reading

6.  The itch-scratch cycle

Itch sensation

Itch mediators

Non-histaminergic itch

Cells involved

Scratching

Suggested reading

7.  The hygiene hypothesis

The hygiene hypothesis

The intestinal microbiota

Microbial immunosuppression

Dysbiosis

Skin microbiota

Respiratory microbiota

Helminth parasites

Suggested reading

Section 2. Allergic Diseases

8.  Anaphylaxis

IgE-dependent anaphylaxis

Non-IgE-mediated anaphylaxis

Domestic mammal anaphylaxis

Suggested readings

9.  Atopic dermatitis

Introduction

Predisposing conditions

Allergic inflammation

Pathogenesis

Clinical disease

Feline atopic skin syndrome

Suggested readings

10.  Malassezia and staphylococci

Malassezia

Staphylococci

Suggested readings

11.  Allergies in the gastrointestinal tract

The fate of foods

Food allergic animals

Milk allergy in cattle

Parasite “self-cure”

Suggested readings

12.  Allergies to arthropods

Chitin responses

Inhalant allergies

Allergies to insect venoms

Suggested readings

13.  Allergic respiratory disease

Asthma in humans

Respiratory allergies in animals

Suggested readings

14.  Drug allergies

Allergic responses

Immune receptor interactions

Pseudoallergic reactions

Some specific drugs

Management

Suggested readings

15.  Allergies to vaccines

Type I hypersensitivities

Type II hypersensitivities

Type III hypersensitivities

Type IV reactions

Suggested readings

Section 3. Treatments

16.  Allergen-specific immunotherapy

The science of immunotherapy

Suggested readings

17.  Drug therapy

Inhibition of mast cell products

Epidermal barrier dysfunction

Other treatments

Biological therapy

Suggested readings

Section 4. Other Hypersensitivities

18.  Type III hypersensitivity diseases

Pathogenesis

Suggested reading

19.  Selected type IV hypersensitivities

Cutaneous basophil hypersensitivity

Contact dermatitis

Canine contact dermatitis

Suggested reading

20.  Diagnostic assays

In vitro assays

In vivo assays

Suggested reading

21.  Allergies in veterinarians

Allergens

Specific environments

Veterinarians

Pathogenesis

Specific immunotherapy

Suggested reading

Abbreviations and acronyms

Index