Description:
A thorough understanding of pathology is crucial for doctors and a foundation for safe and effective clinical practice. This internationally renowned, award-winning textbook provides a comprehensive overview, aligned to the needs of current medical students and early career stage doctors. The book starts with a clear introduction to the basic principles of pathology, then moves on to more detailed discussion of disease mechanisms and the pathology of specific disorders ordered by body system. The text has been fully updated for this eighth edition and optimized for efficient study. Complete with unrivalled photographs, images, graphics and supplementary electronic materials, Underwood’s Pathology is the complete learning package no medical student should be without.
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Features:
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- Comprehensive but concise and understandable for medical students - also suitable for junior doctors, early career pathologists/histopathologists, dental students and biomedical scientists
- Ideal for integrated, systems-based courses and problem-based learning – reflects modern medical curricula
- Structure makes content highly accessible – easy to look up any pathology seen in the classroom or on the wards
- Presents pathology in the context of modern cellular and molecular biology and contemporary clinical practice
- Unrivalled collection of nearly 700 clinical photographs, histopathology images and graphics
- Includes a full patient symptoms index plus multiple quick-reference summary tables
- Prepared by leading pathology experts and educators – for coverage you can trust
- A complete digital with BONUS electronic materials further supports and enhances the learning experience
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New To This Edition:
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- Fully revised throughout
- New sections on the pathology of Covid-19 in all relevant sections
- Extensive revision of the molecular pathology of tumours
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Table Of Contents:
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Preface Contributors Acknowledgements Index of Patient Symptoms PART 1 BASIC PATHOLOGY 1 What is pathology? 2 What is disease? 3 What causes disease? PART 2 DISEASE MECHANISMS 4 Disorders of growth, differentiation and morphogenesis 5 Responses to cellular injury 6 Disorders of metabolism and homoeostasis 7 Ischaemia, infarction and shock 8 Immunology and immunopathology 9 Inflammation 10 Neoplasia and carcinogenesis 11 Ageing and death 12 How do pathologists help patient care? PART 3 SYSTEMATIC PATHOLOGY 13 Cardiovascular system 14 Respiratory system 15 Alimentary system 16 Liver, biliary system and pancreas 17 Endocrine system 18 Breast 19 Female genital tract 20 Urinary and male genital tracts 21 Kidney diseases 22 Lymph nodes and extranodal lymphoid tissue, spleen and thymus 23 Blood and bone marrow 24 Skin 25 Osteoarticular and connective tissues 26 Central and peripheral nervous systems Glossary Index
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Description: Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike.
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Features:
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- Helps you navigate the latest changes in the classification of hematolymphoid neoplasms, providing guidance for use of both the International Consensus Classification (ICC) and 5th edition of the WHO classification.
- Incorporates the latest molecular/cytogenetic information, regarding newly recognized entities and the latest diagnostic criteria.
- Provides you with today's most effective guidance in evaluating specimens from the lymph nodes, bone marrow, peripheral blood, and more, with authoritative information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each.
- Details the latest insights on the molecular biology of benign and malignant hematologic disorders.
- Features more than 1,100 high-quality color images that mirror the findings you encounter in practice.
- Uses an easy-to-navigate, templated format with standard headings in each chapter.
- Includes information on disease progression and prognosis, helping you better understand the clinical implications of diagnosis.
- Shares the knowledge and expertise of new editors, Drs. Lisa Rimsza, Attilio Orazi, and Steven Swerdlow, providing expertise in molecular diagnostics, bone marrow and lymph node biopsies.
- An digital version is included with purchase. The digital allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.
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Table Of Contents:
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PART I Technical Aspects 1 Processing of the Lymph Node Biopsy Specimen 2 Fine-Needle Aspiration of Lymph Nodes 3 Immunohistochemistry for the Hematopathology Laboratory 4 Flow Cytometry 5 Molecular Pathology of Hematologic Neoplasms 6 Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them PART II Normal and Reactive Conditions of Hematopoietic Tissues 7 Normal Lymphoid Organs and Tissues 8 Reactive Lymphadenopathies 9 The Normal Bone Marrow 10 Evaluation of Anemia, Leukopenia, and Thrombocytopenia 11 Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders PART III Lymphoid Neoplasms 12 Principles of Classification of Lymphoid Neoplasms SECTION 1 • MATURE B-CELL NEOPLASMS 13 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia 14 Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia 15 Hairy Cell Leukemia 16 Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen 17 Follicular Lymphoma 18 Extranodal Marginal Zone Lymphoma: MALT Lymphoma 19 Primary Cutaneous B-Cell Lymphomas 20 Nodal Marginal Zone Lymphoma 21 Mantle Cell Lymphoma 22 Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas 23 Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements 24 Plasmablastic Neoplasms Other Than Plasma Cell Myeloma 25 Plasma Cell Neoplasms 26 Nodular Lymphocyte-Predominant B-Cell Lymphoma 27 Classic Hodgkin Lymphoma 28 Virally Associated B-Cell Lymphoproliferative Disease SECTION 2 • MATURE T-CELL AND NK-CELL NEOPLASMS 29 Epstein-Barr Virus–Associated T-Cell and Natural Killer–Cell Lymphoproliferative Disorders 30 T-Cell and NK-Cell Large Granular Lymphocyte Proliferations 31 T-Cell Prolymphocytic Leukemia 32 Adult T-Cell Leukemia/Lymphoma 33 Hepatosplenic T-Cell Lymphoma 34 Peripheral T-Cell Lymphoma, Not Otherwise Specified 35 Follicular Helper T-Cell Lymphoma 36 Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative 37 Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas 38 Mycosis Fungoides and Sézary Syndrome 39 Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders 40 Primary Cutaneous T-Cell Lymphomas: Rare Subtypes SECTION 3 • PRECURSOR B- AND T-CELL NEOPLASMS 41 Precursor B-Cell and T-Cell Neoplasms 42 Acute Leukemias of Ambiguous Lineage PART IV Myeloid, Histiocytic, and Related Proliferations 43 Principles of Classification of Myeloid Neoplasms 44 The Myelodysplastic Syndromes 45 Myeloid and Hematologic Neoplasms With Germline Predisposition 46 Acute Myeloid Leukemia 47 Myeloproliferative Neoplasms 48 Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions 49 Mastocytosis 50 Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions 51 Blastic Plasmacytoid Dendritic Cell Neoplasm 52 Histiocytic and Dendritic Cell Proliferations—Systemic and Neoplastic PART V Immunodeficiency Disorders 53 The Pathology of Primary Immunodeficiencies 54 Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders PART VI Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia 55 Bone Marrow Evaluation for Lymphoma 56 Evaluation of the Bone Marrow After Therapy 57 Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes 58 Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions 59 Diagnosis of Lymphoma in Extranodal Sites Other Than Skin APPENDIX A: THE INTERNATIONAL CONSENSUS CLASSIFICATION OF MYELOID, LYMPHOID, AND HISTIOCYTIC NEOPLASMS INDEX
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