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Description:
A thorough understanding of pathology is crucial for doctors and a foundation for safe and effective clinical practice. This internationally renowned, award-winning textbook provides a comprehensive overview, aligned to the needs of current medical students and early career stage doctors.
The book starts with a clear introduction to the basic principles of pathology, then moves on to more detailed discussion of disease mechanisms and the pathology of specific disorders ordered by body system. The text has been fully updated for this eighth edition and optimized for efficient study.
Complete with unrivalled photographs, images, graphics and supplementary electronic materials, Underwood’s Pathology is the complete learning package no medical student should be without.
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Features:
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- Comprehensive but concise and understandable for medical students - also suitable for junior doctors, early career pathologists/histopathologists, dental students and biomedical scientists
- Ideal for integrated, systems-based courses and problem-based learning – reflects modern medical curricula
- Structure makes content highly accessible – easy to look up any pathology seen in the classroom or on the wards
- Presents pathology in the context of modern cellular and molecular biology and contemporary clinical practice
- Unrivalled collection of nearly 700 clinical photographs, histopathology images and graphics
- Includes a full patient symptoms index plus multiple quick-reference summary tables
- Prepared by leading pathology experts and educators – for coverage you can trust
- A complete digital with BONUS electronic materials further supports and enhances the learning experience
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New To This Edition:
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- Fully revised throughout
- New sections on the pathology of Covid-19 in all relevant sections
- Extensive revision of the molecular pathology of tumours
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Table Of Contents:
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Preface
Contributors
Acknowledgements
Index of Patient Symptoms
PART 1 BASIC PATHOLOGY
1 What is pathology?
2 What is disease?
3 What causes disease?
PART 2 DISEASE MECHANISMS
4 Disorders of growth, differentiation and morphogenesis
5 Responses to cellular injury
6 Disorders of metabolism and homoeostasis
7 Ischaemia, infarction and shock
8 Immunology and immunopathology
9 Inflammation
10 Neoplasia and carcinogenesis
11 Ageing and death
12 How do pathologists help patient care?
PART 3 SYSTEMATIC PATHOLOGY
13 Cardiovascular system
14 Respiratory system
15 Alimentary system
16 Liver, biliary system and pancreas
17 Endocrine system
18 Breast
19 Female genital tract
20 Urinary and male genital tracts
21 Kidney diseases
22 Lymph nodes and extranodal lymphoid tissue, spleen and thymus
23 Blood and bone marrow
24 Skin
25 Osteoarticular and connective tissues
26 Central and peripheral nervous systems
Glossary
Index
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Description:
Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike.
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Features:
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- Helps you navigate the latest changes in the classification of hematolymphoid neoplasms, providing guidance for use of both the International Consensus Classification (ICC) and 5th edition of the WHO classification.
- Incorporates the latest molecular/cytogenetic information, regarding newly recognized entities and the latest diagnostic criteria.
- Provides you with today's most effective guidance in evaluating specimens from the lymph nodes, bone marrow, peripheral blood, and more, with authoritative information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each.
- Details the latest insights on the molecular biology of benign and malignant hematologic disorders.
- Features more than 1,100 high-quality color images that mirror the findings you encounter in practice.
- Uses an easy-to-navigate, templated format with standard headings in each chapter.
- Includes information on disease progression and prognosis, helping you better understand the clinical implications of diagnosis.
- Shares the knowledge and expertise of new editors, Drs. Lisa Rimsza, Attilio Orazi, and Steven Swerdlow, providing expertise in molecular diagnostics, bone marrow and lymph node biopsies.
- An digital version is included with purchase. The digital allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.
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Table Of Contents:
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PART I Technical Aspects
1 Processing of the Lymph Node Biopsy Specimen
2 Fine-Needle Aspiration of Lymph Nodes
3 Immunohistochemistry for the Hematopathology Laboratory
4 Flow Cytometry
5 Molecular Pathology of Hematologic Neoplasms
6 Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them
PART II Normal and Reactive Conditions of Hematopoietic Tissues
7 Normal Lymphoid Organs and Tissues
8 Reactive Lymphadenopathies
9 The Normal Bone Marrow
10 Evaluation of Anemia, Leukopenia, and Thrombocytopenia
11 Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders
PART III Lymphoid Neoplasms
12 Principles of Classification of Lymphoid Neoplasms
SECTION 1 • MATURE B-CELL NEOPLASMS
13 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia
14 Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia
15 Hairy Cell Leukemia
16 Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen
17 Follicular Lymphoma
18 Extranodal Marginal Zone Lymphoma: MALT Lymphoma
19 Primary Cutaneous B-Cell Lymphomas
20 Nodal Marginal Zone Lymphoma
21 Mantle Cell Lymphoma
22 Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas
23 Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements
24 Plasmablastic Neoplasms Other Than Plasma Cell Myeloma
25 Plasma Cell Neoplasms
26 Nodular Lymphocyte-Predominant B-Cell Lymphoma
27 Classic Hodgkin Lymphoma
28 Virally Associated B-Cell Lymphoproliferative Disease
SECTION 2 • MATURE T-CELL AND NK-CELL NEOPLASMS
29 Epstein-Barr Virus–Associated T-Cell and Natural Killer–Cell Lymphoproliferative Disorders
30 T-Cell and NK-Cell Large Granular Lymphocyte Proliferations
31 T-Cell Prolymphocytic Leukemia
32 Adult T-Cell Leukemia/Lymphoma
33 Hepatosplenic T-Cell Lymphoma
34 Peripheral T-Cell Lymphoma, Not Otherwise Specified
35 Follicular Helper T-Cell Lymphoma
36 Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative
37 Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas
38 Mycosis Fungoides and Sézary Syndrome
39 Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
40 Primary Cutaneous T-Cell Lymphomas: Rare Subtypes
SECTION 3 • PRECURSOR B- AND T-CELL NEOPLASMS
41 Precursor B-Cell and T-Cell Neoplasms
42 Acute Leukemias of Ambiguous Lineage
PART IV Myeloid, Histiocytic, and Related Proliferations
43 Principles of Classification of Myeloid Neoplasms
44 The Myelodysplastic Syndromes
45 Myeloid and Hematologic Neoplasms With Germline Predisposition
46 Acute Myeloid Leukemia
47 Myeloproliferative Neoplasms
48 Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions
49 Mastocytosis
50 Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions
51 Blastic Plasmacytoid Dendritic Cell Neoplasm
52 Histiocytic and Dendritic Cell Proliferations—Systemic and Neoplastic
PART V Immunodeficiency Disorders
53 The Pathology of Primary Immunodeficiencies
54 Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
PART VI Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia
55 Bone Marrow Evaluation for Lymphoma
56 Evaluation of the Bone Marrow After Therapy
57 Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes
58 Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions
59 Diagnosis of Lymphoma in Extranodal Sites Other Than Skin
APPENDIX A: THE INTERNATIONAL CONSENSUS CLASSIFICATION OF MYELOID, LYMPHOID, AND HISTIOCYTIC NEOPLASMS
INDEX
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