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  • 450.00 lei

     

    Description:

    Motor Assessment of the Developing Infant, 2nd Edition presents theories of infant motor development and discusses the unique challenges involved in assessing the motor skills of developing infants as compared to that of adults. It provides step-by-step instructions for using the Alberta Infant Motor Scale (AIMS) - a scale that measures infant gross motor skills. It also features a review of two current theories of motor development, line drawings and photographs of 58 gross motor skills, and a percentile graph to plot an infant’s score and derive an estimate of his or her percentile ranking. Clinicians, researchers, and parents/caregivers have all reported satisfaction with both the ease of an AIMS assessment and the strong psychometric properties of the scale. Thus, the descriptors of the 58 motor items and the administration and scoring guidelines have stood the test of time and remain unchanged in this second edition.



    Features:


    • Comprehensive coverage of how to use the Alberta Infant Motor Scale, a standardized measurement scale used to assess the gross motor abilities of infants.
    • Line drawings and photographs of 58 gross motor skills.
    • Five copies of the AIMS scoresheet are included with the print edition.
    • The Alberta Infant Motor Scale is trusted by clinicians and researchers across the globe.



    New To This Edition:

     

    • NEW! Enhanced digital version, included with print purchase, contains an electronic view of the scoresheet for ease of reference and allows you to access all of the text, figures, and references from the book on a variety of devices.
    • NEW! Clinical examples in the Clinical Uses of the Alberta Infant Motor Scale chapter offer brief case studies showing the different clinical uses of the AIMS.
    • NEW! Scoring section in the Administration Guidelines chapter includes examples of common scoring errors.
    • NEW! Additional scoring "hints" are provided for items that have been identified as problematic during therapist training sessions.
    • UPDATED! Theories of Motor Development chapter presents the change from the neuromaturational theory to those originating from dynamic systems theory and motor control theories.
    • UPDATED! Motor Assessment of the Developing Infant chapter includes a discussion of the unique challenges of assessing infant motor abilities and the important psychometric properties to consider when choosing an infant assessment tool.
    • UPDATED! Clinical Uses of the Alberta Infant Motor Scale chapter includes recent literature on clinical uses and advises on when not to use the AIMS as an assessment measure.
    • UPDATED! Norm-Referencing of the Alberta Infant Motor Scale chapter reflects the most up-to-date normative data and validity research and discusses research on the instability of infant motor scores over time in typically developing infants using the AIMS.

    Table Of Contents:

     

    1. Theories of Motor Development
    2. Motor Assessment of the Developing Infant
    3. Alberta Infant Motor Scale: Construction of a Motor Assessment Tool for the Developing Infant
    4. Administration Guidelines
    5. Prone Subscale
    6. Supine Subscale
    7. Sit Subscale
    8. Stand Subscale
    9. Clinical Uses of the Alberta Infant Motor Scale
    10. Psychometric Properties of the AIMS
    11. Norm-Referencing of the Alberta Infant Motor Scale
    Appendix I: Percentile Ranks – AIMS Score
    Appendix II: Percentile Ranks by Age Grouping
    Appendix III: Normative Data
    Appendix IV: Percentile Ranks
    Index

       

     

  • 460.00 lei

     

    Description:

    Master the patient assessment skills you need to provide effective respiratory care! Wilkins' Clinical Assessment in Respiratory Care, 9th Edition prepares you to assist physicians in the decision-making process regarding treatment, evaluation of the treatment’s effectiveness, and determining if changes in the treatment need to be made. Chapters are updated to reflect the latest standards of practice and the newest advances in technology. From lead author Dr. Albert Heuer, a well-known educator and clinician, this market-leading text also aligns content with National Board for Respiratory Care exam matrices to help you prepare for success on the NBRC’s CRT and RRT credentialing exams.



    Features:


    • Comprehensive approach addresses all of the most important aspects and topics of assessment, so you can learn to assess patients effectively.
    • Case studies provide real-life clinical scenarios challenging you to interpret data and make accurate patient assessments.
    • Questions to Ask boxes identify the questions practitioners should ask patients (e.g., coughing, sputum, shortness of breath) or questions to ask themselves (e.g., lung sounds they are hearing, blood pressure, respiratory rate) when confronted with certain pathologies.
    • Learning objectives, key terms, and chapter outlines begin each chapter and introduce the content to be mastered.
    • Assessment questions in each chapter are aligned to the learning objectives and reflect the NBRC Exam format, with answers located on the Evolve companion website.
    • Key Points at the end of each chapter emphasize the topics identified in the learning objectives, providing easy review.
    • Simply Stated boxes highlight and summarize key points to help you understand important concepts.

    New To This Edition:

    • NEW! Updated content throughout the text reflects the latest evidence-based practices and clinical developments, including infection control measures, imaging techniques, assessment of critically ill patients, and the increased reliance on telehealth and electronic health records.
    • NEW! Updated and revised content aligns with the latest NBRC credentialing exam matrix.
    • NEW! Take-Home points are included for each chapter, plus cases as well as questions and answers for students to use in testing and applying their knowledge.

     

     

    Table Of Contents:

    1. Preparing for the Patient Encounter
    2. The Medical History and the Interview
    3. Cardiopulmonary Symptoms
    4. Vital Signs
    5. Fundamentals of Physical Examination
    6. Neurological Assessment of the Respiratory Patient
    7. Clinical Laboratory Studies
    8. Interpretation of Blood Gases
    9. Pulmonary Function Testing
    10. Chest Imaging
    11. Interpretation of the Electrocardiogram
    12. Assessment of the Neonatal and Pediatric Patient
    13. Assessment of the Older Patient
    14. Respiratory Monitoring in the Intensive Care Unit
    15. Assessment of Hemodynamic Pressures
    16. Assessment of Cardiac Output
    17. Flexible Fiberoptic Bronchoscopy
    18. Nutritional Assessment of Patients with Respiratory Disease
    19. Assessment of Sleep and Breathing
    20. Assessment of the Home Care Patient
    21. Documentation of the Patient Assessment
    Answer Appendix
    Glossary
    Index

       

  • 505.00 lei

     

    Book Description:

    Peritoneal malignancy is a rapidly growing field within surgical oncology. National and International treatment programmes and training curricula are being established worldwide to co-ordinate treatment and management of these challenging clinical problems. A large body of evidence now exists, but the practical implications of this evidence base remain unclear. The Peritoneal Malignancy Institute in Basingstoke, the largest centre in the world, is at the forefront of new developments and techniques. This manual combines the experience of the PMI with the latest evidence to provide a practice-oriented guide to the successful set up and running of a peritoneal malignancy unit.

    Table of Contents:

    1. Appendix tumours and pseudomyxoma peritonei a "paradigm" for peritoneal disease

    Akash Mehta and Tom Cecil

    2. Colorectal Peritoneal metastases

    John Bunni and Brendan Moran

    3. Peritoneal mesothelioma

    Faraz Khan and Faheez Mohamed

    4. Miscellaneous peritoneal malignancies

    Andreas Brandl and Akash Mehta

    5. Quantitative Assessment of Peritoneal Disease

    John Bunni and Sanjeev Dayal

    6. Imaging in Peritoneal Malignancy

    Anuradha Chandramohan & Andrew Thrower

    Dialogue: Intraperitoneal chemotherapy and Cytoreductive surgery

    7. Intraperitoneal Chemotherapy

    Akash Mehta and Faheez Mohamed

    8. Peri-Operative and Anaesthetic Care

    Nina Kashani and John Bell

    9. Cytoreductive surgery and HIPEC

    John Bunni and Tom Cecil

    10. Postoperative care

    Nina Kashani and James Coakes

    Chapter 11 Postoperative complication

    Kim Govaerts and Brendan Moran

    Closure: On going care and future management options

    12. Histopathological Aspects of Peritoneal Malignancy

    Babatunde Rowaiye and Norman Carr

    13. Follow-Up Protocols in Peritoneal Malignancy

    Anuradha Chandramohan, Sourav Panda and Nehal Shah

    14. Treatment options for recurrence

    Jamish Ghandi and Alexios Tzivanakis

    15. Future perspectives in peritoneal malignancy

    Ioanna Panagiotopoulou and Tom Cecil

     

  • 1,61100lei 1380.00 lei

     

    Description:


    Through five well-regarded editions, Dr. David Dabbs’ Diagnostic Immunohistochemistry has set the standard for concise, complete, guidance on the use and interpretation of immunohistochemical stains. The 6th Edition continues this tradition of excellence, bringing you fully up to date with all aspects of this dynamic field. Easy to use and understand, this practical resource distills the large body of information on immunohistochemistry into a single, convenient reference that is invaluable for today’s surgical pathologists. 

     

    Key Features:

    • Covers all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options. 
    • Includes the latest grading schemes in several organs along with new antibodies to cover more genomic immunohistochemistry applications. 
    • Contains current biomarker guidelines and up-to-date references throughout. 
    • Offers a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors. 
    • Contains numerous charts and tables, as well as 1,500 high-quality color histologic images that assist in making a definitive diagnosis. 
    • Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. 
    • Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. 
    • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. 

    Table Of Contents:

    1. Techniques of Immunohistochemistry: Principles, Pitfalls, and Standardization

    2. Molecular Anatomic Pathology: Principles, Techniques, and Application to Immunohistologic Diagnosis

    3. Immunohistology of Infectious Diseases

    4. Immunohistology of Neoplasms of Soft Tissue and Bone

    5. Immunohistology of Bone Marrow, Spleen and Histiocytic Disorders

    6. Immunohistology of Lymph Node and Lymph Node Neoplasms

    7. Immunohistology of Melanocytic Neoplasms

    8. Immunohistology of Metastatic Carcinoma of Unknown Primary Site

    9. Immunohistology of Head and Neck Lesions

    10. Immunohistology of Endocrine Tumors

    11. Immunohistology of the Mediastinum

    12. Immunohistology of Lung and Pleural Neoplasms

    13. Immunohistology of Skin Tumors

    14. Immunohistology of the Gastrointestinal Tract

    15. Immunohistology of Pancreas and Hepatobiliary Tract

    16. Immunohistology of the Prostate

    17. Immunohistology of the Bladder, Kidney, and Testis

    18. Immunohistology of the Female Genital Tract

    19. Immunohistology of the Breast

    20. Immunohistology of the Nervous System

    21. Immunocytology

    22. Immunohistology of Pediatric Neoplasms

    23. Imaging and Quantitative Immunohistochemistry

     

     

  • 62000lei 580.00 lei

     

    Description:


    This handbook covers the diagnosis, etiology, and treatment of conditions affecting the locomotor system in small animals. The 4th edition presents up-to-date information on various types of fractures and methods of fixation, lameness and joint surgery, and musculoskeletal diseases. Other key topics include: acute and chronic bone infections; transplantation, plating, wiring, and pinning techniques; bone grafting; reconstructive joint surgery; and osteochondrosis.



    Features:


    • Clear, concise coverage covers the pathology, diagnostic work-up, surgical indications and planning, surgical approach, surgical techniques, complications, and follow-up recommendations for the most common orthopedic conditions.
    • Step-by-step line drawings clearly illustrate different types of fractures and demonstrate the surgical procedures used to affect repairs – detail that can’t be conveyed in clinical photographs.
    • Anatomical organization provides quick access to information on both fractures and other conditions for each region of the body.



    New To This Edition:

    • NEW! Advances in joint surgeries, specifically the knee, shoulder, and elbow, keep practitioners abreast of the latest technology and best practices.
    • NEW! Coverage of minimally invasive surgery has been added to the many chapters.
    • NEW! Advances in imaging (MRI, CT, and radiographs) are included to keep practitioners up to date on the latest technology.
    • Updates on new fixation technologies include angle stable interlocking nails and locking plate fracture fixation systems.
    • Updates on common surgeries include triple pelvic osteotomy and total hip replacement
    • NEW! High-definition clinical photographs have been added to give readers a closer view of various fractures and repair techniques.

    Table Of Contents:


    Part I: Diagnosis and Treatment of Fractures, Lameness and Joint Disease
    1. Orthopedic Examination and Diagnostic Tools
    2. Fractures: Classification, Diagnosis, and Treatment
    3. Bone Grafting
    4. Delayed Union and Nonunion
    5. Treatment of Acute and Chronic Bone Infections
    6. Arthrology
    7. Principles of Joint Surgery
    8. Arthroscopy in Joint Surgery

    Part II: Fractures and Orthopedic Conditions of the Forelimb
    9. Fractures of the Scapula
    10. The Shoulder Joint
    11. Fractures of the Humerus
    12. The Elbow Joint
    13. Fractures of the Radius and Ulna
    14. Fractures and Other Orthopedic Conditions of the Carpus, Metacarpus, and Phalanges

    Part III: Fractures and Orthopedic Conditions of the Hindlimb
    15. Fractures of the Pelvis
    16. The Hip Joint
    17. Fractures of the Femur and Patella
    18. The Stifle Joint
    19. Fractures of the Tibia and Fibula
    20. Fractures and Other Orthopedic Injuries of the Tarsus, Metatarsus, and Phalanges

    Part IV: Other Fractures and Reconstruction of Bone Deformity
    21. Fractures and Luxations of the Mandible and Maxilla
    22. Fractures in Growing Animals
    23. Correction of Abnormal Bone Growth and Healing

    Part V: Miscellaneous Conditions of the Musculoskeletal System
    24. Disease Conditions in Small Animals

       

  • Ioachim's Lymph Node Pathology
    La comanda in aproximativ 4 saptamani
    1320.00 lei

     

    Description:

    Fully revised and up- to- date, Ioachim's Lymph Node Pathology, 5th Edition, offers valuable guidance in the diagnostic interpretation of lymph node biopsies. Continuing the tradition of excellence established by Dr. Harry L. Ioachim, Dr. L. Jeffrey Medeiros of The University of Texas MD Anderson Cancer Center offers a comprehensive, clinically useful approach to all the various nonmalignant lesions, lymphomas, other neoplasms, and metastatic tumors in lymph nodes. Discussion of each pathologic entity includes definition, clinical syndrome, histopathology, immunopathology, molecular genetic findings, and differential diagnosis. In addition, chapters have a useful checklist for each entity.  

     

     

    Table of Contents:

     

    Part One ▪ Normal Lymph Node

    Chapter 1: Normal Lymph Node

    FUNCTIONS

    CELL POPULATIONS

    STRUCTURES

    Cortical area

    Paracortical area

    Medullary area

    LYMPHATIC SINUSES

    BLOOD VESSELS

    SUPPORTING FRAMEWORK OR STROMA

    Part Two ▪ Diagnostic Methods

    Chapter 2: The Lymph Node Biopsy

    ENLARGED LYMPH NODES

    NONDIAGNOSTIC LYMPHADENOPATHIES

    CAUSES OF MISDIAGNOSIS

    FROZEN SECTION DIAGNOSIS

    Frozen section diagnosis of infectious tissues

    SENTINEL LYMPH NODE MAPPING AND BIOPSY

    LYMPH NODE TRIAGE AND WORKUP

    Allotment of tissue

    Routine fixation and staining

    Special stains

    TOUCH IMPRINTS

    REPORTING RESULTS AND THE EVOLVING ROLE OF THE PATHOLOGIST

    Chapter 3: Cytopathology

    FINE NEEDLE ASPIRATION

    Indications

    Morphologic caveats

    Reliability

    Limitations

    NEEDLE CORE BIOPSY

    Indications

    Morphologic caveats

    FINE NEEDLE ASPIRATION VERSUS NEEDLE CORE BIOPSY

    IMMUNOPHENOTYPIC ANALYSIS

    Flow cytometry

    Immunocytochemistry

    MOLECULAR DIAGNOSIS

    TOUCH IMPRINTS/SCRAPE PREPARATIONS

    Role in diagnosis

    Technique

    Potential role in diagnosis

    Chapter 4: Electron Microscopy

    NON-HODGKIN LYMPHOMAS

    HODGKIN LYMPHOMAS

    HISTIOCYTIC AND ACCESSORY CELL NEOPLASMS

    Chapter 5: Flow Cytometry

    FLOW CYTOMETRY METHODS

    HOW MANY FLUOROCHROMES (COLORS)?

    ANTIBODIES

    HOW MANY ANTIBODIES?

    USING A SCOUT TUBE

    GATING

    ANTIGEN DENSITY

    ANALYSIS OF FLOW CYTOMETRY RESULTS

    More than just numbers

    Not just positive or negative

    Patterns of antigen expression are important

    Immunophenotypic stability

    Nonspecific staining

    INDICATIONS FOR FLOW CYTOMETRY IMMUNOPHENOTYPING

    DNA PLOIDY AND CELL CYCLE

    B-CELL NON-HODGKIN LYMPHOMAS

    Monotypic versus polytypic

    False-negative results

    Aberrant immunophenotypes

    Monotypic B-cell populations in benign diseases

    HODGKIN LYMPHOMA

    T-CELL NON-HODGKIN LYMPHOMAS

    NATURAL KILLER CELL NEOPLASMS

    HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS

    ACUTE MYELOID LEUKEMIA

    NONHEMATOPOIETIC NEOPLASMS

    Chapter 6: Immunohistochemistry

    ADVANTAGES OF IMMUNOHISTOCHEMISTRY

    HEMATOLOGIC NEOPLASMS IN LYMPH NODES

    IMMUNOHISTOCHEMICAL METHODS

    FROZEN TISSUE SECTIONS

    ROUTINELY PROCESSED TISSUE SECTIONS

    ANTIBODY PANELS AND CONTROLS

    IN SITU HYBRIDIZATION

    B-CELL NON-HODGKIN LYMPHOMAS

    Immunoglobulin light chain analysis

    B-cell immunophenotypes

    HODGKIN LYMPHOMAS

    T-CELL NON-HODGKIN LYMPHOMAS

    NATURAL KILLER CELL NEOPLASMS

    HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS

    MYELOID SARCOMA

    METASTATIC SOLID TUMORS IN LYMPH NODES

    Chapter 7: Molecular Assessment of Clonality

    ANTIGEN RECEPTOR GENES

    Generation of diversity

    Somatic recombination

    Complementarity-determining regions

    In-frame alignment of gene segments

    Genetic hierarchy

    Allelic exclusion

    Multiple constant regions and class switching

    Anatomy of antigen receptor genes

    Immunoglobulin heavy chain gene

    Immunoglobulin κ light chain gene

    Immunoglobulin λ light chain gene

    T-cell receptor β chain gene

    T-cell receptor γ chain gene

    T-cell receptor α chain gene

    T-cell receptor δ chain gene

    METHODS USED TO DETECT CLONALITY

    Southern blot analysis

    Polymerase chain reaction–based methods

    Application to antigen receptor gene rearrangements

    Sensitivity of polymerase chain reaction–based assays for antigen receptor gene rearrangements

    False-positive and false-negative results

    Lineage infidelity

    Polymerase chain reaction–based assays versus Southern blotting

    Next-generation sequencing methods to assess clonality

    Chapter 8: Molecular Assessment of Genetic Abnormalities

    CONVENTIONAL CYTOGENETIC ANALYSIS

    FLUORESCENCE IN SITU HYBRIDIZATION

    Colorimetric in situ hybridization

    POLYMERASE CHAIN REACTION

    Reverse transcriptase and semiquantitative polymerase chain reaction

    Digital droplet polymerase chain reaction

    HIGH-THROUGHPUT TECHNIQUES USED IN MOLECULAR DIAGNOSTICS

    Comparative genomic hybridization

    Single-nucleotide polymorphism arrays

    MicroRNA analysis

    Mutational analysis

    Liquid biopsy

    Gene expression profiling

    Proteomics

    MOLECULAR ABNORMALITIES IN LYMPHOID NEOPLASMS

    Chromosomal translocations

    Copy number alterations

    Gene mutations

    Part Three ▪ Lymphadenitides

    Section I ▪ Viral Lymphadenitides

    Chapter 9: Infectious Mononucleosis Lymphadenitis

    DEFINITION

    ETIOLOGY

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR FINDINGS

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Chapter 10: Cytomegalovirus Lymphadenitis

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY AND IN SITU HYBRIDIZATION

    DIFFERENTIAL DIAGNOSIS

    Chapter 11: Herpes Simplex Virus Lymphadenitis

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    METHODS OF VIRUS DETECTION

    DIFFERENTIAL DIAGNOSIS

    Chapter 12: Varicella-Zoster Viral Lymphadenitis

    DEFINITION

    ETIOLOGY

    PATHOGENESIS

    EPIDEMIOLOGY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY AND MOLECULAR FEATURES

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Chapter 13: Vaccinial Lymphadenitis

    DEFINITION

    ETIOLOGY AND PATHOGENESIS

    CLINICAL FEATURES

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 14: Measles Lymphadenitis

    DEFINITION

    ETIOLOGY AND PATHOGENESIS

    EPIDEMIOLOGY

    CLINICAL FEATURES

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGIC FINDINGS

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Chapter 15: Human Immunodeficiency Virus Lymphadenitis

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY

    PATHOGENESIS

    CLINICAL FEATURES

    Opportunistic infections

    Lymphomas and other HIV-associated nodal diseases

    HISTOPATHOLOGY

    Pattern A

    Pattern B

    Pattern C

    CYTOPATHOLOGY

    ELECTRON MICROSCOPY

    IMMUNOHISTOCHEMISTRY

    LABORATORY TESTS FOR DIAGNOSIS

    DIFFERENTIAL DIAGNOSIS

    Pattern A (Acute)

    Pattern B (Chronic)

    Pattern C (Burned-out)

    Section II ▪ Bacterial Lymphadenitides

    Chapter 16: Ordinary Bacterial Lymphadenitis

    DEFINITION

    INTRODUCTION

    CLINICAL AND LABORATORY FINDINGS

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGIC FINDINGS

    CYTOLOGIC FINDINGS

    ADJUVANT DIAGNOSTIC METHODS

    DIFFERENTIAL DIAGNOSIS

    Chapter 17: Cat-Scratch Lymphadenitis

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY

    CLINICAL FEATURES

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    Lymph nodes

    Skin

    ELECTRON MICROSCOPY

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Chapter 18: Bacillary Angiomatosis

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    ELECTRON MICROSCOPY

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Chapter 19: Lymphogranuloma Venereum Lymphadenitis

    DEFINITION

    ETIOLOGY

    EPIDEMIOLOGY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Chapter 20: Syphilitic Lymphadenitis

    DEFINITION

    ETIOLOGY

    EPIDEMIOLOGY

    CLINICAL SYNDROME

    HISTOPATHOLOGY

    Methods of T pallidum detection in tissues

    LABORATORY TESTS

    TREATMENT AND PROGNOSIS

    DIFFERENTIAL DIAGNOSIS

    Chapter 21: Lymphadenitis of Whipple Disease

    DEFINITION

    ETIOLOGY

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    ELECTRON MICROSCOPY

    IMMUNOHISTOCHEMISTRY

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Section III ▪ Mycobacterial Lymphadenitides

    Chapter 22: Mycobacterium Tuberculosis Lymphadenitis

    DEFINITION

    INTRODUCTION

    ETIOLOGY

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    Lymphadenitis

    BACILLE CALMETTE-GUÉRIN LYMPHADENITIS

    TREATMENT AND PROGNOSIS

    GROSS PATHOLOGY

    HISTOLOGIC FINDINGS

    CYTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    TESTS FOR DETECTING MYCOBACTERIUM TUBERCULOSIS INFECTION

    DIFFERENTIAL DIAGNOSIS

    Chapter 23: Nontuberculous Mycobacterial Lymphadenitis

    DEFINITION

    ETIOLOGY

    PATHOGENESIS

    EPIDEMIOLOGY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGIC FINDINGS

    General comments

    Lymph nodes

    Mycobacterial spindle cell pseudotumor

    CYTOLOGY

    IMMUNOHISTOCHEMISTRY

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Chapter 24: Mycobacterium Leprae Lymphadenitis

    DEFINITION

    INTRODUCTION

    ETIOLOGY

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Skin

    Lymph node

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Section IV ▪ Fungal Lymphadenitides

    Chapter 25: Cryptococcus Lymphadenitis

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Chapter 26: Histoplasma Lymphadenitis

    DEFINITION

    ETIOLOGY

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Chapter 27: Coccidioidomycosis Lymphadenitis

    DEFINITION

    INTRODUCTION

    ETIOLOGY

    GEOGRAPHIC DISTRIBUTION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Chapter 28: Pneumocystis Lymphadenitis

    DEFINITION

    ETIOLOGY

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    LABORATORY DIAGNOSIS

    DIFFERENTIAL DIAGNOSIS

    Section V ▪ Protozoal Lymphadenitides

    Chapter 29: Toxoplasma Lymphadenitis

    DEFINITION

    INTRODUCTION

    ETIOLOGY AND PATHOGENESIS

    EPIDEMIOLOGY

    CLINICAL FEATURES

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR PATHOLOGY

    DIAGNOSTIC TESTS

    DIFFERENTIAL DIAGNOSIS

    Chapter 30: Leishmania Lymphadenitis

    DEFINITION

    ETIOLOGY

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    ANCILLARY METHODS FOR DIAGNOSIS

    DIFFERENTIAL DIAGNOSIS

    Chapter 31: Filaria Lymphadenitis

    DEFINITION

    INTRODUCTION

    ETIOLOGY AND PATHOGENESIS

    EPIDEMIOLOGY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Part Four ▪ Lymphadenopathies

    Section I ▪ Reactive Lymphadenopathies

    Chapter 32: Reactive Lymphoid Hyperplasia

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    Age

    HISTOPATHOLOGY

    Reactive follicular hyperplasia

    Reactive paracortical hyperplasia

    Sinusoidal hyperplasia

    Marginal zone hyperplasia

    Plasmacytosis of medullary cords

    Mixed patterns

    IMMUNOPHENOTYPIC FINDINGS

    Assessment of clonality

    Reactive follicular hyperplasia

    Reactive paracortical hyperplasia

    Sinus histiocytosis

    Plasmacytosis

    MOLECULAR TESTING

    CONVENTIONAL CYTOGENETIC RESULTS

    DIFFERENTIAL DIAGNOSIS

    Reactive follicular hyperplasia

    Reactive paracortical hyperplasia

    Sinusoidal hyperplasia

    Chapter 33: Progressive Transformation of Germinal Centers

    DEFINITION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Section II ▪ Lymphadenopathies Associated with Clinical Syndromes

    Chapter 34: IgG4-Related Lymphadenopathy

    DEFINITION

    INTRODUCTION

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Multicentric Castleman disease–like (type I)

    Follicular hyperplasia (type II)

    Interfollicular expansion (type III)

    Progressive transformation of germinal centers (type IV)

    Inflammatory pseudotumor–like (type V)

    Infectious mononucleosis–like

    IMMUNOPHENOTYPIC AND MOLECULAR FEATURES

    DIFFERENTIAL DIAGNOSIS

    Chapter 35: Kimura Lymphadenopathy

    DEFINITION

    INTRODUCTION

    ETIOLOGY AND EPIDEMIOLOGY

    CLINICAL FEATURES

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 36: Rosai-Dorfman Disease

    DEFINITION

    INTRODUCTION

    ETIOLOGY

    EPIDEMIOLOGY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    ROSAI-DORFMAN DISEASE ASSOCIATED WITH LYMPHOMA

    CYTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 37: Kikuchi-Fujimoto Disease

    DEFINITION

    INTRODUCTION

    PATHOGENESIS

    CLINICAL FEATURES

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    IMMUNOPHENOTYPE AND MOLECULAR STUDIES

    DIFFERENTIAL DIAGNOSIS

    Chapter 38: Sarcoidosis Lymphadenopathy

    DEFINITION

    HISTORICAL INTRODUCTION

    EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    KVEIM TEST

    DIFFERENTIAL DIAGNOSIS

    Chapter 39: Systemic Lupus Lymphadenopathy

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    CLINICAL FEATURES

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Lupus lymphadenitis with necrosis

    Other nodal lymphoproliferations in SLE

    Lymphoma risk

    IMMUNOHISTOCHEMISTRY AND MOLECULAR FEATURES

    LABORATORY TESTS

    DIFFERENTIAL DIAGNOSIS

    Chapter 40: Rheumatoid Lymphadenopathy

    DEFINITION

    EPIDEMIOLOGY

    PATHOGENESIS

    Risk of lymphoma

    CLINICAL SYNDROME

    LABORATORY TESTS

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Chapter 41: Dermatopathic Lymphadenopathy

    DEFINITION

    INTRODUCTION AND PATHOGENESIS

    FREQUENCY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 42: Unicentric Castleman Disease

    DEFINITION

    INTRODUCTION

    PATHOGENESIS

    CLINICAL SYNDROME

    Hyaline vascular variant

    Plasma cell variant

    HISTOPATHOLOGY

    Hyaline vascular variant

    Plasma cell variant

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FINDINGS

    CASTLEMAN-LIKE CHANGES IN LYMPH NODES INVOLVED BY LYMPHOMA

    NEOPLASMS ASSOCIATED WITH CASTLEMAN DISEASE

    DIFFERENTIAL DIAGNOSIS

    Hyaline vascular variant

    Plasma cell variant

    Chapter 43: Multicentric Castleman Disease

    DEFINITION

    INTRODUCTION

    PATHOGENESIS

    Human herpesvirus 8–positive multicentric Castleman disease

    Idiopathic multicentric Castleman disease

    POEMS syndrome

    CLINICAL SYNDROME

    Human herpesvirus 8–positive multicentric Castleman disease

    Idiopathic multicentric Castleman disease

    POEMS syndrome

    TREATMENT AND PORGNOSIS

    HISTOPATHOLOGY

    IMMUNOPHENOTYPIC FEATURES

    CYTOGENETIC AND MOLECULAR FINDINGS

    NEOPLASMS ASSOCIATED WITH MULTICENTRIC CASTLEMAN DISEASE

    DIFFERENTIAL DIAGNOSIS

    Chapter 44: Tumor-Reactive Lymphadenopathy

    DEFINITION

    PATHOGENESIS

    CLINICAL IMPORTANCE

    HISTOPATHOLOGIC FEATURES

    Lymphocyte predominance

    Germinal center predominance

    Sinus histiocytosis

    Lymphocyte depletion

    Granulomatous reaction

    Marginal zone hyperplasia

    Dermatopathic lymphadenopathy

    Plasmacytosis or eosinophilia

    Vascular transformation of lymph node sinuses

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Chapter 45: Amyloid Lymphadenopathy

    DEFINITION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    ANCILLARY METHODS

    Special stains

    Electron microscopy

    Immunohistochemistry

    Proteomics

    DIFFERENTIAL DIAGNOSIS

    Section III ▪ Lymphadenopathy Associated with Drug Therapy

    Chapter 46: Drug-Induced Lymphadenopathy

    DEFINITION

    INTRODUCTION

    PATHOGENESIS

    CLINICAL SYNDROME

    Drug-associated changes not obviously related to DRESS

    Lymphomas arising in patients taking anticonvulsant medications

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR DIAGNOSIS

    DIFFERENTIAL DIAGNOSIS

    Section IV ▪ Vascular Lymphadenopathies

    Chapter 47: Lymph Node Infarction

    DEFINITION

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR STUDIES

    DIFFERENTIAL DIAGNOSIS

    Chapter 48: Vascular Transformation of Sinuses

    DEFINITION

    PATHOGENESIS

    CLINICAL SYNDROME

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Section V ▪ Foreign Body Lymphadenopathies

    Chapter 49: Lipogranulomatous Lymphadenopathy

    DEFINITION

    INTRODUCTION AND PATHOGENESIS

    LYMPHANGIOGRAPHY-ASSOCIATED LYMPHADENOPATHY

    CLINICAL SYNDROME, TREATMENT, AND PROGNOSIS

    GROSS AND HISTOPATHOLOGIC FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 50: Silicone Lymphadenopathy

    DEFINITION

    INTRODUCTION

    PATHOGENESIS

    CLINICAL SYMPTOMS

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    CYTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    ELECTRON MICROSCOPY AND SPECTROSCOPY

    DIFFERENTIAL DIAGNOSIS

    Chapter 51: Lymphadenopathy Associated With Joint Prostheses

    DEFINITION

    INTRODUCTION

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    ELECTRON MICROSCOPY

    IMMUNOHISTOCHEMISTRY AND MOLECULAR STUDIES

    DIFFERENTIAL DIAGNOSIS

    Chapter 52: Tattoo Lymphadenopathy

    DEFINITION

    INTRODUCTION

    PATHOGENESIS

    CLINICAL SYNDROME

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Chapter 53: Gold Lymphadenopathy

    DEFINITION

    INTRODUCTION

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Ancillary techniques

    DIFFERENTIAL DIAGNOSIS

    Section VI ▪ Lymph Node Inclusions

    Chapter 54: Epithelial Cell Inclusions in Lymph Nodes

    DEFINITION

    PATHOGENESIS

    Upper cervical lymph nodes

    Lower cervical lymph nodes

    Axillary lymph nodes

    Mediastinal lymph nodes

    Mesenteric lymph nodes

    Peripancreatic lymph nodes

    Perirenal lymph nodes

    Peritoneal lymph nodes

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Cervical lymph nodes

    Axillary lymph nodes

    Mediastinal lymph nodes

    Mesenteric lymph nodes

    Peripancreatic lymph nodes

    Perirenal lymph nodes

    Pelvic and abdominal lymph nodes

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Chapter 55: Nevus Cell Inclusions in Lymph Nodes

    DEFINITION

    INTRODUCTION

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR TESTING

    DIFFERENTIAL DIAGNOSIS

    Part Five ▪ Lymphomas

    Section I ▪ Nomenclature and Classification of Lymphomas

    Chapter 56: Nomenclature and Classification of Lymphomas

    HODGKIN LYMPHOMAS

    PRECURSOR LYMPHOBLASTIC NEOPLASMS

    B-CELL NON-HODGKIN LYMPHOMAS

    T-CELL NON-HODGKIN LYMPHOMAS

    GRAY-ZONE LYMPHOMAS

    Section II ▪ Hodgkin Lymphomas

    Chapter 57: Classic Hodgkin Lymphomas

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    ETIOLOGY

    PATHOGENESIS

    PATTERN OF SPREAD

    STAGE

    CLINICAL FEATURES

    PROGNOSIS AND TREATMENT

    HISTOPATHOLOGY

    Neoplastic cells

    Reed-Sternberg cell variants

    Nonneoplastic cells

    Nodular sclerosis HL

    Lymphocyte-rich classic HL

    Mixed cellularity HL

    Lymphocyte-depleted HL

    ELECTRON MICROSCOPY

    IMMUNOPHENOTYPE

    Neoplastic cells

    Nonneoplastic cells

    CYTOGENETICS AND MOLECULAR GENETICS

    DIFFERENTIAL DIAGNOSIS

    Nodular sclerosis HL

    Lymphocyte-rich classic HL

    Mixed cellularity HL

    Lymphocyte-depleted HL

    Chapter 58: Nodular Lymphocyte–Predominant Hodgkin Lymphoma

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    CLINICAL FEATURES

    PROGNOSIS AND TREATMENT

    HISTOLOGIC FEATURES

    Diffuse lymphocyte–predominant Hodgkin lymphoma

    IMMUNOPHENOTYPIC FINDINGS

    MOLECULAR AND CYTOGENETIC FINDINGS

    DIFFUSE LARGE B-CELL LYMPHOMA IN PATIENTS WITH NODULAR LYMPHOCYTE–PREDOMINANT HODGKIN LYMPHOMA

    IMMUNOPHENOTYPE

    Lymphocyte-predominant cells

    Reactive cells in nodular pattern

    Reactive cells in areas of diffuse pattern

    DIFFERENTIAL DIAGNOSIS

    Section III ▪ Precursor Lymphoid Neoplasms

    Chapter 59: B Lymphoblastic Leukemia/Lymphoma

    DEFINITION

    EPIDEMIOLOGY AND PATHOGENESIS

    CURRENT CLASSIFICATION OF B ACUTE LYMPHOBLASTIC LEUKEMIA

    CLINICAL FINDINGS

    THERAPY AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Blood and bone marrow

    Lymph node

    IMMUNOPHENOTYPIC FINDINGS

    DNA CONTENT ANALYSIS

    CYTOGENETIC FINDINGS

    MOLECULAR FINDINGS

    BCR-ABL1–LIKE B ACUTE LYMPHOBLASTIC LEUKEMIA

    IMMUNOPHENOTYPE

    B lymphoblastic leukemia/lymphoma

    DIFFERENTIAL DIAGNOSIS

    Chapter 60: T Lymphoblastic Lymphoma/Leukemia

    DEFINITION

    EPIDEMIOLOGY AND PATHOGENESIS

    CLINICAL FINDINGS

    THERAPY AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Lymph node

    Blood and bone marrow

    IMMUNOPHENOTYPIC FINDINGS

    CYTOGENETICS AND MOLECULAR FINDINGS

    EARLY T-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA

    IMMUNOPHENOTYPE

    T lymphoblastic leukemia/lymphoma

    DIFFERENTIAL DIAGNOSIS

    NATURAL KILLER LYMPHOBLASTIC LEUKEMIA/LYMPHOMA

    Definition

    Epidemiology

    CLINICAL FINDINGS

    HISTOLOGIC, IMMUNOPHENOTYPIC, AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    BLASTIC HEMATOPOIETIC NEOPLASM ASSOCIATED WITH T(8;13)(P11;Q12)/ZMYM2-FGFR1

    Definition

    Introduction

    CLINICAL FINDINGS

    PROGNOSIS AND TREATMENT

    HISTOLOGIC AND IMMUNOPHENOTYPIC FINDINGS

    PERIPHERAL BLOOD AND BONE MARROW

    MOLECULAR FINDINGS

    Section IV ▪ Mature B-Cell Neoplasms

    Chapter 61: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

    DEFINITION

    EPIDEMIOLOGY

    CLINICAL SYNDROME

    PROGNOSIS AND TREATMENT

    HISTOPATHOLOGY

    Lymph node

    Peripheral blood

    Bone marrow

    IMMUNOPHENOTYPE

    Flow cytometry

    Immunohistochemistry

    CYTOGENETICS

    MOLECULAR DIAGNOSIS

    HISTOLOGIC TRANSFORMATION OF CLL/SLL

    Accelerated phase

    Prolymphocytoid transformation

    Richter syndrome

    MONOCLONAL B-CELL LYMPHOCYTOSIS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE OF CLL/SLL

    Chapter 62: Lymphoplasmacytic Lymphoma and Waldenstrom Macroglobulinemia

    DEFINITION

    EPIDEMIOLOGY AND ETIOLOGY

    CLINICAL FINDINGS

    LABORATORY FINDINGS

    Serum IgM paraprotein

    Other laboratory abnormalities

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    Bone marrow

    Lymph node

    IMMUNOPHENOTYPE

    CYTOGENETIC FINDINGS

    MOLECULAR FINDINGS

    LARGE-CELL TRANSFORMATION OF LPL/WM

    DIFFERENTIAL DIAGNOSIS

    Chapter 63: Hairy Cell Leukemia

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL FEATURES

    TREATMENT AND PROGNOSIS

    Second malignancies in hairy cell leukemia patients

    HISTOPATHOLOGY

    Peripheral blood

    Bone marrow

    Spleen

    Lymph node

    Atypical morphologic variants and histologic transformation

    ELECTRON MICROSCOPY

    CYTOCHEMISTRY

    IMMUNOPHENOTYPE

    CYTOGENETICS AND COMPARATIVE GENOMIC HYBRIDIZATION

    MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 64: Nodal Marginal Zone B-Cell Lymphoma

    DEFINITION

    PHYSIOLOGIC ROLE OF MARGINAL ZONE B CELLS

    HISTORICAL INTRODUCTION

    EPIDEMIOLOGY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 65: Extranodal Marginal Zone Lymphomas

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    CLINICAL FINDINGS

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FEATURES

    Lymph nodes

    Bone marrow

    Other extranodal sites

    IMMUNOPHENOTYPE

    CYTOGENETICS AND MOLECULAR FINDINGS

    Site-specific abnormalities in extranodal marginal zone lymphoma

    DIFFERENTIAL DIAGNOSIS

    Chapter 66: Splenic Marginal Zone Lymphoma

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Lymph nodes

    Spleen

    Peripheral blood and bone marrow

    IMMUNOPHENOTYPIC FEATURES

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 67: Plasmacytoma

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    CLINICAL SYNDROME

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    Ancillary studies

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 68: Follicular Lymphoma

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Grading

    Blood and bone marrow

    Morphologic variants of systemic follicular lymphoma

    In situ follicular neoplasia

    Partial involvement by follicular lymphoma

    Follicular lymphoma with marginal zone (monocytoid) differentiation

    Floral variant of follicular lymphoma

    Follicular lymphoma with Castleman-like features

    Signet-ring cell follicular lymphoma

    Follicular lymphoma with abundant extracellular PAS+ material

    Follicular lymphoma with a diffuse pattern

    CYTOPATHOLOGY

    ELECTRON MICROSCOPY

    IMMUNOPHENOTYPIC FEATURES

    Immunophenotypic variants of follicular lymphoma

    CD5+ follicular lymphoma

    EBV+ follicular lymphoma

    CYTOGENETIC AND MOLECULAR FINDINGS

    TRANSFORMATION OF SYSTEMIC FOLLICULAR LYMPHOMA TO DIFFUSE LARGE B-CELL LYMPHOMA

    SPECIFIC TYPES OF NODAL FOLLICULAR LYMPHOMA

    Pediatric-type follicular lymphoma

    Follicular lymphoma associated with IRF4/MUM1 rearrangement

    Follicular lymphoma with del(1p36)/TNFRSF14 abnormalities

    FOLLICULAR LYMPHOMA, GRADE 3B

    SPECIFIC TYPES OF EXTRANODAL FOLLICULAR LYMPHOMA

    Primary cutaneous follicle center cell lymphoma

    Primary intestinal follicular lymphoma

    Follicular lymphoma of the testis

    DIFFERENTIAL DIAGNOSIS

    Chapter 69: Mantle Cell Lymphoma

    DEFINITION

    HISTORICAL INTRODUCTION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL FINDINGS

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Cytologic spectrum of mantle cell lymphoma

    Common sites of involvement by mantle cell lymphoma

    Lymph node

    Gastrointestinal tract

    Spleen

    Bone marrow

    Peripheral blood

    VARIANTS OF MANTLE CELL LYMPHOMA

    In situ mantle cell neoplasia

    Leukemic non-nodal mantle cell lymphoma

    Cyclin D1− mantle cell lymphoma

    IMMUNOPHENOTYPIC FINDINGS

    Cyclin D1

    CYTOGENETICS

    MOLECULAR DIAGNOSIS

    Immunoglobulin genes

    Methods for detecting the t(11;14)

    Gene expression profiling

    Additional molecular alterations in mantle cell lymphoma

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 70: Diffuse Large B-Cell Lymphoma

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    ETIOLOGY

    PATHOGENESIS

    Germinal center

    Chromosomal translocations

    Gene mutations

    Mutations in genes that modify histones and chromatin

    Escape from immunosurveillance

    FOXO1 mutations

    EZH2 mutations

    Abnormal B-cell migration

    TNFRSF14 mutations

    Activation of NF-κB pathway

    Inhibition of terminal differentiation

    Cell-of-origin

    Tumor microenvironment

    CLINICAL SYNDROME

    International Prognostic Index

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    Lymph node

    Cytopathologic features

    Extranodal sites

    Bone marrow

    Peripheral blood

    IMMUNOPHENOTYPE

    Cell-of-origin

    MYC + Bcl-2

    CD5

    MYC

    P53

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    PHENOTYPE

    Chapter 71: T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    CLINICAL FINDINGS

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 72: ALK-Positive Large B-Cell Lymphoma

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    CLINICAL FINDINGS

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 73: Plasmablastic Lymphoma

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY AND CLINICAL FINDINGS

    HIV associated

    Transplantation associated

    Autoimmune disease associated

    Immunocompetent patients

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 74: Primary Mediastinal Large B-Cell Lymphoma

    DEFINITION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Mediastinum

    Lymph nodes

    IMMUNOPHENOTYPIC FEATURES

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 75: Epstein-Barr Virus–Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    CLINICAL SYNDROME

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 76: HHV8-Positive Lymphoproliferative Disorders

    INTRODUCTION

    GENERAL FEATURES OF HHV8

    PRIMARY EFFUSION LYMPHOMA

    Definition

    Clinical features

    Therapy and prognosis

    Histopathology

    Immunophenotypic features

    Cytogenetic and molecular features

    Cell or origin

    Differential diagnosis

    HHV8+ DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED

    Definition

    Clinical features

    Therapy and prognosis

    Histologic findings

    Immunophenotypic features

    Cytogenetic and molecular findings

    Differential diagnosis

    HHV8+ GERMINOTROPIC LYMPHOPROLIFERATIVE DISORDER

    Introduction and clinical findings

    Histologic features

    Immunophenotypic and molecular features

    Differential diagnosis

    Chapter 77: Extranodal Variants of Diffuse Large B-Cell Lymphoma

    PRIMARY DLBCL OF THE CENTRAL NERVOUS SYSTEM

    Definition

    Clinical findings

    Therapy and prognosis

    Morphologic and immunophenotypic findings

    Cytogenetic and molecular findings

    PRIMARY CUTANEOUS DIFFUSE LARGE B-CELL LYMPHOMA, LEG-TYPE

    Definition

    Clinical findings

    Therapy and prognosis

    Morphologic and immunophenotypic findings

    Cytogenetic and molecular features

    DIFFUSE LARGE B-CELL LYMPHOMA ASSOCIATED WITH CHRONIC INFLAMMATION

    Definition

    Introduction and pathogenesis

    Clinical findings

    Therapy and prognosis

    Morphologic and immunophenotypic findings

    Cytogenetic and molecular features

    FIBRIN-ASSOCIATED EBV-POSITIVE LARGE B-CELL LYMPHOMA

    Definition

    Introduction and clinical findings

    Therapy and prognosis

    Morphologic, immunophenotypic, and molecular findings

    LYMPHOMATOID GRANULOMATOSIS

    Definition

    Clinical findings

    Therapy and prognosis

    Morphologic and immunophenotypic findings

    Cytogenetic and molecular findings

    INTRAVASCULAR LARGE B-CELL LYMPHOMA

    Definition

    Clinical findings

    Morphologic and immunophenotypic findings

    EBV-POSITIVE MUCOCUTANEOUS ULCER

    Definition

    Clinical findings

    Therapy and prognosis

    Morphologic and immunophenotypic findings

    Cytogenetic and molecular findings

    PRIMARY TESTICULAR DIFFUSE LARGE B-CELL LYMPHOMA

    Definition

    Clinical findings

    Therapy and prognosis

    Morphologic and immunophenotypic findings

    Cytogenetic and molecular findings

    Chapter 78: Burkitt Lymphoma

    DEFINITION

    HISTORICAL INTRODUCTION

    EPIDEMIOLOGY

    Endemic

    Sporadic

    Immunodeficiency-associated

    PATHOGENESIS

    Genetic alterations

    Burkitt lymphoma without MYC translocation

    Cofactors involved in Burkitt lymphoma pathogenesis

    Epstein-Barr virus

    Malaria

    Other potential cofactors

    CLINICAL FINDINGS

    THERAPY AND PROGNOSIS

    HISTOPATHOLOGY

    Morphologic variants

    IMMUNOPHENOTYPE

    CONVENTIONAL CYTOGENETICS

    MOLECULAR FINDINGS

    Burkitt-like lymphoma with 11q aberration

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 79: High-Grade B-Cell Lymphomas

    INTRODUCTION

    HIGH-GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 AND/OR BCL6 REARRANGEMENT

    Definition

    Introduction

    Clinical features

    Therapy and prognosis

    Histologic findings

    Cytologic findings

    Immunophenotypic features

    Cytogenetic and molecular findings

    Atypical double-hit lymphoma

    Double-expressor lymphoma

    Differential Diagnosis

    HIGH-GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED

    Definition

    Introduction

    Clinical features

    Therapy and prognosis

    Histologic findings

    Immunophenotypic features

    Cytogenetic and molecular findings

    Differential Diagnosis

    Chapter 80: B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma

    DEFINITION

    GENERAL FEATURES

    CLINICAL FEATURES

    THERAPY AND PROGNOSIS

    HISTOLOGIC FINDINGS

    CYTOLOGIC FINDINGS

    IMMUNOPHENOTYPE

    Epstein-Barr virus

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 81: Composite Lymphoma

    DEFINITION

    HISTORICAL INTRODUCTION

    DISCORDANT AND SEQUENTIAL LYMPHOMAS

    LYMPHOID AND NONLYMPHOID HEMATOLOGIC NEOPLASMS

    FREQUENCY AND PATHOGENESIS

    Mechanisms involved in clonally related cases

    Hypotheses that may explain clonally unrelated cases

    CLINICAL FINDINGS

    THERAPY AND PROGNOSIS

    MORPHOLOGIC AND IMMUNOPHENOTYPIC FINDINGS

    MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Section V ▪ Mature T-Cell Neoplasms

    Chapter 82: Peripheral T-Cell Lymphoma, Not Otherwise Specified

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY AND PATHOGENESIS

    CLINICAL FINDINGS

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Morphologic variants

    IMMUNOPHENOTYPIC FINDINGS

    Diagnostic value of aberrant immunophenotypes

    Immunophenotypic algorithm for diagnosis

    Physiologic T-cell heterogeneity and attempts to correlate with PTCL-NOS subsets

    CYTOGENETICS

    MOLECULAR FEATURES

    Lymphoepithelioid variant/Lennert lymphoma

    PRIMARY EBV-POSITIVE NODAL T-/NK-CELL LYMPHOMA

    PTCL-NOS WITH ASSOCIATED B-CELL PROLIFERATIONS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 83: Angioimmunoblastic T-Cell Lymphoma

    DEFINITION

    HISTORICAL PERSPECTIVE

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL FINDINGS

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Lymph node

    Peripheral blood

    Bone marrow

    Extranodal sites

    IMMUNOPHENOTYPE

    CYTOGENETIC FINDINGS

    MOLECULAR FINDINGS

    Morphologic-molecular correlations

    SECOND LYMPHOMAS IN AITL PATIENTS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 84: Peripheral T-Cell Lymphoma With T Follicular Helper Cell Immunophenotype

    DEFINITION

    INTRODUCTION

    CLINICAL FEATURES

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FEATURES

    T-zone variant

    Follicular T-cell lymphoma

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FEATURES

    DIFFERENTIAL DIAGNOSIS

    Chapter 85: Adult T-Cell Leukemia/Lymphoma

    DEFINITION

    HUMAN LYMPHOTROPIC VIRUS TYPE 1

    Other human T-cell lymphotropic viruses

    EPIDEMIOLOGY OF HUMAN LYMPHOTROPIC VIRUS TYPE 1 INFECTION

    EPIDEMIOLOGY OF ADULT T-CELL LEUKEMIA/LYMPHOMA

    PATHOGENESIS

    CLINICAL FEATURES

    THERAPY AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Lymph nodes

    Peripheral blood and bone marrow

    Skin

    Other extranodal sites

    IMMUNOPHENOTYPE

    CYTOGENETICS

    MOLECULAR FINDINGS

    METHODS FOR DETECTING HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE 1

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 86: Mycosis Fungoides and Sézary Syndrome

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    PROGNOSIS

    TREATMENT

    HISTOLOGIC FINDINGS

    Skin

    Mycosis fungoides variants involving the skin

    Folliculotropic mycosis fungoides

    Pagetoid reticulosis

    Granulomatous slack skin disease

    Large-cell transformation of mycosis fungoides

    Peripheral blood and bone marrow

    Lymph node

    Visceral disease

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FINDINGS

    T-cell clonality

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE OF MYCOSIS FUNGOIDES

    DEFINITION

    ADDITIONAL DEFINITIONS

    INTRODUCTION AND EPIDEMIOLOGY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Peripheral blood and bone marrow

    Skin

    Lymph nodes

    ELECTRON MICROSCOPY

    IMMUNOPHENOTYPIC FINDINGS

    MOLECULAR STUDIES

    DIFFERENTIAL DIAGNOSIS

    Chapter 87: ALK-Positive Anaplastic Large-Cell Lymphoma

    INTRODUCTION

    DEFINITION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL FINDINGS

    THERAPY AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Other variants of ALK+ anaplastic large-cell lymphoma

    IMMUNOPHENOTYPIC FINDINGS

    Immunohistochemistry

    Flow cytometry

    CYTOGENETICS AND MOLECULAR DIAGNOSIS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 88: ALK-Negative Anaplastic Large-Cell Lymphoma

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FINDINGS

    IMMUNOPHENOTYPIC FINDINGS

    CYTOGENETIC AND MOLECULAR FINDINGS

    ANAPLASTIC LYMPHOMA KINASE-NEGATIVE ANAPLASTIC LARGE-CELL LYMPHOMA WITH DUSP22 REARRANGEMENT

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 89: Extranodal Anaplastic Large-Cell Lymphomas

    PRIMARY CUTANEOUS ANAPLASTIC LARGE-CELL LYMPHOMA

    Definition

    INTRODUCTION AND EPIDEMIOLOGY

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Skin

    Lymph nodes

    IMMUNOPHENOTYPE

    MOLECULAR FINDINGS

    DUSP22 REARRANGEMENT

    ANAPLASTIC LYMPHOMA KINASE TRANSLOCATIONS

    DIFFERENTIAL DIAGNOSIS

    BREAST IMPLANT–ASSOCIATED ANAPLASTIC LARGE-CELL LYMPHOMA

    Definition

    EPIDEMIOLOGY AND PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Breast

    Lymph nodes

    Other sites

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Part Six ▪ Lymphoproliferative Disorders Associated with Immune Deficiencies

    Chapter 90: Lymphoproliferative Disorders Associated With Primary Immunodeficiency Syndromes

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    RISK OF LYMPHOPROLIFERATIVE DISORDERS

    PATHOGENESIS

    CLINICAL FINDINGS

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Benign/reactive findings

    Lymphoproliferative disorders

    IMMUNOPHENOTYPIC FINDINGS

    MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 91: Iatrogenic Lymphoproliferative Disorders

    DEFINITION

    INTRODUCTION

    Methotrexate

    PATHOGENESIS

    CLINICAL FINDINGS

    TREATMENT AND PROGNOSIS

    Diffuse large B-cell lymphoma

    Classic Hodgkin lymphoma

    Polymorphic lymphoproliferative disorder and EBV+ mucocutaneous ulcer

    Other types of lymphoproliferative disorder

    HISTOLOGIC AND IMMUNOPHENOTYPIC FINDINGS

    Reactive hyperplasia

    Diffuse large B-cell lymphoma

    Classic Hodgkin lymphoma

    Polymorphic lymphoproliferative disorders

    Other iatrogenic lymphoproliferative disorders

    CYTOGENETIC AND MOLECULAR FINDINGS

    Epstein-Barr virus

    CANCER THERAPY–ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS

    Definition

    GENERAL FEATURES

    CLINICAL FEATURES

    THERAPY AND PROGNOSIS

    HISTOLOGIC, IMMUNOPHENOTYPIC, AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 92: Posttransplant Lymphoproliferative Disorders

    DEFINITION

    EPIDEMIOLOGY

    RISK FACTORS

    PATHOGENESIS

    CLINICAL FINDINGS

    TREATMENT AND PROGNOSIS

    HISTOLOGIC AND IMMUNOPHENOTYPIC FINDINGS

    Nondestructive lesions

    Polymorphic posttransplant lymphoproliferative disorders

    Monomorphic posttransplant lymphoproliferative disorders

    B-cell lesions

    Classic Hodgkin lymphoma

    Monomorphic lesions: T/natural killer cell

    CYTOGENETIC AND MOLECULAR FINDINGS

    Nondestructive lesions

    Polymorphic posttransplant lymphoproliferative disorders

    Monomorphic posttransplant lymphoproliferative disorders

    PATIENTS CAN HAVE MORE THAN ONE POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER

    DIFFERENTIAL DIAGNOSIS

    Chapter 93: Lymphomas Associated With Human Immunodeficiency Virus Infection

    DEFINITION

    EPIDEMIOLOGY

    HUMAN IMMUNODEFICIENCY VIRUS

    Natural history of HIV infection

    Pathogenesis of HIV-associated lymphomas

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Benign lesions

    Polymorphic lymphoproliferative lesions

    Lymphomas

    IMMUNOHISTOCHEMISTRY AND MOLECULAR FINDINGS

    Benign lesions

    Polymorphous lymphoproliferative lesions

    Lymphomas

    Part Seven ▪ Dendritic Cell and Histiocytic and Granulocytic/Monocytic Neoplasms

    Chapter 94: Follicular Dendritic Cell Sarcoma

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY AND CLINICAL FINDINGS

    TREATMENT AND PROGNOSIS

    GROSS AND HISTOLOGIC FINDINGS

    CYTOPATHOLOGY

    ELECTRON MICROSCOPY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR DIAGNOSIS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 95: Interdigitating Dendritic Cell Sarcoma

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    CLINICAL FINDINGS

    TREATMENT AND PROGNOSIS

    SECOND NEOPLASMS

    GROSS AND HISTOLOGIC FINDINGS

    ELECTRON MICROSCOPY

    IMMUNOPHENOTYPE

    MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 96: Langerhans Cell Histiocytosis and Langerhans Sarcoma

    DEFINITION

    LANGERHANS CELL HISTIOCYTOSIS

    Historical introduction

    Langerhans cells and myeloid dendritic cells

    Pathogenesis

    Epidemiology

    Clinical features

    Treatment and prognosis

    Histologic findings

    Cytopathology

    Electron microscopy

    Immunohistochemistry

    Molecular findings

    Tumor-associated Langerhans cell histiocytosis

    Differential diagnosis

    LANGERHANS CELL SARCOMA

    Definition

    Clinical and histologic findings

    Electron microscopy and immunohistochemistry

    Molecular findings

    Differential diagnosis

    IMMUNOPHENOTYPE

    Langerhans cell histiocytosis and sarcoma

    Chapter 97: Histiocytic Sarcoma

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    CLINICAL FINDINGS

    TREATMENT AND PROGNOSIS

    HISTOLOGIC FINDINGS

    CYTOPATHOLOGY

    IMMUNOPHENOTYPE

    MOLECULAR DIAGNOSIS

    TRANSDIFFERENTIATION

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 98: Myeloid Sarcoma

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    CLINICAL SYNDROME

    THERAPY AND PROGNOSIS

    GROSS PATHOLOGY

    HISTOPATHOLOGY

    Lymph node

    Other anatomic sites

    CYTOPATHOLOGY

    CYTOCHEMISTRY

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 99: Blastic Plasmacytoid Dendritic Cell Neoplasm

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    CLINICAL FEATURES

    THERAPY AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Lymph node

    Skin

    Bone marrow

    Peripheral blood

    CYTOLOGIC FINDINGS

    IMMUNOPHENOTYPE

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 100: Mastocytosis

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    CLINICAL FINDINGS

    Aggressive systemic mastocytosis

    Systemic mastocytosis with an associated hematologic neoplasm

    Mast cell leukemia

    Mast cell sarcoma

    THERAPY AND PROGNOSIS

    HISTOLOGIC FINDINGS

    Lymph node

    Spleen and liver

    Bone marrow

    Mast cell leukemia

    Systemic mastocytosis with an associated hematologic neoplasm

    CYTOPATHOLOGY

    CYTOCHEMISTRY AND HISTOCHEMISTRY

    IMMUNOPHENOTYPIC FINDINGS

    CYTOGENETIC AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Part Eight ▪ Spindle Cell Neoplasms of Lymph Nodes

    Chapter 101: Intranodal Palisaded Myofibroblastoma

    DEFINITION

    INTRODUCTION AND PATHOGENESIS

    CLINICAL SYNDROME

    GROSS PATHOLOGY

    HISTOPATHOLOGY

    ELECTRON MICROSCOPY

    IMMUNOHISTOCHEMISTRY AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 102: Inflammatory Pseudotumor of Lymph Nodes

    DEFINITION

    ETIOLOGY AND PATHOGENESIS

    CLINICAL SYNDROME

    THERAPY AND PROGNOSIS

    GROSS PATHOLOGY

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY AND MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Part Nine ▪ Vascular Neoplasms of Lymph Nodes

    Chapter 103: Vascular Neoplasms of Lymph Nodes

    DEFINITION

    INTRODUCTION

    CLINICAL SYNDROME

    HISTOPATHOLOGY AND IMMUNOPHENOTYPE

    Hemangioma

    Angiomyomatous hamartoma

    Hemangioendothelioma

    Polymorphous hemangioendothelioma

    Lymphangioma

    Angiomyolipoma

    Angiosarcoma

    DIFFERENTIAL DIAGNOSIS

    Chapter 104: Kaposi Sarcoma

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Part Ten ▪ Metastatic Tumors in Lymph Nodes

    Chapter 105: Tumor Metastases in Lymph Nodes

    DEFINITION

    PATHOBIOLOGY OF METASTASIS

    TUMOR METASTASIS IN LYMPH NODES

    Staging and prognosis

    ANATOMIC SITE OF INVOLVED LYMPH NODES

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    ELECTRON MICROSCOPY

    IMMUNOHISTOCHEMISTRY

    LYMPH NODE METASTASES OF OCCULT PRIMARY TUMORS

    DIFFERENTIAL DIAGNOSIS

    Small-cell tumors

    Epithelioid tumors

    Anaplastic tumors

    Spindle cell tumors

    Chapter 106: Metastatic Melanoma

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    Sentinel lymph node

    HISTOPATHOLOGY

    ELECTRON MICROSCOPY

    CYTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 107: Metastatic Breast Carcinoma

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    ETIOLOGY

    PATHOGENESIS

    LYMPH NODE METASTASES

    False-negative assessment of lymph nodes

    Sentinel lymph node biopsy

    Molecular assessment of axillary lymph nodes

    CLINICAL SYNDROME

    Metastatic carcinoma in axillary lymph nodes without a detectable breast mass

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Effect of chemotherapy

    IMMUNOHISTOCHEMISTRY

    MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Chapter 108: Metastatic Nasopharyngeal Carcinoma

    DEFINITION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Other anatomic sites involved by nonkeratinizing squamous cell carcinoma

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Chapter 109: Metastatic Thyroid Carcinoma

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    Papillary carcinoma

    Medullary carcinoma

    CLINICAL SYNDROME

    Papillary carcinoma

    Medullary carcinoma

    TREATMENT AND PROGNOSIS

    Papillary carcinoma

    Medullary carcinoma

    HISTOPATHOLOGY

    Papillary carcinoma

    Medullary carcinoma

    CYTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR GENETICS

    DIFFERENTIAL DIAGNOSIS

    Papillary carcinoma

    Medullary carcinoma

    IMMUNOPHENOTYPE

    Chapter 110: Metastatic Renal Cell Carcinoma

    DEFINITION

    INTRODUCTION

    EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 111: Metastatic Seminoma

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 112: Metastatic Prostate Carcinoma

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    LYMPH NODE METASTASES

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Chapter 113: Metastatic Mucinous Adenocarcinoma

    DEFINITION

    INTRODUCTION

    Signet ring cell carcinoma

    Mucinous carcinoma

    HISTOPATHOLOGY

    IMMUNOHISTOCHEMISTRY

    DIFFERENTIAL DIAGNOSIS

    Chapter 114: Metastatic Neuroendocrine Tumors

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    CLINICAL SYNDROME

    Neuroendocrine tumors of the pancreas

    Treatment and prognosis

    Neuroendocrine tumors of the gastrointestinal tract

    Treatment and prognosis

    Neuroendocrine tumors of the lungs

    Treatment and prognosis

    HISTOPATHOLOGY

    High-grade neuroendocrine tumors

    ELECTRON MICROSCOPY AND HISTOCHEMISTRY

    IMMUNOHISTOCHEMISTRY

    Well-differentiated neuroendocrine tumors

    Small-cell carcinoma

    MOLECULAR FINDINGS

    Well-differentiated neuroendocrine tumors

    Small-cell carcinoma

    DIFFERENTIAL DIAGNOSIS OF SMALL-CELL CARCINOMA

    IMMUNOPHENOTYPE

    Chapter 115: Metastatic Neuroblastoma

    DEFINITION

    INTRODUCTION AND EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    ELECTRON MICROSCOPY

    IMMUNOHISTOCHEMISTRY

    CYTOGENETICS AND MOLECULAR FINDINGS

    OLFACTORY NEUROBLASTOMA

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 116: Metastatic Ewing Sarcoma

    DEFINITION

    HISTORICAL INTRODUCTION

    EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    CLINICAL SYNDROME

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    ELECTRON MICROSCOPY

    IMMUNOHISTOCHEMISTRY

    CYTOGENETICS AND MOLECULAR GENETICS

    DIFFERENTIAL DIAGNOSIS

    IMMUNOPHENOTYPE

    Chapter 117: Metastatic Rhabdomyosarcoma

    DEFINITION

    EPIDEMIOLOGY

    ETIOLOGY AND PATHOGENESIS

    CLINICAL FINDINGS

    Lymph node metastases

    TREATMENT AND PROGNOSIS

    HISTOPATHOLOGY

    Therapy effect

    ELECTRON MICROSCOPY

    IMMUNOHISTOCHEMISTRY

    MOLECULAR FINDINGS

    DIFFERENTIAL DIAGNOSIS

    Index

     

  • Pocket Neurology (Pocket Notebook Series)
    La comanda in aproximativ 4 saptamani
    320.00 lei

    Description:

    Pocket Neurology, a bestseller in the Pocket Notebook series, delivers highly relevant neurologic clinical information  in an easily portable source. Drs. Marcelo Matiello, Michael P. Bowley, Sahar F. Zafar, and M. Brandon Westover edit this book by overseeing  the work of current neurology residents,  fellows and neurology attendings at Harvard Medical School who provide must-know information on hospital- and clinic-based neurologic workup, diagnosis, and management. This thoroughly revised third edition puts key clinical information about a broad range of issues in neurology at your fingertips in seconds.

     

     

    Table of Contents:

     

    NEUROLOGIC EMERGENCIES: QUICK REFERENCE, Colin Casault, Eric S. Rosenthal

    LESION LOCALIZATION IN CLINICAL NEUROLOGY, Denis T. K. Balaban, Michael P. Bowley

    NEUROIMAGING, Joshua P. Klein

    ELECTROENCEPHALOGRAPHY, Nitish Harid, Chris M. McGraw, Sahar F. Zafar

    NERVE CONDUCTION STUDIES AND ELECTROMYOGRAPHY, Ariel Marks, Christopher T. Doughty

    VASCULAR NEUROLOGY, Mariel Gailey Kozberg, Juan Carlos Martinez Gutierrez, Mark Richard Etherton

    INTERVENTIONAL NEUROLOGY, Salvatore Anthony D’Amato, Neal Michael Nolan, Thabele (Bay) Leslie-Mazwi

    NEUROCRITICAL CARE, Samuel Bass Snider, Terrance Thomas Kummer, Brian L. Edlow

    SEIZURES & EPILEPSY, Neishay Ayub, Eliezer J. Sternberg, Claire S. Jacobs

    DELIRIUM, Wai-Ying Wendy Yau, Eyal Y. Kimchi

    POISONS AND VITAMIN DEFICIENCIES, James M. Hillis, Michael P. Bowley

    MENINGITIS, ENCEPHALITIS, AND BRAIN ABSCESSES, John Brooks, Amir M. Mohareb, Shibani S. Mukerji

    NEUROLOGIC INFECTIOUS DISEASES, John Brooks, Amir M. Mohareb, Shibani S. Mukerji

    MULTIPLE SCLEROSIS, Jacqueline M. Solomon, Sarah Esther Conway, Marcelo Matiello

    NEUROIMMUNOLOGIC DISORDERS, Denis T. K. Balaban, Giovanna S. Manzano, Marcelo Matiello

    SPINE AND SPINAL CORD DISEASES, G. Kyle Harrold, Haatem M. Reda

    MOTOR NEURON DISEASE, Lauren R. Kett, James D. Berry, Michael P. Bowley

    PERIPHERAL NEUROPATHY, Salman Bhai, William S. David

    RADICULOPATHY AND PLEXOPATHY, Joome Suh, Reza Seyedsedjadi

    NEUROMUSCULAR JUNCTION DISORDERS, Leeann B. Burton, Amanda C. Guidon

    MYOPATHY, Leeann B. Burton, Anthony A. Amato

    PAIN, Andrew C. Young, Brian J. Wainger

    HEADACHE, Andrea M. Harriott

    DIZZINESS AND DEAFNESS, Pavan Vaswani, Marcelo Matiello

    NEURO-OPHTHALMOLOGY, Yael Redler, Bart K. Chwalisz

    RAPIDLY PROGRESSIVE DEMENTIA, Michael J. Young, Alessandro Biffi

    DEMENTIA, John R. Dickson, Alessandro Biffi

    BEHAVIORAL NEUROLOGY, Michael P. H. Stanley, Alessandro Biffi

    MOVEMENT DISORDERS, Grace Crotty, Albert Hung

    NEURO-ONCOLOGY, Brian M. Andersen, Justin T. Jordan

    NEUROLOGY OF PREGNANCY, Amy Hessler, Mary Angela O’Neal

    SLEEP MEDICINE, Naina Limbekar, Josna Adusumilli

    APPENDIX 1: LIST OF ABBREVIATIONS

    APPENDIX 2: NEUROLOGY COMPLICATIONS OF COVID-19—QUICK GUIDE

    Index

     


  • 427.00 lei

     

    Description:

    Prepare today’s LPN/LVN students for success on the NCLEX-PN® and in clinical practice with this proven introduction to the essentials of maternity and pediatric nursing. Designed specifically for the LPN curriculum, Introductory Maternity and Pediatric Nursing, 5th Edition, focuses on need-to-know coverage of pregnancy, birth, and pediatrics, combining a clear, straightforward approach with built-in workbook features that reinforce understanding without the need for an additional study guide. Accompanied by engaging online resources, this up-to-date learning package provides the ideal foundation for your students’ success in LPN/LVN practice. 

     

    Table of Contents:

     

    Unit 1 Overview of Maternal and Pediatric Health Care

    1 The Nurse’s Role in a Changing Maternal–Child Healthcare Environment

    2 Family-Centered and Community-Based Maternal and Pediatric Nursing

    Unit 2 Foundations of Maternity Nursing

    3 Structure and Function of the Reproductive System

    4 Special Issues of Women’s Healthcare and Reproduction

    Unit 3 Pregnancy

    5 Fetal Development

    6 Maternal Adaptation During Pregnancy

    7 Prenatal Care

    Unit 4 Labor and Birth

    8 The Labor Process

    9 Pain Management During Labor and Birth

    10 Nursing Care During Labor and Birth

    11 Assisted Delivery and Cesarean Birth217

    Unit 5 Postpartum and Newborn

    12 The Postpartum Woman

    13 Nursing Care During Newborn Transition

    14 Nursing Care of the Normal Newborn

    15 Newborn Nutrition

    Unit 6 Childbearing at Risk

    16 Pregnancy at Risk: Conditions That Complicate Pregnancy

    17 Pregnancy at Risk: Pregnancy-Related Complications

    18 Labor at Risk

    19 Postpartum Woman at Risk

    20 The Newborn at Risk: Gestational and Acquired Disorders

    21 The Newborn at Risk: Congenital Disorders

    Unit 7 Health Promotion for Normal Growth and Development

    22 Principles of Growth and Development

    23 Growth and Development of the Infant: 28 Days to 1 Year

    24 Growth and Development of the Toddler: 1 to 3 Years

    25 Growth and Development of the Preschool-Aged Child: 3 to 6 Years

    26 Growth and Development of the School-Aged Child: 6 to 10 Years

    27 Growth and Development of the Adolescent: 11 to 18 Years

    Unit 8 Foundations of Pediatric Nursing

    28 Data Collection (Assessment) for the Child

    29 Care of the Hospitalized Child

    30 Procedures and Treatments

    31 Medication Administration and Intravenous Therapy

    Unit 9 Special Concerns of Pediatric Nursing

    32 The Child With a Chronic Health Problem

    33 Abuse in the Family and Community

    34 The Dying Child

    Unit 10 The Child With a Health Disorder

    35 The Child With a Sensory/Neurologic Disorder

    36 The Child With a Respiratory Disorder

    37 The Child With a Cardiovascular/Hematologic Disorder

    38 The Child With a Gastrointestinal/Endocrine Disorder

    39 The Child With a Genitourinary Disorder

    40 The Child With a Musculoskeletal Disorder

    41 The Child With an Integumentary Disorder/Communicable Disease

    42 The Child With a Cognitive, Behavioral, or Mental Health Disorder

    Appendix A Standard and Transmission-Based Precautions

    Appendix B Good Sources of Essential Nutrients

    Appendix C Breast-Feeding and Medication Use

    Appendix D Cervical Dilation Chart

    Appendix E Growth Charts

    Appendix F Pulse, Respiration, and Blood Pressure Values for Children

    Appendix G Temperature and Weight Conversion Charts

    Glossary

    References and Selected Readings

    Index

     

     

     

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    Description:

    The go-to tool for mastering histology, Gartner & Hiatt's Atlas and Text of Histology, 8th Edition, equips medical, dental, allied health, and biology students with a concise review of all of the major tissue classes and body systems in an engaging approach optimized for superior classroom and clinical success. A consistent presentation combines relevant text and detailed photomicrographs to facilitate understanding and provide valuable review for in-class and licensing examinations. Helpful explanatory text in each chapter details Histophysiology, Clinical Considerations, Summaries of Histologic Organization, and more, accompanied by more than 700 vivid, full-color, high-quality images.

     

     

    Table of Contents:

     

    CHAPTER 1 INTRODUCTION TO HISTOLOGIC TECHNIQUES

    Light Microscopy

    Terminology of Staining for Light Microscopy

    Common Stains Used in Histology

    Transmission Electron Microscopy

    Scanning Electron Microscopy

    Interpreting Microscopic Sections

    CHAPTER 2 CELL BIOLOGY

    Plasmalemma

    Cytoplasm

    Mitochondria

    Ribosomes

    Endoplasmic Reticulum

    Golgi Apparatus

    CLINICAL CONSIDERATIONS 2-1

    CLINICAL CONSIDERATIONS 2-2

    CLINICAL CONSIDERATIONS 2-3

    CLINICAL CONSIDERATIONS 2-4

    Endosomes

    Lysosomes

    Peroxisomes

    CLINICAL CONSIDERATIONS 2-5

    Proteasomes

    Cytoskeleton

    CLINICAL CONSIDERATIONS 2-6

    Inclusions

    Nucleus

    Nucleolus

    Chromatin and Chromosomes

    CLINICAL CONSIDERATIONS 2-7

    CLINICAL CONSIDERATIONS 2-8

    Cell Cycle

    Mitosis

    Meiosis

    Necrosis and Apoptosis

    PLATE

    2-1A Typical Cell

    2-1B Typical Cell 

    2-2A Cell Organelles and Inclusions

    2-2B Cell Organelles and Inclusions

    2-3A Cell Surface Modifications

    2-3B Cell Surface Modifications

    2-4A Mitosis, Light and Electron Microscopy

    2-4B Mitosis, Light and Electron Microscopy

    2-5 Typical Cell, Electron Microscopy

    Chapter Review Questions

    CHAPTER 3 EPITHELIUM AND GLANDS

    Epithelial Tissue

    Epithelial Tissue Characteristics

    Epithelial Tissue Classification

    Epithelial Cell Membrane Specializations

    Glands

    CLINICAL CONSIDERATIONS 3-1

    CLINICAL CONSIDERATIONS 3-2

    CLINICAL CONSIDERATIONS 3-3

    CLINICAL CONSIDERATIONS 3-4

    PLATE

    3-1A Simple Epithelia and Pseudostratified Epithelium

    3-1B Simple Epithelia and Pseudostratified Epithelium

    3-2 Stratified Epithelium and Transitional Epithelium

    3-3A Epithelial Junctions, Electron Microscopy

    3-3B Epithelial Junctions, Electron Microscopy

    3-4A Glands

    3-4B Glands

    3-4C Glands

    3-4D Glands

    Selected Review of Histologic Images

    Review Plate 3-1A

    Review Plate 3-1B

    Review Plate 3-1C

    Summary of Histologic Organization

    I. Epithelium

    A. Types

    B. General Characteristics

    II. Glands

    A. Exocrine Glands

    B. Endocrine Glands

    Chapter Review Questions

    CHAPTER 4 CONNECTIVE TISSUE

    Extracellular Matrix

    Fibers

    CLINICAL CONSIDERATIONS 4-1

    CLINICAL CONSIDERATIONS 4-2

    CLINICAL CONSIDERATIONS 4-3

    Ground Substance

    Cells

    CLINICAL CONSIDERATIONS 4-4

    CLINICAL CONSIDERATIONS 4-5

    Connective Tissue Types

    Mesenchymal and Mucous Connective Tissues

    Loose (Areolar) Connective Tissue

    Dense Irregular Connective Tissue

    Dense Regular Connective Tissue

    Reticular Connective Tissue

    Elastic Connective Tissue

    Adipose Tissue

    CLINICAL CONSIDERATIONS 4-6

    CLINICAL CONSIDERATIONS 4-7

    PLATE

    4-1 Fibroblasts and Collagen, Transmission Electron Microscopy

    4-2 Mast Cell, Transmission Electron Microscopy

    4-3 Mast Cell Degranulation, Electron Microscopy

    4-4 Developing Fat Cell, Transmission Electron Microscopy

    4-5 Connective Tissues

    4-6 Connective Tissues

    4-7 Connective Tissues and Cells

    Selected Review of Histologic Images

    Review Plate 4-1A

    Review Plate 4-1B

    Summary of Histologic Organization

    I. Embryonic Connective Tissue

    A. Mesenchymal Connective Tissue (Mesenchyme)

    B. Mucous Connective Tissue

    II. Connective Tissue Types

    A. Loose (Areolar) Connective Tissue

    B. Reticular Connective Tissue

    C. Adipose Tissue

    III. Extracellular Matrix

    A. Dense Irregular Connective Tissue

    B. Dense Regular Connective Tissue

    C. Elastic Connective Tissue

    Chapter Review Questions

    CHAPTER 5 CARTILAGE AND BONE

    Cartilage

    Cartilage Extracellular Matrix

    Cartilage Cellular Component

    Perichondrium

    Cartilage Growth

    Cartilage Types

    Bone

    CLINICAL CONSIDERATIONS 5-1

    CLINICAL CONSIDERATIONS 5-2

    Bone Extracellular Matrix

    Periosteum and Endosteum

    Bone Cells

    Osteogenesis

    CLINICAL CONSIDERATIONS 5-3

    CLINICAL CONSIDERATIONS 5-4

    CLINICAL CONSIDERATIONS 5-5

    Hormonal Influences on Bone

    PLATE

    5-1A Cartilage

    5-1B Cartilage

    5-2A Bone

    5-2B Bone

    5-2C Bone

    5-3B Cells of the Bone

    5-3B Cells of the Bone

    5-3B Cells of the Bone

    Selected Review of Histologic Images

    Review Plate 5-1A

    Review Plate 5-1B

    Review Plate 5-2

    Summary of Histologic Organization

    I. Cartilage

    A. Embryonic Cartilage

    B. Hyaline Cartilage

    C. Elastic Cartilage

    D. Fibrocartilage

    II. Bone

    A. Compact Bone

    B. Cancellous (Spongy, Medullary) Bone

    C. Osteogenesis

    Chapter Review Questions

    CHAPTER 6 BLOOD AND HEMOPOIESIS

    Blood

    Formed Elements of Blood

    CLINICAL CONSIDERATIONS 6-1

    CLINICAL CONSIDERATIONS 6-2

    CLINICAL CONSIDERATIONS 6-3

    CLINICAL CONSIDERATIONS 6-4

    CLINICAL CONSIDERATIONS 6-5

    CLINICAL CONSIDERATIONS 6-6

    CLINICAL CONSIDERATIONS 6-7

    Plasma and Serum

    Hemopoiesis

    Erythrocytic Series

    Granulocytic Series

    Lymphoid Series

    Hemopoietic Growth Factors

    CLINICAL CONSIDERATIONS 6-8

    PLATE

    6-1A Circulating Blood

    6-1B Circulating Blood

    6-2 Circulating Blood (Drawing)

    6-3 Blood and Hemopoiesis

    6-4A Bone Marrow

    6-4B Blood Smear and Bone Marrow Smear

    6-5 Erythropoiesis

    6-6 Granulocytopoiesis

    Selected Review of Histologic Images

    Review Plate 6-1A

    Review Plate 6-1B

    Review Plate 6-2A

    Review Plate 6-2B

    Summary of Histologic Organization

    I. Circulating Blood

    A. Erythrocytes (RBC)

    B. Agranulocytes

    C. Granulocytes

    D. Platelets

    E. Erythrocytic Series

    F. Granulocytic Series

    Chapter Review Questions

    CHAPTER 7 MUSCLE

    Skeletal Muscle

    Myofilaments

    CLINICAL CONSIDERATIONS 7-1

    Sliding Filament Model of Skeletal Muscle Contraction

    CLINICAL CONSIDERATIONS 7-2

    CLINICAL CONSIDERATIONS 7-3

    Skeletal Muscle Motor Innervation

    Cardiac Muscle

    CLINICAL CONSIDERATIONS 7-4

    Morphologic Components of Cardiac Muscle Cells

    CLINICAL CONSIDERATIONS 7-5

    Smooth Muscle

    Smooth Muscle Contraction

    PLATE

    7-1A Skeletal Muscle

    7-1B Skeletal Muscle

    7-2 Skeletal Muscle, Electron Microscopy

    7-3A Myoneural Junction, Light Microscopy

    7-3B Myoneural Junction, Electron Microscopy

    7-4 Muscle Spindle, Light and Electron Microscopy

    7-5A Smooth Muscle

    7-5B Smooth Muscle

    7-6 Smooth Muscle, Electron Microscopy

    7-7A Cardiac Muscle

    7-7B Cardiac Muscle

    7-8 Cardiac Muscle, Electron Microscopy

    Selected Review of Histologic Images

    Review Plate 7-1A

    Review Plate 7-1B

    Review Plate 7-2A

    Review Plate 7-2B

    Review Plate 7-3A

    Review Plate 7-3B

    Summary of Histologic Organization

    I. Skeletal Muscle

    A. Longitudinal Section

    B. Transverse Section

    II. Cardiac Muscle

    A. Longitudinal Section

    B. Transverse Section

    III. Smooth Muscle

    A. Longitudinal Section

    B. Transverse Section

    Chapter Review Questions

    CHAPTER 8 NERVOUS TISSUE

    Nervous System

    Neurons

    CLINICAL CONSIDERATIONS 8-1

    CLINICAL CONSIDERATIONS 8-2

    CLINICAL CONSIDERATIONS 8-3

    CLINICAL CONSIDERATIONS 8-4

    Histologic Basis for Neuroanatomy

    CLINICAL CONSIDERATIONS 8-5

    Membrane Resting Potential

    CLINICAL CONSIDERATIONS 8-6

    CLINICAL CONSIDERATIONS 8-7

    Action Potential

    Neuromuscular (Myoneural) Junction

    Neurotransmitters and Neuromodulators

    Blood-Brain Barrier

    CLINICAL CONSIDERATIONS 8-8

    PLATE

    8-1 Central Nervous System

    8-2 Cerebrum and Neuroglial Cells

    8-3 Sympathetic Ganglia and Sensory Ganglia

    8-4 Peripheral Nerve

    8-5 Peripheral Nerve, Electron Microscopy

    8-6 Neuron Cell Body, Electron Microscopy

    Selected Review of Histologic Images

    Review Plate 8-1

    Review Plate 8-2A

    Review Plate 8-2B

    Summary of Histologic Organization

    I. Neurons

    A. Cell Body/Soma/Perikaryon

    B. Dendrite

    C. Axon

    II. Neuroglia

    A. CNS

    B. PNS

    III. Spinal Cord

    A. White Matter (Outer Layer)

    B. Gray Matter (Core)

    IV. Brain

    A. Gray Matter (Outer Layer)

    B. White Matter (Core)

    C. Ventricles

    D. Meninges

    V. Dorsal Root Ganglia

    VI. Peripheral Nerve

    A. Longitudinal Section

    B. Transverse Section

    Chapter Review Questions

    CHAPTER 9 CIRCULATORY SYSTEM

    Cardiovascular System

    Histologic Layers of Blood Vessels

    Heart

    CLINICAL CONSIDERATIONS 9-1

    Arteries

    Elastic Arteries

    Muscular Arteries

    CLINICAL CONSIDERATIONS 9-2

    CLINICAL CONSIDERATIONS 9-3

    CLINICAL CONSIDERATIONS 9-4

    Arterioles

    CLINICAL CONSIDERATIONS 9-5

    Capillaries

    CLINICAL CONSIDERATIONS 9-6

    Veins

    Lymph Vascular System

    PLATE

    9-1A Elastic Artery

    9-1B Elastic Artery

    9-2A Muscular Artery, Vein

    9-2B Muscular Artery and Large Vein

    9-3A Arterioles and Venules

    9-3B Capillaries and Lymph Vessels

    9-4A Heart: Endocardium and Myocardium

    9-4B Heart Valve

    9-5 Capillary, Transmission Electron Microscopy

    9-6 Freeze Etch, Fenestrated Capillary, Electron Microscopy

    Selected Review of Histologic Images

    Review Plate 9-1A

    Review Plate 9-1B

    Review Plate 9-2

    Summary of Histologic Organization

    I. Elastic Artery (Conducting Artery)

    A. Tunica Intima

    B. Tunica Media

    C. Tunica Adventitia

    II. Muscular Artery (Distributing Artery)

    A. Tunica Intima

    B. Tunica Media

    C. Tunica Adventitia

    III. Arterioles

    A. Tunica Intima

    B. Tunica Media

    C. Tunica Adventitia

    IV. Capillaries

    V. Venules

    A. Tunica Intima

    B. Tunica Media

    C. Tunica Adventitia

    VI. Medium-Sized Veins

    A. Tunica Intima

    B. Tunica Media

    C. Tunica Adventitia

    VII. Large Veins

    A. Tunica Intima

    B. Tunica Media

    C. Tunica Adventitia

    VIII. Heart

    IX. Lymphatic Vessels

    Chapter Review Questions

    CHAPTER 10 LYMPHOID (IMMUNE) SYSTEM

    General Plan of the Immune System

    CLINICAL CONSIDERATIONS 10-1

    Antibodies

    CLINICAL CONSIDERATIONS 10-2

    Immune Response

    Cells of the Adaptive and Innate Immune Systems

    CLINICAL CONSIDERATIONS 10-3

    CLINICAL CONSIDERATIONS 10-4

    CLINICAL CONSIDERATIONS 10-5

    Diffuse Lymphoid Tissue

    Lymphoid Follicles (Lymphoid Nodules)

    Lymphoid Organs

    CLINICAL CONSIDERATIONS 10-6

    CLINICAL CONSIDERATIONS 10-7

    CLINICAL CONSIDERATIONS 10-8

    CLINICAL CONSIDERATIONS 10-9

    CLINICAL CONSIDERATIONS 10-10

    CLINICAL CONSIDERATIONS 10-11

    PLATE

    10-1A Lymphatic Infiltration

    10-1B Lymphoid Nodules

    10-2A Lymph Node

    10-2B Lymph Node

    10-3A Lymph Node

    10-3B Tonsils

    10-4 Lymph Node, Electron Microscopy

    10-5A Thymus

    10-5B Thymus

    10-6A Spleen

    10-6B Spleen

    Selected Review of Histologic Images

    Review Plate 10-1A

    Review Plate 10-1B

    Review Plate 10-2A

    Review Plate 10-2B

    Summary of Histologic Organization

    I. Lymph Node

    A. Capsule

    B. Cortex

    C. Paracortex

    D. Medulla

    E. Reticular Fibers

    II. Tonsils

    A. Palatine Tonsils

    B. Pharyngeal Tonsils

    C. Lingual Tonsils

    III. Spleen

    A. Capsule

    B. White Pulp

    C. Marginal Zone

    D. Red Pulp

    E. Reticular Fibers

    IV. Thymus

    A. Capsule

    B. Cortex

    C. Medulla

    D. Involution

    E. Reticular Fibers and Sinusoids

    Chapter Review Questions

    CHAPTER 11 ENDOCRINE SYSTEM

    Pituitary Gland

    Vascular Supply of the Pituitary Gland

    Pars Anterior (Pars Distalis)

    Pars Intermedia

    Pars Tuberalis

    Pars Nervosa and Infundibular Stalk

    Thyroid Gland

    Thyroid Hormone

    Synthesis of Thyroid Hormone

    CLINICAL CONSIDERATIONS 11-1

    Release of Thyroid Hormone

    Parathyroid Glands

    CLINICAL CONSIDERATIONS 11-2

    CLINICAL CONSIDERATIONS 11-3

    Suprarenal Glands

    Cortex

    Medulla

    Pineal Gland

    CLINICAL CONSIDERATIONS 11-4

    Mechanism of Hormonal Action

    Nonsteroid-Based Hormones and Amino Acid Derivatives

    Steroid-Based Hormones

    Selected Review of Histologic Images

    Review Plate 11-1A

    Review Plate 11-1B

    Review Plate 11-2A

    Review Plate 11-2B

    Review Plate 11-3A

    Review Plate 11-3B

    Review Plate 11-4A

    Review Plate 11-4B

    Review Plate 11-5A

    Review Plate 11-5B

    Summary of Histologic Organization

    I. Pituitary Gland

    A. Adenohypophysis (Anterior Pituitary)

    B. Neurohypophysis (Posterior Pituitary)

    II. Thyroid Gland

    A. Capsule

    B. Parenchymal Cells

    C. Connective Tissue

    III. Parathyroid Gland

    A. Capsule

    B. Parenchymal Cells

    C. Connective Tissue

    IV. Suprarenal (Adrenal) Gland

    A. Cortex

    B. Medulla

    V. Pineal Gland

    A. Capsule

    B. Parenchymal Cells

    C. Brain Sand (Corpora Arenacea)

    Chapter Review Questions

    CHAPTER 12 INTEGUMENT

    Skin

    Epidermis

    CLINICAL CONSIDERATIONS 12-1

    CLINICAL CONSIDERATIONS 12-2

    Dermis

    CLINICAL CONSIDERATIONS 12-3

    Derivatives of Skin

    Selected Review of Histologic Images

    Review Plate 12-1A

    Review Plate 12-1B

    Review Plate 12-1C

    Review Plate 12-1C

    Review Plate 12-1D

    Summary of Histologic Organization

    I. Skin

    A. Epidermis

    B. Dermis

    II. Appendages

    A. Hair

    B. Sebaceous Glands

    C. Arrector Pili Muscle

    D. Sweat Glands

    E. Nail

    Chapter Review Questions

    CHAPTER 13 RESPIRATORY SYSTEM

    Conducting Portion of the Respiratory System

    Respiratory Epithelium

    Extrapulmonary Region

    Intrapulmonary Region

    Respiratory Portion of the Respiratory System

    Mechanism of Gaseous Exchange

    CLINICAL CONSIDERATIONS 13-1

    CLINICAL CONSIDERATIONS 13-2

    CLINICAL CONSIDERATIONS 13-3

    CLINICAL CONSIDERATIONS 13-4

    Selected Review of Histologic Images

    Review Plate 13-1A

    Review Plate 13-1B

    Review Plate 13-1C

    Summary of Histologic Organization

    I. Conducting Portion

    A. Nasal Cavity

    B. Larynx

    C. Trachea

    D. Extrapulmonary Bronchi

    E. Intrapulmonary Bronchi

    F. Bronchioles

    G. Terminal Bronchioles

    II. Respiratory Portion

    A. Respiratory Bronchiole

    B. Alveolar Ducts

    C. Alveolar Sacs

    D. Alveolus

    Chapter Review Questions

    CHAPTER 14 DIGESTIVE SYSTEM I

    Oral Region: Oral Cavity

    Oral Mucosa

    Lips

    CLINICAL CONSIDERATIONS 14-1

    Salivary Glands

    Palate

    Teeth

    Structure of Teeth

    CLINICAL CONSIDERATIONS 14-2

    Supporting Apparatus of the Tooth

    CLINICAL CONSIDERATIONS 14-3

    CLINICAL CONSIDERATIONS 14-4

    Odontogenesis

    Morphology of Odontogenesis

    CLINICAL CONSIDERATIONS 14-5

    CLINICAL CONSIDERATIONS 14-6

    Tongue

    CLINICAL CONSIDERATIONS 14-7

    Lingual Papillae

    Taste Buds and Taste Perception

    PLATE

    14-1A Lip

    14-1B Lip

    14-2A Tooth

    14-2B Pulp

    14-3A Periodontal Ligament

    14-3B Gingiva

    14-4A Tooth Development

    14-4B Tooth Development

    14-5A Tongue

    14-5B Tongue

    14-6A Tongue

    14-6B Palate

    14-7A Teeth

    14-7B Nasal Aspect of the Hard Palate

    14-8 Scanning Electron Micrograph of Tooth Enamel

    14-9 Scanning Electron Micrograph of Tooth Dentin

    Selected Review of Histologic Images

    Review Plate 14-1A

    Review Plate 14-1B

    Review Plate 14-2

    Summary of Histologic Organization

    I. Lips

    A. External Surface

    B. Transitional Zone

    C. Mucous Membrane

    D. Core of the Lip

    II. Teeth

    A. Enamel

    B. Dentin

    C. Cementum

    D. Pulp

    III. Gingiva

    IV. Tongue

    A. Oral Region (Anterior Two-Thirds)

    B. Pharyngeal Region (Posterior One-Third)

    V. Palate

    VI. Tooth Development

    Chapter Review Questions

    CHAPTER 15 DIGESTIVE SYSTEM II

    Layers of the Wall of the Alimentary Canal

    Mucosa

    Submucosa

    Muscularis Externa

    Serosa or Adventitia

    Regions of the Alimentary Canal

    Esophagus

    CLINICAL CONSIDERATIONS 15-1

    Stomach

    CLINICAL CONSIDERATIONS 15-2

    Small Intestine

    Large Intestine

    Rectum, Anal Canal, and Appendix

    Progress of Food Through the Alimentary Canal

    Microbiota of the Large Intestine

    Digestion and Absorption

    Carbohydrates

    Proteins

    Lipids

    Water and Ions

    Composition of Feces

    CLINICAL CONSIDERATIONS 15-3

    PLATE

    15-1A Esophagus

    15-1B Esophagus and Esophagogastric Junction

    15-2A Stomach

    15-2B Stomach

    15-3A Stomach

    15-3B Stomach

    15-4A Duodenum

    15-4B Duodenum

    15-5A Jejunum

    15-5B Ileum

    15-6A Colon

    15-6B Appendix

    15-7 Colon, Electron Microscopy

    15-8 Colon, Scanning Electron Microscopy

    Selected Review of Histologic Images

    Review Plate 15-1A

    Review Plate 15-1B

    Review Plate 15-2A

    Review Plate 15-2B

    Summary of Histologic Organization

    I. Esophagus

    A. Mucosa

    B. Submucosa

    C. Muscularis Externa

    D. Adventitia

    II. Stomach

    A. Mucosa

    B. Submucosa

    C. Muscularis Externa

    D. Serosa

    III. Small Intestine

    A. Mucosa

    B. Submucosa

    C. Muscularis Externa

    D. Serosa

    IV. Large Intestine

    A. Colon

    B. Appendix

    C. Anal Canal

    Chapter Review Questions

    CHAPTER 16 DIGESTIVE SYSTEM III

    Major Salivary Glands

    Parotid Gland

    Submandibular Gland

    Sublingual Gland

    Tubarial Gland

    Pancreas

    CLINICAL CONSIDERATIONS 16-1

    Vascular Supply of the Pancreas

    CLINICAL CONSIDERATIONS 16-2

    Exocrine Pancreas

    Endocrine Pancreas

    Liver

    CLINICAL CONSIDERATIONS 16-3

    CLINICAL CONSIDERATIONS 16-4

    CLINICAL CONSIDERATIONS 16-5

    Kupffer Cells and Perisinusoidal Stellate Cells

    Perisinusoidal Space (Space of Disse)

    Hepatocytes

    Functions of the Liver

    Gallbladder

    CLINICAL CONSIDERATIONS 16-6

    CLINICAL CONSIDERATIONS 16-7

    CLINICAL CONSIDERATIONS 16-8

    CLINICAL CONSIDERATIONS 16-9

    PLATE

    16-1A Salivary Glands

    16-1B Salivary Glands

    16-2A Pancreas

    16-2B Pancreas

    16-3A Liver

    16-3B Liver

    16-4A Liver

    16-4B Gallbladder

    16-5 Salivary Gland, Electron Microscopy

    16-6 Liver, Electron Microscopy

    16-7 Pancreatic Islet of Langerhans, Electron Microscopy

    Selected Review of Histologic Images

    Review Plate 16-1A

    Review Plate 16-1B

    Review Plate 16-2A

    Review Plate 16-2B

    Summary of Histologic Organization

    I. Major Salivary Glands

    A. Parotid Gland

    B. Submandibular Gland

    C. Sublingual Gland

    II. Pancreas

    III. Liver

    A. Capsule

    B. Lobules

    IV. Gallbladder

    A. Epithelium

    B. Lamina Propria

    C. Muscularis Externa

    D. Serosa

    Chapter Review Questions

    CHAPTER 17 URINARY SYSTEM

    Kidney

    Uriniferous Tubule

    CLINICAL CONSIDERATIONS 17-1

    CLINICAL CONSIDERATIONS 17-2

    Concentration of Urine in the Nephron (Countercurrent Multiplier System)

    Function of the Vasa Recta (Countercurrent Exchange System)

    Collecting Tubules

    CLINICAL CONSIDERATIONS 17-3

    CLINICAL CONSIDERATIONS 17-4

    Extrarenal Excretory Passages

    CLINICAL CONSIDERATIONS 17-5

    CLINICAL CONSIDERATIONS 17-6

    PLATE

    17-1A Kidney, Survey and General Morphology

    17-1B Kidney Cortex and Its Vascular Supply

    17-2A Renal Cortex

    17-2B Renal Cortex

    17-3 Glomerulus, Scanning Electron Microscopy

    17-4 Renal Corpuscle, Electron Microscopy

    17-5A Renal Medulla

    17-5B Renal Medulla

    17-6A Ureter

    17-6B Urinary Bladder

    Selected Review of Histologic Images

    Review Plate 17-1A

    Review Plate 17-1B

    Review Plate 17-2

    Summary of Histologic Organization

    I. Kidney

    A. Capsule

    B. Cortex

    C. Medulla

    D. Renal Pelvis

    II. Extrarenal Passages

    A. Ureter

    B. Bladder

    Chapter Review Questions

    CHAPTER 18 FEMALE REPRODUCTIVE SYSTEM

    Ovary

    Ovarian Follicles

    Corpus Luteum and Corpus Albicans

    Genital Ducts

    Oviduct

    Uterus

    Fertilization and Implantation

    Placenta

    Fetal Component

    Maternal Component

    Vagina

    External Genitalia

    CLINICAL CONSIDERATIONS 18-1

    CLINICAL CONSIDERATIONS 18-2

    Mammary Gland

    CLINICAL CONSIDERATIONS 18-3

    CLINICAL CONSIDERATIONS 18-4

    CLINICAL CONSIDERATIONS 18-5

    PLATE

    18-1 Ovary and Corpus Luteum

    18-2 Ovary and Oviduct

    18-3 Oviduct, Electron Microscopy

    18-4 Uterus

    18-5 Uterus

    18-6 Mammary Gland

    Selected Review of Histologic Images

    Review Plate 18-1A

    Review Plate 18-1B

    Review Plate 18-2A

    Review Plate 18-2B

    Summary of Histologic Organization

    I. Ovary

    A. Cortex

    B. Medulla

    C. Corpus Luteum

    D. Corpus Albicans

    II. Genital Ducts

    A. Oviduct

    B. Uterus

    C. Placenta

    D. Vagina

    E. Mammary Glands

    Chapter Review Questions

    CHAPTER 19 MALE REPRODUCTIVE SYSTEM

    Testes

    Seminiferous Tubules

    CLINICAL CONSIDERATIONS 19-1

    CLINICAL CONSIDERATIONS 19-2

    CLINICAL CONSIDERATIONS 19-3

    Genital Ducts

    CLINICAL CONSIDERATIONS 19-4

    CLINICAL CONSIDERATIONS 19-5

    Accessory Genital Glands

    Seminal Vesicle

    Prostate Gland

    Bulbourethral Glands (Cowper’Glands)

    Urethra

    CLINICAL CONSIDERATIONS 19-6

    CLINICAL CONSIDERATIONS 19-7

    CLINICAL CONSIDERATIONS 19-8

    Penis

    Erection

    Ejaculation

    PLATE

    19-1A Testis

    19-1B Testis

    19-2A Testis

    19-2B Epididymis

    19-3A Epididymis and Ductus Deferens

    19-3B Seminal Vesicle

    19-4A Prostate

    19-4B Penis and Urethra

    19-5 Epididymis, Electron Microscopy

    Selected Review of Histologic Images

    Review Plate 19-1A

    Review Plate 19-1B

    Review Plate 19-2A

    Review Plate 19-2B

    Summary of Histologic Organization

    I. Testes

    A. Capsule

    B. Seminiferous Tubules

    C. Stroma

    II. Genital Ducts

    A. Tubuli Recti

    B. Rete Testis

    C. Epididymis

    D. Ductus (Vas) Deferens

    III. Accessory Glands

    A. Seminal Vesicles

    B. Prostate Gland

    C. Bulbourethral Glands

    IV. Penis

    V. Urethra

    A. Epithelium

    B. Lamina Propria

    Chapter Review Questions

    CHAPTER 20 SPECIAL SENSES

    Eye

    Fibrous Tunic

    CLINICAL CONSIDERATIONS 20-1

    Vascular Tunic

    CLINICAL CONSIDERATIONS 20-2

    Retinal Tunic

    CLINICAL CONSIDERATIONS 20-3

    CLINICAL CONSIDERATIONS 20-4

    CLINICAL CONSIDERATIONS 20-5

    Accessory Structures of the Eye

    Ear

    External and Middle Ear

    Inner Ear

    CLINICAL CONSIDERATIONS 20-6

    Selected Review of Histologic Images

    Review Plate 20-1A

    Review Plate 20-1B

    Review Plate 20-2A

    Review Plate 20-2B

    Summary of Histologic Organization

    I. Eye

    A. Fibrous Tunic

    B. Vascular Tunic

    C. Retinal Tunic

    D. Lens

    E. Lacrimal Gland

    F. Eyelid

    II. Ear

    A. External Ear

    B. Middle Ear

    C. Inner Ear

    Chapter Review Questions

    Appendix A

    Appendix B

    Index

     

  • Diagnostic Imaging: Nuclear Medicine
    La comanda in aproximativ 4 saptamani
    1,49500lei 1380.00 lei

     

    Description:

    Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Nuclear Medicine, third edition, is an invaluable resource for nuclear medicine physicians, general radiologists, and trainees-anyone who requires an easily accessible, highly visual reference on today’s rapidly changing nuclear medicine therapies. Updated throughout, it addresses the most appropriate nuclear medicine options available to answer specific clinical questions within the framework of all imaging modalities, making this edition a useful learning tool as well as a handy reference for daily practice.

     

    Table Of Contents:

     

    Cardiac

    Introduction

    Approach to Cardiac Imaging

    Function and Coronary Artery Disease

    Left Ventricular Function

    Myocardial Infarction and Ischemia

    Myocardial Viability

    Right-to-Left Shunt

    Cardiomyopathy

    Cardiac Sarcoidosis

    Cardiac Amyloidosis

    Central Nervous System

    Introduction

    Approach to Central Nervous System Imaging

    Cerebrospinal Fluid

    CSF Leak Evaluation

    CSF Shunt Patency

    Normal Pressure Hydrocephalus

    Dementia

    Alzheimer Disease

    Frontotemporal Dementia

    Lewy Body Disease

    Multi-Infarct Dementia

    Infection and Inflammation

    Brain Abscess and Encephalitis

    Movement Disorders

    Parkinsonian Syndromes

    Vascular

    Brain Death

    Cerebrovascular Ischemia

    Gastrointestinal

    Introduction

    Approach to Gastrointestinal Imaging

    Hepatobiliary

    Acute Cholecystitis and Biliary Obstruction

    Biliary Leak

    Functional Hepatobiliary Disease

    Benign Solid Liver Lesions

    Gastrointestinal

    Gastrointestinal Bleeding

    Gastroparesis

    Rapid Gastric Transit

    Infection and Inflammation

    Abdominal Infection and Inflammatory Disease

    Spleen

    Spleen Localization

    Lymphatic and Vascular

    Introduction

    Approach to Lymphatic and Vascular Imaging

    Lymphatic

    Lymphedema

    Sentinel Lymph Node Mapping

    Vascular

    Large Vessel Vasculitis

    Vascular Graft Infection

    Musculoskeletal

    Introduction

    Approach to Musculoskeletal Imaging

    Bone Tumors

    Bone Neoplasms

    Metastatic Bone Tumors

    Bone Dysplasias

    Fibrous Dysplasia

    Paget Disease

    Bone Mineral Density

    Osteopenia and Osteoporosis

    Infection and Inflammation

    Arthroplasty Complication

    Inflammatory Arthritis

    Osteomyelitis and Septic Arthritis

    Metabolic Disease

    Metabolic Bone Disease

    Trauma

    Heterotopic Ossification

    Occult Fracture

    Stress and Insufficiency Fracture

    Vascular

    Avascular Necrosis

    Complex Regional Pain Syndrome

    Sickle Cell Disease

    Thyroid and Parathyroid

    Introduction

    Approach to Thyroid and Parathyroid Imaging

    Thyroid

    Graves Disease

    Nodular Thyroid Disease

    Parathyroid

    Parathyroid Adenoma

    Thoracic

    Introduction

    Approach to Thoracic Imaging

    Infection and Inflammation

    Atypical Infectious Diseases

    Granulomatous Disease

    Lung Perfusion and Ventilation

    Pulmonary Embolism

    Quantitative Lung Perfusion

    Urinary Tract

    Introduction

    Approach to Urinary Tract Imaging

    Infection and Inflammation

    Renal Scar and Pyelonephritis

    Renal Function

    Hydronephrosis

    Vesicoureteral Reflux

    Renal Transplant Evaluation

    Renovascular Hypertension

    GFR Analysis

    Pediatrics

    Introduction

    Approach to Pediatric Imaging

    Central Nervous System

    Seizure

    Thyroid

    Congenital Hypothyroidism

    Pediatric Salivary Function

    Gastrointestinal

    Gastric Motility

    Meckel Diverticulum

    Aspiration

    Hepatobiliary

    Biliary Atresia

    Infection and Inflammation

    Fever of Unknown Origin

    Osteomyelitis and Septic Joint

    Musculoskeletal

    Avascular Necrosis

    Pediatric Lower Back Pain

    Nonaccidental Trauma

    Miscellaneous

    Nasolacrimal Complex Obstruction

    Salivary Gland Scintigraphy

    Oncology

    Introduction

    Approach to Oncologic Imaging

    Breast

    Benign Breast Conditions

    Breast Malignancy

    Central Nervous System

    Brain Metastases

    Post-Radiation CNS Evaluation

    Meningioma

    Cutaneous

    Melanoma

    Gastrointestinal Tract

    Esophageal Cancer

    Gastric Carcinoma and Gastrointestinal Stromal Tumor

    Colorectal and Anal Cancer

    Head and Neck

    Salivary Gland Tumors

    Squamous Cell Carcinoma

    Hepatobiliary

    Hepatocellular Carcinoma

    Cholangiocarcinoma and Gallbladder Cancer

    Lymphoma

    Hodgkin Lymphoma

    Non-Hodgkin Lymphoma

    Musculoskeletal

    Multiple Myeloma

    Neuroendocrine

    Carcinoid Tumor

    Pancreatic Neuroendocrine Tumors

    Pheochromocytoma and Paraganglioma

    Medullary Thyroid Carcinoma

    Pancreas

    Pancreatic Adenocarcinoma

    Reproductive Organs

    Uterine and Endometrial Cancers

    Ovarian Cancer

    Cervical Cancer

    Vulvar and Vaginal Cancer

    Prostate Cancer

    Testicular Cancer

    Thoracic

    Malignant Pleural Mesothelioma

    Non-Small Cell Lung Cancer

    Small Cell Lung Cancer

    Thymoma and Thymic Carcinoma

    Solitary Pulmonary Nodule

    Pulmonary Carcinoid Tumor

    Thyroid

    Papillary and Follicular Thyroid Cancer

    Urinary Tract

    Renal Cell Carcinoma

    Transitional Cell Carcinoma

    Pediatrics

    Ewing Sarcoma

    Neuroblastoma

    Osteosarcoma

    Pediatric Somatostatin Receptor Positive Tumors

    Nuclear Medicine Therapy

    I-131 Thyroid Cancer Therapy

    I-131 Hyperthyroid Therapy

    Lymphoma Therapy

    Hepatic Metastases Therapy

    Metastatic Bone Tumor Therapy

    Approach to Nuclear Medicine Therapy

    Neuroendocrine Tumor Therapy

    Prostate Cancer Therapy

    Physics

    Basic Physics and Radionuclides

    Nonimaging Detectors

    Gamma Camera Imaging

    SPECT

    PET

    Radiation Biology and Dose

    Safety

    Medical Use of Byproduct Material

    Medical Use of Byproduct Material

    General Administrative Requirements

    General Technical Requirements

    Radioactive Spills

    Records and Reports

    Written Directive Requirements

    Standards for Protection Against Radiation

    Standards for Protection Against Radiation

    Dose Limits

    Radiopharmaceutical Administration

    Records and Reports

    Restricted Areas and Precautionary Procedures

    Surveys and Monitoring

    Transportation of Byproduct Materials

    Waste Disposal

    Ordering, Receiving, and Opening of Packages

       

  • 1135.00 lei

     

    Description:

    For today’s nephrologist who is tasked with diagnosing a wide range of renal pathologic entities, Diagnostic Atlas of Renal Pathology is a must-have reference for everyday use. The updated 4th Edition offers an in-depth examination of pathophysiology, clinical presentations, and the latest evidence-based practices. Hundreds of pertinent macro- and/or microscopic images are presented in a user-friendly manner intended specifically for renal pathology.

    Offers templated, detailed discussions on key characteristic pathologic findings and prognostic, pathogenetic, and etiologic information for each disorder.

    Features numerous tables and sidebars with key points and differential diagnoses.

    Covers major new advances in the classification and diagnosis of select tubular cystic diseases, new advances in classification of fibrillary processes and C3 related diseases, new insights in monoclonal protein-related diseases, ongoing work in lupus, and advances in IgA nephropathy as well as transplantation.

    Contains more than 700 high-quality representative images of light, immunofluorescence, and electron microscopy, including new colorized electron microscopy images, with correlations to clinical presentation and pathogenesis.

    Features new animations that clearly depict the progression of membranous nephropathy, membranoproliferative GN, and crescentic GN.

    Includes schematic representations of glomerular diseases, which are particularly useful for illustrating difficult concepts.

     

     

    Table of Contents:

     

    1.  Approach to diagnosis of the kidney biopsy

    2.  Normal growth and maturation

    3.  Glomerular diseases

    Primary glomerular diseases

    Glomerular diseases that cause nephrotic syndrome: Nonimmune complex

    Glomerular diseases that cause nephrotic/nephritic syndrome: Complement-related

    Glomerular diseases that cause nephrotic syndrome because of deposits

    Glomerular diseases that cause hematuria or nephritic syndrome: Immune complex

    Secondary glomerular diseases

    Diseases associated with nephrotic syndrome

    Diseases associated with nephritic syndrome or rapidly progressive glomerulonephritis: Immune-mediated

    Diseases associated with the nephritic syndrome or rapidly progressive glomerulonephritis: Pauci-immune- or nonimmune-mediated

    Diseases with abnormal collagen/basement membranes

    Glomerular involvement with bacterial infections

    4.  Vascular diseases

    Diabetic nephropathy

    Thrombotic microangiopathy/thrombotic thrombocytopenic purpura

    Scleroderma (systemic sclerosis)

    Antiphospholipid antibody disease

    Preeclampsia and eclampsia

    Fibromuscular dysplasia

    Arterionephrosclerosis

    Accelerated/severe hypertension

    Atheroemboli

    5.  Tubulointerstitial diseases

    Introduction

    Infections of the kidney

    Acute pyelonephritis

    Chronic pyelonephritis and reflux nephropathy

    Xanthogranulomatous pyelonephritis

    Malakoplakia

    Acute tubulointerstitial nephritis—viral infection

    Acute tubulointerstitial nephritis—drug-related

    Tubulointerstitial nephritis with uveitis

    Anti-tubular basement membrane antibody nephritis

    Idiopathic hypocomplementemic tubulointerstitial nephritis

    IgG4-related tubulointerstitial nephritis

    Interstitial nephritis of sjögren syndrome

    Sarcoidosis

    Acute kidney injury/acute tubular injury

    Warfarin-induced acute kidney injury/anticoagulant-related nephropathy

    Heavy metal nephropathy (lead and cadmium nephropathy)

    Analgesic nephropathy and papillary necrosis

    Monoclonal gammopathy of renal significance

    Light chain cast nephropathy and tubulopathy

    Tubular crystallopathies

    Drug-induced crystallopathies

    Lithium nephropathy

    Aristolochic acid nephropathy

    6.  Endemic nephropathies

    Introduction

    Aristolochic acid nephropathy (chinese herb nephropathy, balkan endemic nephropathy)

    Other endemic fibrosing nephropathies

    7.  Chronic kidney disease

    Introduction

    Age-related sclerosis

    Glomerular versus tubulointerstitial versus vascular disease

    Segmental glomerulosclerosis: Primary versus secondary

    8.  Renal transplantation

    Introduction

    Evaluation of donor kidneys

    Classification of rejection

    Antibody-mediated rejection

    Chronic active antibody-mediated rejection and transplant glomerulopathy

    Acute T cell–mediated rejection

    Chronic active T cell–mediated rejection

    Interstitial fibrosis/tubular atrophy

    Molecular profiling of rejection

    Calcineurin inhibitor nephrotoxicity

    mTOR inhibitor toxicity

    De novo and recurrent thrombotic microangiopathy in allografts

    Posttransplant lymphoproliferative disease

    Viral infections

    Recurrent renal disease

    9.  Cystic diseases of the kidney

    Introduction

    Autosomal dominant polycystic kidney disease

    Autosomal recessive polycystic kidney disease

    Nephronophthisis

    Autosomal dominant tubulointerstitial kidney disease

    Medullary sponge kidney

    Acquired cystic disease

    Cystic renal dysplasia

    10.  Renal neoplasia

    Introduction

    Renal neoplasms

    Nephroblastoma (wilms tumor)

    Renal angiomyolipoma

    Urothelial (transitional cell) carcinoma of the renal pelvis

    Index

     

  • 184.00 lei

     

    Description:

    For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. A new volume in this trusted series, Diabetes Secrets offers practical, up-to-date coverage of the full range of essential topics in this dynamic field. It features the Secrets’ popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style - making inquiry, reference, and review quick, easy, and enjoyable.



    Table Of Contents:


     Top 100 Secrets
    1 Diabetes Mellitus: Classification, Etiology and Pathogenesis
    2 Comprehensive Medical Evaluation of Persons with Diabetes
    3 Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Syndrome
    4 Diabetic Nephropathy
    5 Diabetic Retinopathy
    6 Diabetic Neuropathies 
    7 Prevention of Macrovascular Complications
    8 Diabetes and Non-alcoholic Fatty Liver Disease
    9 Diabetes Management: Lifestyle Measures – Nutrition
    10 Exercise and Diabetes
    11 Diabetes Management: Insulin Therapy
    12 Diabetes Management: Non-Insulin Therapies
    13 Carbohydrate Counting and Precise Insulin Dosing
    14 Type 2 Diabetes Management: Selecting Glycemic Targets and Choosing the Right Therapy
    15 Diabetes Prevention
    16 Diabetes and Pregnancy
    17 Diabetes Management in Cancer Patients
    18 Diabetes in Older Adults
    19 Diabetes Management During Exercise, Sports and Competition
    20 Diabetes Management in Hospitalized Patients
    21 Continuous Glucose Monitoring
    22 Continuous Glucose Monitoring Interpretation: Practice Cases
    23 Insulin Pumps and Integrated Systems
    24 Looping
    25 Hypoglycemia
    26 Weight Management in Patients with Type 2 Diabetes Mellitus
    27 Identifying and Overcoming Barriers to Achieving Glucose Control
    28 Diabetes in Africa
     FM
     BM
    29 Diabetes Diagnosis and Management in New Zealand

       

     

  • 120.00 lei

     

    Description:

    This is an indispensable companion to the ‘Sunflower book’ - the highly acclaimed Illustrated Textbook of Paediatrics (6th Edition). It is essential for those who wish to test or improve their learning, or for exam revision for undergraduate or early postgraduate speciality exams.

    It includes high quality questions, some including images or diagrams, on  important topics covering the paediatrics and child health curriculum. Explanations about both correct and incorrect answers are provided.

    The authors are highly experienced examiners and question writers, ensuring that the questions are similar to those encountered in exams or help explain difficult topics.




    Features:


    • Over 250 Single Best Answer questions
    • Over 200 question stems for Extended Matching questions
    • Explanations provided not only of the correct but also of incorrect answers
    • Clinical photographs included to ask questions about clinical signs



    Table Of Contents:


            Preface
            Acknowledgements
    1      The child in society
    2      History and examination
    3      Normal child development, hearing and vision
    4      Developmental problems and the child with special needs
    5      Care of the sick child and young person
    6      Paediatric emergencies
    7      Accidents and poisoning
    8      Maltreatment of children and young people
    9      Genetics
    10     Perinatal medicine
    11     Neonatal medicine
    12     Growth and puberty
    13     Nutrition
    14     Gastroenterology
    15     Infection and immunity
    16     Allergy
    17     Respiratory disorders
    18     Cardiac disorders
    19     Kidney and urinary tract disorders
    20     Genital disorders
    21     Liver disorders
    22     Malignant disease
    23     Haematological disorders
    24     Child and adolescent mental health
    25     Dermatological disorders
    26     Diabetes and endocrinology
    27     Inborn errors of metabolism
    28     Musculoskeletal disorders
    29     Neurological disorders
    30     Adolescent medicine
    31     Global child health
             index

       

    Bottom of Form

     

  • 335.00 lei

     

    Description:

    Provide safe and effective care to every patient with the fully revised 4th Edition of Essential Clinical Procedures. Written by experts in the field, this widely used reference shows you step by step how to perform more than 70 of the most common diagnostic and treatment-related procedures in today’s primary care and specialist settings. You’ll find clear, concise coverage of the skills you need to know, including new and advanced procedures and new procedure videos.



    Table Of Contents:


    1. Anoscopy

    2. Arterial Puncture

    3. Blood Pressure Measurement

    4. Casting and Splinting

    5. Cryosurgery

    6. Dermatologic Procedures

    7. Draining/Evacuation of Subungual Hematomas

    8. Endometrial Biopsy

    9. Endotracheal Intubation

    10. Epistaxis and Nasal Foreign Body Removal

    11. Foot Examination of the Patient with Diabetes

    12. Incision and Drainage of an Abscess

    13. Injections

    14. Inserting Intravenous Catheters

    15. Joint and Bursal Aspiration

    16. Local Anesthesia

    17. Lumbar Puncture

    18. Nasogastric Tube Placement

    19. Obtaining Blood Cultures

    20. Office Pulmonary Function Testing

    21. Introduction to Point-of-Care Ultrasonography (POCUS)

    22. Procedural Sedation

    23. Recording an Electrocardiogram

    24. Reduction of the Shoulder/Finger Subluxations

    25. Removal of Cerumen and Foreign Bodies from the Ear

    26. Ring Removal

    27. The Pelvic Examination and Obtaining a Routine Papanicolaou Smear

    28. Trauma-Oriented Ocular Examination, Corneal Abrasion, and Ocular Foreign Body Removal

    29. Treating Ingrown Toenails

    30. Urinary Bladder Catheterization

    31. Venipuncture

    32. Wound Closure

    33. Wound Dressing Techniques

    34. Informed Consent

    35. Standard Precautions

    36. Sterile Technique

    37. Patient Education Concepts

    38. Outpatient Coding for Medical Services

    39. Procedural Notes and Documentation

    40. Giving Sad and Bad News

       

    Bottom of Form

     

  • Pathologic Basis of Veterinary Disease
    Not yet published- 4 saptamani de la data aparitiei
    760.00 lei

     

    Description:

    Use the veterinarian’s #1 reference on general pathology and the pathology of organ systems! Pathologic Basis of Veterinary Disease, 7th Edition helps you understand and diagnose diseases of domestic animals by using the latest scientific and medical research. Focusing on dogs, cats horses, cattle, sheep, goats, and pigs, this reference describes and vividly illustrates and explores the pathogeneses of animal diseases, how cells and tissues respond to injury, and the morphology (lesions) of this injury. New to this edition is basic coverage of tumor, inflammatory, and microbial cytology. Edited by veterinary pathologist James F. Zachary and a team of expert veterinary pathologists, this book includes access to an enhanced eBook with every new print purchase, featuring a fully searchable version of the entire text, an image collection, and much more – and available on a variety of devices.

     

    Table of Contents:

     

    Introduction. Fundamentals for Understanding Veterinary Pathology

    Information Fundamental for Effective Use of this Book

    In Conclusion

    Section I. Cellular and Molecular Mechanisms of Disease (General Pathology)

    Introduction

    Chapter 1. Mechanisms and Morphology of Cellular Injury, Adaptation, and Death

    Introduction

    Normal Cell

    Causes of Cell Injury

    Irreversible Cell Injury and Cell Death

    Chronic Cell Injury and Cell Adaptations

    Cell Cycle

    Cellular Aging

    Genetic Basis of Disease

    Chapter 2. Vascular Disorders and Thrombosis

    Introduction

    Circulatory System

    Microcirculation, Interstitium, and Cells

    Fluid Distribution and Homeostasis

    Abnormal Fluid Distribution

    Hemostasis

    Disorders of Hemostasis: Hemorrhage and Thrombosis

    Normal Blood Flow, Distribution, and Perfusion

    Alterations in Blood Flow and Perfusion

    Shock

    Chapter 3. Inflammation and Healing

    Introduction

    Evolution of the Current Understanding of Inflammation

    Beneficial and Harmful Aspects of Inflammation

    Acute Inflammation

    Substances Inducing the Acute Inflammatory Response

    Fluidic (Exudative) Phase of the Acute Inflammatory Response

    Cellular Phase of the Acute Inflammatory Response

    Additional Regulation of Inflammation

    Inflammation and Pain

    Effector Cells of the Acute Inflammatory Response

    Chemical Mediators of the Acute Inflammatory Response

    Reparative Phase of the Acute Inflammatory Response

    Nomenclature of the Inflammatory Response (Morphologic Diagnoses)

    Morphologic Classification of Exudates in Acute Inflammatory Lesions

    Chronic Inflammation

    Beneficial and Harmful Aspects of Chronic Inflammation

    Progression of the Acute Inflammatory Response to Chronic Inflammation, Fibrosis, and Abscess Formation

    Gross and Microscopic Lesions and Nomenclature of the Chronic Inflammatory Response

    Effector Cells and Cellular Mechanisms of Chronic Inflammatory Responses

    Inflammation and the Sensation of Pain

    The Effect of Inflammation on the Febrile Response and Other Activities

    Unique Types of Inflammation

    Cytologic and Histologic Comparisons of Inflammatory Exudates

    Wound Healing and Angiogenesis

    Chapter 4. Mechanisms of Microbial Infections

    Introduction

    Chronologic Sequence of Steps in Microbial Diseases

    Portals of Entry

    Target Cells and Substances

    Pathways of Spread

    Defense Mechanisms

    Genetic Resistance of Animals to Infectious Diseases

    Bacterial Diseases

    Viral Diseases

    Fungal Diseases (Mycoses)

    Protozoan Diseases

    Prion Diseases (Spongiform Encephalopathies)

    Chapter 5. Diseases of Immunity

    General Features of the Immune System

    Innate Immunity (Nonspecific Immunity)

    Adaptive Immunity (Specific Immunity)

    Disorders of the Immune System

    Chapter 6. Neoplasia and Tumor Biology

    Introduction

    General Nomenclature

    Tumor Characteristics (Essential Concept 6.1)

    Neoplastic Transformation (Essential Concept 6.2)

    Tumor Microenvironment (Essential Concept 6.3)

    Tumor Immunity (see Essential Concept 6.3)

    Tumor Dissemination (Essential Concept 6.4)

    Systemic Clinical Effects on the Animal (see Essential Concept 6.3)

    Heritable Alterations in Cancer (Essential Concept 6.5)

    Molecular Determinants of Cancer

    Mechanisms of Carcinogenesis

    Cancer in Animals

    Section II. Pathology of Organ Systems

    Introduction

    Chapter 7. Alimentary System and the Peritoneum, Omentum, Mesentery, and Peritoneal Cavity

    Introduction

    Structure and Function

    Dysfunction/Responses to Injury

    Portals of Entry/Pathways of Spread

    Defense Mechanisms/Barrier Systems

    Diseases Affecting Multiple Species of Domestic Animalsc,d

    Diseases of Horses

    Diseases of Ruminants (Cattle, Sheep, and Goats)

    Diseases of Pigs

    Diseases of Dogs

    Diseases of Cats

    Chapter 8. Hepatobiliary System and Exocrine Pancreas

    Liver and Intrahepatic Biliary System

    Gallbladder and Extrahepatic Bile Ducts

    Exocrine Pancreas

    Chapter 9. Respiratory System, Thoracic Cavities, Mediastinum, and Pleurae

    Introduction

    Structure and Function

    Dysfunction/Responses to Injury

    Portals of Entry/Pathways of Spread

    Defense Mechanisms/Barrier Systems

    Diseases Affecting Multiple Species of Domestic Animals

    Diseases of Horses

    Diseases of Ruminants (Cattle, Sheep, and Goats)</