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  • 14500lei 100.00 lei

    Profita acum de reducerea de 31% pentru pachetul de psihologie! 
    *Promotie valabila in perioada 09-25 iulie

     

    SEX

     

    Ce ne poate invata psihologia despre sex? Cum reacţioneaza oamenii – corpuri si minti diferite – atunci cand vine vorba despre sex? Cum putem sa ne opunem stigmatizarii oamenilor pe considerente ce tin de sexualitatea lor?

      

    Psihologia sexului iţi va arata diferitele modalitati prin care psihologii au creat si au sustinut anumite perspective de-a lungul timpului asupra sexului si sexualitatii. Avand in permanenta in vedere caracterul subiectiv al sexului, cartea exploreaza preocuparile culturale care planeaza asupra sexualizarii, pornografiei si dependentei de sex si, de asemenea, apeleaza la cercetarile realizate in diferite comunitati sexuale si la domeniul aplicat al terapiei sexuale.

     

    Meg‑John Barker este autoare si terapeut, cu specializare in domeniul sexului, al genului si al relatiilor. Este conferentiar in Psihologie la Open University si psihoterapeut acreditat UKCP

     (United Kingdom Council for Psychotherapy).

     

    ADDICTION

     

    Când se transforma un obicei nevinovat in dependenta? De ce doar unii dintre noi devenim dependenti? Cum este posibila recuperarea?

     Psihologia dependentei si a comportamentului adictiv este o introducere fascinanta in problemele psihologice din jurul adictiei, prezentand impactul pe care il au acestea asupra politicilor sociale, recuperarii si vietii de zi cu zi a unei persoane dependente. Cartea se concentreaza pe adictiile de droguri si alcool si dezbate subiecte precum: „importanta reţelelor sociale in recuperare” sau „consumul de droguri conduce intotdeauna la adictie?”. De asemenea, atinge si teme ca dependenta de activităţi precum pariurile, jocurile video și sexul.

     Jenny Svanberg este psiholog clinician consultant. Are o experientă clinica bogata in lucrul cu persoanele dependente de droguri si alcool.

     

     FASHION


    Ce spun despre noi hainele pe care le purtam? In ce mod ne afecteaza imbracamintea dispozitia si emotiile? Cum reuseste industria modei sa ne induca dorinta de a arata intr‑un anumit fel?

     Fashion. Psihologia modei ne ofera o introducere lucida in universul captivant si dinamic al modei, vazut in raport cu comportamentul uman, de la felul in care hainele ne pot afecta procesele cognitive pana la cel in care comerciantii manipuleaza reactiile consumatorilor. Cartea exploreaza capacitatea creatiei vestimentare de a influenta obiectivitatea percepţiei pe care o avem asupra propriei persoane, modul în care psihologia poate oferi o perspectivă mai practică asupra procesului de producţie și de reciclare a hainelor, precum și motivele pentru care dezvoltăm anumite obiceiuri consumeriste.

    Intr‑un moment in care strazile, revistele si canalele audiovizuale abunda de imagini promovand moda, volumul de fata ne arata cum hainele si psihologia pot aduce o schimbare pozitiva in vietile noastre.

     


    Prof. Carolyn Mair este consultant independent, specializat in psihologia modei. Colaboreaza cu institutii de invaţamant, companii producatoare de imbracaminte si canale mass‑media. A creat programele de licenta si de masterat in psihologia modei de la College of Fashion din Londra.



    MUSIC

     

     Cum ne afecteaza muzica starea de spirit? Care este cel mai bun mod de a‑ti dezvolta abilitatile muzicale? Cum variaza defi­nitia muzicii de la o cultura la alta?

     Music. Psihologia muzicii exploreaza impactul fundamental pe care muzica il are asupra vietii noastre de zi cu zi si influenta acesteia asupra societatii, grupurilor si indivizilor. Lucrarea de­monstreaza beneficiile muzicii in ceea ce priveste functionarea intelectului nostru, sanatatea si starea generala de bine si anali­zeaza talentul muzical dintr‑o dubla perspectiva: ca dar innascut si ca abilitate ce poate fi cultivata si dezvoltata prin practica si exercitiu.

    Muzica ne prilejuieste o mai buna intelegere a umanitatii si a vietii moderne, iar volumul de fata ne arata semnificatia ei si pu­terea pe care o rasfrange asupra comportamentului nostru.

     

    Susan Hallam este profesor emerit de Educatie si Psihologie a Muzicii in cadrul Institutului de Educatie de la UCL (Colegiul Universitar din Londra). In 2015 a fost distinsa cu un ordin ono­rific – MBE (The Most Excellent Order of the British Empire); ina­inte de a deveni profesor universitar, Susan Hallam s‑a bucurat de o cariera de succes atat ca muzician profesionist, cat si ca profesor de muzica.

     

    TRUST

     

     Ce anume ne convinge sa avem incredere in oameni? Cum se dezvolta increderea si cum poate fi aceasta mentinuta? Se confrunta, oare, societatea occidentala cu o criza de incredere?

     Psihologia increderii trateaza chestiuni legate de incredere si experientele din viata de zi cu zi. Cartea identifica factorii care ii determina pe oameni sa fie încrezatori in ceilalti si consecintele acestei decizii asupra problemelor reale de sanatate, politica, terorism, la locul de munca sau in credinta religioasa, din intreaga lume. Cartea exploreaza si impactul lipsei de incredere, precum si cauzele manifestarii acesteia la persoane, grupuri sau organizatii. 

    Intr-o lume in care siguranta influenteaza viata noastra cotidiana, Psihologia increderii arata rolul pe care aceasta il are in relatiile noastre si ne ofera indrumari practice in legătura cu increderea pe care o acordam celor din jurul nostru. 

     

    Ken J. Rotenberg este Profesor de Psihologie la Universitatea Keele din Marea Britanie. Este cercetator activ de peste 40 de ani, interesat in special de increderea din timpul copilariei si al adolescentei.

     

     

     

     

  • 140.00 lei

     This is the ultimate reference on cooking with chocolate from Ferrandi, the Parisian school of culinary arts that was dubbed the “Harvard of gastronomy” by Le Monde newspaper.


    This book offers a complete chocolate course for the home chef from the world-renowned professional culinary school Ferrandi Paris. It presents comprehensive techniques for working with chocolate, from tempering and decorative flourishes to recipes such as the Opéra pastry or molten chocolate cake.

    From rich chocolate ganache to melt-in-your mouth truffles, this book leads aspiring bakers through every step―from basic to special occasion skills. Starting with advice on how to equip your kitchen, to essential techniques, fillings, and decorations, the books covers everything from quick desserts to holiday specialties and from frozen ice creams and sorbets to candies.

    Ferrandi offers an intensive course in the art of baking with chocolate. Written by the school’s experienced teaching team of master chefs and adapted for the home cook, this fully illustrated cookbook provides all of the fundamental techniques and recipes that are the building blocks of the illustrious French chocolate tradition, explained step by step in text and images. Practical information is presented in tables, diagrams, and sidebars for handy reference. Easy-to-follow recipes are graded for level of difficulty, allowing readers to develop their skills over time.

  • 40000lei 360.00 lei

     

    Since its original publication, no text has served as a better overview of the field of archives than Hunter’s manual. Newly revised and updated to thoroughly address our increasingly digital world, it remains the most comprehensive guide to the discipline.

    Developing and Maintaining Practical Archives covers such key topics as:

    • a history of archives, including the roles of historical societies and local history collections in libraries
    • new sections on community archives, diversity, and inclusion
    • conducting a survey and starting an archival program
    • selection, appraisal, acquisition, accessioning and deaccessioning
    • important points of copyright, privacy and ethics
    • arrangement of archival collections, with a discussion of new theories
    • description, including DACS, EAD and tools such as ArchivesSpace
    • access, reference, and outreach, with a look at how recent innovations in finding aids can help researchers
    • preservation, including guidance on how to handle rare books, maps, architectural records and artefacts
    • digital records
    • disaster planning, security, and theft prevention
    • metrics, assessment, establishing employee procedures and policies, working with interns and volunteers and other managerial duties
    • public relations and marketing, from social media and the Web to advocacy and
    • professional guidelines and codes such as the newly developed SAA Statement of Core Values of Archivists.

    Providing in-depth coverage of both theory and practice, this manual is essential for archivists at all levels of experience and of all backgrounds.

     

  • Do Archives Have Value?
    La comanda in aproximativ 4 saptamani
    40000lei 360.00 lei

     

    This book will explore ways of establishing value and measuring in the archives and specials collections.

    There is a vast literature about ways of measuring value for cultural heritage assets as a whole, particularly museums and visitor attractions, but archives and special collections in libraries have largely been overlooked. They have been very poor at garnering statistical data and devising ways of measuring the impact of what they do, unlike museums and visitor attractions with their much heavier footfall.

    Do Archives Have Value? discusses the various valuation methods available, including contingent valuation, willingness to pay and value chain, and assesses their suitability for use by archives and special collections. The book also assesses the impact of the transition to the digital in archival holdings, which will transform their character and will almost certainly cost more. The discussion will be set in the context of changing societal expectations of the archive in the wake of child abuse and other scandals where records to address grievances must be kept irrespective of cost.

     

  • Participatory Archives
    La comanda in aproximativ 4 saptamani
    38000lei 342.00 lei

     Participatory Archives: Theory and practice is divided into four sections with each focused on a particular aspect of participatory archives: social tagging and commenting; transcription; crowdfunding; and outreach & activist communities. Each section includes chapters summarizing the existing literature, a discussion of theoretical challenges and benefits, and a series of case studies. The case studies are written by a range of international practitioners and provide a wide range of examples in practice, whilst the remaining chapters are supplied by leading scholars from Australia, Canada, Denmark, the Netherlands, Norway, the United Kingdom, and the United States.

    This book will be useful for students on archival studies programs, scholarly researchers in archival studies who could use the book to frame their own research projects, and practitioners who might be most interested in the case studies to see how participatory archives function in practice. The book may also be of interest to other library and information science students, and similar audiences within the broader cultural heritage institution fields of museums, libraries, and galleries.

  • 38000lei 342.00 lei

     

    Effective library assessment is crucial for a successful academic library. But what do we mean by library assessment and how can it be used to improve the library service? This book provides a practical guide for library administrators, managers and practitioners on how to make effective use of existing sources of information for assessment activities with the aim of
    improving academic library services.


    Putting Library Assessment Data to Work brings together key library assessment methodologies detailing how they can be used to improve an academic library. The book takes common sources of data that academic libraries will already be collecting, and presents simple qualitative and quantitative techniques that can be used to evaluate and assess their services, both in detail and overall.
    The different assessment methods are presented from a practical perspective with a theoretical grounding, and include practical case studies to illustrate how the methodologies have successfully been applied.

     


    The book includes coverage of:




    ·         The theoretical framework for assessment, it’s purpose and
    the tools and techniques used



    ·         Institutional, national and international student surveys
    and how they can be sued to improve library service



    ·         The history and development of standardised library surveys
    (eg libQUAL+), how they have been used and their impact



    ·         The benefits of In house library surveys and case studies of
    where they gave been used



    ·         Qualitative feedback in the library



    ·         Taking a holistic approach to library assessment through advocacy
    and strategic planning.

     

    This book will be essential reading for library and information service managers, administrators, assessment practitioners, educators and policy shapers. It will also be useful for students and
    researchers interested in library assessment.


     



  • 40000lei 360.00 lei

     Who could be partners to archivists working in digital preservation? This book features chapters from international contributors from diverse backgrounds and professions discussing their challenges with and victories over digital problems that share common issues with those facing digital preservationists. The only certainty about technology is that it will change. The speed of that change, and the ever-increasing diversity of digital formats, tools, and platforms, will present stark challenges to the long-term preservation of digital records.

    Archivists are frequently challenged by the technical expertise, subject matter knowledge, time, and resource requirements needed to solve the broad set of challenges sure to be faced by the archival profession. Partners for Preservation advocates the need for archivists to recruit partners and learn lessons from across diverse professions to work more effectively within the digital landscape. Includes discussion of: the internet of things digital architecture research data and collaboration open source programming privacy, memory and transparency inheritance of digital media.

  • 38000lei 342.00 lei

     

    This book combines current research in open data practices in the heritage sector with technical step-by-step guides on how to work with heritage data for visualisation, mapping, and mining. 

     

    The book begins with an overview of the extent of open heritage data, a thorough review of the current literature and original case studies from practitioners at Europeana, the Digital Public Library of America, fx. Rijksmuseum, the National Gallery of Denmark and the Metropolitan Museum of Art.

     

    The second part of the book puts the theory into practice with a series of step-by-step guides that take the reader through creating, publishing, using and reusing open heritage data. 

     

    The book covers:

     

    ·         copyright and licensing for digitised and born-digital heritage material

    ·         publishing different data types as open data (images, maps, structured data)

    ·         finding open data with a guide to using APIs

    ·         visualizing open data

    ·         mapping open data

    ·         mining open data

    ·         the use of open data with examples of how to reuse, remix, hack and mashup open data.

     

    Open Heritage Data will be useful reading for practitioners working in libraries, museums, archives, historical societies as well as researchers, educators and students in digital humanities, information science, computer science, heritage studies, archaeology, history and related fields.

     

  • 35000lei 315.00 lei

    Library staff, information managers, academics, learning technologists, researchers and other practitioners who collect, use, create, share or provide access to published and unpublished resources, such as content, data, databases, personal data and software, need to be aware of the legal and licensing issues that might arise from these activities. This fully up-to-date guide adopts a practical hands-on approach to this complex area, which is viewed from both an operational and strategic perspective.

     

    The issue of information law compliance is more crucial now than ever with the new, more stringent adoption of the General Data Protection Regulations (GDPR) provisions across the Europe Union. It’s not just about what data you handle, but why you have it, where it is held, and who you are sharing it with. It is therefore a vital component of digital literacy.

     

    Information Law: Compliance for librarians, knowledge managers and information professionals is based on a Compliance Model developed by Naomi Korn, which has been implemented across many parts of the UK’s public sector. The model is presented here as an approach to information law compliance which can be applied across any organization in order to instigate compliant-aware cultures.

     

    The book includes case studies flow charts, sample contractual clauses and model licences, top tips and checklists. There is also a Glossary of Terms, an annotated guide to further reading, and useful contact lists.

     

    The book will be of interest to library and information managers and knowledge managers (academic, special, public, and national). It will also appeal to academics, learning technologists, researchers and other practitioners who use or provide access to digitised published and unpublished materials. In addition, the book will be of use to students and those who teach them in LIS and archival studies.  

     

  • 38000lei 342.00 lei

     This is the first book to study how the political content of information literacy arises from the way it has become defined and is taught. It introduces new methods for research into the development of information literacy in learners, and explores the implications of this research for the design of IL teaching, both in formal educational settings and in workplaces. Power is not an inherently dominating thing, wielded only from ‘the top’ (governments, senior managers in organisations, etc.) and used to oppress. The idea that information literacy education can be empowering , giving those at ‘the bottom’ the power to investigate information practices and change them if necessary, is supported by the models of power emerging from the work of Michel Foucault. He sees power as being available, potentially, to all actors and agents in a given setting. This is view of power as something emerging from, and shaping, micro-level discourses, and which can generate capital, helping learners change their world and the practices that shape it.


    To understand how such an approach can be empowering, the book explores how we can draw on difference in productive ways in IL education with a theory-led, empirical investigation of how the way information literacy is taught – whether formally or informally, and whether in schools, universities or workplaces – influences the development of information practices at the micro-level.

    The book also draws on original research to provide a detailed account of how information practices emerge from communities of learners in different settings and how discursive mapping can be taught to learners. It also covers how the capacity to engage in it emerges from educational environments in a more indirect way, and how learners respond to and resist institutionalised power by developing their own capacity to stewarding their information landscapes and digital habitats.

    Readership: Information literacy educators, whether in libraries, other HE courses, high schools or the workplace, will benefit by learning about how mapping – implicitly and explicitly – can be used as a method of teaching IL. Also, how they can design learning environments that exploit the positive value of difference, and empower their learners accordingly. The book will also be useful reading for academics and researchers of information literacy and students of library and information science.

  • 38000lei 342.00 lei

     Discovery is central to academic activities at all levels and is a major focus for libraries and museums. Of all the parts of modern library provision, discovery services are the most clearly affected by developments in IT, from databases to search engines to linked data to machine learning. It is crucial to the relationship between libraries and their communities. This book will help its readers learn how to adapt in a fast changing area to continue to provide a high level of service.

    Resource Discovery for the Twenty-First Century Library contains a range of contributions analysing the ways in which libraries are tackling the challenges facing them in discovery in the (post)-Google era. Chapters are written by experts, both global and local – describing specific areas of discovery and local implementations and ideas. The book will help with enhancing discovery both inbound – making locally held resources globally discoverable, and outbound – making global resources locally discoverable, in ways which are relevant to your user community.

     Content covered includes:

    • a survey of what resource discovery is today
    • case studies from around the world of interesting approaches to discovery
    • analysis of how users approach discovery
    • how to understand and make the best use of Internet search engines
    • using limited resources to help users find collections
    • linked open data and discovery
    • the future of discovery.

    This book will be useful for subject librarians and others who give direct support to library users, digital library technicians, managers, staff with responsibility for managing electronic resources, metadata and discovery specialists, trainers and user education specialists. It will also be of use to curators and others who give direct support to researchers, managers of digitisation and cataloguing products, IT staff, trainers and user education specialists.

     

  • 1410.00 lei

     

    Comprehensive, yet accessible, Wyllie’s Treatment of Epilepsy: Principles and Practice has provided a detailed and cohesive overview of seizure disorders and treatment options through six well-regarded editions. The 7th Edition remains the definitive reference in the field with extensive updates from Dr. Elaine Wyllie and her team of world-renowned editors and authors. Ideal for both clinical reference and exam preparation, this single-volume work on contemporary epileptology is an indispensable resource for neurologists, epilepsy specialists and epilepsy neurosurgeons, neurology and neurosurgery residents and fellows, and neuropsychologists.

    • Features considerable new or significantly revised content reflecting the most current evidence-based treatment options.
    • Offers an in-depth review of all aspects of epileptology, including neuroimaging; epilepsy surgery; antiseizure medications; principles of electroencephalography; psychosocial impact, quality of life, and comorbidities; economics of epilepsy; and more.
    • Provides more than 500 CME-eligible review questions online, highlighting key concepts for the ABPN subspecialty exam and clinical practice.

    Enrich Your Ebook Reading Experience

    • Read directly on your preferred device(s), such as computer, tablet, or smartphone.
    • Easily convert to audiobook, powering your content with natural language text-to-speech. 

     

    TABLE OF CONTENTS:


    PART I  EPIDEMIOLOGY, GENETICS, AND MECHANISMS OF EPILEPTOGENESIS
    HOWARD P. GOODKIN, ASSOCIATE EDITOR • TOBIAS LODDENKEMPER, QUESTIONS EDITOR
    CHAPTER 1 Epidemiologic Aspects of Epilepsy 2
    CHRISTINE LINEHAN • ANNE T. BERG
    CHAPTER 2 The Natural History and Prognosis of Epilepsy 13
    DING DING
    CHAPTER 3 Experimental Models of Seizures and Mechanisms of Status Epilepticus and Epileptogenesis 18
    TIM A. BENKE • MOLLY M. HUNTSMAN • AMY BROOKS-KAYAL
    CHAPTER 4 Genetic Aspects of the Epilepsies 29
    ERIKA TAKLE AXEEN • ANNAPURNA PODURI
    CHAPTER 5 Pictorial Atlas of Epilepsy Substrates 36
    AJAY GUPTA • RICHARD A. PRAYSON


    PART II  BASIC PRINCIPLES OF ELECTROENCEPHALOGRAPHY
    TOBIAS LODDENKEMPER, ASSOCIATE EDITOR, QUESTIONS EDITOR
    CHAPTER 6 Neurophysiologic Basis of the Electroencephalogram 53
    ERWIN-JOSEF SPECKMANN • CHRISTIAN E. ELGER • ALI GORJI
    CHAPTER 7 Localization and Field Determination in Electroencephalography 68
    RICHARD C. BURGESS
    CHAPTER 8 Electroencephalographic Atlas of Epileptiform Abnormalities 90
    SOHEYL NOACHTAR • ELAINE WYLLIE
    CHAPTER 9 Quality Standards and Logistics of Establishing an Epilepsy Monitoring Unit 130
    DEEPAK K. LACHHWANI

    PART III  EPILEPTIC SEIZURES AND SYNDROMES
    SECTION A ¦ ELECTROCLINICAL SYNDROMES
    TOBIAS LODDENKEMPER, ASSOCIATE EDITOR, QUESTIONS EDITOR
    CHAPTER 10 The Revised Definition and Classification of Seizures and Epilepsies 137
    ROBERT S. FISHER • TOBIAS LODDENKEMPER
    CHAPTER 11 Seizure Types and Semiology 145
    CLAUDE STERIADE • PATRICK CHAUVEL • PRAKASH KOTAGAL
    CHAPTER 12 Epileptic Auras 161
    NORMAN K. SO
    CHAPTER 13 Focal Epileptogenic Networks 172
    DILEEP NAIR • JUAN C. BULACIO • PATRICK CHAUVEL
    CHAPTER 14 Electroclinical Syndromes of Infancy 183
    ELIA M. PESTANA KNIGHTCHAPTER 15 Electroclinical Syndromes in Childhood and Adolescence 200
    KATHERINE NICKELS • RENÉE SHELLHAAS • ELAINE WYLLIE • ELAINE C. WIRRELL
    CHAPTER 16 Continuous Spike-and-Wave During Sleep, Including Landau–Kleffner Syndrome 220
    IVÁN SÁNCHEZ FERNÁNDEZ • TOBIAS LODDENKEMPER
    CHAPTER 17 Epilepsy with Reflex Seizures 230
    DOROTHÉE G. A. KASTELEIJN-NOLST TRENITÉ
    SECTION B ¦ SPECIFIC ETIOLOGIES
    HOWARD P . GOODKIN, ASSOCIATE EDITOR • TOBIAS LODDENKEMPER, QUESTIONS EDITOR
    CHAPTER 18 Hippocampal Sclerosis and Dual Pathology 245
    OLESYA GRINENKO • INGMAR BLÜMCKE • IMAD M. NAJM
    CHAPTER 19 Malformations of Cortical Development and Epilepsy 252
    RICHARD J. LEVENTER • RENZO GUERRINI
    CHAPTER 20 New Neuropathologic Concepts in Focal Cortical Dysplasias 263
    HARVEY B. SARNAT
    CHAPTER 21 Brain Tumors and Epilepsy 272
    LARA JEHI • INGMAR BLÜMCKE
    CHAPTER 22 Posttraumatic Epilepsy 284
    JAY R. GAVVALA • STEPHAN U. SCHUELE
    CHAPTER 23 Epilepsy in the Setting of Cerebrovascular Disease 298
    CHARLES ÁKOS SZABÓ • STEPHEN HANTUS • BERND POHLMANN-EDEN
    CHAPTER 24 Epilepsy in the Setting of Neurocutaneous Syndromes 306
    PHILLIP L. PEARL • AJAY GUPTA
    CHAPTER 25 Epilepsy in the Setting of Inherited Metabolic and Mitochondrial Disorders 317
    SUMIT PARIKH • DOUGLAS R. NORDLI JR • DARRYL C. DE VIVO
    CHAPTER 26 Progressive Myoclonic Epilepsies 344
    BERND A. NEUBAUER • ANDREAS HAHN
    CHAPTER 27 Central Nervous System Infections and Epilepsy 359
    GAGANDEEP SINGH • J. M. K. MURTHY
    CHAPTER 28 Autoimmune Epilepsy and Encephalitis 369
    CLAUDE STERIADE • NICOLAS GASPARD • AHSAN N. V. MOOSA
    CHAPTER 29 Rasmussen Encephalitis 380
    CHRISTIAN G. BIEN • FRANÇOIS DUBEAU
    SECTION C ¦ DIAGNOSIS AND TREATMENT OF SEIZURES IN SPECIAL CLINICAL SETTINGS
    HOWARD P . GOODKIN, ASSOCIATE EDITOR • TOBIAS LODDENKEMPER, QUESTIONS EDITOR
    CHAPTER 30 Febrile Seizures and Genetic Epilepsy with Febrile Seizures Plus (GEFS+) 392
    SYNDI A. SEINFELD • MICHAEL DUCHOWNY
    CHAPTER 31 Approach to the Patient with a First Seizure 398
    EMILY L. JOHNSON • GREGORY K. BERGEY
    CHAPTER 32 Neonatal Seizures and EEG 404
    COURTNEY J. WUSTHOFF • ELI M. MIZRAHI • ROBERT R. CLANCY • ELIA M. PESTANA KNIGHT
    CHAPTER 33 Epilepsy in the Elderly 421
    ANDREY S. STOJIC • CAMILO I. GARCÍA GRACIA • LARA JEHI • ILO E. LEPPIK
    CHAPTER 34 Seizures Associated with Nonneurologic Medical Conditions 430
    STEPHAN EISENSCHENK • SWAPNA SURABHI • YUE WANGCHAPTER 35 Sleep and Epilepsy 439
    NANCY FOLDVARY-SCHAEFER • SILVIA NEME-MERCANTE
    CHAPTER 36 Status Epilepticus 449
    VINEET PUNIA • HOWARD P . GOODKIN
    CHAPTER 37 Electroencephalography and Seizures in the Intensive Care Setting 464
    STEPHEN HANTUS • NICHOLAS S. ABEND
    SECTION D ¦ DIFFERENTIAL DIAGNOSIS OF EPILEPSY
    LARA JEHI, ASSOCIATE EDITOR, QUESTIONS EDITOR
    CHAPTER 38 Psychogenic Nonepileptic Seizures 473
    W. CURT LAFRANCE JR • HAMADA HAMID ALTALIB • BECKY BIKAT TILAHUN
    CHAPTER 39 Other Nonepileptic Paroxysmal Disorders 483
    ELIA M. PESTANA KNIGHT • ADRIANA S. TANNER

    PART IV  ANTISEIZURE MEDICATIONS
    SECTION A ¦ GENERAL PRINCIPLES OF ANTISEIZURE MEDICATION THERAPY
    BARRY E. GIDAL, ASSOCIATE EDITOR
    CHAPTER 40 Antiseizure Medication Development and Experimental Models 503
    MELISSA BARKER-HALISKI • H. STEVE WHITE
    CHAPTER 41 Mechanisms of Action of Antiseizure Medication 509
    MICHAEL A. ROGAWSKI • JOSÉ E. CAVAZOS
    CHAPTER 42 Pharmacokinetics and Drug Interactions 520
    GAIL D. ANDERSON
    CHAPTER 43 Initiation and Discontinuation of Antiseizure Medications 531
    VARDA GROSS-TSUR • RUTH C. SHINNAR • SHLOMO SHINNAR
    CHAPTER 44 Treatment of Acute and Repetitive Seizures 544
    IVÁN SÁNCHEZ FERNÁNDEZ • TOBIAS LODDENKEMPER
    CHAPTER 45 Hormones, Catamenial Epilepsy, Sexual Function, and Reproductive and Bone Health in Epilepsy 553
    NITIN K. SETHI • CYNTHIA L. HARDEN
    CHAPTER 46 Treatment of Epilepsy During Pregnancy 561
    PAGE B. PENNELL • P . EMANUELA VOINESCU
    CHAPTER 47 Individual Approach to Laboratory Monitoring of Antiseizure Medication 569
    SVEIN I. JOHANNESSEN • PHILIP N. PATSALOS
    SECTION B ¦ SPECIFIC ANTIEPILEPTIC MEDICATIONS AND TREATMENTS
    BARRY E. GIDAL, ASSOCIATE EDITOR
    CHAPTER 48 Benzodiazepines 575
    L. JOHN GREENFIELD JR • KINSHUK SAHAYA • SANG-HUN LEE
    CHAPTER 49 Carbamazepine, Oxcarbazepine, and Eslicarbazepine 599
    CARLOS A. M. GUERREIRO • MARILISA M. GUERREIRO • SCOTT MINTZER
    CHAPTER 50 Ethosuximide 610
    ANDRES M. KANNER • RAMSES RIBOT
    CHAPTER 51 Felbamate 623
    MONICA B. DHAKAR • EDWARD FAUGHT
    CHAPTER 52 Gabapentin and Pregabalin 629
    PIERO PERUCCACHAPTER 53 Lacosamide 641
    ROBERT T. WECHSLER • RAJ D. SHETH
    CHAPTER 54 Lamotrigine 646
    JOHN M. STERN • BARRY E. GIDAL
    CHAPTER 55 Levetiracetam and Brivaracetam 654
    ERIN M. OKAZAKI • JOSEPH I. SIRVEN • KATHERINE H. NOE • MATTHEW T. HOERTH • PAVEL KLEIN
    CHAPTER 56 Perampanel 663
    GREGORY L. KRAUSS • BARRY E. GIDAL
    CHAPTER 57 Phenobarbital and Primidone 669
    JACQUELYN L. BAINBRIDGE • MARK C. SPITZ • PEI SHIEEN WONG • SARAH N. FISCHER
    CHAPTER 58 Phenytoin and Fosphenytoin 678
    JEANNINE M. CONWAY
    CHAPTER 59 Rufinamide 693
    GREGORY L. KRAUSS • RAMA MAGANTI
    CHAPTER 60 Topiramate 701
    WILLIAM E. ROSENFELD
    CHAPTER 61 Valproate 715
    ANGELA K. BIRNBAUM • SUSAN E. MARINO
    CHAPTER 62 Vigabatrin 724
    KELLY G. KNUPP • ELIZABETH A. THIELE
    CHAPTER 63 Zonisamide 731
    TIMOTHY E. WELTY
    CHAPTER 64 Adrenocorticotropin and Steroids 738
    CRISTINA GO • O. CARTER SNEAD III
    CHAPTER 65 Cannabidiol 747
    JERZY P . SZAFLARSKI • ORRIN DEVINSKY
    CHAPTER 66 Antiseizure Medications in Clinical Development 752
    DEANA M. GAZZOLA • NORMAN DELANTY • JACQUELINE A. FRENCH
    CHAPTER 67 Less Commonly Used Antiseizure Medications 763
    ROBERT J. KOTLOSKI • ROBERT T. WECHSLER • BASIM M. UTHMAN • BAILEY G. SALIMES
    CHAPTER 68 Dietary Therapies for Epilepsy 772
    ERIC H. W. KOSSOFF

    PART V  EPILEPSY SURGERY
    SECTION A ¦ IDENTIFYING SURGICAL CANDIDATES AND DEFINING THE EPILEPTOGENIC NETWORK
    LARA JEHI, ASSOCIATE EDITOR, QUESTIONS EDITOR
    CHAPTER 69 Issues of Medical Intractability for Surgical Candidacy 780
    SAMUEL WIEBE • CHURL-SU KWON • NATHALIE JETTÉ
    CHAPTER 70 Magnetic Resonance Imaging in the Evaluation for Epilepsy Surgery 788
    AHSAN N. V. MOOSA • PAUL M. RUGGIERI
    CHAPTER 71 Video–EEG Monitoring in the Presurgical Evaluation 806
    JEFFREY W. BRITTON • DAVID B. BURKHOLDER
    CHAPTER 72 Nuclear Imaging (PET, SPECT) 820
    WILLIAM DAVIS GAILLARDCHAPTER 73 Magnetoencephalography 831
    RICHARD C. BURGESS • JOHN C. MOSHER
    CHAPTER 74 MRI Postprocessing Techniques and Clinical Applications 849
    ZHONG IRENE WANG • STEPHEN E. JONES • ANDREA BERNASCONI
    CHAPTER 75 MRI Connectivity Analyses: Imaging Networks in Epilepsy 860
    EZEQUIEL GLEICHGERRCHT • LEONARDO BONILHA
    CHAPTER 76 Diffusion Tensor Imaging (DTI) and EEG-Correlated fMRI 867
    BEATE DIEHL • LOUIS LEMIEUX
    CHAPTER 77 Mapping Epileptic Networks with Intracranial Electrodes 881
    JUAN C. BULACIO • JORGE A. GONZÁLEZ-MARTÍNEZ
    SECTION B ¦ MAPPING ELOQUENT CORTEX
    LARA JEHI, ASSOCIATE EDITOR, QUESTIONS EDITOR
    CHAPTER 78 Functional Mapping with Neurophysiologic Techniques 891
    RIKI MATSUMOTO • SASHA DIONISIO • MARTIN STAUDT • JUAN C. BULACIO • DILEEP NAIR
    CHAPTER 79 Language and Memory Mapping 905
    JEFFREY R. BINDER • CHAD CARLSON
    SECTION C ¦ EPILEPSY SURGERY IN SPECIFIC CLINICAL SETTINGS
    TOBIAS LODDENKEMPER, ASSOCIATE EDITOR, QUESTIONS EDITOR
    CHAPTER 80 Surgery for Medically Refractory Temporal Lobe Epilepsy 917
    ALVIN Y. CHAN • WILLIAM E. BINGAMAN • IMAD M. NAJM • SUMEET VADERA
    CHAPTER 81 Surgery for Focal Cortical Dysplasias (FCDs) 924
    ANDRE PALMINI • IMAD M. NAJM • WILLIAM E. BINGAMAN
    CHAPTER 82 Hemispherectomy: Indications, Procedures, and Outcome 934
    AHSAN N. V. MOOSA • JORGE A. GONZÁLEZ-MARTÍNEZ • WILLIAM E. BINGAMAN
    CHAPTER 83 Surgical Approach in Multilesional or Multilobar Epilepsies 945
    ELIA M. PESTANA KNIGHT • ELAINE WYLLIE
    CHAPTER 84 Surgical Approach in Nonlesional Cases 954
    DEEPAK K. LACHHWANI • JORGE A. GONZÁLEZ-MARTÍNEZ
    CHAPTER 85 Hypothalamic Hamartoma 964
    JOHN F. KERRIGAN • ANGUS A. WILFONG
    CHAPTER 86 Corpus Callosotomy and Multiple Subpial Transection 982
    MICHAEL C. SMITH • RICHARD W. BYRNE • ANDRES M. KANNER
    CHAPTER 87 Epilepsy Surgery: Special Considerations in Children 991
    AHSAN N. V. MOOSA • ELAINE WYLLIE
    CHAPTER 88 Ablative Treatments for Epilepsy 1001
    PATRICK J. KARAS • A. BASIT KHAN • DANIEL J. CURRY
    CHAPTER 89 Outcome and Complications of Epilepsy Surgery 1012
    ROBERT A. MCGOVERN • LARA JEHI • JORGE A. GONZÁLEZ-MARTÍNEZ • WILLIAM E. BINGAMAN
    CHAPTER 90 Vagus Nerve Stimulation Therapy 1027
    JAMES W. WHELESS • ANDREW J. GIENAPP • BASANAGOUD MUDIGOUDAR
    CHAPTER 91 Responsive Neurostimulation Therapy: RNS System 1043
    CHRISTIANNE N. HECK • WILLIAM O. TATUM
    CHAPTER 92 Deep Brain Stimulation Epilepsy 1048
    ROBERT S. FISHERPART VI ¦ PSYCHOSOCIAL IMPACT, QUALITY OF LIFE, AND COMORBIDITIES, AND ECONOMICS OF EPILEPSY
    LARA JEHI, ASSOCIATE EDITOR, QUESTIONS EDITOR
    CHAPTER 93 Cognitive Effects of Epilepsy and Its Treatments 1058
    KIMFORD J. MEADOR
    CHAPTER 94 Psychiatric Comorbidity of Epilepsy 1064
    BETH A. LEEMAN-MARKOWSKI • STEVEN C. SCHACHTER
    CHAPTER 95 Sudden Unexpected Death in Epilepsy (SUDEP) 1078
    DAVID P . HARRIS • LISA M. BATEMAN
    CHAPTER 96 Driving and Social Issues in Epilepsy 1085
    AMY Z. CREPEAU • JOSEPH F. DRAZKOWSKI
    CHAPTER 97 Ambulatory Seizure Monitoring and Acute Seizure Detection 1092
    STEVEN C. SCHACHTER
    CHAPTER 98 Quality of Life with Epilepsy 1095
    TATIANA FALCONE • JESSICA R. FESLER
    APPENDIX ¦ ASSOCIATE EDITOR: BARRY E. GIDAL
    Indications for Antiseizure Medications Sanctioned by the U.S. Food and Drug Administration 1101
    BRITANY WALLS
    Index 1103

     


  • Scheuer's Liver Biopsy Interpretation
    La comanda in aproximativ 4 saptamani
    78200lei 680.00 lei

    Description:

    Trusted for more than 50 years by pathologists in practice and in training, Scheuer’s Liver Biopsy Interpretation is a well-organized, superbly illustrated guide designed to help solve diagnostic problems at the microscope. Authored by renowned expert Dr. Jay Lefkowitch and reflecting the extensive experience of the late Dr. Peter Scheuer, this practical text contains technical tips, diagnostic clues, and pearls on all aspects of liver pathology diagnosis, including acute and chronic hepatitis, biliary tract diseases, childhood disorders, and hepatic neoplasms - as well as ancillary topics such as biopsy assessment, laboratory techniques, normal liver histology, and transplantation. Throughout the text, histopathologic features are correlated with clinical features, molecular genetics, and immunohistochemistry to provide a practical account of how pathology impacts the diagnosis and management of liver disease.

    Key Features:

    Covers key topics such as genomic alterations in liver tumours, diagnosis of acute liver allograft rejection, scoring systems for non-alcoholic fatty liver disease, and discussions of immunohistochemical features wherever relevant.

    Presents the latest information on next generation sequencing and drug-induced liver injury, including adverse reactions to new biologics and alternative medicines to help both the clinician and pathologist avoid diagnostic errors.

    Features many new illustrations, including over 300 large, full-color and fully annotated photomicrographs that illustrate a wide range of pathologic appearances and help identify each diagnostic entity under discussion.

    Offers coverage of cytopathology in the assessment of liver tumors to provide further clinical clues to diagnosis.

    Provides basic overview of major histopathologic diagnostic problems in paediatric liver biopsy, including biliary atresia and several types of progressive familial intrahepatic cholestasis

    Provides new and updated algorithms, tables and images highlighting key features of each diagnostic entity - ideal as a concise review during sign out or for studying and board preparation.

    Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

     

    Table of Contents:

    1. General Principles of Biopsy Assessment
    2. Laboratory Techniques
    3. The Normal Liver
    4. Assessment and Differential Diagnosis of Pathological Features
    5. Biliary Disease
    6. Acute Viral Hepatitis
    7. Steatosis, Steatohepatitis and Related Conditions
    8. Drugs and Toxins
    9. Chronic Hepatitis
    10. Cirrhosis
    11. Neoplasms and Nodules
    12. Vascular Disorders
    13. Childhood Liver Disease and Metabolic Disorders
    14. Disturbances of Copper and Iron Metabolism
    15. The Liver in Systemic Disease and Pregnancy
    16. The Liver in Organ Transplantation
    17. Electron Microscopy and Other Techniques
     

     


  • 108.00 lei

     

    “The Way We Live” transcends all other style books to reveal global connections and patterns in home decoration. This world tour of interior design elements is lavishly presented in more than 1,000 colour photographs; fabrics, textures and ornamental details reflect the complexity of different spaces and lifestyles, offering countless ideas for self-expression. Beautiful and practical, 'The Way We Live' is much more than a decorating guide – it is a design for living.

    Table of Contents

    Introduction:

    the way we live

    • Where We Live: Environments and Locations around the World

    • Building for Living: Constructions, public and private, secular and sacred

    • Just Living: Inside and Outside the Home

    • Designing for Living: The home environment

    • The Indexes: the complete guide to design and style ideas

  • 43400lei 390.00 lei

     

    Description:

    Co-authored by an interprofessional collaborative team of physicians and nurses, Merenstein & Gardner’s Handbook of Neonatal Intensive Care, 9th Edition is the leading resource for interprofessional, collaborative care of critically ill newborns. It offers comprehensive coverage with a unique interprofessional collaborative approach and a real-world perspective that make it a practical guide for both nurses and physicians. The new ninth edition features a wealth of expanded content on delivery-room care; new evidence-based care "bundles"; palliative care in the NICU; interprofessional collaborative care of parents with depression, grief, and complicated grief; and new pain assessment tools. Updated high-quality references have also been reintegrated into the book, making it easier for clinicians to locate research evidence and standards of care with minimal effort. These additions, along with updates throughout, ensure that clinicians are equipped with the very latest clinical care guidelines and practice recommendations - all in a practical quick-reference format for easy retrieval and review.

    Features:

    • UNIQUE! Core author team of two physicians and two nurses gives this internationally recognized reference a true interprofessional collaborative approach that is unmatched by any other resource.
    • Consistent organization within clinical chapters include Physiology/Pathophysiology, Etiology, Prevention, Data Collection (History, Signs and Symptoms, and Laboratory Data), Treatment/Intervention, Complications, and Parent Teaching sections.
    • UNIQUE! Color-highlighted point-of-care clinical content makes high-priority clinical content quick and easy to find.
    • UNIQUE! Parent Teaching boxes outline the relevant information to be shared with a patient’s caregivers.
    • Critical Findings boxes outline symptoms and diagnostic findings that require immediate attention to help the provider prioritize assessment data and steps in initial care.
    • Case studies demonstrate how to apply essential content to realistic clinical scenarios for application-based learning.

    New To This Edition:

    • NEW! Updated content throughout reflects the latest evidence-based practice, national and international guidelines, and current protocols for interprofessional collaborative practice in the NICU.
    • NEW! Up-to-date, high-quality references are now reintegrated into the text for quick retrieval, making it easier for clinicians to locate research evidence and standards of care with minimal effort.
    • NEW! Expanded content on delivery-room care includes the impact of staffing on quality of care, delayed cord clamping, resuscitation, and more.
    • NEW! Coverage of the new evidence-based care "bundles" keeps clinicians up to date on new guidelines that have demonstrated improved outcomes of very preterm infants.
    • NEW! Coverage of new pain assessment tools equips NICU providers with essential resources for maintaining patient comfort.
    • NEW! Expanded coverage of palliative care in the NICU provides the tools needed to ensure patient comfort.
    • NEW! Expanded coverage of interprofessional collaborative care of parents with depression, grief, and complicated grief prepares clinicians for this essential area of practice.

    Table of Contents:

    Unit One: Evidence-Based Practice
    1. Evidence-Based Clinical Practice

    Unit Two: Support of the Neonate
    2. Prenatal Environment: Effect on Neonatal Outcome
    3. Perinatal Transport and Levels of Care
    4. Care at Birth
    5. Immediate Newborn Care
    6. Heat Balance 
    7. Physiologic Monitoring
    8. Acid-Base Homeostasis and Oxygenation
    9. Diagnostic Imaging in the Neonate
    10. Pharmacology in Neonatal Care
    11. Drug Withdrawal in the Neonate
    12. Pain and Pain Relief 
    13. The Neonate and the Environment: Impact on Development

    Unit Three: Metabolic and Nutritional Care of the Neonate
    14. Fluid and Electrolyte Management
    15. Glucose Homeostasis
    16. Total Parenteral Nutrition
    17. Enteral Nutrition
    18. Breast Feeding the Neonate with Special Needs
    19. Skin and Skin Care

    Unit Four: Infection and Hematologic Diseases of the Neonate
    20. Newborn Hematology
    21. Jaundice
    22. Infection in the Neonate

    Unit Five: Common Systemic Diseases of the Neonate
    23. Respiratory Diseases
    24. Cardiovascular Diseases and Surgical Interventions
    25. Neonatal Nephrology
    26. Neurologic Disorders
    27. Genetic Disorders, Malformations, and Inborn Errors of Metabolism
    28. Neonatal Surgery

    Unit Six: Psychosocial Aspects of Neonatal Care
    29. Families in Crisis: Theoretical and Practical Considerations
    30. Grief and Perinatal Loss
    31. Discharge Planning and Follow-Up of the Neonatal Intensive Care Unit Infant
    32. Ethics, Values, and Palliative Care in Neonatal Intensive Care

    Index

     

     

  • Stereo Atlas of Vitreoretinal Diseases
    La comanda in aproximativ 4 saptamani
    1,10000lei 980.00 lei

     

    Practical stereo atlas on diagnosis and treatment

    Includes clinical cases with illustrations

    Written by experienced professionals who manage vitreoretinal diseases

     

    About this book

     

    This book introduces up-to-date knowledge of vitreal and retinal diseases with color fundus illustrations. The retinal layers of different lesions normally look like a single plane for junior doctors in Ophthalmology. With the help of the fundus camera, the stereo color images with different shooting angles are taken and the retina looks vivid and stereoscopic in the photograph.

     

    Although the technology of "deciphering" retina diseases is constantly advancing, the stereo fundus photography (SFP) is still indispensable, which can not only reveals the retina stereoscopically and comprehensively, but also has been the gold standard for certain diseases, such as glaucoma and retina angiomatous proliferation (RAP). Meanwhile, the equipment demands for SFP are not so high and can be easily promoted in the grass-roots hospitals. In this book, we carefully collected and organized more than 300 stereo color fundus images and angiography pictures of various vitreal and retinal diseases for readers to recognize the three dimensional features at first glance, such as retinal bleeding at different layers, optic disc change of glaucoma, macular diseases, tumors, RAP and polypoidal choroidal vasculopathy (PCV).

     

    Table of contents (7 chapters)

     

    Basic Principles of Stereo Fundus Photography

    Pages 1-5

    Min, Hanyi (et al.)

    Retinal Diseases

    Pages 7-110

    Wang, Gensheng (et al.)

    Macular Diseases

    Pages 111-161

    Min, Hanyi (et al.)

    Vitreous Diseases

    Pages 163-190

    Ye, Qinying (et al.)

    Papillary Diseases

    Pages 191-254

    Cheng, Gangwei (et al.)

    Choroidal Diseases

    Pages 255-286

    Li, Donghui (et al.)

    Fundus Changes After Vitreoretinal Surgery

    Pages 287-303

    Min, Hanyi (et al.)

     

  • 82200lei 735.00 lei

     

    ·         Provides an understanding of the underpinnings of neurorehabilitation

    ·         Edited by respected figures in the field of neurorehabilitation

    ·         Presents clinical recommendations based on established evidence and clinical experience

    ·         Comes with online access to informative videos

    New to this Edition:

    ·         Fully updated to reflect important developments in the field.

    ·         Includes new chapters on vocational rehabilitation, self-management strategies in neurorehabilitation, and music supported therapy in neurorehabilitation.

    Description

     

    Neurorehabilitation is an expanding field with an increasing clinical impact due to an ageing population. During the last 20 years, neurorehabilitation has developed from a discipline with little scientific background, separated from other medical centers, to a medical entity largely based on the principles of 'evidenced based medicine' with strong ties to basic research and clinical neurology. Today neurorehabilitation is still a work in progress and treatment standards are not yet established for all aspects of the field. There are very few books that address contemporary neurorehabilitation from this perspective.

    This new edition of the Oxford Textbook of Neurorehabilitation provides an understanding of the theoretical underpinnings of the subject as well as a clear perspective on how (and why) to approach treatment decisions on an individualized basis. The book has been thoroughly updated to reflect novel important developments in the field and includes new chapters on vocational rehabilitation, self-management strategies in neurorehabilitation, and music supported therapy in neurorehabilitation. This indispensable book will be of great interest to rehabilitation physicians, neurologists, and allied health care professionals who look after patients requiring neurorehabilitation.

     

    Table of Contents

    SECTION I: General aspects of neurorehabilitation
    1:The International Classification of Functioning, Disability, and Health, 
    Diane Playford
    2:A teamwork approach to neurological rehabilitation, 
    Derick Wade
    3:The economic benefits of rehabilitation for neurological conditions, 
    Rory J. O Connor
    4:Predicting activities after stroke, 
    Gert Kwakkel and Boudewijn Kollen
    5:Designing a clinical trial for neurorehabilitation, 
    Bruce Dobkin and Clarisa Martinez
    6:The influence of age on neurorehabilitation, 
    Markus Wirz and Louise Rutz-LaPitz
    7:The applicability of motor learning to neurorehabilitation, 
    John W. Krakauer
    SECTION II: Physiological consequences of CNS damage
    8:Spinal neuronal dysfunction after deprivation of supraspinal input, 
    Michèle Hubli and Volker Dietz
    9:Secondary changes after damage of the central nervous system: Significance of spastic muscle tone in rehabilitation, 
    Volker Dietz and Thomas Sinkjær
    10:Autonomous nervous system dysfunction, 
    Tom E. Nightingale, Ulrich Mehnert, Thomas M. Kessler, and Andrei Krassioukov
    11:Functional recovery in CNS disease: Impact of animal models, 
    Steffen Franz, Andreas Hug, and Norbert Weidner
    SECTION III: Neuroplasticity and repair
    12:Animal models of damage, repair, and plasticity in the brain, 
    Andreas R. Luft
    13:Animal models of damage, repair and plasticity in the spinal cord, 
    Patrick Freund, V. Reggie Edgerton, Roland R. Roy, Daniel C. Lu, and Yury Gerasimenko
    14:Stem cell application in neurorehabilitation, 
    Sebastian Jessberger, Armin Curt, and Roger A. Barker
    15:The role of neuroimaging in understanding the impact of neuroplasticity after CNS damage, 
    Nick S. Ward
    16:Enhancement of neuroplasticity by cortical stimulation, 
    Orlando B. C. Swayne and John C. Rothwell
    17:Enhancement of neuroplasticity by drug therapy, 
    Ulf Ziemann
    SECTION IV: Clinical concepts
    18:Rehabilitation of gait and balance after CNS damage, 
    Jacques Duysens, Geert Verheyden, Firas Massaad, Pieter Meyns, Bouwien Smits-Engelsman, and Ilse Jonkers
    19:Neurorehabilitation approaches for disorders of the peripheral nervous system, 
    William Huynh, Michael Lee, and Matthew C. Kiernan
    20:Treatment of arm and hand dysfunction after CNS damage, 
    Nick S. Ward
    21:Acquired disorders of language and their treatment, 
    Alex Leff and Jenny Crinion
    22:Neuropsychological rehabilitation of higher cortical functions after brain damage, 
    Radek Ptak and Armin Schnider
    23:The clinical neurology of problems with oral feeding, 
    Tom Hughes and Tom Richards
    24:Management of bladder, bowel, and sexual dysfunction, 
    Ulrich Mehnert and Thomas Kessler
    25:The assessment and treatment of pain syndromes in neurorehabilitation, 
    Eva Widerström-Noga
    26:The impact of fatigue on neurorehabilitation, 
    Killian A. Welch and Mansur A. Kutlubaev
    27:Vocational Rehabilitation, 
    Andy Tyerman
    28:Self-management strategies in neurorehabilitation, 
    Fiona Jones and Sara Demain
    29:Neuropalliative rehabilitation: Managing neurological disability in the context of deteriorating illness, 
    Gail Eva, Jo Bayly, and Diane Playford
    30:Recognition and management of functional symptoms after traumatic brain injury, 
    Lucia Ricciardi, Alan J. Carson, and Mark J. Edwards
    SECTION V: Technical concepts
    31:Music supported therapy in neurorehabilitation, 
    Eckart Altenmüller and Lauren Stewart
    32:Application of orthoses and neurostimulation in neurorehabilitation, 
    Jacopo Carpaneto and Silvestro Micera
    33:Technology to enhance arm and hand function, 
    Arthur Prochazka
    34:Technology to enhance locomotor function, 
    Rüdiger Rupp, Daniel Schließmann, Christian Schuld, and Norbert Weidner
    35:Enhancing independent community access and participation: Services, technologies, and policies, 
    Émilie Raymond, Luc Noreau, Normand Boucher, Geoffrey Edwards, Patrick Fougeyrollas, Ernesto Morales, Francois Routhier, Claude Vincent, and G. Hubert Gascon
    36:Virtual reality for neurorehabilitation, 
    Mathias Bannwart and Robert Riener
    37:Promises and challenges of neurorehabilitation technology, 
    Arun Jayaraman, Sheila Burt, and William Z. Rymer

     

  • 99000lei 860.00 lei

     About this book

     

    This book offers practical guidance on all procedures that may be performed within the field of hip preservation surgery, arthroscopy, and endoscopy. European experts share their experiences on everything from basic injections to the most challenging hip procedures, offering step-by-step tutorials and highlighting important tips and tricks.

    Whereas most books on hip arthroscopy and hip preservation surgery concentrate on pathologies, surgical indications, and the basics of the treatment, here the focus is very much on the individual techniques and recognized variants. These techniques are clearly and precisely described with the aid of a wealth of photo and video illustrations.

    The coverage encompasses procedures applicable in the widest range of scenarios, including synovial pathologies, labral, chondral, and bony injuries, hip impingement, dysplasia and instability, snapping hips, gluteus medius and minimus tendonitis and tears, other tendinopathies, post-arthroplasty complications, and rehabilitation. The book is published in cooperation with ESSKA and will be an essential aid for orthopaedic surgeons at all levels of experience.

     

    Table of contents (28 chapters)

     

    Joint Lavage, Synovectomy, Biopsy, and Loose Body Removal

    Pages 3-15

    Tourabaly, Idriss (et al.)

    Painful Hip Arthroplasty Assessment: Removal of Cement or Loose Bodies

    Pages 17-32

    Marin-Peña, Oliver (et al.)

    Femoral Osteochondroplasty

    Pages 35-49

    Sadakah, M. A. (et al.)

    Acetabular Rim Trimming

    Pages 51-53

    Seppänen, Matti

    Open Femoral Osteochondroplasty and Rim Trimming

    Pages 55-66

    Aprato, Alessandro (et al.)

    Subspine Impingement Decompression

    Pages 67-75

    Bajwa, Ali (et al.)

    Endoscopic Deep Gluteal Syndrome Techniques: Ischiofemoral Impingement Decompression

    Pages 77-87

    Perez-Carro, Luis (et al.)

    Os Acetabuli: Removal or Fixation

    Pages 89-94

    Randelli, Filippo (et al.)

    Arthroscopic Core Decompression and Cell Therapy

    Pages 95-102

    Triantafyllopoulos, Ioannis K. (et al.)

    Fracture Treatment

    Pages 103-109

    Zini, Raul (et al.)

    Open Periacetabular Osteotomy

    Pages 111-121

    Søballe, Kjeld

    Reverse Periacetabular Osteotomy

    Pages 123-137

    Wettstein, Michael

    Proximal Femoral Osteotomy

    Pages 139-153

    Laude, Frédéric

    Labral Debridement – Repair – Reattachment

    Pages 157-163

    Zurita, Nestor (et al.)

    Labral Reconstruction

    Pages 165-179

    Andrade, A. J.

    Ligamentum Teres Injuries and Treatment

    Pages 181-190

    Lindner, Dror (et al.)

    Capsular Plication and Repair

    Pages 191-195

    Lund, Bent

    Chondral Debridement–Abrasion: Microfracture

    Pages 199-208

    Tey Pons, Marc (et al.)

    Open Femoral Head Mosaicplasty

    Pages 209-216

    Viguelloux, Augustin (et al.)

    Endoscopic Trochanteric Bursectomy

    Pages 219-223

    Sarmento, André (et al.)

    Iliotibial Band Release and Gluteus Maximus Tendon Release (Polesello)

    Pages 225-227

    May, Olivier

    Gluteus Medius Repair – Endoscopic

    Pages 229-237

    Cardenas Nylander, Carlomagno

    Gluteus Medius and Minimus Tears Open Repair/Reconstruction

    Pages 239-252

    Christofilopoulos, Panayiotis (et al.)

    Open Adductor Tenotomy

    Pages 253-262

    Aletto, C. (et al.)

    Psoas Tenotomy

    Pages 263-269

    Andronic, Octavian (et al.)

    Proximal Hamstring Repair/Reinsertion: Open Surgery Technique

    Pages 271-277

    Lempainen, Lasse (et al.)

    Hamstring Repair/Reinsertion: Endoscopic Treatment Options

    Pages 279-282

    Bataillie, F. (et al.)

    Sciatic Nerve Release/Piriformis Tenotomy: Endoscopic Surgery

    Pages 285-297

    Perez-Carro, Luis (et al.)

     

  • 150.00 lei

    In this book an eminent musical theorist presents the first systematic and in-depth study of the early atonal works of avant-garde Austrian composer Anton Webern. Analyzing such elements as pitch, register, timbre, rhythm, form, and text setting, Allen Forte shows how Webern displaced the functional connections of traditional tonality to create a totally new sonic universe. Composers of the Twentieth Century Series Allen Forte, general editor

  • 76400lei 700.00 lei

     

    DESCRIPTION

    Comprehensively describes bone augmentation techniques and their application to the different anatomical regions of the upper and lower jaws.

    Bone Augmentation by Anatomical Region is a unique, evidence-based guide focusing on each specific anatomical region – anterior maxilla, posterior maxilla, anterior mandible, and posterior mandible – in order to emphasize the correct implemented procedures needed to successfully perform oral osseous reconstruction.

    Numerous ridge augmentation techniques are covered, including: horizontal and vertical guided bone regeneration, autologous block transplantation, interpositional bone grafting, allogeneic blocks, sandwich technique, split-expansion ridge technique, and sinus floor grafting.  Non-augmented approaches such as forced socket site extrusion and the installation of digitally printed implants are also presented and discussed.

    ·         Guides readers on tackling bone augmentation via anatomical region of the jaws and their related surrounding muscles, vascularization and innervation

    ·         Presents innovative augmentation techniques for the anterior maxilla, posterior maxilla, anterior mandible, and posterior mandible

    ·         Includes clinical photographs in each section and a decision tree to help readers select the appropriate surgical modality

    Bone Augmentation by Anatomical Region is a specialist resource suitable for dentists who practice implant dentistry, oral surgeons, oral and maxillofacial surgeons, periodontists, and postgraduate dental students in the above-mentioned disciplines.

    TABLE OF CONTENTS

    List of Contributors xi

    Preface xv

    Acknowledgement xvii

    About the Companion Website xix

    Introduction xxi

    Part I Basic Mechanisms 1

    1 The Anatomy of the Maxilla and the Mandible: Related Structures and Inserted Muscles 3
    Dmitri Lev and Zvi Artzi

    2 Biologic Conditions for Bone Growth and Maintenance: Managing the Oxidative Stress 17
    Joseph Choukroun, Elisa Choukroun, and Maximilien Parnot

    3 Biomaterials Selection – Cellular Interactions During Regenerative and Remodeling Phases 43
    Itzhak Binderman, Michal Halperin-Sternfeld, Erez Netanely, Snježana Pohl, Robert A. Horowitz, and Zvi Artzi

    4 Allogeneic Bone Grafts 61
    Michele Jacotti and Fabio Bernardello

    5 The Role of Osteopromotive Membranes in Guided Bone Regeneration 69
    Elena Calciolari, Aliye Akcalı, and Nikolaos Donos

    Part II The Anterior Maxilla 95

    6 Esthetic Considerations 97
    Goran I. Benic, Riccardo Kraus, Shaoxia Pan, and Christoph H.F. Hämmerle

    7 Soft Tissue Management in the Anterior Maxilla 117
    Daniel S. Thoma, Hyun-Chang Lim, and Christoph H.F. Hämmerle

    8 Treatment Alternatives for Soft Tissue Procedures in the Maxilla 131
    Carlos E. Nemcovsky

    9 Modifications of Anterior Maxillary Sandwich Osteotomy for Vertical Bone Augmentation 163
    Ole T. Jensen

    10 Autogenous Bone Block Transplantation in the Anterior Maxilla 169
    Federico Hernández-Alfaro and Gian Maria Ragucci

    11 Allogeneic Block Grafts in the Anterior Maxilla 181
    Michele Jacotti and Fabio Bernardello

    12 Confronting Severe Deficiencies in the Anterior Maxilla 195
    Zvi Artzi

    13 Management of Complications in Anterior Maxilla During Guided Bone Regeneration 235
    Isabella Rocchietta, Federico Moreno, and David Nisand

    Part III The Posterior Maxilla 255

    14 Sinus Augmentation: The Transcrestal Approach 257
    Leonardo Trombelli, Roberto Farina, Giovanni Franceschetti, and Zvi Artzi

    15 Sinus Augmentation: The Lateral Approach 283
    Tiziano Testori, Riccardo Scaini, Matteo Deflorian, and Stephen S. Wallace
    16 Maxillary Sinus Floor Augmentation: The Lateral Approach in Unusual Cases 309
    Zvi Artzi

    Part IV The Anterior Mandible 329

    17 Re-establishment of Adequate Osseous Volume in an Atrophic Anterior Mandible 331
    Zvi Artzi

    18 Anterior Atrophic Mandible Restoration Using Cancellous Bone Block Allograft 379
    Gavriel Chaushu, Liat Chaushu, Karen Anavi Lev, Joseph Nissan, and Zvi Artzi

    Part V The Posterior Mandible 399

    19 Options for Restoring the Atrophic Posterior Mandible – Vertical and Horizontal Bone Augmentation 401
    Zvi Artzi

    20 Cortico-Cancellous Block (CCB) Transplantation in the Posterior Mandible 431
    Zvi Artzi

    21 Allogeneic Block Grafts in the Posterior Mandible 445
    Michele Jacotti and Fabio Bernardello

    Part VI Other Advancing Techniques 453

    22 Interpositional Bone Grafts: Sandwich Interposition in the Lateral Mandible and Le Fort I Interposition in the Maxilla 455
    Hendrik Terheyden

    23 Preprosthetic Orthognathic Surgery 471
    Dror M. Allon

    Part VII Additional Related Subjects 487

    24 Biofilms Around Dental Implants 489
    David Herrera, Patricia Bermejo, María del Carmen Sánchez, Elena Figuero, and Mariano Sanz

    25 Prevention and Management of Peri-Implant Diseases 505
    Sofia Aroca, Giovanni E. Salvi, Andrea Roccuzzo, Uri Renert, Anton Sculean, and Zvi Artzi

    Index 523

  • 78200lei 625.00 lei

     

    Description:

    Highly readable, well-illustrated, and easy to understand, Gabbe’s Obstetrics: Normal and Problem Pregnancies is an ideal day-to-day reference or study tool for residents and clinicians. This 8th Edition of this bestselling text offers fast access to evidence-based, comprehensive information, now fully revised with substantial content updates, new and improved illustrations, and a new, international editorial team that continues the tradition of excellence established by Dr. Steven Gabbe.

     

    Key Features:

    Puts the latest knowledge in this complex specialty at your fingertips, allowing you to quickly access the information you need to treat patients, participate knowledgably on rounds, and perform well on exams.

     Contains at-a-glance features such as key points boxes, bolded text, chapter summaries and conclusions, key abbreviations boxes, and quick-reference tables, management and treatment algorithms, and bulleted lists throughout.

     Features detailed illustrations from cover to cover—many new and improved—including more than 100 ultrasound images that provide an important resource for normal and abnormal fetal anatomy.

     Covers key topics such as prevention of maternal mortality, diabetes in pregnancy, obesity in pregnancy, vaginal birth after cesarean section, and antepartum fetal evaluation.

    Provides access to 11 videos that enhance learning in areas such as cesarean delivery and operative vaginal delivery.

    Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices

  • 1,54300lei 1310.00 lei

     

    Written from a global perspective by experts in the field

    Demonstrates surgical procedures in a step by step manner with the aid of photographs and illustrations

    Describes alternate surgical approaches to highlight all options

     

    About this book

     

    This book provides a guide to the correction of maxillofacial trauma surgery. Chapters covering the initial considerations, assessment, and techniques required in post-traumatic surgery are included to give the reader an understanding of how and why a particular procedure takes place. The treatment of eye, nose, cheek, ear, jaw, and soft tissue deformities are also discussed.

    Atlas of Operative Maxillofacial Trauma Surgery: Post-Traumatic Deformity aims to give a framework to trainee and practising surgeons to help them manage trauma and allow them to assess and treat patients with facial deformities.

     

    Table of contents (52 chapters)

     

    Psychological Aspects of Posttraumatic DeformityPages 3-7

    Piff, Christine

    Complications in Craniofacial Trauma: An Overview of Some Common Problems

    Pages 9-40

    Alibhai, Mustansir (et al.)

    Hardware Removal in Craniomaxillofacial Trauma

    Pages 41-53

    Pabla, Ravinder (et al.)

    Posttraumatic Gustatory Dysfunction

    Pages 55-61

    Landis, Basile N. (et al.)

    Chronic Pain: An Overview of Causes and Management

    Pages 63-69

    Barry, Thomas (et al.)

    The Early Zygomatic Malunion

    Pages 71-90

    Holmes, Simon (et al.)

    Principles of Correction: An Overview of Secondary Correction of Posttraumatic Bony Deformities

    Pages 93-100

    Sawhney, Raja (et al.)

    Three-Dimensional Facial Imaging for the Diagnosis of Complex Soft Tissue Secondary to Craniofacial Trauma

    Pages 101-105

    Zou, Lifong (et al.)

    Computer-Assisted Treatment Planning in Complex Cases: Digital Technology

    Pages 107-123

    Holmes, Simon (et al.)

    Photography for Revision Surgery

    Pages 125-142

    Holmes, Simon (et al.)

    The Role of Computer-Aided Design and Three-Dimensional Printing in Posttraumatic Correction

    Pages 143-162

    Eggbeer, Dominic (et al.)

    Orthoptic Assessment and Intervention Postorbital Fracture Repair

    Pages 163-171

    Holmes, Simon (et al.)

    Surgical Materials in Secondary Reconstruction

    Pages 175-184

    Ujam, Atheer

    Topical Negative Wound Pressure Therapy: Its Uses in Plastic and Maxillofacial Surgery

    Pages 185-191

    Edwards, Daren (et al.)

    An Overview of Augmentation of Soft Tissue Deformities Using Injectable Techniques (Fillers Versus Fat)

    Pages 193-207

    Komath, Deepak (et al.)

    Tissue Expansion for Craniofacial Defects

    Pages 209-235

    Kirkpatrick, Niall (et al.)

    Fat Grafting in Soft Tissue Augmentation

    Pages 237-250

    Clauser, Luigi C. (et al.)

    Augmenting Soft Tissues with Fat, Dermis and Dermal Fat Grafts

    Pages 251-268

    Perry, Michael (et al.)

    Cranioplasty

    Pages 271-301

    White, Christopher J. (et al.)

    Hair Loss and Transplantation

    Pages 303-318

    Matsa, Sainath (et al.)

    Eyebrow Reconstruction

    Pages 319-331

    Gandelman, Marcelo

    Secondary Management of the Orbit

    Pages 335-381

    Holmes, Simon (et al.)

    The Anophthalmic Orbit

    Pages 383-400

    Castela, Guilherme (et al.)

    The Role of the Ocularist in Reconstructing the Posttraumatic Anophthalmic Orbit

    Pages 401-410

    Flavell, Brett

    Eyelid Deformities

    Pages 411-450

    Sethi, Charanjit J. (et al.)

    Repositioning the Corners of the Eye

    Pages 451-473

    Perry, Michael (et al.)

    The Twisted/Crooked Nose

    Pages 477-486

    Raja, Hemal (et al.)

    Nasal Augmentation

    Pages 487-497

    Perry, Michael

    Augmentation of the Nasal Pyramid: ‘Saddle-Shaped’ and Lateral Deformities

    Pages 499-518

    Seah, Tian Ee (et al.)

    Deformities of the Nasal Septum

    Pages 519-540

    Boenisch, Miriam

    Nasal Tip Deformities

    Pages 541-570

    Messiha, Ashraf

    Total and Near-Total Nasal Reconstruction

    Pages 571-582

    Hill, Sean M. (et al.)

    Posttraumatic Rhinoplasty: Is There a Role for Internal Fixation?

    Pages 583-593

    Perry, Michael

    Nasomaxillary Osteotomy

    Pages 595-603

    Perry, Michael

    Deformities of the Zygoma

    Pages 607-644

    Holmes, Simon (et al.)

    Reconstruction of Zygomatic and Periorbital Deformity with Alloplastic Material

    Pages 645-666

    McLeod, Niall M. H. (et al.)

    Contemporary Management of Traumatic Parotid-Cutaneous Communications and Fistulae

    Pages 667-671

    Blythe, John (et al.)

    Surgical Reconstruction of the Ear (Pinna)

    Pages 675-694

    Richardson, David

    Ear Reconstruction with Temporoparietal Fascia Flaps and Porous Polyethylene

    Pages 695-709

    Derderian, Christopher A., MD

    Hearing Impairment and Tinnitus: Cochlear Implantation and Other Rehabilitative Solutions

    Pages 711-731

    Rao, Sampath Chandra Prasad (et al.)

    Management of Posttraumatic Facial Palsy

    Pages 733-744

    Tzafetta, Kallirroi (et al.)

    The Management of Posttraumatic Facial Skeletal Deformity Affecting the Occlusion: The Early Malunited Mandible

    Pages 747-751

    Boffano, Paolo (et al.)

    Temporomandibular Joint Disorders

    Pages 753-777

    Dimitroulis, George

    Replacing Missing Teeth: Dental Implants

    Pages 779-799

    Tiong, Noah Teo Bo (et al.)

    Injuries to the Teeth: Long-Term Effects and Their Management

    Pages 801-813

    Gaind, Priya

    Scar Revision and Camouflage: An Overview

    Pages 817-838

    Perry, Michael (et al.)

    Scar Revision

    Pages 839-878

    Holmes, Simon (et al.)

    Nonsurgical Management of Traumatic Scars

    Pages 879-892

    Handley, Julian

    Nonsurgical Scar Management and Camouflage Techniques

    Pages 893-901

    Selim, Flordelyn

    Missile Injuries: An Overview of Correction

    Pages 905-916

    Kummoona, Raja

    Vascularised Composite Allotransplantation (Face Transplantation)

    Pages 917-928

    Sosin, Michael, MD (et al.)

    Facial Prostheses

    Pages 929-943

    Kaczkowski, Michael D.

     

     

  • 86900lei 710.00 lei

     

    Description:

    Successfully correlate electrodiagnostic findings and neuromuscular ultrasound with key clinical findings with Electromyography and Neuromuscular Disorders, 4th Edition. This popular text is the go-to resource for clinicians at all levels of experience who have an interest in neuromuscular medicine, including those studying for the AANEM board exam. An easy-to-read writing style, abundant case studies, and learning features online help you master the electrodiagnostic evaluation and improve safety and accuracy.


    Table Of Contents:

    Section I: Overview of Nerve Conduction Studies and Electromyography

    Chapter-1: Approach to Nerve Conduction Studies and Electromyography

    Chapter-2: Anatomy and Neurophysiology

    Section II: Fundamentals of Nerve Conduction Studies

    Chapter-3: Basic Nerve Conduction Studies

    Chapter-4: Late Responses

    Chapter-5: Blink Reflex

    Chapter-6: Repetitive Nerve Stimulation

    Section III: Sources of Error: Anomalies, Artifacts, Technical Factors and Statistics

    Chapter-7: Anomalous Innervations

    Chapter-8: Artifacts and Technical Factors

    Chapter-9: Basic Statistics for Electrodiagnostic Studies

    Section IV: Detailed Nerve Conduction Studies

    Chapter-10: Routine Upper Extremity, Facial, and Phrenic Nerve Conduction Techniques

    Chapter-11: Routine Lower Extremity Nerve Conduction Techniques

    Section V: Fundamentals of Electromyography

    Chapter-12: Basic Overview of Electromyography

    Chapter-13: Anatomy for Needle Electromyography

    Chapter-14: Basic Electromyography: Analysis of Spontaneous Activity

    Chapter-15: Basic Electromyography: Analysis of Motor Unit Action Potentials

    Section VI: Clinical-Electrophysiologic Correlations Part I: Common Mononeuropathies:

    Chapter-16: Clinical-Electrophysiologic Correlations: Overview and Common Patterns

    Chapter-17: Median Neuropathy at the Wrist

    Chapter-18: Proximal Median Neuropathy

    Chapter-19: Ulnar Neuropathy at the Elbow

    Chapter-20: Ulnar Neuropathy at the Wrist

    Chapter-21: Radial Neuropathy

    Chapter-22: Peroneal Neuropathy

    Chapter-23: Femoral Neuropathy

    Chapter-24: Tarsal Tunnel Syndrome

    Chapter-25: Facial and Trigeminal Neuropathy

    Part II: Polyneuropathy

    Chapter-26: Polyneuropathy

    Part III: Motor Neuron Disease

    Chapter-27: Amyotrophic Lateral Sclerosis and Its Variants

    Chapter-28: Atypical Motor Neuron Disorders

    Part IV: Radiculopathy, Plexopathies, and Proximal Neuropathies

    Chapter-29: Radiculopathy

    Chapter-30: Brachial Plexopathy

    Chapter-31: Proximal Neuropathies of the Shoulder and Arm

    Chapter-32: Lumbosacral Plexopathy

    Chapter-33: Sciatic Neuropathy

    Part V: Disorders of Neuromuscular Junction and Muscle

    Chapter-34: Neuromuscular Junction Disorders

    Chapter-35: Myopathy

    Chapter-36: Myotonic Muscle Disorders and Periodic Paralysis Syndromes

    Section VII: Electromyography in Special Clinical Settings

    Chapter-37: Approach to Electrodiagnostic Studies in the Intensive Care Unit

    Chapter-38: Approach to Pediatric Electromyography

    Section VIII: Electronics and Instrumentation

    Chapter-39: Basics of Electricity and Electronics for Electrodiagnostic Studies

    Chapter-40: Electrical Safety and Iatrogenic Complications of Electrodiagnostic Studies

     

     

  • 43700lei 380.00 lei

     

    About this book

     

    This book provides a comprehensive and practical overview of treatments for endovascular endoleaks, which represent the most frequent complications after endovascular abdominal aortic repair (EVAR). Written by a highly experienced interventional radiologist, it explains in practical terms the management of endoleaks using various embolization materials and different types of stent graft.

    Highlighting a range of typical and challenging cases, the book familiarizes readers with the various treatment options currently available. As such, it offers an invaluable practical guide for experienced endovascular specialists and beginners who need to treat patients with EVAR.

     

    Table of contents (5 chapters)

     

    Endoleak Classifications

    Pages 1-4

    Duvnjak, Stevo

    Endoleak Type I

    Pages 5-125

    Duvnjak, Stevo

    Endoleak Type II

    Pages 127-210

    Duvnjak, Stevo

    Endoleak Type III

    Pages 211-241

    Duvnjak, Stevo

    Endoleak Types IV and V

    Pages 243-252

    Duvnjak, Stevo

     

  • 1,95500lei 1620.00 lei

     

    Description:

    Master the information you need to know for practice and prepare for certification or recertification with a succinct, comprehensive account of the entire spectrum of imaging modalities and their clinical applications. Throughout six outstanding editions, Grainger and Allison’s Diagnostic Radiology has stood alone as the single comprehensive reference on general diagnostic radiology. Now in two succinct volumes, the 7th Edition of this landmark text continues to provide complete coverage of all currently available imaging techniques and their clinical applications - the essential information you need to succeed in examinations and understand current best practices in radiological diagnosis.

     

    Key Features:

    Organizes content along an organ and systems basis, covering all diagnostic imaging techniques in an integrated, correlative fashion, with a focus on the topics that matter most to a trainee radiologist in the initial years of training.

    Contains more than 4,000 high-quality illustrations that enhance and clarify the text.

    Features an expanded section on cardiac imaging to reflect major developments in cardiac MRI, including 3D ultrasound, PET, and SPECT.

    Integrates functional and molecular imaging throughout each section, and includes the latest image-guided biopsy and ablation techniques.

    Provides an ideal resource for written, oral, and re-certifying board study as well as for a clinical practice refresher on topics that may have been forgotten.

    Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.


    Table Of Contents:

    Chest and Cardiovascular System

    Abdominal Imaging

    Musculoskeletal System

    Spine

    Neuroimaging

    Oncological Imaging

    Paediatric Imaging

    Interventional Radiology

     

     

  • 1470.00 lei

     

    Book Description

     

    This book provides comprehensive coverage of the anatomical and physiological aspects of complex colorectal and pelvic malformations. Also described are the surgical protocols for this specialized field within pediatric surgery. The benefits of high-level collaboration between surgical services when treating these anomalies are explained, as are treatment algorithms and care of complications.

    ·         Includes evaluation and management of the newborn

    ·         Describes surgical interventions of the newborn, and when a primary repair versus a staged approach is required 

    ·         Explains the value of laparoscopy and deciding in which cases to use it 

    ·         Looks at the importance of a transition program to adulthood

    Pediatric surgeons worldwide and the teams in which they work will benefit from this well illustrated and comprehensive work.


    Table of Contents

    Editors

    Contributors

    Where are we in pediatric colorectal and pelvic reconstructive surgery? New insights and the future

    1. Pediatric colorectal and reconstructive surgery: Fundamentals of surgical preparation

    Rebecca M. Rentea and Andrea S. Wagner

    2. Basic anatomic principles of pediatric colorectal and reconstructive surgery

    Rebecca M. Rentea

    3. Anorectal malformations: The newborn period

    Sabine Sarnacki, Sebastian King, and Wilfried Krois

    4. Anorectal malformation: Definitive repair and surgical protocol

    Belinda Dickie, Taiwo Lawal, and Paola Midrio

    5. Cloaca: Important steps and decision-making for pre- and post-definitive repair

    Richard J. Wood, Ivo de Blaauw, and D. Gregory Bates

    6. Cloaca: Definitive repair and surgical protocol

    Richard J. Wood, Carlos A. Reck-Burneo, and Marc A. Levitt

    7. Long-term urologic and gynecologic follow-up in anorectal anomalies: The keys to success

    Geri Hewitt, Daniel G. DaJusta, and Christina B. Ching

    8. A patient with an anorectal malformation who has been previously repaired and who is "not doing well"

    Victoria Lane and Jeffrey Avansino

    9. Neonatal diagnosis of Hirschsprung disease

    Martin Lacher and Duarte Vaz Pimentel

    10. Hirschsprung disease: Definitive repair with transanal pull-through

    Jacob C. Langer, Chris Westgarth-Taylor, Victor Etwire, and Stuart Hosie

    11. Total colonic Hirschsprung disease: Ileo-Duhamel

    Jonathan H. Sutcliffe, Alejandra Vilanova-Sánchez, and Jacob C. Langer

    12. Total colonic Hirschsprung: Pre- and postoperative care

    Alejandra Vilanova-Sánchez, Carlos A. Reck-Burneo, and Brenda Ruth

    13. The post pull-through Hirschsprung patient who is not doing well with obstructive or incontinence symptoms

    Jacob C. Langer and Marc A. Levitt

    14. Long-term outcomes of anorectal malformations and Hirschsprung disease

    Tomas Wester, Mikko Pakarinen, and Risto Rintala

    15. Antegrade access as an adjunct to bowel management: Appendicostomy and neoappendicostomy

    Rebecca M. Rentea, Devin R. Halleran, and Alejandra Vilanova-Sánchez

    16. Severe functional constipation: Surgery and gastroenterologic collaboration

    Peter L. Lu, Desalegn Yacob, and Carlo Di Lorenzo

    17. Colonic resection in children with colonic dysmotility

    Karen A. Diefenbach, Desalegn Yacob, Rita D. Shelby, and Richard J. Wood

    18. Importance of collaboration in pelvic reconstruction: How to avoid complications and extra interventions

    Molly E. Fuchs, Kate McCracken, and Daniel G. DaJusta

    19. Bowel management

    Michael D. Rollins and Onnalisa Nash

    20. Evaluation of continence in children with Hirschsprung disease and anorectal malformation

    Michael D. Rollins, Richard J. Wood, and Victoria Lane

    21. Minor anal pathology: Rectal prolapse, perianal abscesses, hemorrhoids, anal fissures, and pilonidal disease

    Caitlin A. Smith, Alessandra C. Gasior, and Devin R. Halleran

    22. Familial adenomatous polyposis

    Alessandra C. Gasior and Mark Arnold

    23. Ulcerative colitis and indeterminate colitis in children

    Alessandra C. Gasior and Ross Maltz

    24. Crohn’s disease in children

    Alessandra C. Gasior and Jennifer L. Dotson

    25. Pediatric colorectal surgery in low- and middle-income settings: Adaptation to the resources available

    Chris Westgarth-Taylor and Marion Arnold

    26. Transitional care in colorectal and pelvic reconstruction surgery

    Alessandra C. Gasior

    27. Operative reports of the most common procedures in pediatric colorectal surgery: Key steps

    Alejandra Vilanova-Sánchez, Giulia Brisighelli, and Carlos A. Reck-Burneo

    28. Tracking operative results and outcomes

    Laura Weaver and Devin R. Halleran

    29. Patient education

    Meghan Fisher, Stephanie Vyrostek, and Kristina Booth

    30. Resources for families and the burden of therapy

    Greg Ryan, Lori Parker, and Sarah Driesbach

    31. Creating a collaborative program

    Jeffrey Avansino, Robert Dyckes, Dennis Minzler, and Julie Choueiki

    Index

     

     

  • Werner & Ingbar's The Thyroid
    La comanda in aproximativ 4 saptamani
    1,54600lei 1330.00 lei

     

    Through ten outstanding editions, Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text has been the go-to reference for the most comprehensive coverage of the thyroid, including anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. Now in full color throughout, the 11th Edition of this award-winning text remains the clinician’s preferred source of authoritative information on the thyroid—an essential resource for all endocrinologists and thyroid surgeons.

    • Includes thorough updates and new content throughout the text, especially on thyroid cytopathology, thyroid imaging, and targeted therapy of thyroid cancer as well as a new full-color format.
    • Covers all aspects of the thyroid, including thyroid hormone synthesis and secretion, thyroid function, and disorders such as thyrotoxicosis, hypothyroidism, and cancer.
    • Discusses surgical management of thyroid cancer, thyroid disruptors, thyroid hormone analogs, thyroid dysfunction’s effects on other organ systems, the aging thyroid, subclinical hypothyroidism and hyperthyroidism, and thyroid disease in pregnancy.
    • Features insights from international experts, including new editor Dr. Peter Kopp of Northwestern University’s Feinberg School of Medicine.

    Enrich Your Ebook Reading Experience

    • Read directly on your preferred device(s), such as computer, tablet, or smartphone.
    • Easily convert to audiobook, powering your content with natural language text-to-speech.



    Table of Contents
    :

     

    Cover

    Title Page

    Copyright

    Dedication

    Contributors

    Preface to the Eleventh Edition

    Preface to the First Edition

    Contents

    Section I: The Normal Thyroid

    A. History, Development, Anatomy

    Chapter 1: The heritage of the thyroid: A brief history

    GOITER, CRETINISM, AND THE THYROID GLAND

    GOITER AND IODINE

    THYROTOXICOSIS

    HYPOTHYROIDISM AND THE RECOGNITION OF THYROID FUNCTION

    THERAPY OF HYPOTHYROIDISM

    DISCOVERY OF THE ACTIVE PRINCIPLE AND THERAPY OF HYPOTHYROIDISM

    SCREENING AND THERAPY OF CONGENITAL HYPOTHYROIDISM

    DISCOVERY OF CURRENT CONCEPTS OF THYROID HORMONE SYNTHESIS, TRANSPORT, AND ACTION

    AUTOIMMUNE ETIOLOGY OF GRAVES DISEASE AND HASHIMOTO THYROIDITIS

    THYROID CANCER

    OUTLOOK

    REFERENCES

    Chapter 2: Development and anatomy of the hypothalamic–pituitary–thyroid axis

    THE HYPOTHALAMIC–PITUITARY AXIS

    SIGNALING AND TRANSCRIPTIONAL MECHANISMS INVOLVED IN HYPOTHALAMUS ORGANOGENESIS

    SIGNALING AND TRANSCRIPTIONAL MECHANISMS INVOLVED IN PITUITARY ORGANOGENESIS

    THE THYROID GLAND

    THYROID BUD FORMATION

    THYROID MIGRATION

    THYROID FOLLICULOGENESIS

    DIFFERENTIATED THYROID FOLLICULAR CELLS

    HISTOLOGY AND STRUCTURE

    THYROID TRANSCRIPTION FACTORS

    OTHER TRANSCRIPTION FACTORS INVOLVED IN THYROID DEVELOPMENT

    IN VITRO GENERATION OF THYROID CELLS FROM PLURIPOTENT STEM CELLS

    MODELING THYROID BY TRANSCRIPTION FACTORS OVEREXPRESSION

    MODELING THYROID BY CHEMICAL PATHWAYS MANIPULATIONS

    CONCLUSIONS

    ACKNOWLEDGMENTS

    REFERENCES

    B. Thyroid Hormone Synthesis and Secretion

    Chapter 3: Thyroid hormone synthesis: Thyroid iodide transport

    IDENTIFICATION BY FUNCTIONAL EXPRESSION OF THE CDNA ENCODING RAT NIS

    THE NIS MOLECULE

    ISOLATION OF THE CDNA ENCODING HUMAN NIS (hNIS) AND ELUCIDATION OF THE GENOMIC ORGANIZATION OF hNIS

    NIS IN EXTRATHYROIDAL TISSUES

    NIS MECHANISM AND STOICHIOMETRY

    SUBSTRATE SPECIFICITY OF NIS

    NIS TRANSPORTS THE ENVIRONMENTAL POLLUTANT ClO4− WITH A 1 Na+:1 ClO4− STOICHIOMETRY

    IODIDE TRANSPORT DEFECT, A CONGENITAL CONDITION CAUSED BY MUTATIONS IN THE NIS (SLC5A5) GENE

    NIS KO MICE, A USEFUL MODEL FOR STUDYING MULTIPLE RAMIFICATIONS OF HYPOTHYROIDISM

    REGULATION OF NIS TRANSCRIPTION

    REGULATION OF NIS IN THE THYROID BY TSH

    REGULATION OF NIS BY I−

    REGULATION OF NIS BY A K+ CHANNEL

    NIS IN THYROID CANCER

    I− EFFLUX

    NIS IN BREAST CANCER

    IMPACT OF NIS ON PUBLIC HEALTH

    NIS GENE TRANSFER

    CONCLUDING REMARKS AND AVENUES FOR FUTURE INVESTIGATION

    REFERENCES

    Chapter 4: Thyroid hormone synthesis

    IODIDE UPTAKE INTO THE THYROID

    THE GENE AND PROTEIN STRUCTURE OF THE SODIUM/IODIDE SYMPORTER

    FUNCTIONAL CHARACTERIZATION OF THE SODIUM/IODIDE SYMPORTER

    REGULATION OF IODIDE UPTAKE AND SODIUM/IODIDE SYMPORTER FUNCTION AND EXPRESSION

    MUTATIONS IN THE SODIUM/IODIDE SYMPORTER GENE

    IODIDE EFFLUX FROM THE THYROID

    PENDRED SYNDROME AND PENDRIN (PDS/SLC26A4)

    PROTEIN STRUCTURE OF PENDRIN

    EXPRESSION AND REGULATION OF PENDRIN

    FUNCTIONAL CHARACTERIZATION OF PENDRIN

    GOITER AND THYROID DYSFUNCTION IN PENDRED SYNDROME

    ANOCTAMIN

    SLC26A7

    THYROGLOBULIN

    STRUCTURE OF THE THYROGLOBULIN GENE AND PROTEIN

    MUTATIONS IN THE THYROGLOBULIN GENE

    THYROID PEROXIDASE

    THE GENE AND PROTEIN STRUCTURE OF THYROID PEROXIDASE

    FUNCTIONAL CHARACTERIZATION OF THYROID PEROXIDASE

    EXPRESSION AND REGULATION OF THYROID PEROXIDASE

    MUTATIONS IN THYROID PEROXIDASE

    THE HYDROGEN PEROXIDE–GENERATING SYSTEM

    CLONING OF THE DUAL OXIDASE AND THE DUAL OXIDASE MATURATION FACTOR GENES

    THE PROTEIN STRUCTURE OF DUAL OXIDASES AND THE DUAL OXIDASE MATURATION FACTORS

    EXPRESSION AND REGULATION OF DUAL OXIDASES AND THE DUAL OXIDASE MATURATION FACTORS

    MECHANISM OF HYDROGEN PEROXIDE GENERATION

    REGULATION OF HYDROGEN PEROXIDE ACTIVITY

    GENETIC DEFECTS IN HYDROGEN PEROXIDE GENERATION

    IODINATION AND THYROID HORMONE SYNTHESIS

    OXIDATION OF THYROID PEROXIDASE TO COMPOUND I AND COMPOUND II

    OXIDATION OF IODIDE

    IODINATION AND COUPLING OF TYROSYL RESIDUES

    INHIBITION OF THYROID PEROXIDASE BY THIONAMIDE DRUGS

    CELLULAR UPTAKE AND PROTEOLYSIS OF THYROGLOBULIN

    SECRETION OF THYROID HORMONES

    DEHALOGENATION OF MONOIODOTYROSINE AND DIIODOTYROSINE

    IODOTYROSINE (IYD/DEHAL1) DEIODINASE GENE AND PROTEIN

    DEHALOGENASE DEFICIENCY

    REFERENCES

    C. Peripheral Thyroid Hormone Binding and Metabolism

    Chapter 5: Thyroid hormone transport proteins

    EVOLUTIONARY CONSIDERATIONS

    FUNCTIONS OF THBPs

    CLINICAL CONSIDERATIONS

    THYROID-BINDING GLOBULIN

    STRUCTURE AND FUNCTION

    PHYSIOLOGIC REGULATION OF TBG IN HUMANS

    PATHOLOGY

    HUMAN SERPINA7 GENE SEQUENCE VARIANTS AFFECTING TBG CONCENTRATION OR FUNCTION

    TRANSTHYRETIN

    STRUCTURE AND FUNCTION

    PHYSIOLOGIC REGULATION OF TTR IN HUMANS

    PATHOLOGY

    HUMAN TTR GENE SEQUENCE VARIANTS AFFECTING TTR CONCENTRATION OR FUNCTION

    DYSTRANSTHYRETINEMIC HYPERTHYROXINEMIA

    ALBUMIN

    STRUCTURE AND FUNCTION

    PATHOPHYSIOLOGY

    HUMAN ALB GENE VARIANTS AFFECTING ALB CONCENTRATION OR FUNCTION

    p.Arg242His

    OTHER SEQUENCE VARIANTS AT Arg242

    p.Arg246Ile

    T3 VARIANTS OF FDH

    MINOR CARRIERS

    CLINICAL IMPLICATIONS OF THBPs

    REFERENCES

    Chapter 6: Intracellular pathways of iodothyronine metabolism/implications of deiodination for thyroid hormone action

    STRUCTURE OF THE DEIODINASES

    TOPOLOGY AND SUBCELLULAR LOCALIZATION

    STRUCTURE–FUNCTION RELATIONSHIPS OF DEIODINASES AND MECHANISM OF DEIODINATION

    SPECIFIC PROPERTIES OF THE DEIODINASES

    TYPE 1 DEIODINASE

    TYPE 2 DEIODINASE

    TYPE 3 DEIODINASE

    NONDEIODINATIVE METABOLISM OF IODOTHYRONINES

    PHYSIOLOGIC ROLES OF THE SELENODEIODINASES

    DEIODINASES AND THE REGULATION OF T3 PRODUCTION

    ADAPTATION TO HYPOTHYROIDISM

    INTRACELLULAR TRIIODOTHYRONINE HOMEOSTASIS

    DEIODINASES AND REGULATION OF THYROTROPIN SECRETION

    DEIODINASES AND THE BIOLOGIC EFFECTS OF THYROID HORMONE

    DEIODINASES AND THE CENTRAL NERVOUS SYSTEM

    DEIODINASES AND THE SKELETON

    DEIODINASES AND METABOLISM

    DEVELOPMENTAL ROLES OF THE DEIODINASES

    MATERNAL–FETAL PHYSIOLOGY

    TRIIODOTHYRONINE MODULATION OF PLACENTAL THYROID HORMONE TRANSFER

    D3 EXPRESSION AND THE REQUIREMENT FOR THYROXINE IN NORMAL PREGNANCY

    THE DEIODINASES IN HUMAN PATHOPHYSIOLOGY

    NONTHYROIDAL ILLNESS

    CONSUMPTIVE HYPOTHYROIDISM

    DEIODINASES IN CANCER

    HYPERTHYROIDISM AND OVEREXPRESSION OF DEIODINASES

    DEIODINASES IN THE ISCHEMIC HEART

    DEIODINASES IN LUNG INJURY

    CONCLUSION

    ACKNOWLEDGMENT

    REFERENCES

    D. Thyroid Hormone Action

    Chapter 7: Intracellular actions by thyroid hormones

    THYROID HORMONE TRANSPORT AND METABOLISM

    TR-DEPENDENT SIGNALING OF TH WITH DIRECT BINDING TO DNA (TYPE 1)

    THYROID HORMONE RESPONSE ELEMENTS

    TRANSCRIPTIONAL REGULATION BY TRs

    THYROID HORMONE RECEPTOR–INTERACTING COREPRESSORS/BASAL REPRESSION

    THYROID HORMONE RECEPTOR–INTERACTING COACTIVATORS/TRANSCRIPTIONAL ACTIVATION

    NEGATIVE REGULATION BY TRs

    POSTTRANSLATIONAL MODIFICATION OF TR

    RESISTANCE TO TH

    THYROID HORMONE RECEPTOR ISOFORM KNOCKOUT AND KNOCKIN MICE

    TRANSCRIPTIONAL CASCADES

    TR-DEPENDENT SIGNALING OF TH WITH INDIRECT BINDING TO DNA (TYPE 2)

    TR-DEPENDENT SIGNALING OF TH WITHOUT DNA BINDING (TYPE 3)

    TR-INDEPENDENT TH SIGNALING (TYPE IV)

    TH ANALOGS, DISRUPTORS, AND METABOLITES

    SUMMARY

    REFERENCES

    Chapter 8: Thyroid hormone structure–function relationships

    THYROID HORMONE STRUCTURE, METABOLISM, AND ACTIVITY

    TR ACTIVATION BY NATURAL AND SYNTHETIC AGONISTS

    DEVELOPMENT OF SELECTIVE TR SUBTYPE AGONISTS

    STRUCTURE–FUNCTION RELATIONSHIPS AT TR MUTANTS—THE ISSUE OF TH RESISTANCE

    TR ANTAGONISM

    THYROID HORMONE INTERACTIONS WITH ALTERNATE RECEPTORS AND BINDING PROTEINS

    THYRONAMINES AND ANALOGS

    CONCLUSION

    REFERENCES

    E. Factors That Control Thyroid Function

    Chapter 9: Chemistry and biosynthesis of thyrotropin

    CHEMISTRY

    GENES ENCODING THE SUBUNITS OF THYROTROPIN

    CHROMOSOME LOCALIZATION

    STRUCTURE OF THE COMMON α-SUBUNIT GENE

    STRUCTURE OF THE THYROTROPIN-β–SUBUNIT GENE

    CENTRAL HYPOTHYROIDISM DUE TO THYROTROPIN-β–SUBUNIT GENE ABNORMALITIES

    PRETRANSLATIONAL REGULATION OF THYROTROPIN BIOSYNTHESIS

    NEGATIVE REGULATORS

    POSITIVE REGULATORS

    SUMMARY OF PRETRANSLATION REGULATION OF THE HUMAN COMMON α- AND TSH-β–SUBUNIT GENE EXPRESSION

    POSTTRANSLATIONAL PROCESSING OF THYROTROPIN

    IN VITRO TRANSLATION OF THYROTROPIN-β–SUBUNIT AND α-SUBUNIT MESSENGER RNA

    BIOSYNTHESIS OF THYROTROPIN IN INTACT CELLS

    PROCESSING OF HIGH-MANNOSE PRECURSOR OLIGOSACCHARIDES

    TERMINAL SULFATION AND SIALYLATION OF COMPLEX OLIGOSACCHARIDES

    DEVELOPMENTAL AND ENDOCRINE REGULATION OF THYROTROPIN GLYCOSYLATION

    BIOACTIVITY AND METABOLIC CLEARANCE OF THYROTROPIN

    THREE-DIMENSIONAL CONFORMATION OF THYROTROPIN

    RECOMBINANT HUMAN THYROTROPIN

    REFERENCES

    Chapter 10: The thyrotropin receptor

    THE STRUCTURE OF THE THYROTROPIN RECEPTOR

    THE THYROTROPIN RECEPTOR GENE

    RECOGNITION OF THE RECEPTOR BY THYROTROPIN

    PROPOSED MECHANISM OF ACTIVATION OF THE RECEPTOR BY TSH

    ACTIVATION BY THYROSTIMULIN

    ACTIVATION BY CHORIONIC GONADOTROPIN

    ACTIVATION BY THYROTROPIN-RECEPTOR ANTIBODIES

    ACTIVATION BY LOW–MOLECULAR-WEIGHT DRUG-LIKE CHEMICALS

    DOWNREGULATION OF THE THYROTROPIN RECEPTOR

    REFERENCES

    Chapter 11: Aging and the thyroid

    CHANGES IN THYROID ANATOMY WITH AGE

    PHYSIOLOGIC CHANGES IN THYROID FUNCTION WITH AGE

    CHALLENGES IN THE DIAGNOSIS AND MANAGEMENT OF THYROID DYSFUNCTION WITH AGE

    CHALLENGES IN THE DIAGNOSIS AND MANAGEMENT OF NODULAR DISEASE AND THYROID CANCER

    SUMMARY

    REFERENCES

    Chapter 12: Effects of drugs on TSH secretion, thyroid hormones’ absorption, synthesis, metabolism, and action

    INTRODUCTION

    DRUGS THAT ALTER SERUM TSH LEVELS (FIG. 12-1, PANEL 1)

    DOPAMINE/DOPAMINE AGONISTS AND ANTAGONISTS

    SOMATOSTATIN AND SOMATOSTATIN ANALOGS

    REXINOIDS

    OTHER DRUGS THAT SUPPRESS TSH SECRETION

    DRUGS THAT REDUCE THYROID HORMONE ABSORPTION

    BILE ACID SEQUESTRANTS

    FERROUS SULFATE

    SUCRALFATE AND ALUMINUM-CONTAINING ANTACIDS

    CALCIUM CARBONATE AND PHOSPHATE BINDERS

    OTHER MEDICATIONS THAT MAY REDUCE T4 INTESTINAL ABSORPTION

    DRUGS THAT REDUCE SYNTHESIS AND SECRETION OF THYROID HORMONES (FIG. 12-1, PANEL 2)

    THIONAMIDES (ANTITHYROID DRUGS)

    IONIC INHIBITORS (PERCHLORATE, THIOCYANATE; SEE Chapter 13 ON THYROID DISRUPTORS)

    LITHIUM

    DRUGS THAT ALTER THE METABOLISM OF THYROID HORMONES (FIGS. 12-1, PANEL 3 AND 12-2)

    DRUGS THAT INDUCE CYP3a (PHENYTOIN, CARBAMAZEPINE, PHENOBARBITAL, RIFAMPIN, RITONAVIR, SERTRALINE)

    DRUGS THAT INHIBIT THE DEIODINATION OF T4 AND T3

    PROPYLTHIOURACIL

    PROPRANOLOL AND NADOLOL

    DRUGS THAT ALTER THE TRANSPORT OR ACTION OF THYROID HORMONES (FIG. 12-1, PANEL 3)

    NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (SALICYLATES, SALSALATE, FENCLOFENAC)

    FUROSEMIDE

    HEPARIN AND FATTY ACIDS

    ESTROGEN AND SELECTIVE ESTROGEN MODULATORS (SERM) (TAMOXIFEN, RALOXIFENE)

    ANDROGENS

    OTHER DRUGS ALTERING TBG LEVELS

    DRUGS ACTING AT MULTIPLE SITES TO ALTER THYROID HORMONE HOMEOSTASIS

    IODINATED RADIOGRAPHIC CONTRAST AGENTS

    PHENYTOIN

    AMIODARONE

    GLUCOCORTICOIDS

    CYTOKINES (INTERFERON, INTERLEUKIN, AND TUMOR NECROSIS FACTOR)

    TYROSINE KINASE INHIBITORS

    DRUGS ALTERING THYROID FUNCTION THROUGH ALTERATIONS IN IMMUNITY

    IMMUNE RECONSTITUTION SYNDROME

    ANTI-CD52 ANTIBODY ALEMTUZUMAB

    CHECKPOINT INHIBITORS

    REFERENCES

    Chapter 13: Thyroid disruptors

    INTRODUCTION

    SUBSTANCES THAT INHIBIT THYROIDAL IODINE UPTAKE

    PERCHLORATE

    THIOCYANATE

    NITRATE

    COMPOUNDS WITH DIRECT ACTIONS ON THE THYROID HORMONE RECEPTOR

    POLYCHLORINATED BIPHENYLS

    POLYBROMINATED DIPHENYL ETHERS

    BISPHENOL-A AND PHTHALATES

    TRICLOSAN

    COMPOUNDS THAT DISPLACE T4 FROM SERUM THYROID BINDING PROTEINS

    PCBs AND PBDEs

    COMPOUNDS THAT INHIBIT THYROPEROXIDASE ACTIVITY

    ISOFLAVONES

    COMPOUNDS THAT DECREASE T4 HALF-LIFE BY ACTIVATING HEPATIC ENZYMES

    ORGANOCHLORINE PESTICIDES

    DIOXINS AND FURANS

    COMPOUNDS THAT INHIBIT DEIODINASE ACTIVITY

    OTHER EXPOSURES

    STYRENES

    PERFLUORINATED AND GEN X COMPOUNDS

    ORGANOPHOSPHATE PESTICIDES

    SUNSCREENS

    LEAD

    SUMMARY

    REFERENCES

    Chapter 14: Nonthyroidal illness syndrome

    INTRODUCTION

    DESCRIPTION OF NTIS

    CHANGES IN SERUM THYROID HORMONE AND THYROTROPIN CONCENTRATIONS

    CHANGES IN THYROID HORMONE KINETICS

    CHANGES IN THE HYPOTHALAMIC–PITUITARY–THYROID AXIS

    CHANGES IN PERIPHERAL THYROID HORMONE METABOLISM

    PATHOGENESIS OF NTIS

    PATHOGENESIS OF CHANGES IN THE HYPOTHALAMIC–PITUITARY–THYROID AXIS

    CHANGES IN HPT AXIS DURING FASTING

    CHANGES IN HPT AXIS DURING ILLNESS

    PATHOGENESIS OF CHANGES IN PERIPHERAL THYROID HORMONE METABOLISM

    CHANGES IN SERUM IODOTHYRONINE–BINDING PROTEINS

    CHANGES IN IODOTHYRONINE TRANSPORT INTO TISSUES

    CHANGES IN IODOTHYRONINE DEIODINASES

    CHANGES IN IODOTHYRONINE NUCLEAR RECEPTORS

    CLINICAL RELEVANCE OF NTIS

    PROGNOSTIC IMPORTANCE OF NTIS

    DIAGNOSIS OF THYROID DISEASE IN NTIS

    TREATMENT OF PATIENTS WITH NTIS

    SPECIFIC TYPES OF NTIS

    CHRONIC RENAL FAILURE

    LIVER DISEASE

    HUMAN IMMUNODEFICIENCY VIRUS INFECTION

    PSYCHIATRIC DISEASE

    CONCLUSION

    REFERENCES

    Chapter 15: Iodine deficiency and excess, endemic cretinism

    INTRODUCTION

    THE ECOLOGY OF IODINE

    DIETARY SOURCES, ABSORPTION, AND METABOLISM OF IODINE

    GOITROGENS

    IODINE REQUIREMENTS

    ADULTHOOD

    PREGNANCY AND LACTATION

    INFANCY AND CHILDHOOD

    ASSESSMENT OF IODINE DEFICIENCY

    URINARY IODINE CONCENTRATION

    BREAST MILK IODINE CONCENTRATION

    THYROID SIZE

    THYROID-STIMULATING HORMONE AND THYROID HORMONES

    THYROGLOBULIN

    EFFECTS OF IODINE DEFICIENCY

    THYROIDAL ADAPTATION TO IODINE DEFICIENCY

    EFFECTS OF HYPOTHYROIDISM DUE TO IODINE DEFICIENCY ON THE DEVELOPING BRAIN

    CRETINISM

    THE BENEFITS OF CORRECTION OF IODINE DEFICIENCY

    IODINE INTERVENTIONS IN SEVERELY DEFICIENT PREGNANT WOMEN

    IODINE INTERVENTIONS IN MILD TO MODERATELY DEFICIENT PREGNANT WOMEN

    INFANCY

    CHILDHOOD

    ADULTHOOD

    THYROID CANCER

    EPIDEMIOLOGY

    TREATMENT AND PREVENTION

    SALT FORTIFICATION WITH IODINE

    IODINE SUPPLEMENTATION

    EFFECTS OF EXCESS IODIDE

    PHYSIOLOGIC RESPONSE TO EXCESS IODIDE

    TOLERABLE UPPER LIMITS FOR IODINE INTAKE

    MONITORING OF IODINE EXCESS IN POPULATIONS

    SOURCES OF EXCESS IODIDE

    IODINE-INDUCED HYPOTHYROIDISM OR GOITER IN THE ABSENCE OF APPARENT UNDERLYING THYROID DISEASE

    IODINE AND THYROIDITIS

    IODINE-INDUCED THYROTOXICOSIS

    AMIODARONE-INDUCED THYROID DISEASE (SEE Chapter 11)

    REFERENCES

    Section II: Assessment of Thyroid Structure and Function

    Chapter 16: Physical examination of the thyroid gland

    HISTORY

    PHYSICAL EXAMINATION

    INSPECTION

    PALPATION

    FACING THE PATIENT

    STANDING BEHIND THE PATIENT

    AUSCULTATION

    PALPATING LOBES AND EVALUATING THYROID SIZE

    THYROID NODULES

    HEMIAGENESIS

    CONSISTENCY

    PAIN/TENDERNESS

    LYMPHADENOPATHY

    DISTINGUISHING BENIGN FROM MALIGNANT DISEASE

    REFERENCES

    Chapter 17: Laboratory measurement of thyroid-related hormones, proteins, and autoantibodies in serum

    INTRODUCTION

    NOMENCLATURE FOR SENSITIVITY AND ASSESSMENT OF ASSAYS

    FUNCTIONAL VERSUS ANALYTICAL SENSITIVITY OF ASSAYS

    THYROID-STIMULATING HORMONE

    METHODS FOR SERUM TSH MEASUREMENTS

    REQUIREMENTS FOR SERUM TSH MEASUREMENTS

    TSH ISOFORMS

    INDICATIONS FOR TRH TESTING

    TSH REFERENCE INTERVALS

    THE CLINICAL UTILITY OF TSH MEASUREMENT

    TSH AND THYROID FUNCTION ASSESSMENT IN PREGNANCY (SEE Chapter 66)

    HOSPITALIZED PATIENTS

    THYROID HORMONE MEASUREMENTS

    SERUM TOTAL THYROID HORMONE (TT4 AND TT3) ASSAY METHODOLOGY

    CLINICAL UTILITY OF TT4 AND TT3 MEASUREMENTS

    TT4 AND TT3 REFERENCE INTERVALS

    SERUM FREE THYROID HORMONE TESTS (FT4 AND FT3)

    DIRECT FT4 AND FT3 METHODS

    INDIRECT FT4 AND FT3 ESTIMATE TESTS

    SERUM-FREE THYROXINE AND FREE TRIIODOTHYRONINE INDEXES

    THYROID HORMONE–BINDING PROTEINS

    FAMILIAL DYSALBUMINEMIC AND TRANSTHYRETIN-ASSOCIATED HYPERTHYROXINEMIAS

    SERUM THYROGLOBULIN (Tg)

    REQUIREMENTS FOR SERUM Tg METHODS

    FACTORS THAT INFLUENCE CIRCULATING Tg CONCENTRATIONS

    ANALYTICAL AND TECHNICAL CONSIDERATION

    THYROID-SPECIFIC AUTOANTIBODIES

    ANTI–TSH RECEPTOR AUTOANTIBODIES

    ANTITHYROID PEROXIDASE AUTOANTIBODIES

    ANTITHYROGLOBULIN AUTOANTIBODIES

    INTERFERENCES WITH THYROID TEST OUTCOMES

    INTERFERENCES WITH THYROID MEASUREMENT METHODOLOGIES

    ASSAY INTERFERENCES

    AUTOMATION OF THYROID TESTS

    REFERENCES

    Chapter 18: Nonisotopic thyroid imaging

    INTRODUCTION

    PLAIN RADIOGRAPHY

    ULTRASONOGRAPHY

    BASIC PHYSICS AND TECHNICAL PRINCIPLES (1)

    CONDUCTING THE EXAMINATION

    CLINICAL APPLICATIONS

    DEVELOPMENTAL ABNORMALITIES

    THE NORMAL THYROID GLAND

    GOITER

    DIFFUSE NONNEOPLASTIC THYROID DISEASES

    NODULES AND MULTINODULAR GOITER

    INTERVENTIONAL PROCEDURES

    COMPUTED TOMOGRAPHY

    BASIC PHYSICS PRINCIPLES (22)

    THE NORMAL THYROID GLAND

    DIFFUSE THYROID DISEASE

    INCIDENTALOMAS

    CT IN LARGE BENIGN GOITERS

    ECTOPIC THYROID TISSUE

    CT AND PREOPERATIVE PLANNING OF THYROID CARCINOMAS, LYMPHOMAS, AND METASTASIS

    CT AND FOLLOW-UP OF THYROID CARCINOMAS

    MAGNETIC RESONANCE IMAGING

    BASIC PHYSICS PRINCIPLES (41)

    NORMAL THYROID TISSUE

    DIFFUSE THYROID DISEASE

    THYROID INCIDENTALOMAS AND NODULE CHARACTERIZATION

    PREOPERATIVE PLANNING OF THYROID CARCINOMAS: ASSESSING INVASION (48)

    FOLLOW-UP OF THYROID CARCINOMAS

    CONCLUSION

    REFERENCES

    Chapter 19: Thyroid radionuclide uptake and imaging studies

    INTRODUCTION

    RADIOPHARMACEUTICALS

    MODALITIES

    RADIOIODINE

    UPTAKE STUDIES

    PLANAR IMAGING: HYPERTHYROIDISM

    PLANAR IMAGING: THYROID CANCER

    TOMOGRAPHY

    DOSIMETRY

    FDG PET/CT IN THYROID CANCER

    FDG PET/CT IN INCIDENTAL THYROID DISEASE

    IMAGING OF MEDULLARY THYROID CANCER

    CONCLUSIONS

    REFERENCES

    Chapter 20: Cytopathology of the thyroid gland

    INTRODUCTION

    SPECIMEN PREPARATIONS

    THYROID FNA CLASSIFICATION

    NONDIAGNOSTIC OR UNSATISFACTORY (CATEGORY I)

    BENIGN (CATEGORY II)

    ATYPIA OF UNDETERMINED SIGNIFICANCE/FOLLICULAR LESION OF UNDETERMINED SIGNIFICANCE (AUS/FLUS) (CATEGORY III)

    FOLLICULAR OR ONCOCYTIC (HüRTHLE-CELL) NEOPLASM OR SUSPICIOUS FOR FOLLICULAR OR ONCOCYTIC (HüRTHLE-CELL) NEOPLASM (CATEGORY IV)

    SUSPICIOUS FOR MALIGNANCY (CATEGORY V)

    MALIGNANT (CATEGORY VI)

    CORE NEEDLE BIOPSY

    KEY CYTOMORPHOLOGIC FEATURES OF THYROID FINE-NEEDLE ASPIRATION DIAGNOSES

    DIFFUSE TOXIC GOITER

    CHRONIC LYMPHOCYTIC THYROIDITIS (11,15)

    ATYPIA OF UNDETERMINED SIGNIFICANCE/FOLLICULAR LESION OF UNDETERMINED SIGNIFICANCE (AUS/FLUS)

    SUSPICIOUS FOR FOLLICULAR NEOPLASM/FOLLICULAR NEOPLASM (INCLUDING TUMORS WITH ONCOCYTIC FEATURES)

    MALIGNANT LESIONS

    PAPILLARY THYROID CARCINOMA AND ITS VARIANTS

    MEDULLARY THYROID CARCINOMA

    POORLY DIFFERENTIATED CARCINOMA

    ANAPLASTIC CARCINOMA

    ROLE OF ANCILLARY STUDIES IN THE DIAGNOSIS OF THYROID TUMORS IN CYTOLOGIC SPECIMENS’ IMMUNOHISTOCHEMISTRY

    REFERENCES

    Chapter 21: Histopathology of the thyroid gland

    NORMAL THYROID

    PATHOLOGIC DIAGNOSIS OF THYROID LESIONS

    DEVELOPMENTAL VARIATIONS

    GOITER

    GRAVES DISEASE/DIFFUSE TOXIC GOITER

    DYSHORMONOGENETIC GOITER

    IATROGENIC AND RELATED HYPERPLASIAS

    AUTOIMMUNE THYROIDITIS

    SILENT THYROIDITIS

    SPECIFIC INFECTIOUS THYROIDITIS

    GRANULOMATOUS THYROIDITIS

    PALPATION THYROIDITIS

    AMIODARONE INJURY WITH THYROTOXICOSIS

    RIEDEL THYROIDITIS (AKA RIEDEL STRUMA)

    COMBINED RIEDEL STRUMA AND FIBROSING HASHIMOTO THYROIDITIS

    MISCELLANEOUS DISORDERS

    RADIATION EFFECTS

    AMYLOIDOSIS

    BLACK THYROID

    NEOPLASMS

    BENIGN NEOPLASMS

    ADENOMAS AND ADENOMATOUS NODULES

    MALIGNANT NEOPLASMS

    PAPILLARY CARCINOMA

    FOLLICULAR CARCINOMA

    HÜRTHLE-CELL NEOPLASM/ONCOCYTIC FOLLICULAR NEOPLASM

    PATHOLOGIC DIAGNOSIS OF PAPILLARY AND FOLLICULAR CARCINOMA OF THYROID: CONTROVERSIES

    CLEAR CELL TUMORS

    HIGH-GRADE THYROID CARCINOMA

    POORLY DIFFERENTIATED THYROID CARCINOMA

    ANAPLASTIC CARCINOMA

    SQUAMOUS CELL CARCINOMA, MUCOEPIDERMOID CARCINOMA, AND INTRATHYROIDAL THYMOMA-LIKE NEOPLASMS

    MEDULLARY THYROID CARCINOMA

    CALCITONIN NEGATIVE NEUROENDOCRINE CARCINOMA OF THYROID

    LYMPHOMA

    SARCOMA

    CARCINOMA IN ECTOPIC THYROID TISSUE

    METASTATIC NEOPLASMS

    REFERENCES

    Section III: Thyroid Diseases: Thyrotoxicosis

    A. Causes of Thyrotoxicosis

    Chapter 22: Pathogenesis of Graves disease

    INTRODUCTION

    AUTOIMMUNITY

    DEFINITION OF AN AUTOANTIGEN

    THE NATURE OF T CELLS

    ANTIBODY AND T-CELL INTERACTIONS WITH ANTIGEN

    SECOND SIGNALS

    CRITERIA FOR AN AUTOIMMUNE DISEASE

    RESTRICTION VERSUS POLYCLONALITY

    THYROID IMMUNOLOGY

    INTRATHYROIDAL B CELLS

    AUTOANTIBODIES TO THE HUMAN TSHR

    BIOACTIVITY OF TSHR ANTIBODIES

    PREVALENCE OF TSHR ANTIBODIES IN GRAVES DISEASE

    IMMUNOLOGIC CHARACTERISTICS OF TSHR ANTIBODIES

    TSHR FUNCTION IN GRAVES DISEASE

    LESSONS FROM MONOCLONAL TSHR ANTIBODIES WITH STIMULATING ACTIVITY

    OTHER THYROID ANTIBODIES IN GRAVES DISEASE

    THE INTRATHYROIDAL LYMPHOCYTIC INFILTRATE

    FUNCTIONAL ANALYSIS OF INTRATHYROIDAL T CELLS

    T-CELL SELECTION

    APOPTOSIS IN GRAVES DISEASE

    THE INTRATHYROIDAL T-CELL RECEPTOR V GENE REPERTOIRE

    REGULATORY EFFECTS OF T CELLS IN AUTOIMMUNE THYROID DISEASE

    THE Th17 CELLS

    IMMUNE MECHANISMS IN THE PATHOGENESIS OF GRAVES DISEASE

    FAILURE OF IMMUNE CELL DELETION AND/OR SUPPRESSION

    SPECIFICITY CROSSOVER (MOLECULAR MIMICRY)

    BYSTANDER EFFECTS

    EPIGENETIC CHANGES

    THYROID CELL EXPRESSION OF HLA MOLECULES

    ANIMAL MODELS OF GRAVES DISEASE

    KNOWN RISK FACTORS FOR PRECIPITATING GRAVES DISEASE (TABLE 22-5)

    SUSCEPTIBILITY GENES

    INFECTION

    THYROID AUTOANTIBODIES

    THYROID TISSUE DAMAGE

    STRESS

    SEX STEROIDS

    THE X CHROMOSOME

    THE POSTPARTUM PERIOD

    MATERNAL MICROCHIMERISM

    IODINE

    IRRADIATION

    OVERVIEW OF THE ETIOLOGY OF GRAVES DISEASE

    REFERENCES

    Chapter 23: Thyrotropin-induced thyrotoxicosis

    INTRODUCTION

    EPIDEMIOLOGY

    PATHOLOGIC AND PATHOGENIC ASPECTS

    SIGNS AND SYMPTOMS

    LABORATORY AND BIOCHEMICAL FEATURES

    SERUM THYROTROPIN AND THYROID HORMONE LEVELS

    PITUITARY GLYCOPROTEIN HORMONE α-SUBUNIT

    PARAMETERS OF PERIPHERAL THYROID HORMONE ACTION

    DIAGNOSTIC TESTING

    IMAGING STUDIES AND LOCALIZATION

    DIFFERENTIAL DIAGNOSIS

    TREATMENT AND OUTCOME

    CRITERIA OF CURE AND FOLLOW-UP

    REFERENCES

    Chapter 24: Toxic adenoma and toxic multinodular goiter

    EPIDEMIOLOGY

    CLINICAL ASPECTS OF THYROID AUTONOMY

    DIAGNOSIS OF THYROID AUTONOMY

    NATURAL HISTORY

    MORPHOLOGY

    ETIOLOGY

    LESSONS FROM EPIDEMIOLOGIC STUDIES

    FROM HYPERPLASTIC GROWTH TO NODULAR TRANSFORMATION

    TRANSFORMATION TO HOT THYROID NODULES

    TREATMENT OF AUTONOMOUS THYROID NODULES (SEE CHAPTER 32)

    SURGERY

    RADIOIODINE THERAPY

    COST-EFFECTIVE MANAGEMENT OF THYROID AUTONOMY

    FOLLOW-UP

    ACKNOWLEDGMENT

    REFERENCES

    Chapter 25: Trophoblastic tumors

    INTRODUCTION

    HUMAN CHORIONIC GONADOTROPIN

    GRADATIONS OF SEVERITY

    CLINICAL FEATURES

    DIAGNOSIS

    HYPEREMESIS GRAVIDARUM

    MUTANT THYROID-STIMULATING HORMONE RECEPTOR

    THERAPY

    REFERENCES

    Chapter 26: Sporadic painless, painful subacute and acute infectious thyroiditis

    INTRODUCTION

    DESTRUCTION-INDUCED THYROIDITIS

    PAINFUL THYROID

    SPORADIC PAINLESS THYROIDITIS

    ETIOLOGY

    CLINICAL MANIFESTATIONS

    LABORATORY FINDINGS

    CYTOLOGY

    IMAGING

    PATHOLOGY

    DIFFERENTIAL DIAGNOSIS

    CLINICAL MANAGEMENT

    SUBACUTE THYROIDITIS

    ETIOLOGY

    INFECTIOUS ASSOCIATION

    AUTOIMMUNE ASSOCIATION

    GENETIC ASSOCIATION

    CLINICAL MANIFESTATIONS

    LABORATORY FINDINGS

    CYTOLOGY

    IMAGING

    PATHOLOGY

    DIFFERENTIAL DIAGNOSIS

    CLINICAL MANAGEMENT

    ACUTE INFECTIOUS THYROIDITIS

    ETIOLOGY

    BACTERIAL INFECTIONS

    FUNGAL INFECTIONS

    MYCOBACTERIAL INFECTIONS

    PARASITIC INFECTIONS

    SYPHILITIC INFECTIONS

    THYROIDAL INFECTIONS IN IMMUNOCOMPROMISED PATIENTS

    CLINICAL MANIFESTATIONS

    LABORATORY FINDINGS

    CYTOLOGY

    IMAGING STUDIES

    CLINICAL MANAGEMENT

    REFERENCES

    Chapter 27: Thyrotoxicosis of extrathyroidal origin

    INTRODUCTION

    EXOGENOUS THYROID HORMONE

    CAUSES

    CLINICAL PRESENTATION AND DIAGNOSIS

    TREATMENT

    THYROTOXICOSIS DUE TO METASTATIC THYROID CARCINOMA

    DEFINITION AND EPIDEMIOLOGY

    CLINICAL PRESENTATION AND DIAGNOSIS

    TREATMENT

    STRUMA OVARII

    DEFINITION AND EPIDEMIOLOGY

    CLINICAL PRESENTATION AND DIAGNOSIS

    TREATMENT

    ACKNOWLEDGMENT

    REFERENCES

    B. Organ System Manifestations

    Chapter 28: Overview of the clinical manifestations of thyrotoxicosis

    INTRODUCTION

    PREVALENCE OF CLINICAL FINDINGS

    ORGAN SYSTEM–SPECIFIC MANIFESTATIONS

    CENTRAL NERVOUS SYSTEM

    BEHAVIORAL HEALTH MANIFESTATIONS

    CARDIOVASCULAR MANIFESTATIONS

    PULMONARY MANIFESTATIONS

    GASTROINTESTINAL MANIFESTATIONS

    RENAL MANIFESTATIONS

    INTEGUMENTARY FINDINGS

    MUSCULOSKELETAL MANIFESTATIONS

    REPRODUCTIVE CHANGES

    HEMATOLOGIC MANIFESTATIONS

    MODULATING FACTORS

    AGE

    PREGNANCY

    COMORBIDITY

    ETIOLOGY OF THYROTOXICOSIS

    CLINICAL ASSESSMENT

    REFERENCES

    Chapter 29: Ophthalmopathy

    INTRODUCTION

    EPIDEMIOLOGY AND NATURAL HISTORY

    PATHOGENESIS

    RISK FACTORS AND PREVENTION

    CLINICAL PRESENTATION

    DIAGNOSIS

    TREATMENT OF HYPERTHYROIDISM IN PATIENTS WITH GO

    MANAGEMENT OF GO

    CONCLUSIONS

    REFERENCES

    Chapter 30: The cardiovascular system in thyrotoxicosis

    THYROID HORMONE ACTION ON THE HEART AND VASCULAR SYSTEM

    CLINICAL CONSEQUENCES OF THYROTOXICOSIS

    CARDIOVASCULAR SYMPTOMS AND SIGNS IN THYROTOXICOSIS

    ATRIAL FIBRILLATION

    ELECTROCARDIOGRAPHIC CHANGES

    HEART FAILURE

    HYPERTENSION AND VASCULAR DYSFUNCTION

    MAJOR ADVERSE CARDIOVASCULAR EVENTS

    ROLE OF OTHER HORMONES IN THYROTOXICOSIS

    SUBCLINICAL THYROTOXICOSIS

    AMIODARONE AND IODINE CONTAINING CONTRAST AGENTS

    REFERENCES

    Chapter 31: Thyroid hormones in intermediary metabolism, thermogenesis, and obesity

    THYROID HORMONE SIGNALING, TISSUE- AND TARGET GENE–SPECIFICITY IN RELATION TO INTERMEDIARY AND ENERGY METABOLISM

    THYROID HORMONE ACTION ON INTERMEDIARY METABOLISM

    CARBOHYDRATE METABOLISM

    CLINICAL CORRELATES

    PROTEIN METABOLISM

    CLINICAL CORRELATES

    LIPID METABOLISM

    CLINICAL CORRELATES

    THYROID HORMONE ACTION ON ENERGY METABOLISM

    THYROID HORMONE ACTION ON RESTING ENERGY EXPENDITURE

    THYROID HORMONE ACTION ON ADAPTIVE THERMOGENESIS

    THYROID HORMONE ACTION ON ACTIVITY-RELATED ENERGY EXPENDITURE

    THYROID HORMONE ACTION ON THERMIC EFFECT OF FOOD

    ENERGY STATUS AND THYROID HORMONE HOMEOSTASIS

    CLINICAL CORRELATES

    POTENTIAL USE OF THYROID HORMONE AS TREATMENT FOR WEIGHT LOSS AND DYSLIPIDEMIA

    CONCLUSIONS

    ACKNOWLEDGMENTS

    REFERENCES

    Chapter 32: The skeletal system in thyrotoxicosis

    REGULATION OF THYROID STATUS

    CONTROL OF INTRACELLULAR T3 AVAILABILITY

    MECHANISM OF THYROID HORMONE ACTION

    ROLE OF TSH IN BONE

    BONE REMODELING CYCLE

    SKELETAL CONSEQUENCES OF CHILDHOOD THYROTOXICOSIS

    SKELETAL EFFECTS OF THYROID HORMONES IN ADULTS

    POPULATION STUDIES IN NORMAL EUTHYROID INDIVIDUALS

    STUDIES OF ADULT THYROTOXICOSIS

    EFFECTS OF TREATMENT FOR THYROTOXICOSIS

    SUBCLINICAL HYPERTHYROIDISM

    PATIENTS TREATED WITH SUPPRESSIVE DOSES OF THYROXINE

    REFERENCES

    Chapter 33: Thyroid dermopathy and thyroid acropachy

    THYROID DERMOPATHY

    HISTOLOGIC FINDINGS IN THYROID DERMOPATHY

    CLINICAL MANIFESTATIONS

    PATHOGENESIS

    DIFFERENTIAL DIAGNOSIS

    TREATMENT

    OUTCOMES OF THERAPY OF THYROID DERMOPATHY

    FUTURE DIRECTIONS FOR THERAPY

    THYROID ACROPACHY

    REFERENCES

    Chapter 34: Psychiatric and cognitive effects of thyrotoxicosis

    INTRODUCTION

    NEUROPSYCHIATRIC MANIFESTATIONS OF OVERT THYROTOXICOSIS

    COGNITIVE MANIFESTATIONS OF OVERT THYROTOXICOSIS

    SUBCLINICAL THYROTOXICOSIS: NEUROPSYCHIATRIC AND COGNITIVE ASPECTS

    DIFFERENTIAL DIAGNOSIS: BEHAVIORAL SYNDROMES THAT MAY MIMIC THYROTOXICOSIS

    PSYCHOLOGICAL FACTORS IN THE PATHOPHYSIOLOGY OF THYROTOXICOSIS

    TREATMENT OF THYROTOXICOSIS: NEUROPSYCHIATRIC ASPECTS

    POSSIBLE LINK BETWEEN THYROID HORMONE AND ATTENTION DEFICIT/HYPERACTIVITY DISORDER

    USE OF THYROID HORMONE IN AFFECTIVE DISORDERS

    LITHIUM AND THYROID FUNCTION

    REFERENCES

    Chapter 35: Thyrotoxic storm

    CLINICAL FEATURES

    LABORATORY FINDINGS

    PATHOGENESIS

    TREATMENT

    THERAPY TO REDUCE THYROID HORMONE SYNTHESIS AND SECRETION

    THERAPY DIRECTED AGAINST SYSTEMIC DISTURBANCES

    THERAPY DIRECTED AGAINST THE PERIPHERAL ACTIONS OF THYROID HORMONE

    THERAPY DIRECTED AGAINST PRECIPITATING ILLNESS

    REFERENCES

    C. Diagnosis and Management of Thyrotoxicosis

    Chapter 36: Diagnosis of thyrotoxicosis

    INTRODUCTION

    CLINICAL DIAGNOSIS

    CLUES FROM ROUTINE LABORATORY TESTS

    LABORATORY TESTING FOR THYROTOXICOSIS

    SERUM THYROXINE DETERMINATIONS

    SERUM TRIIODOTHYRONINE DETERMINATIONS

    SERUM THYROTROPIN DETERMINATIONS

    SCREENING, CASE FINDING, AND DIAGNOSIS

    DIAGNOSING THE CAUSE OF THYROTOXICOSIS

    REFERENCES

    Chapter 37: Treatment of thyrotoxicosis

    INTRODUCTION

    THYROTOXICOSIS CAUSED BY GRAVES DISEASE

    DRUG THERAPY OF THYROTOXICOSIS CAUSED BY GRAVES DISEASE

    ANTITHYROID DRUGS (Fig. 37-1)

    MECHANISMS OF ACTION

    INTRATHYROIDAL ACTIONS

    EXTRATHYROIDAL ACTIONS

    EFFECTS ON THE IMMUNE SYSTEM

    CLINICAL PHARMACOLOGY OF THE ANTITHYROID DRUGS

    METHIMAZOLE

    PROPYLTHIOURACIL

    CLINICAL CONSIDERATIONS IN THE USE OF ANTITHYROID DRUGS

    SIDE EFFECTS OF ANTITHYROID DRUGS

    FOLLOW-UP OF PATIENTS TAKING AN ANTITHYROID DRUG FOR GRAVES DISEASE

    REMISSIONS AND ANTITHYROID DRUG THERAPY

    THERAPY FACTORS RELATING TO REMISSION OF GRAVES DISEASE

    DISCONTINUATION OF ANTITHYROID DRUG THERAPY

    OTHER DRUGS USED IN THE TREATMENT OF THYROTOXICOSIS CAUSED BY GRAVES DISEASE

    INORGANIC IODIDE

    ORAL CHOLECYSTOGRAPHIC AGENTS

    β-ADRENERGIC ANTAGONIST DRUGS

    RADIOACTIVE IODINE THERAPY FOR THYROTOXICOSIS (Fig. 37-1)

    PRACTICAL THERAPEUTIC CONSIDERATIONS

    COMPLICATIONS AND POTENTIAL RISKS OF RADIOIODINE THERAPY

    POSTRADIOIODINE WORSENING OF THYROID FUNCTION

    RADIOIODINE THERAPY AND GRAVES OPHTHALMOPATHY

    INDICATIONS FOR RADIOIODINE THERAPY

    SURGICAL THERAPY FOR THYROTOXICOSIS (Fig. 37-1)

    SPECIAL CONSIDERATIONS IN THE TREATMENT OF THYROTOXICOSIS

    TREATMENT OF CHILDREN AND ADOLESCENTS

    TREATMENT OF ELDERLY PATIENTS

    THYROTOXICOSIS IN PREGNANT WOMEN AND DURING LACTATION

    THYROTOXIC STORM

    THYROTOXICOSIS DUE TO TOXIC ADENOMA AND MULTINODULAR GOITER

    TOXIC ADENOMA

    TOXIC MULTINODULAR GOITER

    REFERENCES

    Chapter 38: Subclinical thyrotoxicosis

    ETIOLOGY

    ENDOGENOUS SUBCLINICAL THYROTOXICOSIS

    EXOGENOUS SUBCLINICAL THYROTOXICOSIS

    EVALUATION

    DIFFERENTIAL DIAGNOSIS

    EPIDEMIOLOGY AND NATURAL HISTORY

    CLINICAL AND BIOLOGIC IMPORTANCE

    PHYSIOLOGY OF SUPPRESSION OF TSH SECRETION

    CARDIOVASCULAR CONSEQUENCES

    BONE AND MINERAL METABOLISM

    COGNITIVE DYSFUNCTION AND DEMENTIA

    TREATMENT

    CHOICE OF TREATMENT MODALITY

    SIDE EFFECTS OF TREATMENT FOR SUBCLINICAL THYROTOXICOSIS

    FUTURE DIRECTIONS

    REFERENCES

    Section IV: Thyroid Diseases: Hypothyroidism

    A. Causes of Hypothyroidism

    Chapter 39: Chronic autoimmune thyroiditis

    INTRODUCTION

    PREDISPOSITION TO CHRONIC AUTOIMMUNE THYROIDITIS

    PATHOGENESIS OF CHRONIC AUTOIMMUNE THYROIDITIS

    ANTIGEN PRESENTATION

    T-CELL RESPONSES

    B-CELL RESPONSES

    EFFECTOR MECHANISMS

    EXPERIMENTAL AUTOIMMUNE THYROIDITIS

    CLINICAL ASPECTS

    ASSOCIATED DISORDERS

    REFERENCES

    Chapter 40: Genetic defects causing hypothyroidism

    MONOGENIC CAUSES OF THYROID DYSGENESIS

    KEY TRANSCRIPTION FACTOR MUTATIONS IN TD

    NKX2-1

    PAX8

    FOXE1

    GLIS3

    TSHR

    ADDITIONAL GENES ASSOCIATED WITH TD

    NKX2-5

    JAG1

    CDCA8 (BOREALIN)

    TUBB1

    NETRIN 1 (NTN1)

    SYNDROMES WHICH MAY BE ASSOCIATED WITH CH

    GENETIC CAUSES OF DYSHORMONOGENESIS

    THYROGLOBULIN

    TPO

    DUOX2 AND DUOXA2

    IYD (PREVIOUSLY KNOWN AS DEHAL1)

    SLC5A5 (NIS)

    SLC26A4 (PENDRIN)

    SLC26A7

    EVIDENCE FOR AN UNDIAGNOSED GENETIC COMPONENT IN TD

    REFERENCES

    Chapter 41: Primary hypothyroidism due to other causes

    INTRODUCTION

    RADIOACTIVE IODINE (131I THERAPY)

    THYROIDECTOMY

    TREATMENT OF TOXIC NODULAR GOITER

    TREATMENT OF NONTOXIC NODULAR GOITER

    EXTERNAL RADIATION

    HYPOTHYROIDISM DUE TO THERAPEUTIC PHARMACOLOGIC AGENTS

    LITHIUM CARBONATE

    CYTOKINES

    AMIODARONE

    TYROSINE KINASE INHIBITORS

    IMMUNE CHECKPOINT INHIBITORS

    OTHER DRUGS

    HYPOTHYROIDISM DUE TO INFILTRATIVE DISORDERS

    RIEDEL THYROIDITIS (INVASIVE FIBROUS THYROIDITIS)

    AMYLOIDOSIS

    SARCOIDOSIS

    SCLERODERMA

    HEMOCHROMATOSIS

    CYSTINOSIS

    OTHER INFILTRATIVE OR INFECTIOUS DISORDERS (SEE CHAPTER 22)

    PRIMARY THYROID LYMPHOMA

    CONSUMPTIVE HYPOTHYROIDISM

    INDUSTRIAL AND ENVIRONMENTAL AGENTS (SEE CHAPTER 12)

    EMBRYOLOGIC VARIANTS

    LINGUAL THYROID (SEE CHAPTER 63)

    REFERENCES

    Chapter 42: Central hypothyroidism

    INTRODUCTION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL FEATURES AND DIAGNOSIS

    TREATMENT OF CeH

    REFERENCES

    B. Organ System Manifestations of Hypothyroidism

    Chapter 43: Overview of the clinical manifestations of hypothyroidism

    INTRODUCTION

    CLINICAL MANIFESTATIONS

    OVERT HYPOTHYROIDISM

    SUBCLINICAL HYPOTHYROIDISM

    CARDIOVASCULAR DISEASE AND MORTALITY

    PULMONARY SYSTEM

    NEUROPSYCHIATRIC FEATURES

    MUSCULOSKELETAL SYSTEM

    INFECTIOUS COMPLICATIONS

    SKIN AND CONNECTIVE TISSUE

    KIDNEYS AND ELECTROLYTE METABOLISM

    GASTROINTESTINAL TRACT AND LIVER

    HEMATOLOGY AND HEMOSTASIS

    PITUITARY DISORDERS IN HYPOTHYROIDISM

    ADRENAL DISORDERS IN HYPOTHYROIDISM

    SUMMARY

    REFERENCES

    Chapter 44: Hypothyroidism and the heart

    CLINICAL CONSEQUENCES OF HYPOTHYROIDISM

    CV SYMPTOMS AND SIGNS

    ELECTROCARDIOGRAPHIC CHANGES IN HYPOTHYROIDISM

    CORONARY ARTERY DISEASE IN HYPOTHYROIDISM

    CV RISK FACTORS IN HYPOTHYROIDISM

    LIPIDS

    BLOOD PRESSURE AND VASCULAR DYSFUNCTION

    THROMBOGENESIS

    SUBCLINICAL HYPOTHYROIDISM

    SPECIAL SITUATIONS IN HYPOTHYROIDISM RELATED TO THE HEART

    POSTACUTE MYOCARDIAL INFARCTION

    HEART FAILURE

    TREATMENT OF HYPOTHYROIDISM IN PATIENTS WITH CORONARY ARTERY DISEASE

    CARDIAC SURGERY AND CARDIAC TRANSPLANTATION PROCEDURES

    REFERENCES

    Chapter 45: The skeletal system in hypothyroidism

    PHYSIOLOGIC CONTROL OF THYROID HORMONE ACTION

    THYROID HORMONE TRANSPORT AND METABOLISM IN BONE

    THYROID HORMONE RECEPTOR FUNCTION IN BONE

    ROLE OF TSH ON SKELETAL GROWTH AND MATURATION

    SKELETAL DEVELOPMENT

    SKELETAL CONSEQUENCES OF CHILDHOOD HYPOTHYROIDISM

    SKELETAL CONSEQUENCES OF IMPAIRED SENSITIVITY TO THYROID HORMONE

    SKELETAL CONSEQUENCES OF ADULT HYPOTHYROIDISM

    A POSSIBLE ROLE FOR THYROID HORMONE SIGNALING IN OSTEOARTHRITIS

    REFERENCES

    Chapter 46: Psychiatric and cognitive effects of hypothyroidism

    INTRODUCTION

    PSYCHIATRIC AND COGNITIVE EFFECTS OF OVERT HYPOTHYROIDISM

    PSYCHIATRIC AND COGNITIVE EFFECTS OF SUBCLINICAL HYPOTHYROIDISM

    EFFECT OF THYROID FUNCTION VARIATIONS WITHIN THE NORMAL RANGE ON MOOD AND COGNITION

    HASHIMOTO ENCEPHALOPATHY

    REFERENCES

    Chapter 47: Myxedema Coma

    INTRODUCTION

    CLINICAL FEATURES: PRECIPITATING EVENTS

    GENERAL DESCRIPTION

    HYPOTHERMIA

    RESPIRATORY SYSTEM

    CARDIOVASCULAR MANIFESTATIONS

    GASTROINTESTINAL MANIFESTATIONS

    RENAL AND ELECTROLYTE MANIFESTATIONS

    NEUROPSYCHIATRIC MANIFESTATIONS

    INFECTIONS

    DIAGNOSIS

    TREATMENT

    VENTILATORY SUPPORT

    HYPONATREMIA

    HYPOTHERMIA

    HYPOTENSION

    GLUCOCORTICOID THERAPY

    THYROID HORMONE THERAPY

    COMMENTS

    REFERENCES

    C. Management of Hypothyroidism

    Chapter 48: Diagnosis of hypothyroidism

    INTRODUCTION

    CLINICAL DIAGNOSIS

    CLINICAL MANIFESTATIONS

    PREDISPOSITION TO HYPOTHYROIDISM

    CHRONIC AUTOIMMUNE THYROIDITIS AND HYPOTHYROIDISM

    LABORATORY TESTING

    SERUM THYROXINE DETERMINATIONS

    SERUM TSH DETERMINATIONS

    OTHER MEASURES OF THYROID HORMONE ACTION

    SCREENING, CASE FINDING, AND DIAGNOSIS

    DIAGNOSING THE CAUSE OF HYPOTHYROIDISM

    FUTURE ADVANCES IN LABORATORY ASSESSMENT

    REFERENCES

    Chapter 49: Treatment of hypothyroidism

    HISTORICAL PERSPECTIVE ON THE TREATMENT OF HYPOTHYROIDISM

    LEVOTHYROXINE THERAPY

    ENDPOINTS DURING LEVOTHYROXINE THERAPY

    FACTORS AFFECTING LEVOTHYROXINE DOSE

    INITIATION AND ADJUSTMENT OF LEVOTHYROXINE THERAPY

    CHOICE OF LEVOTHYROXINE PRODUCT

    LEVOTHYROXINE ABSORPTION, METABOLISM, AND TRANSPORT

    LEVOTHYROXINE THERAPY IN SPECIFIC SUBPOPULATIONS

    PATIENT SATISFACTION WITH LEVOTHYROXINE THERAPY

    LEVOTHYROXINE THERAPY AND T3 LEVELS

    THERAPIES OTHER THAN LEVOTHYROXINE

    THYROID EXTRACTS

    SYNTHETIC COMBINATION THERAPY

    LIOTHYRONINE THERAPY

    SUMMARY

    REFERENCES

    Chapter 50: Subclinical hypothyroidism

    INTRODUCTION

    ETIOLOGY AND NATURAL HISTORY

    CLINICAL AND BIOLOGIC IMPORTANCE

    CURRENT EVIDENCE

    TREATMENT CONSIDERATIONS

    TREATMENT RECOMMENDATIONS

    CONCLUSIONS

    REFERENCES

    Section V: Thyroid Diseases: Nontoxic Diffuse and Multinodular Goiter

    Chapter 51: Multinodular goiter: pathogenesis and management

    INTRODUCTION

    ETIOLOGY

    EPIDEMIOLOGY

    NATURAL HISTORY

    CLINICAL MANIFESTATIONS

    DIAGNOSIS EVALUATION

    MANAGEMENT

    IODINE SUPPLEMENTATION

    TSH SUPPRESSIVE THERAPY WITH LEVOTHYROXINE

    ANTITHYROID DRUGS

    SURGERY

    131I THERAPY

    OTHER TREATMENT OPTIONS

    SUMMARY

    REFERENCES

    Chapter 52: Clinical evaluation and management of thyroid nodules

    CLINICAL EVALUATION

    LABORATORY EVALUATION

    SERUM HORMONE AND OTHER MEASUREMENTS

    IMAGING STUDIES

    ULTRASONOGRAPHY

    ELASTOGRAPHY

    RADIONUCLIDE THYROID SCINTIGRAPHY

    OTHER IMAGING STUDIES

    FINE-NEEDLE ASPIRATION BIOPSY

    RISK STRATIFICATION FOR THYROID NODULES

    TECHNIQUE OF FINE-NEEDLE BIOPSY

    RESULTS OF FINE-NEEDLE BIOPSY

    LIMITATIONS OF FINE-NEEDLE ASPIRATION BIOPSY OF THYROID NODULES

    CLINICAL RECOMMENDATIONS BASED UPON FNA CYTOLOGY RESULTS

    NONDIAGNOSTIC CYTOLOGY: BETHESDA I

    BENIGN CYTOLOGY: BETHESDA II

    ATYPIA OF UNDETERMINED SIGNIFICANCE/FOLLICULAR LESION OF UNDERMINED SIGNIFICANCE (AUS/FLUS) CYTOLOGY: BETHESDA III

    FOLLICULAR NEOPLASM CYTOLOGY (INCLUDES HüRTHLE CELL NEOPLASM): BETHESDA IV

    ROLE OF MOLECULAR TESTING FOR BETHESDA III AND IV NODULES

    SUSPICIOUS FOR MALIGNANCY CYTOLOGY: BETHESDA V

    MALIGNANT CYTOLOGY: BETHESDA VI

    TREATMENT AFTER THYROID SURGERY

    REFERENCES

    Section VI: Thyroid Cancers

    Chapter 53: Carcinomas of follicular epithelium: epidemiology and pathogenesis

    RADIATION

    EXTERNAL RADIATION AND THYROID CARCINOMA

    INTERNAL RADIATION AND THYROID CARCINOMA

    COMPARISON OF EXTERNAL AND INTERNAL RADIATION

    PREVENTING IODINE 131–RELATED THYROID CARCINOMA

    EVALUATION OF IRRADIATED PATIENTS

    RADIATION AND OTHER HEAD AND NECK TUMORS

    CLINICAL FEATURES OF RADIATION-RELATED THYROID NEOPLASMS

    GENETIC PREDISPOSITION

    SYNDROMIC NONMEDULLARY THYROID CARCINOMA

    NONSYNDROMIC FAMILIAL NONMEDULLARY THYROID CARCINOMA (FNMTC)

    GENETIC SUSCEPTIBILITY

    PRE-EXISTING THYROID DISEASE

    HORMONAL AND REPRODUCTIVE FACTORS

    DIETARY FACTORS

    IODINE AND GOITROGENS

    OTHER DIETARY FACTORS

    ANTHROPOMORPHIC AND METABOLIC FACTORS

    SMOKING AND OTHER ENVIRONMENTAL AGENTS

    SUMMARY

    REFERENCES

    Chapter 54: Genomic landscapes of thyroid cancers of follicular cell derivation

    GENOMIC HALLMARKS OF NEOPLASMS ARISING FROM THYROID FOLLICULAR CELLS

    FOLLICULAR NEOPLASMS

    AUTONOMOUSLY FUNCTIONING ADENOMA

    FOLLICULAR ADENOMA AND CARCINOMA

    PAPILLARY CARCINOMA

    NIFTP

    RARE PTC VARIANTS

    OTHER SOMATIC MUTATIONS

    TERT PROMOTER MUTATIONS

    SOMATIC COPY NUMBER ALTERATIONS

    HÜRTHLE CELL NEOPLASMS

    POORLY DIFFERENTIATED THYROID CANCER

    ANAPLASTIC THYROID CANCER

    GENETIC SUSCEPTIBILITY AND ENVIRONMENTAL FACTORS

    DIAGNOSTIC IMPLICATIONS OF THYROID CANCER GENOMICS

    REFERENCES

    Chapter 55: Carcinoma of the follicular epithelium: surgical therapy

    INTRODUCTION

    THYROIDECTOMY NOMENCLATURE

    EXTENT OF THYROIDECTOMY AND RISK OF COMPLICATIONS

    SURGERY FOR INDETERMINATE THYROID NODULES

    THYROIDECTOMY FOR THYROID CARCINOMA DERIVED FROM FOLLICULAR EPITHELIUM

    CERVICAL LYMPH NODE DISSECTION NOMENCLATURE

    EXTENT OF LYMPH NODE DISSECTION AND RISK OF COMPLICATIONS

    LYMPHATIC DRAINAGE AND LOCATION OF NODAL METASTASIS IN THYROID CARCINOMA DERIVED FROM FOLLICULAR EPITHELIUM

    CLINICAL ASPECTS OF NODAL METASTASIS IN THYROID CARCINOMA DERIVED FROM FOLLICULAR EPITHELIUM

    PROGNOSIS OF NODAL METASTASIS IN THYROID CARCINOMA DERIVED FROM FOLLICULAR EPITHELIUM

    CENTRAL LYMPH NODE DISSECTION

    LATERAL LYMPH NODE DISSECTION

    SUMMARY

    REFERENCES

    Chapter 56: Staging and prognosis of differentiated thyroid cancer

    INTRODUCTION

    STAGING TO PREDICT RISK OF THYROID CANCER DEATH

    ELEMENTS AND COMPARISON OF PUBLISHED STAGING SYSTEMS

    EVOLUTION OF THE TNM SYSTEM TO THE CURRENT 8TH EDITION

    VALIDATION AND CONTROVERSIES IN 8TH EDITION TNM STAGING

    PREDICTING THE RISK OF THYROID CANCER RECURRENCE

    ELEMENTS OF INITIAL RISK STRATIFICATION SYSTEMS

    VALIDATION AND CONTROVERSIES FOR INITIAL RISK SYSTEMS

    DYNAMIC RISK STRATIFICATION/RESPONSE-TO-THERAPY

    ELEMENTS OF DYNAMIC RISK STRATIFICATION

    VALIDATION AND CONTROVERSIES FOR DYNAMIC RISK STRATIFICATION

    HOW TO USE CURRENT RISK STRATIFICATION SYSTEMS IN PRACTICE

    CONCLUSIONS

    REFERENCES

    Chapter 57: Medical management of differentiated epithelial cell thyroid cancer

    RADIOACTIVE IODINE THERAPY

    THE GOALS OF THE FIRST ADMINISTERED ACTIVITY OF RADIOACTIVE IODINE AFTER THYROIDECTOMY

    ABLATION OF RESIDUAL NORMAL THYROID TISSUE

    RAI TREATMENT AS AN ADJUVANT THERAPY

    PREPARATION FOR RAI THERAPY

    SELECTION OF RADIOACTIVE IODINE ACTIVITY FOR REMNANT ABLATION

    WHOLE-BODY 131I SCANS AND SPECT/CT

    RAI THERAPY FOR LOCAL OR DISTANT METASTATIC DISEASE

    INDICATIONS FOR RAI THERAPY

    TREATMENT OF PATIENTS WITH HIGH SERUM THYROGLOBULIN LEVELS AND NEGATIVE IMAGING STUDIES

    COMPLICATIONS OF RAI THERAPY

    FOLLOW-UP PARADIGMS

    EARLY FOLLOW-UP RECOMMENDATIONS (FIRST YEAR AFTER INITIAL THERAPY)

    FOLLOW-UP PARADIGMS BASED ON RESPONSE TO THERAPY RESTRATIFICATION

    ONGOING, DYNAMIC RISK ASSESSMENT DURING LONG-TERM FOLLOW-UP

    TSH-SUPPRESSIVE THYROID HORMONE THERAPY

    EXTERNAL BEAM RADIOTHERAPY

    SYSTEMIC THERAPY FOR ADVANCED DISEASE

    BIOLOGICALLY TARGETED THERAPIES

    CYTOTOXIC CHEMOTHERAPY

    OTHER PALLIATIVE INTERVENTIONS FOR SYMPTOMATIC METASTATIC DTC

    REFERENCES

    Chapter 58: Papillary microcarcinomas

    INCREASING INCIDENCE OF THYROID CANCER WITH STABLE MORTALITY

    SURGERY OF PAPILLARY MICROCARCINOMA AND OUTCOMES

    FREQUENT MULTIPLICITY AND REGIONAL LYMPH NODE METASTASIS

    PROGNOSIS OF HIGH-RISK AND LOW-RISK PAPILLARY MICROCARCINOMA

    SURGICAL APPROACH TO PMCs

    ACTIVE SURVEILLANCE OF LOW-RISK PAPILLARY MICROCARCINOMA

    HISTORY AND HYPOTHESIS

    PROTOCOL OF THE ACTIVE SURVEILLANCE AT KUMA HOSPITAL

    OUTCOMES OF ACTIVE SURVEILLANCE

    EVALUATION OF THE RISK OF TRACHEA AND RECURRENT LARYNGEAL NERVE INVASION

    INCIDENCES OF UNFAVORABLE EVENTS IN IMMEDIATE SURGERY VERSUS ACTIVE SURVEILLANCE

    MEDICAL ECONOMY OF MANAGEMENT OF PAPILLARY MICROCARCINOMA

    FACTORS THAT MIGHT BE ASSOCIATED WITH DISEASE PROGRESSION

    NATURAL HISTORY OF PAPILLARY CARCINOMA

    LIFETIME PROBABILITY OF DISEASE PROGRESSION

    TUMOR VOLUME KINETICS DURING ACTIVE SURVEILLANCE

    ESTIMATING TUMOR GROWTH BEFORE PRESENTATION

    IMPLEMENTING ACTIVE SURVEILLANCE

    REFERENCES

    Chapter 59: Medullary thyroid cancer

    NATURAL HISTORY

    TUMOR PROGRESSION

    PREOPERATIVE SCREENING

    SURGICAL TREATMENT

    DYNAMIC RISK STRATIFICATION AND FOLLOW-UP

    RECURRENT AND PERSISTENT DISEASE

    REOPERATION

    DISTANT DISEASE

    CONCLUSION

    REFERENCES

    Chapter 60: Poorly differentiated thyroid cancer, anaplastic thyroid cancer, and miscellaneous tumors of the thyroid

    POORLY DIFFERENTIATED THYROID CANCER

    DEFINITION/EPIDEMIOLOGY

    TREATMENT/PROGNOSIS

    ANAPLASTIC THYROID CANCER

    INTRODUCTION

    EPIDEMIOLOGY

    PATHOGENESIS

    CLINICAL PRESENTATION AND DIFFERENTIAL DIAGNOSIS

    PATHOLOGY

    GENOMICS/MOLECULAR PATHOLOGY/IMMUNOLOGY

    STAGING

    MANAGEMENT—GENERAL CONSIDERATIONS

    MANAGEMENT—STAGE IVA

    MANAGEMENT—STAGE IVB

    MANAGEMENT—STAGE IVC

    MANAGEMENT—OLIGOMETASTATIC STAGE IVC

    PALLIATIVE AND HOSPICE CARE

    ATC SUMMARY

    MISCELLANEOUS TUMORS OF THE THYROID GLAND

    HYALINIZING TRABECULAR TUMOR

    SQUAMOUS CELL CARCINOMA

    THYROID MUCOEPIDERMOID CARCINOMA

    SCLEROSING MUCOEPIDERMOID CARCINOMA WITH EOSINOPHILIA

    MUCINOUS CARCINOMA OF THE THYROID

    ECTOPIC THYMOMA

    SPINDLE EPITHELIAL TUMOR WITH THYMUS-LIKE DIFFERENTIATION

    INTRATHYROID THYMIC CARCINOMA

    PARAGANGLIOMA AND MESENCHYMAL/STROMAL TUMORS

    HEMATOLYMPHOID TUMORS

    GERM CELL TUMORS (BENIGN TERATOMA, IMMATURE TERATOMA, MALIGNANT TERATOMA)

    SECONDARY MALIGNANCIES OF THE THYROID

    ACKNOWLEDGMENTS

    REFERENCES

    Chapter 61: Thyroid cancer in children

    RISK OF THYROID CANCER IN THE PEDIATRIC PATIENT WITH A THYROID NODULE

    DIFFERENTIATED THYROID CANCERS

    PAPILLARY THYROID CARCINOMA (PTC)

    PAPILLARY THYROID MICROCARCINOMA (PTMC)

    FOLLICULAR VARIANT PTC

    FOLLICULAR THYROID CARCINOMA (FTC)

    MEDULLARY THYROID CARCINOMA

    MULTIPLE ENDOCRINE NEOPLASIA 2A

    MULTIPLE ENDOCRINE NEOPLASIA 2B

    EARLY THYROIDECTOMY IN MEN2

    MANAGEMENT OF MTC IN MEN2

    REFERENCES

    Section VII: The Thyroid in Infancy and Childhood

    Chapter 62: The maturation of thyroid function in the fetus, in the perinatal period and during childhood

    MATURATION OF THYROID FUNCTION IN UTERO

    ORGANOGENESIS AND STRUCTURAL DIFFERENTIATION OF THE THYROID GLAND

    FUNCTIONAL DIFFERENTIATION OF THE THYROID GLAND AND ONSET OF THYROID HORMONE SYNTHESIS

    THE ROLE OF THE PLACENTA FOR MATERNOFETAL INTERACTION

    MATURATION OF THE HYPOTHALAMIC–PITUITARY–THYROID AXIS

    SYNTHESIS OF THE THYROID HORMONE TRANSPORT PROTEINS

    REGULATION OF THYROID HORMONE LEVELS IN UTERO BY SULFATION

    REGULATION OF THYROID HORMONE LEVELS IN UTERO BY DEIODINATION

    ONTOGENY OF TRANSMEMBRANE THYROID HORMONE TRANSPORTERS

    ONTOGENY OF THYROID HORMONE RECEPTORS

    THE ROLE OF THYROID HORMONES FOR THE FETUS AND THE CHILD

    BRAIN DEVELOPMENT

    COCHLEA DEVELOPMENT

    RETINA DEVELOPMENT

    MUSCLE AND MYOCARDIAL DEVELOPMENT

    BONE DEVELOPMENT AND LINEAR GROWTH

    METABOLIC EFFECTS

    PERINATAL AND POSTNATAL CHANGES IN THYROID HORMONE SYNTHESIS AND METABOLISM

    PHYSIOLOGIC CHANGES IN THE TERM NEONATE

    THYROID FUNCTION IN THE PRETERM NEONATE

    THYROID FUNCTION IN SMALL FOR GESTATIONAL AGE NEONATES

    INFANTS, CHILDREN, AND ADOLESCENTS

    REFERENCES

    Chapter 63: Hypothyroidism in infants and children

    CONGENITAL HYPOTHYROIDISM

    NEWBORN SCREENING

    RATIONALE FOR BIOCHEMICAL SCREENING FOR CH

    PREMATURE AND VERY LOW–BIRTH-WEIGHT NEWBORNS

    NEWBORNS WITH TRISOMY 21

    EVALUATION OF NEWBORNS WITH A POSITIVE SCREENING RESULT

    QUALITY ASSESSMENT OF SCREENING PROGRAMS

    CLASSIFICATION OF CH (Table 63-2)

    ETIOLOGY AND PATHOGENESIS

    PERMANENT CH

    TRANSIENT CH

    CLINICAL PRESENTATION

    DIAGNOSTIC EVALUATION (Table 63-3)

    TREATMENT AND OUTCOME

    ACQUIRED HYPOTHYROIDISM (CH)

    ETIOLOGIES (Table 63-4)

    CLINICAL PRESENTATION (Fig. 63-4)

    EVALUATION

    TREATMENT

    PROGNOSIS

    REFERENCES

    Chapter 64: Impaired sensitivity to thyroid hormone: defects of transport, metabolism, and action

    TH SECRETION, CELL-MEMBRANE TRANSPORT, METABOLISM, AND ACTION

    THE PARADOX OF COEXISTING MANIFESTATIONS OF THYROID HORMONE DEFICIENCY AND EXCESS

    THYROID HORMONE ACTION DEFECTS KNOWN AS RESISTANCE TO THYROID HORMONE

    RESISTANCE TO THYROID HORMONE BETA (RTHβ)

    CLINICAL CLASSIFICATION

    INCIDENCE AND INHERITANCE

    ETIOLOGY AND GENETICS

    MOLECULAR MECHANISMS OF TR ACTION

    PROPERTIES OF MUTANT TRβ RECEPTORS AND ASSOCIATED DOMINANT-NEGATIVE EFFECT

    MOLECULAR BASIS OF THE VARIABLE RTHβ PHENOTYPE

    RTHβ WITHOUT THRB GENE MUTATIONS (NON–TRβ-RTH)

    ANIMAL MODELS OF RTHβ

    PATHOGENESIS

    PATHOLOGY

    CLINICAL FEATURES

    COURSE OF THE DISEASE

    LABORATORY FINDINGS

    TH AND ITS METABOLITES

    THYROTROPIN AND OTHER THYROID STIMULATORS

    THYROID GLAND ACTIVITY AND INTEGRITY OF HORMONE SYNTHESIS

    IN VIVO EFFECTS OF TH

    IN VITRO TESTS OF THYROID HORMONE ACTION

    RESPONSES TO THE ADMINISTRATION OF THYROID HORMONE

    EFFECTS OF OTHER DRUGS

    DIFFERENTIAL DIAGNOSIS

    TREATMENT

    RESISTANCE TO THYROID HORMONE ALPHA (RTHα)

    BACKGROUND

    INCIDENCE AND INHERITANCE

    ETIOLOGY AND GENETICS

    MOLECULAR BASIS OF THE DEFECT AND PROPERTIES OF THE MUTANT TRα

    ANIMAL MODELS OF RTHα (SEE ALSO ANIMAL MODELS UNDER RTHβ, ABOVE)

    CLINICAL FEATURES

    LABORATORY FINDINGS

    DIFFERENTIAL DIAGNOSIS

    TREATMENT

    THYROID HORMONE CELL MEMBRANE TRANSPORTER DEFECT (THCMTD)

    CELL MEMBRANE TRANSPORTERS OF TH

    INHERITANCE AND INCIDENCE

    ETIOLOGY

    THE MCT8 GENE AND MUTATIONS

    CLINICAL FEATURES AND COURSE OF THE DISEASE

    LABORATORY FINDINGS

    SERUM TESTS OF THYROID FUNCTION

    OTHER SERUM TESTS

    X-RAYS AND IMAGING

    TESTS IN TISSUES

    GENETIC TESTING

    ANIMAL MODELS OF MCT8 DEFICIENCY

    MOLECULAR BASIS OF THE DISORDER

    DIFFERENTIAL DIAGNOSIS

    TREATMENT

    THYROID HORMONE METABOLISM DEFECT

    INTRACELLULAR METABOLISM OF TH

    ETIOLOGY AND GENETICS

    INCIDENCE AND INHERITANCE

    THE SBP2 GENE AND MUTATIONS

    CLINICAL FEATURES AND COURSE OF THE DISEASE

    LABORATORY FINDINGS

    MOLECULAR BASIS OF THE DISORDER

    THMD CAUSED BY MUTATION IN THE TRU-TCA1-1 GENE

    ANIMAL MODELS OF THMD

    DIFFERENTIAL DIAGNOSIS

    TREATMENT

    ACKNOWLEDGMENTS

    REFERENCES

    Chapter 65: Hyperthyroidism in the neonate, child, and adolescent

    CLINICAL EVALUATION OF THE HYPERTHYROID STATE

    BIOCHEMICAL EVALUATION OF THYROID FUNCTION

    GRAVES DISEASE

    ANTITHYROID DRUG THERAPY

    RADIOACTIVE IODINE THERAPY

    THYROIDECTOMY AND RISKS

    SOMATIC COMPLICATIONS OF GD

    NEONATAL THYROTOXICOSIS

    FETAL CONSIDERATIONS

    OTHER CAUSES OF HYPERTHYROIDISM

    HASHITOXICOSIS

    SUMMARY

    REFERENCES

    Section VIII: Thyroid Disorders in Pregnancy and Postpartum

    Chapter 66: Thyroid disorders during preconception, pregnancy, and the postpartum period

    PRECONCEPTION

    EPIDEMIOLOGY

    PHYSIOLOGY

    CLINICAL OUTCOMES AND MANAGEMENT

    PREGNANCY

    EPIDEMIOLOGY

    PHYSIOLOGY

    DIAGNOSIS OF THYROID DISEASE

    OVERT HYPOTHYROIDISM

    SUBCLINICAL HYPOTHYROIDISM

    ISOLATED HYPOTHYROXINEMIA

    AUTOIMMUNE THYROID DISEASE IN PREGNANCY

    HYPERTHYROIDISM

    POSTPARTUM

    POSTPARTUM THYROIDITIS

    REFERENCES

    Index

     

     

  • 1,30100lei 1040.00 lei

    Description:

    This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Physicians should have the knowledge derived from morphological findings to identify the likelihood of a cancer patient having an additional underlying familial syndrome- and to decide if that patient should undergo molecular genetic evaluation. This volume is specifically designed to help pathologists, oncologists, and other physicians who diagnose and treat cancer to recognize syndromes and syndrome- associated neoplasms and advise patients and their families on the possibility of a familial syndrome and their risk of developing other tumors. Diagnostic Pathology: Familial Cancer Syndromes, second edition, is an easy-to-use, one-stop reference for information on hereditary cancer syndromes, including differential diagnosis and management, that offers a templated, highly formatted design; concise, bulleted text; and superior color images throughout.

     

    Table Of Contents:

    I. Diagnosis Associated With Syndromes by Organ

    Breast

    Breast Carcinoma, Female

    Breast Carcinoma, Male

    Breast Table

    Blood and Bone Marrow

    Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma

    Acute Myeloid Leukemia and Myelodysplastic Syndrome

    Blood and Bone Marrow Table

    Bone and Soft Tissue

    Chondrosarcoma

    Chordoma

    Malignant Peripheral Nerve Sheath Tumor

    Osteosarcoma

    Rhabdomyosarcoma

    Schwannoma

    Bone and Soft Tissue Table

    Head and Neck

    Endolymphatic Sac Tumor

    Squamous Cell Carcinoma

    Head and Neck Table

    Salivary Glands Table

    Endocrine

    Adrenal Cortex

    Adrenal Cortical Adenoma

    Adrenal Cortical Carcinoma

    Adrenal Cortical Neoplasms in Children

    Primary Pigmented Nodular Adrenocortical Disease

    Adrenal Cortex Table

    Adrenal Medulla and Paraganglia

    Adrenal Medullary Hyperplasia

    Neuroblastoma

    Pheochromocytoma and Paraganglioma

    Adrenal Medulla and Paraganglia Table

    Pancreas

    Pancreatic Neuroendocrine Neoplasms

    Pancreas Table

    Parathyroid

    Parathyroid Adenoma

    Parathyroid Carcinoma

    Parathyroid Hyperplasia

    Parathyroid Table

    Pituitary

    Pituitary Adenoma

    Pituitary Hyperplasia

    Pituitary Table

    Thyroid, Medullary

    C-Cell Hyperplasia

    Medullary Thyroid Carcinoma

    Thyroid, Medullary Table

    Thyroid, Nonmedullary

    Familial Thyroid Carcinoma

    Follicular Thyroid Carcinoma

    Thyroid, Nonmedullary Table

    Gastrointestinal

    Tubular Gut

    Colon Adenoma

    Esophageal Adenocarcinoma

    Esophageal Squamous Cell Carcinoma

    Gastric Adenocarcinoma

    Gastrointestinal Stromal Tumor

    Hamartomatous Polyps of GI Tract

    Small Bowel Adenocarcinoma

    Colon/Rectum Table

    Esophagus/Stomach/Small Bowel Table

    Tubular Gut Table

    Hepatobiliary and Pancreas

    Biliary Tract Neoplasia

    Hepatoblastoma

    Hepatocellular Carcinoma

    Pancreatic Adenocarcinoma

    Biliary Tract/Liver/Pancreas Table

    Hepatobiliary and Pancreas Table

    Genitourinary

    Bladder

    Bladder Table

    Kidney

    Angiomyolipoma

    Clear Cell Renal Cell Carcinoma

    HLRCC Syndrome-Associated Renal Cell Carcinoma

    Papillary Renal Cell Carcinoma

    Renal Oncocytoma, Chromophobe, and Hybrid Tumors

    Wilms Tumor

    Kidney Table

    Prostate

    Prostate Table

    Renal Pelvis and Ureter

    Renal Pelvis and Ureter Table

    Testicle

    Germ Cell Tumor

    Sertoli Cell Neoplasms

    Testicle Table

    Gynecology

    Cervical Tumors

    Fallopian Tube Tumors

    Ovarian Tumors

    Uterine Tumors

    Cervix

    Endometrium

    Fallopian Tube

    Ovary

    Nervous System

    Central Nervous System

    Eye

    Peripheral Nervous System

    Pulmonary

    Adenocarcinoma, Lung

    Adenocarcinoma With Lepidic (Bronchioloalveolar) Predominant Pattern

    Lymphangioleiomyomatosis

    Neuroendocrine Carcinoma, Lung

    Pleuropulmonary Blastoma

    Lung Table

    Skin

    BAP1-Inactivated Melanocytic Tumor

    Basal Cell Carcinoma

    Cutaneous Melanoma

    Cutaneous Squamous Cell Carcinoma

    Sebaceous Carcinoma

    Skin Table

    II. Overview of Syndromes

    Introduction

    Pathology of Familial Tumor Syndromes

    Clinical Diagnosis and Management of Familial/Hereditary Tumor Syndromes

    Molecular Aspects of Familial/Hereditary Tumor Syndromes

    Syndromes

    Ataxia Telangiectasia

    BAP1 Tumor Predisposition Syndrome

    Basal Cell Nevus Syndrome/Gorlin Syndrome

    Beckwith-Wiedemann Syndrome

    Birt-Hogg-Dubé Syndrome

    Bloom Syndrome

    Brooke-Spiegler Syndrome

    Carney Complex

    Costello Syndrome

    Cystic Nephroma Syndrome

    Denys-Drash Syndrome

    Diamond-Blackfan Anemia

    DICER1 Syndrome

    Down Syndrome

    Dyskeratosis Congenita

    Familial Acute Myeloid Leukemia and Myelodysplastic Syndrome

    Familial Adenomatous Polyposis

    Familial Chordoma

    Familial Gastrointestinal Stromal Tumor

    Familial Infantile Myofibromatosis

    Familial Isolated Hyperparathyroidism

    Familial Medullary Thyroid Carcinoma

    Familial Nonmedullary Thyroid Carcinoma

    Familial Paraganglioma-Pheochromocytoma Syndrome

    Familial Testicular Tumor

    Familial Uveal Melanoma

    Familial Wilms Tumor

    Fanconi Anemia

    GATA2 Spectrum Disorders

    Glucagon Cell Hyperplasia and Neoplasia

    Hereditary Breast/Ovarian Cancer Syndrome: BRCA1

    Hereditary Breast/Ovarian Cancer Syndrome: BRCA2

    Hereditary Diffuse Gastric Cancer

    Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome (HLRCC)

    Hereditary Multiple Exostosis

    Hereditary Neuroblastoma

    Hereditary Pancreatic Cancer Syndrome

    Hereditary Papillary Renal Cell Carcinoma

    Hereditary Paraganglioma/Pheochromocytoma Syndromes

    Hereditary Prostate Cancer

    Hereditary Renal Epithelial Tumors, Others

    Hereditary Retinoblastoma

    Hereditary SWI/SNF Complex Deficiency Syndromes

    Heritable Gastrointestinal Stromal Tumors Syndromes

    Howel-Evans Syndrome/Keratosis Palmares and Plantares With Esophageal Cancer

    Hyperparathyroidism-Jaw Tumor Syndrome

    Juvenile Polyposis Syndrome

    Li-Fraumeni Syndrome/Li-Fraumeni-Like Syndrome

    Lynch Syndrome

    McCune-Albright Syndrome

    Melanoma/Pancreatic Carcinoma Syndrome

    Multiple Endocrine Neoplasia Type 1 (MEN1)

    Multiple Endocrine Neoplasia Type 2 (MEN2)

    Multiple Endocrine Neoplasia Type 4 (MEN4)

    MYH-Associated Polyposis

    Neurofibromatosis Type 1

    Neurofibromatosis Type 2

    Nijmegen Breakage Syndrome

    Pancreatic Neuroendocrine Tumor Syndromes

    *PDGFRA*-Mutant Syndrome

    Peutz-Jeghers Syndrome

    PTEN Hamartoma Tumor Syndromes

    RASopathies: Noonan Syndrome

    Rhabdoid Predisposition Syndrome

    Schwannomatosis

    Shwachman-Diamond Syndrome

    Steatocystoma Multiplex

    Succinate Dehydrogenase (SDH)-Deficient Renal Cell Carcinoma

    Tuberous Sclerosis Complex

    Tumor Syndromes Predisposing to Osteosarcoma

    von Hippel-Lindau Syndrome

    Werner Syndrome/Progeria

    Wilms Tumor-Associated Syndrome

    Wiskott-Aldrich Syndrome

    Xeroderma Pigmentosum

    Reference

    Molecular Factors

    Molecular Factors Index

     

     


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    2. Identifying sources that are likely to produce relevant information for the user’s query
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    • the importance of working with faculty to increase use
    • unusual collaboration opportunities
    • examples of libraries nimbly expanding their spaces to include tech students need
    • unique ways patrons employ the technology
    • best practices for designing collaborative creative spaces


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    • 3D modeling and printing
    • makerspace additions beyond the usual
    • instructional technologies used by patrons
    • video production and editing equipment
    • tool library
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    In the five years since the first edition of Developing Library Collections for Today’s Young Adults was published, numerous changes have taken place in the landscape of young adult literature and young adult library services. Informed by the professional activism—including the “We Need Diverse Books” (#wndb) movement—today’s professionals recognize that library collections for young adults are incomplete if they fail to address and reflect a diversity of racial, ethnic, and cultural identities; gender identities; sexual orientations; and identities related to ability and disability. Contemporary librarians working to diversify their collections select material in a number of formats and must consider the accessibility of both old and new media as they select titles and resources.

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    Preservation how-to for every medium.
     

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    This revised second edition contains a wide range of topic-specific expertise that comprises both an enduring text for preservation and collections care students, as well as an essential one-stop reference for cultural heritage professionals—particularly those in small- to medium sized organizations where resources are limited and professional help, is not always accessible.

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    This book provides strategic insights drawn from librarians who are meeting the challenge of digital scholarship, utilizing the latest technologies and creating new knowledge in partnership with researchers, scholars, colleagues and students. The impact of digital on libraries has extended far beyond its transformation of content, to the development of services, the extension and enhancement of access to research and to teaching and learning systems. As a result,the fluidity of the digital environment can often be at odds with the more systematic approaches to development traditionally taken by academic libraries, which has also led to a new generation of roles and shifting responsibilities with staff training and development often playing ‘catch-up’.

  • Digital Literacy Unpacked
    La comanda in aproximativ 4 saptamani
    380.00 lei

    Digital literacy is a powerful subject, which supports inclusivity, social mobility and digital citizenship globally. This book brings together thought-leaders and experts in the field, providing a blend of research and practice across sectors, and provides a valuable and timely insight into digital literacy and learning.   Digital Literacy Unpacked not only offers a snapshot of innovative approaches to digital literacy, but also intends to provoke discussion, encourage collaboration and inspire – whatever the role or context. 

  • 350.00 lei

    This book provides a straight forward and pragmatic guide to leadership, management and team working in contemporary library and information services. Contemporary managers and leaders in library and information services are working in a challenging context; dealing with multiple demands on their time, expertise and resources. This book translates theories in team work, management and leadership into practical guidance backed up with examples and case studies from current library and information workers globally.

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