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    Tuberculosis remains one of the most prevalent, deadly, and underdiagnosed infectious diseases in the world. In children, this burden is doubly problematic because of the disease's unique clinical characteristics and its need for special public health and diagnostic techniques. After decades of relative inattention to these factors, childhood tuberculosis has now grown into an important area of competency for child health programs in low-burden areas, including the United States.

    The Handbook of Child and Adolescent Tuberculosis is a state of the art clinical reference written and edited by the world's leading experts in childhood tuberculosis. It offers clinicians in any geography or setting practical, evidence-based advice on all aspects of the disease, including its natural history, epidemiology, presentation, treatment, and prevention — all in a format that synthesizes literature with the clinical experience of the leading authorities in this challenging field.

    As the need for childhood tuberculosis services in child health programs grows, this handbook provides a new benchmark for practitioners and trainees in pediatrics, infectious disease, pulmonary medicine, and public health to better understand this persisting and difficult disease.

    Table of Contents

    1 A Brief History of Childhood Tuberculosis
    Peter R. Donald
    2 Microbiology and Pathology of Tuberculosis
    Anne-Marie Demers, Andrew C. Whitelaw, Kathleen D. Eisenach
    3 Immunology of Tuberculosis
    Beate Kampmann, Elizabeth Whittaker
    4 Natural History of Childhood Tuberculosis
    Ben J. Marais
    5 Global Epidemiology of Childhood Tuberculosis
    Charalambos Sismanidis, Philille Glaziou, Malgosia Grzemska, Katherine Floyd, Mario Raviglione
    6 Diagnosis of Tuberculosis Infection in Children
    Anna M. Mandalakas, Andrew DiNardo
    7 Microbiologic Diagnosis of Tuberculosis Disease in Children
    Mark P. Nicol, Heather J. Zar
    8 Radiology of Childhood Tuberculosis
    Savvas Andronikou, Tracy Kilborn
    9 Diagnosis of Intrathoracic Tuberculosis
    Carlos M. Perez-Velez
    10 Diagnosis of the Most Common Forms of Extrathoracic Tuberculosis in Children
    H. Simon Schaaf, Anthony J. Garcia-Prats
    11 Central Nervous System Tuberculosis in Children
    Ronald van Toorn
    12 Tuberculosis in Adolescents
    Andrea T. Cruz
    13 Tuberculosis in Neonates and Infants
    Adrie Bekker
    14 Tuberculosis in HIV-infected and -Exposed Infants, Children and Adolescents
    Helena Rabie, Mark F. Cotton
    15 Antituberculosis Drugs in Children
    Helen McIlleron
    16 Treatment of Tuberculosis Infection in Children
    Amina Ahmed
    17 Management of Drug-Susceptible Tuberculosis in Children
    Soumya Swaminathan, N Poorana Ganga Devi
    18 Management of Drug-Resistant Tuberculosis in Children
    James Seddon
    19 Tuberculosis Vaccines: the old and the New
    Kim Connelly Smith, Ian M. Orme, Jeffrey R. Starke
    20 Mycobacterium bovis [non-BCG] in Children
    Jeffrey R. Starke
    21 Public Health and Programmatic Issues for Childhood Tuberculosis
    Jeffrey R. Starke
    22 The Roadmap for Childhood Tuberculosis
    Stephen M. Graham, Anne Detjen