Skin Lymphoma: The Illustrated Guide

DESCRIPTION:

A complete guide to the diagnosis and management of cutaneous lymphomas and pseudolymphomas

Easily misdiagnosed as benign skin diseases, malignant cutaneous lymphomas can present a variety of challenges to trainees and practicing specialists alike. Skin Lymphoma: The Illustrated Guide has been designed to alleviate some of these difficulties, providing all those working in the dermatological field with a complete and easily consulted text on this potentially fatal cancer. Authored by renowned dermatopathologist Professor Lorenzo Cerroni, its exhaustive contents cover the clinical presentations and pathological correlates of cutaneous lymphomas in their various forms, alongside their prognoses and strategies for treatment.

This expanded fifth edition features a wealth of enhancements and additions, including new chapters, updated content, and more than 1,300 full-color illustrations. Revised to reflect the most recent World Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classifications, its cutting-edge approach to its subject incorporates the latest molecular data, alongside more familiar histopathological and clinical features. The book’s considerable scope has been broadened into new and groundbreaking areas, the details of which are explored in chapters discussing primary cutaneous acral CD8+ T-cell lymphoma, composite lymphomas, and non-neoplastic cutaneous signs of systemic lymphomas, as well as in new sections on previously unexamined entities such as implant–associated anaplastic large cell lymphoma.

·         Fully updated with new genetic data and most recent WHO classifications

·         Contains four newly written chapters

·         Features unconventional presentation sections with commentary on diagnosis

·         Includes more than 1,300 color illustrations

Skin Lymphoma: The Illustrated Guide is an indispensable resource forclinical dermatologists, dermatopathologists, and any other medical practitioners and trainees involved in the diagnosis and treatment of skin lymphomas.

TABLE OF CONTENTS:

List of Teaching Cases xi

Preface xiii

Acknowledgments xv

1 Introduction 1

Section 1: Cutaneous NK/T‐Cell lymphomas

2 The ‘‘parapsoriases’’: A Riddle, Wrapped in a Mystery, Inside an Enigma 15

3 Mycosis Fungoides 23

4 Sézary Syndrome 113

5 Primary Cutaneous CD30⁺ Lymphoproliferative Disorders 133

Lymphomatoid Papulosis 134

Cutaneous Anaplastic Large Cell Lymphoma 150

“Borderline” Cases 167

Intralymphatic CD30⁺ Large T‐Cell Lymphoma 168

Implant‐Associated Anaplastic Large Cell Lymphoma 170

6 Subcutaneous Panniculitis‐like T‐cell Lymphoma 180

7 Aggressive Cutaneous Cytotoxic Lymphomas 195

Primary Cutaneous Aggressive Epidermotropic CD8⁺ Cytotoxic T‐Cell Lymphoma 196

Primary Cutaneous γ/δ T‐Cell Lymphoma 201

Cutaneous Extranodal NK/T‐Cell Lymphoma, Nasal Type 208

8 Cutaneous Peripheral T‐cell Lymphoma, Not Otherwise Specified (NOS) 219

9 Cutaneous CD4⁺ Small/Medium T‐cell Lymphoproliferative Disorder 228

10 Acral CD8⁺ Cutaneous T‐cell Lymphoma 235

11 Cutaneous Adult T‐cell Leukemia/Lymphoma 239

12 Other Cutaneous NK/T‐cell Lymphomas 243

Cutaneous Angioimmunoblastic T‐Cell Lymphoma 243

Hydroa Vacciniforme‐Like Lymphoproliferative Disorder 246

Severe Mosquito Bite Allergy 250

Section 2: Cutaneous B‐Cell lymphomas

13 Cutaneous Follicle Center Lymphoma 255

14 Cutaneous Marginal Zone Lymphoma (Cutaneous MALT Lymphoma) and Variants 274

Cutaneous Marginal Zone Lymphoma, Conventional Variant 276

Cutaneous Marginal Zone Lymphoma, Lymphoplasmacytic Variant 287

Cutaneous Marginal Zone Lymphoma, Plasmacytic Variant 290

Cutaneous Marginal Zone Lymphoma, Blastoid Variant 292

Cutaneous Amyloidoma 293

15 Cutaneous Diffuse Large B‐cell Lymphoma, Leg Type 299

16 Intravascular Large Cell Lymphomas 315

Intravascular Large B‐Cell Lymphoma 316

Intravascular Large NK/T‐Cell Lymphoma 321

17 Other Cutaneous B‐cell Lymphomas 326

Epstein–Barr Virus (EBV)‐Positive Cutaneous Diffuse Large B‐Cell Lymphoma, Not Otherwise Specified (NOS) 326

Specific Cutaneous Manifestations in Mantle Cell Lymphoma 329

Specific Cutaneous Manifestations in Extracavitary Primary Effusion Lymphoma 331

Specific Cutaneous Manifestations in Multiple Myeloma 334

Specific Cutaneous Manifestations in Burkitt Lymphoma 336

Cutaneous Lymphomatoid Granulomatosis 340

Cutaneous Plasmablastic Lymphoma 342

Cutaneous T‐Cell/Histiocyte‐Rich Large B‐Cell Lymphoma 344

Cutaneous Manifestations in Waldenstrom Macroglobulinemia 346

Epstein–Barr Virus (EBV)‐Associated Mucocutaneous Ulcers 347

Section 3: Cutaneous lymphomas in immunosuppressed individuals

18 Cutaneous Lymphomas in Immunosuppressed Individuals 357

Cutaneous Posttransplant Lymphoproliferative Disorders 358

Cutaneous Lymphomas in HIV‐Infected Individuals 365

Cutaneous Lymphoproliferative Disorders in Other Iatrogenic and Non‐Iatrogenic Immune Deficiencies 368

Section 4: Specific cutaneous manifestations of leukemias and of precursor hematologic neoplasms

19 Cutaneous Manifestations of B‐cell Chronic Lymphocytic Leukemia 379

Progression to Diffuse Large B‐Cell Lymphoma (Richter Syndrome) 385

20 Cutaneous Manifestations of Myelogenous Leukemia 390

Chronic Myeloid Leukemia 399

Myelodysplastic Syndromes 400

21 Blastic Plasmacytoid Dendritic Cell Neoplasm 407

Mature Plasmacytoid Dendritic Cell Proliferations Associated With Myeloid Neoplasms 415

22 Cutaneous Manifestations of Other Leukemias 419

T‐Cell Prolymphocytic Leukemia 419

Aggressive Natural Killer Cell Leukemia 421

Specific Skin Manifestations of Other Types of Leukemia 422

23 Cutaneous Lymphoblastic Lymphomas 424

Cutaneous B‐Lymphoblastic Lymphoma 424

Cutaneous T‐Lymphoblastic Lymphoma 428

Section 5: Cutaneous manifestations of other lymphomas and non‐neoplastic cutaneous signs of systemic lymphomas

24 Cutaneous Manifestations of Hodgkin Lymphoma 437

Primary Cutaneous Hodgkin Lymphoma 440

25 Cutaneous Composite Lymphomas 443

26 Nonneoplastic Cutaneous Signs of Systemic Lymphomas 450

Section 6: Cutaneous lymphomas in children and adolescents

27 Cutaneous Lymphomas in Children and Adolescents 463

Mycosis Fungoides 463

Sézary Syndrome 464

Lymphomatoid Papulosis 467

Cutaneous Anaplastic Large Cell Lymphoma 467

Subcutaneous Panniculitis‐Like T‐Cell Lymphoma 468

Primary Cutaneous Aggressive Epidermotropic CD8⁺ Cytotoxic T‐Cell Lymphoma 468

Primary Cutaneous γ/δ T‐Cell Lymphoma 468

Extranodal NK/T‐Cell Lymphoma, Nasal Type 468

Primary Cutaneous Peripheral T‐Cell Lymphoma, not Otherwise Specified (NOS) 468

Cutaneous CD4⁺ Small/Medium T‐Cell Lymphoproliferative Disorder 468

Cutaneous Angioimmunoblastic T‐Cell Lymphoma 468

Epstein–Barr Virus (EBV)‐Positive T‐Cell and NK‐Cell Lymphoproliferative Diseases of Childhood (Hydroa Vacciniforme‐Like Lymphoproliferative Disorder, Severe Mosquito Bite Allergy) 468

Adult T‐Cell Lymphoma/Leukemia 469

Acral CD8⁺ T‐Cell Lymphoma 469

Cutaneous Follicle Center Lymphoma 469

Cutaneous Marginal Zone Lymphoma (Cutaneous MALT Lymphoma) 469

Cutaneous Burkitt Lymphoma 469

Cutaneous Intravascular Large Cell Lymphoma 469

Cutaneous Lymphomatoid Granulomatosis 469

EBV⁺ Mucocutaneous Ulcer 469

Cutaneous Lymphomas in Immunosuppressed Children and Adolescents 469

Cutaneous Manifestations of Myelogenous Leukemia 469

Blastic Plasmacytoid Dendritic Cell Neoplasm 470

Cutaneous Lymphoblastic Lymphoma (B or T Cell) 470

Section 7: Pseudolymphomas of the skin

28 Pseudolymphomas of the Skin 475

Chronic Actinic Dermatitis (Actinic Reticuloid) 477

Lymphomatoid Contact Dermatitis 478

Non‐mycosis Fungoides‐associated Follicular Mucinosis and Other Mimickers of Pilotropic Mycosis Fungoides 479

Solitary Idiopathic B/T‐cell Pseudolymphoma 481

Lichenoid (Lymphomatoid) Keratosis 483

T‐cell‐Rich Angiomatoid Polypoid Pseudolymphoma/ Acral Pseudolymphomatous Angiokeratoma in Children/ Pretibial Lymphoplasmacytic Plaque in Children (“T/B‐cell Angiomatoid Pseudolymphoma”) 486

Lichen Aureus/Lichenoid Pigmented Purpuric Dermatitis 487

Lichen Sclerosus 489

Vitiligo 489

Annular Lichenoid Dermatitis of Youth 490

Pseudolymphomatous Acrodermatitis Chronica Atrophicans 493

Pseudolymphomatous Atopic Dermatitis 495

Nonneoplastic Erythroderma in Adult Patients 496

Pseudolymphomatous Cutaneous Infiltrates in Human Immunodeficiency Virus (HIV)‐Infected Patients and in Other Immune Deficiencies 499

CD30⁺ T‐cell Pseudolymphomas 502

Persistent Nodular Arthropod Bite Reactions and Nodular Scabies 502

Pseudolymphomas in Herpes Simplex and Herpes Zoster Infections 504

Hydroa Vacciniforme 506

Pityriasis Lichenoides 507

Pseudolymphomas Associated with Lupus Erythematosus 511

Lymphomatoid Drug Reactions 515

Lymphocytoma Cutis 516

Lymphocytoma Cutis Associated with Borrelia Infection 518

Pseudolymphomas at Sites of Vaccination 522

Pseudolymphomas in Tattoos 524

Localized Scleroderma/Morphea 524

Cutaneous IgG4‐Related Disease 526

Pseudolymphomas in Syphilis 529

Cutaneous Plasma Cell Granuloma 534

Cutaneous and Systemic Plasmacytosis 535

Cutaneous Manifestations of Castleman Disease 536

Cutaneous Extramedullary Hematopoiesis 537

Histiocytoid Sweet Syndrome 538

Intralymphatic Histiocytosis 539

Benign Intralymphatic Proliferation of T‐cell Lymphoid Blasts 541

Other “Accidental” Pseudolymphomas 543

“Malignant” Pseudolymphomas 546

Section 8: The cutaneous “atypical lymphoid proliferation”

29 The Cutaneous “Atypical Lymphoid Proliferation” 565

Index 569