Ketogenic Diet and Metabolic Therapies

Description:

Ketogenic diets have treated epilepsy for nearly 100 years, yet metabolic therapy has remained obscure and underutilized for most of this time. In recent decades, the clinical efficacy of ketogenic therapy was confirmed definitively for pediatric epilepsy and has now expanded to adult epilepsy. Now, the benefits of metabolic therapy have been extended well beyond epilepsy to additional neurological, metabolic, and genetic disorders, and the importance of metabolic health is recognized as paramount.This new edition of Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease highlights the growing research and clinical applications of metabolic therapies as effective in disease treatment, reversal and prevention. Emerging mechanisms include the landscape of the microbiome and epigenetics. Consistent with the first observations in 1921, in some cases metabolism-based strategies have proven equal or superior to pharmacological treatments for specific diseases and for treating multiple comorbidities.This second edition commemorates the 100th anniversary of the ketogenic diet, shares new research in this rapidly moving field, and offers a valuable collection of high-resolution color figures. The team of editors for this edition have been working in this area for decades, and in this volume, they have assembled world leaders in this cutting-edge research. As the first academic, interdisciplinary book on ketogenic diet and metabolic therapy, this volume will be crucial during this time of increased appreciation for metabolic health in professionals and the public alike.

Table of contents:

Section I Ketogenic Diet for Epilepsy in the Clinic

2. Overview: Ketogenic Diets and Pediatric Epilepsy: An Update

3. Alternative Ketogenic Diets

4. Ketogenic Diet Therapies in Adults: History, Demand, and Results

5. How Do You Implement the Diet?

6. GLUT1 Deficiency Syndrome and the Ketogenic Dietary Therapies

7. Ketogenic Diet in Established Epilepsy Indications

8. Ketogenic Diet for Other Epilepsies

9. The Ketogenic Diets in Genetic Generalized Epilepsy Syndromes

10. Ketogenic Diet Therapy for Infants

11. Ketogenic Diet in Status Epilepticus

12. Preventing Side Effects and Diet Discontinuation

Section II Ketogenic Diet: Emerging Clinical Applications and Future Potential

13. Overview: Expanded Uses of Ketogenic Therapies

14. Metabolism-Based Treatments for Managing Cancer: Scientific Rationale

15. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer

16. Ketogenic Diet, Social Behavior, and Autism: Insights from Animal Models

17. Ketotherapeutics to Rescue Brain Energy Deficits: An Emerging Strategy to Delay Cognitive Decline in Alzheimer’s Disease

18. Ketogenic Diet and Ketones for Improving Neurologic Outcomes after Acute Neurotrauma

19. Ketogenic Diets and Neuroinflammation

20. The Ketogenic Diet in the Treatment of Schizophrenia

21. The Ketogenic Diet and the Gut Microbiome

Section III Ketogenic Diet in the Laboratory

22. Overview: Ketogenic Diet in the Laboratory: Progress on Models and Mechanisms

23. Ketogenic Diet and PPARγ

24. Ketogenic Diet and Adenosine in Epilepsy: Models and Mechanisms

25. Ketogenic Diet and Epigenetic Mechanisms of Epileptogenesis

26. Ketogenic Diet, Aging, and Neurodegeneration

27. Metabolic Seizure Resistance via BAD and KATP Channels

28. Lactate Dehydrogenase: A Novel Metabolic Target

29. Effects of the Ketogenic Diet on the Blood–Brain Barrier

30. Metabolic and Redox Alterations by Ketogenic Diets

31. Nicotinamide Adenine Dinucleotide as a Central Mediator of Ketogenic Therapy

Section IV Ketone-Based Metabolism: General Health and Metabolic Alternatives

32. Overview: Ketone-Based Metabolism—General Health and Metabolic Alternatives

33. Ketone Supplementation for Health and Disease

34. Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-Evoked Ketosis

35. Amino Acids in the Treatment of Neurologic Disorders

36. Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet

37. Triheptanoin in Epilepsy and Beyond

38. Antiseizure and Antiepileptic Effects of Glycolysis Inhibition with 2-Deoxyglucose

39. Low-Carbohydrate, Ketogenic Diets for the Treatment of Type 2 Diabetes and Obesity

40. Intermittent Exogenous Ketosis for Athletic Performance, Recovery, and Adaptation

41. Advancing the Awareness and Application of Ketogenic Therapies Globally: The Charlie Foundation for Ketogenic Therapies and Matthew’s Friends

Index