Harrison’s Principles of Internal Medicine, 21st Edition (Vol.1 & Vol.2)

 

Description:

The Voice of Clinical ReasonHarrison’s Principles of Internal Medicine is the world's most trusted clinical medicine text—and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine. Harrison's Principles of Internal Medicine stands as the benchmark for authoritative, practical information on patient care and the pathogenesis and clinical management of symptoms and signs and specific diseases. Written and edited by the world’s top experts in their respective fields, this landmark guide provides the comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. Harrison’s is world-renowned as the most authoritative source for: • Descriptions of disease mechanisms and how the clinician can apply that knowledge for the best patient care and optimal diagnosis and treatment of specific diseases • Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases • The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow • Updated clinical trial results and recommended guidelines • Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings • Coverage of both therapeutic approaches and specific treatment regimens • Practical clinical decision trees and algorithms • Organ-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, general and specific approaches to therapy Harrison’s remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world’s top experts are featured in the 21st edition: • Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer • Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries • More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes • More than a dozen atlases featuring curated collections of visual aspects of diagnosis and management • Complete, updated curation and synthesis of primary medical literature which incorporates current data from major studies and clinical trials • Clinical reasoning resources and helpful disease/presentation schemas • Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms.

 

Table of Contents:

 

PART 1 The Profession of Medicine

1 The Practice of Medicine

2 Promoting Good Health

3 Vaccine Opposition and Hesitancy

4 Decision-Making in Clinical Medicine

5 Precision Medicine and Clinical Care

6 Screening and Prevention of Disease

7 Global Diversity of Health System Financing and Delivery

8 The Safety and Quality of Health Care

9 Diagnosis: Reducing Errors and Improving Quality

10 Racial and Ethnic Disparities in Health Care

11 Ethical Issues in Clinical Medicine

12 Palliative and End-of-Life Care

PART 2 Cardinal Manifestations and Presentation of Diseases

SECTION 1 Pain

13 Pain: Pathophysiology and Management

14 Chest Discomfort

15 Abdominal Pain

16 Headache

17 Back and Neck Pain

SECTION 2 Alterations in Body Temperature

18 Fever

19 Fever and Rash

20 Fever of Unknown Origin

SECTION 3 Nervous System Dysfunction

21 Syncope

22 Dizziness and Vertigo

23 Fatigue

24 Neurologic Causes of Weakness and Paralysis

25 Numbness, Tingling, and Sensory Loss

26 Gait Disorders, Imbalance, and Falls

27 Confusion and Delirium

28 Coma

29 Dementia

30 Aphasia, Memory Loss, and Other Cognitive Disorders

31 Sleep Disorders

SECTION 4 Disorders of Eyes, Ears, Nose, and Throat

32 Disorders of the Eye

33 Disorders of Smell and Taste

34 Disorders of Hearing

35 Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat

36 Oral Manifestations of Disease

SECTION 5 Alterations in Circulatory and Respiratory Functions

37 Dyspnea

38 Cough

39 Hemoptysis

40 Hypoxia and Cyanosis

41 Edema

42 Approach to the Patient with a Heart Murmur

43 Palpitations

SECTION 6 Alterations in Gastrointestinal Function

44 Dysphagia

45 Nausea, Vomiting, and Indigestion

46 Diarrhea and Constipation

47 Unintentional Weight Loss

48 Gastrointestinal Bleeding

49 Jaundice

50 Abdominal Swelling and Ascites

SECTION 7 Alterations in Renal and Urinary Tract Function

51 Interstitial Cystitis/Bladder Pain Syndrome

52 Azotemia and Urinary Abnormalities

53 Fluid and Electrolyte Disturbances

54 Hypercalcemia and Hypocalcemia

55 Acidosis and Alkalosis

SECTION 8 Alterations in the Skin

56 Approach to the Patient with a Skin Disorder

57 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders

58 Skin Manifestations of Internal Disease

59 Immunologically Mediated Skin Diseases

60 Cutaneous Drug Reactions

61 Photosensitivity and Other Reactions to Sunlight

SECTION 9 Hematologic Alterations

62 Interpreting Peripheral Blood Smears

63 Anemia and Polycythemia

64 Disorders of Granulocytes and Monocytes

65 Bleeding and Thrombosis

66 Enlargement of Lymph Nodes and Spleen

PART 3 Pharmacology

67 Principles of Clinical Pharmacology

68 Pharmacogenomics

PART 4 Oncology and Hematology

SECTION 1 Neoplastic Disorders

69 Approach to the Patient with Cancer

70 Prevention and Early Detection of Cancer

71 Cancer Genetics

72 Cancer Cell Biology

73 Principles of Cancer Treatment

74 Infections in Patients with Cancer

75 Oncologic Emergencies

76 Cancer of the Skin

77 Head and Neck Cancer

78 Neoplasms of the Lung

79 Breast Cancer

80 Upper Gastrointestinal Tract Cancers

81 Lower Gastrointestinal Cancers

82 Tumors of the Liver and Biliary Tree

83 Pancreatic Cancer

84 Gastrointestinal Neuroendocrine Tumors

85 Renal Cell Carcinoma

86 Cancer of the Bladder and Urinary Tract

87 Benign and Malignant Diseases of the Prostate

88 Testicular Cancer

89 Gynecologic Malignancies

90 Primary and Metastatic Tumors of the Nervous System

91 Soft Tissue and Bone Sarcomas and Bone Metastases

92 Carcinoma of Unknown Primary

93 Paraneoplastic Syndromes: Endocrinologic/Hematologic

94 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis

95 Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment

SECTION 2 Hematopoietic Disorders

96 Hematopoietic Stem Cells

97 Iron Deficiency and Other Hypoproliferative Anemias

98 Disorders of Hemoglobin

99 Megaloblastic Anemias

100 Hemolytic Anemias

101 Anemia Due to Acute Blood Loss

102 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia

103 Polycythemia Vera and Other Myeloproliferative Neoplasms

104 Acute Myeloid Leukemia

105 Chronic Myeloid Leukemia

106 Acute Lymphoid Leukemia

107 Chronic Lymphocytic Leukemia

108 Non-Hodgkin’s Lymphoma

109 Hodgkin’s Lymphoma

110 Less Common Lymphoid and Myeloid Malignancies

111 Plasma Cell Disorders

112 Amyloidosis

113 Transfusion Therapy and Biology

114 Hematopoietic Cell Transplantation

SECTION 3 Disorders of Hemostasis

115 Disorders of Platelets and Vessel Wall

116 Coagulation Disorders

117 Arterial and Venous Thrombosis

118 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

PART 5 Infectious Diseases

SECTION 1 Basic Considerations in Infectious Diseases

119 Approach to the Patient with an Infectious Disease

120 Molecular Mechanisms of Microbial Pathogenesis

121 Microbial Genomics and Infectious Disease

122 Approach to the Acutely Ill Infected Febrile Patient

123 Immunization Principles and Vaccine Use

124 Health Recommendations for International Travel

125 Climate Change and Infectious Disease

SECTION 2 Clinical Syndromes: Community-Acquired Infections

126 Pneumonia

127 Lung Abscess

128 Infective Endocarditis

129 Infections of the Skin, Muscles, and Soft Tissues

130 Infectious Arthritis

131 Osteomyelitis

132 Intraabdominal Infections and Abscesses

133 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning

134 Clostridioides difficile Infection, Including Pseudomembranous Colitis

135 Urinary Tract Infections, Pyelonephritis, and Prostatitis

136 Sexually Transmitted Infections: Overview and Clinical Approach

137 Encephalitis

138 Acute Meningitis

139 Chronic and Recurrent Meningitis

140 Brain Abscess and Empyema

141 Infectious Complications of Bites

SECTION 3 Clinical Syndromes: Health Care–Associated Infections

142 Infections Acquired in Health Care Facilities

143 Infections in Transplant Recipients

SECTION 4 Therapy for Bacterial Diseases

144 Treatment and Prophylaxis of Bacterial Infections

145 Bacterial Resistance to Antimicrobial Agents

SECTION 5 Diseases Caused by Gram-Positive Bacteria

146 Pneumococcal Infections

147 Staphylococcal Infections

148 Streptococcal Infections

149 Enterococcal Infections

150 Diphtheria and Other Corynebacterial Infections

151 Listeria monocytogenes Infections

152 Tetanus

153 Botulism

154 Gas Gangrene and Other Clostridial Infections

SECTION 6 Diseases Caused by Gram-Negative Bacteria

155 Meningococcal Infections

156 Gonococcal Infections

157 Haemophilus and Moraxella Infections

158 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria

159 Legionella Infections

160 Pertussis and Other Bordetella Infections

161 Diseases Caused by Gram-Negative Enteric Bacilli

162 Acinetobacter Infections

163 Helicobacter pylori Infections

164 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species

165 Salmonellosis

166 Shigellosis

167 Infections Due to Campylobacter and Related Organisms

168 Cholera and Other Vibrioses

169 Brucellosis

170 Tularemia

171 Plague and Other Yersinia Infections

172 Bartonella Infections, Including Cat-Scratch Disease

173 Donovanosis

SECTION 7 Miscellaneous Bacterial Infections

174 Nocardiosis

175 Actinomycosis

176 Whipple’s Disease

177 Infections Due to Mixed Anaerobic Organisms

SECTION 8 Mycobacterial Diseases

178 Tuberculosis

179 Leprosy

180 Nontuberculous Mycobacterial Infections

181 Antimycobacterial Agents

SECTION 9 Spirochetal Diseases

182 Syphilis

183 Endemic Treponematoses

184 Leptospirosis

185 Relapsing Fever and Borrelia miyamotoi Disease

186 Lyme Borreliosis

SECTION 10 Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae

187 Rickettsial Diseases

188 Infections Due to Mycoplasmas

189 Chlamydial Infections

SECTION 11 Viral Diseases: General Considerations

190 Principles of Medical Virology

191 Antiviral Chemotherapy, Excluding Antiretroviral Drugs

SECTION 12 Infections Due to DNA Viruses

192 Herpes Simplex Virus Infections

193 Varicella-Zoster Virus Infections

194 Epstein-Barr Virus Infections, Including Infectious Mononucleosis

195 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8

196 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections

197 Parvovirus Infections

198 Human Papillomavirus Infections

SECTION 13 Infections Due to DNA and RNA Respiratory Viruses

199 Common Viral Respiratory Infections, Including COVID-19

200 Influenza

SECTION 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

201 The Human Retroviruses

202 Human Immunodeficiency Virus Disease: AIDS and Related Disorders

SECTION 15 Infections Due to RNA Viruses

203 Viral Gastroenteritis

204 Enterovirus, Parechovirus, and Reovirus Infections

205 Measles (Rubeola)

206 Rubella (German Measles)

207 Mumps

208 Rabies and Other Rhabdovirus Infections

209 Arthropod-Borne and Rodent-Borne Virus Infections

210 Ebolavirus and Marburgvirus Infections

SECTION 16 Fungal Infections

211 Pathogenesis, Diagnosis, and Treatment of Fungal Infections

212 Histoplasmosis

213 Coccidioidomycosis

214 Blastomycosis

215 Cryptococcosis

216 Candidiasis

217 Aspergillosis

218 Mucormycosis

219 Less Common Systemic Mycoses and Superficial Mycoses

220 Pneumocystis Infections

SECTION 17 Protozoal and Helminthic Infections: General Considerations

221 Introduction to Parasitic Infections

222 Agents Used to Treat Parasitic Infections

SECTION 18 Protozoal Infections

223 Amebiasis and Infection with Free-Living Amebae

224 Malaria

225 Babesiosis

226 Leishmaniasis

227 Chagas Disease and African Trypanosomiasis

228 Toxoplasma Infections

229 Protozoal Intestinal Infections and Trichomoniasis

SECTION 19 Helminthic Infections

230 Introduction to Helminthic Infections

231 Trichinellosis and Other Tissue Nematode Infections

232 Intestinal Nematode Infections

233 Filarial and Related Infections

234 Schistosomiasis and Other Trematode Infections

235 Cestode Infections

PART 6 Disorders of the Cardiovascular System

SECTION 1 Introduction to Cardiovascular Disorders

236 Approach to the Patient with Possible Cardiovascular Disease

237 Basic Biology of the Cardiovascular System

238 Epidemiology of Cardiovascular Disease

SECTION 2 Diagnosis of Cardiovascular Disorders

239 Physical Examination of the Cardiovascular System

240 Electrocardiography

241 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging

242 Diagnostic Cardiac Catheterization and Coronary Angiography

SECTION 3 Disorders of Rhythm

243 Principles of Clinical Cardiac Electrophysiology

244 The Bradyarrhythmias: Disorders of the Sinoatrial Node

245 The Bradyarrhythmias: Disorders of the Atrioventricular Node

246 Approach to Supraventricular Tachyarrhythmias

247 Physiologic and Nonphysiologic Sinus Tachycardia

248 Focal Atrial Tachycardia

249 Paroxysmal Supraventricular Tachycardias

250 Common Atrial Flutter and Macroreentrant and Multifocal Atrial Tachycardias

251 Atrial Fibrillation

252 Approach to Ventricular Arrhythmias

253 Premature Ventricular Contractions, Nonsustained Ventricular Tachycardia, and Accelerated Idioventricular Rhythm

254 Sustained Ventricular Tachycardia

255 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation

256 Electrical Storm and Incessant Ventricular Tachycardia

SECTION 4 Disorders of the Heart, Muscles, Valves, and Pericardium

257 Heart Failure: Pathophysiology and Diagnosis

258 Heart Failure: Management

259 Cardiomyopathy and Myocarditis

260 Cardiac Transplantation and Prolonged Assisted Circulation

261 Aortic Stenosis

262 Aortic Regurgitation

263 Mitral Stenosis

264 Mitral Regurgitation

265 Mitral Valve Prolapse

266 Tricuspid Valve Disease

267 Pulmonic Valve Disease

268 Multiple and Mixed Valvular Heart Disease

269 Congenital Heart Disease in the Adult

270 Pericardial Disease

271 Atrial Myxoma and Other Cardiac Tumors

272 Cardiac Trauma

SECTION 5 Coronary and Peripheral Vascular Disease

273 Ischemic Heart Disease

274 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)

275 ST-Segment Elevation Myocardial Infarction

276 Percutaneous Coronary Interventions and Other Interventional Procedures

277 Hypertension

278 Renovascular Disease

279 Deep-Venous Thrombosis and Pulmonary Thromboembolism

280 Diseases of the Aorta

281 Arterial Diseases of the Extremities

282 Chronic Venous Disease and Lymphedema

283 Pulmonary Hypertension

PART 7 Disorders of the Respiratory System

SECTION 1 Diagnosis of Respiratory Disorders

284 Approach to the Patient with Disease of the Respiratory System

285 Disturbances of Respiratory Function

286 Diagnostic Procedures in Respiratory Disease

SECTION 2 Diseases of the Respiratory System

287 Asthma

288 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia

289 Occupational and Environmental Lung Disease

290 Bronchiectasis

291 Cystic Fibrosis

292 Chronic Obstructive Pulmonary Disease

293 Interstitial Lung Disease

294 Disorders of the Pleura

295 Disorders of the Mediastinum

296 Disorders of Ventilation

297 Sleep Apnea

298 Lung Transplantation

299 Interventional Pulmonary Medicine

PART 8 Critical Care Medicine

SECTION 1 Respiratory Critical Care

300 Approach to the Patient with Critical Illness

301 Acute Respiratory Distress Syndrome

302 Mechanical Ventilatory Support

SECTION 2 Shock and Cardiac Arrest

303 Approach to the Patient with Shock

304 Sepsis and Septic Shock

305 Cardiogenic Shock and Pulmonary Edema

306 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death

SECTION 3 Neurologic Critical Care

307 Nervous System Disorders in Critical Care

Part 9 Disorders of the Kidney and Urinary Tract

308 Approach to the Patient with Renal Disease or Urinary Tract Disease

309 Cell Biology and Physiology of the Kidney

310 Acute Kidney Injury

311 Chronic Kidney Disease

312 Dialysis in the Treatment of Kidney Failure

313 Transplantation in the Treatment of Renal Failure

314 Glomerular Diseases

315 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development

316 Tubulointerstitial Diseases of the Kidney

317 Vascular Injury to the Kidney

318 Nephrolithiasis

319 Urinary Tract Obstruction

320 Interventional Nephrology

PART 10 Disorders of the Gastrointestinal System

SECTION 1 Disorders of the Alimentary Tract

321 Approach to the Patient with Gastrointestinal Disease

322 Gastrointestinal Endoscopy

323 Diseases of the Esophagus

324 Peptic Ulcer Disease and Related Disorders

325 Disorders of Absorption

326 Inflammatory Bowel Disease

327 Irritable Bowel Syndrome

328 Diverticular Disease and Common Anorectal Disorders

329 Mesenteric Vascular Insufficiency

330 Acute Intestinal Obstruction

331 Acute Appendicitis and Peritonitis

SECTION 2 Nutrition

332 Nutrient Requirements and Dietary Assessment

333 Vitamin and Trace Mineral Deficiency and Excess

334 Malnutrition and Nutritional Assessment

335 Enteral and Parenteral Nutrition

SECTION 3 Liver and Biliary Tract Disease

336 Approach to the Patient with Liver Disease

337 Evaluation of Liver Function

338 The Hyperbilirubinemias

339 Acute Viral Hepatitis

340 Toxic and Drug-Induced Hepatitis

341 Chronic Hepatitis

342 Alcohol-Associated Liver Disease

343 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis

344 Cirrhosis and Its Complications

345 Liver Transplantation

346 Diseases of the Gallbladder and Bile Ducts

SECTION 4 Disorders of the Pancreas

347 Approach to the Patient with Pancreatic Disease

348 Acute and Chronic Pancreatitis

PART 11 Immune-Mediated, Inflammatory, and Rheumatologic Disorders

SECTION 1 The Immune System in Health and Disease

349 Introduction to the Immune System

350 Mechanisms of Regulation and Dysregulation of the Immune System

351 Primary Immune Deficiency Diseases

SECTION 2 Disorders of Immune-Mediated Injury

352 Urticaria, Angioedema, and Allergic Rhinitis

353 Anaphylaxis

354 Mastocytosis

355 Autoimmunity and Autoimmune Diseases

356 Systemic Lupus Erythematosus

357 Antiphospholipid Syndrome

358 Rheumatoid Arthritis

359 Acute Rheumatic Fever

360 Systemic Sclerosis (Scleroderma) and Related Disorders

361 Sjögren’s Syndrome

362 Spondyloarthritis

363 The Vasculitis Syndromes

364 Behçet Syndrome

365 Inflammatory Myopathies

366 Relapsing Polychondritis

367 Sarcoidosis

368 IgG4-Related Disease

369 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases

SECTION 3 Disorders of the Joints and Adjacent Tissues

370 Approach to Articular and Musculoskeletal Disorders

371 Osteoarthritis

372 Gout and Other Crystal-Associated Arthropathies

373 Fibromyalgia

374 Arthritis Associated with Systemic Disease, and Other Arthritides

375 Periarticular Disorders of the Extremities

PART 12 Endocrinology and Metabolism

SECTION 1 Endocrinology

376 Approach to the Patient with Endocrine Disorders

377 Mechanisms of Hormone Action

378 Physiology of Anterior Pituitary Hormones

379 Hypopituitarism

380 Pituitary Tumor Syndromes

381 Disorders of the Neurohypophysis

382 Thyroid Gland Physiology and Testing

383 Hypothyroidism

384 Hyperthyroidism and Other Causes of Thyrotoxicosis

385 Thyroid Nodular Disease and Thyroid Cancer

386 Disorders of the Adrenal Cortex

387 Pheochromocytoma

388 Multiple Endocrine Neoplasia Syndromes

389 Autoimmune Polyendocrine Syndromes

SECTION 2 Sex- and Gender-Based Medicine

390 Sex Development

391 Disorders of the Testes and Male Reproductive System

392 Disorders of the Female Reproductive System

393 Menstrual Disorders and Pelvic Pain

394 Hirsutism

395 Menopause and Postmenopausal Hormone Therapy

396 Infertility and Contraception

397 Sexual Dysfunction

398 Women’s Health

399 Men’s Health

400 Lesbian, Gay, Bisexual, and Transgender (LGBT) Health

SECTION 3 Obesity, Diabetes Mellitus, and Metabolic Syndrome

401 Pathobiology of Obesity

402 Evaluation and Management of Obesity

403 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology

404 Diabetes Mellitus: Management and Therapies

405 Diabetes Mellitus: Complications

406 Hypoglycemia

407 Disorders of Lipoprotein Metabolism

408 The Metabolic Syndrome

SECTION 4 Disorders of Bone and Mineral Metabolism

409 Bone and Mineral Metabolism in Health and Disease

410 Disorders of the Parathyroid Gland and Calcium Homeostasis

411 Osteoporosis

412 Paget’s Disease and Other Dysplasias of Bone

SECTION 5 Disorders of Intermediary Metabolism

413 Heritable Disorders of Connective Tissue

414 Hemochromatosis

415 Wilson’s Disease

416 The Porphyrias

417 Disorders of Purine and Pyrimidine Metabolism

418 Lysosomal Storage Diseases

419 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism

420 Inherited Disorders of Amino Acid Metabolism in Adults

421 Inherited Defects of Membrane Transport

PART 13 Neurologic Disorders

SECTION 1 Diagnosis of Neurologic Disorders

422 Approach to the Patient with Neurologic Disease

423 Neuroimaging in Neurologic Disorders

424 Pathobiology of Neurologic Diseases

SECTION 2 Diseases of the Central Nervous System

425 Seizures and Epilepsy

426 Introduction to Cerebrovascular Diseases

427 Ischemic Stroke

428 Intracranial Hemorrhage

429 Subarachnoid Hemorrhage

430 Migraine and Other Primary Headache Disorders

431 Alzheimer’s Disease

432 Frontotemporal Dementia

433 Vascular Dementia

434 Dementia with Lewy Bodies

435 Parkinson’s Disease

436 Tremor, Chorea, and Other Movement Disorders

437 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

438 Prion Diseases

439 Ataxic Disorders

440 Disorders of the Autonomic Nervous System

441 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders

442 Diseases of the Spinal Cord

443 Concussion and Other Traumatic Brain Injuries

444 Multiple Sclerosis

445 Neuromyelitis Optica

SECTION 3 Nerve and Muscle Disorders

446 Peripheral Neuropathy

447 Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies

448 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction

449 Muscular Dystrophies and Other Muscle Diseases

SECTION 4 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

450 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

SECTION 5 Psychiatric and Addiction Disorders

451 Biology of Psychiatric Disorders

452 Psychiatric Disorders

453 Alcohol and Alcohol Use Disorders

454 Nicotine Addiction

455 Marijuana and Marijuana Use Disorders

456 Opioid-Related Disorders

457 Cocaine, Other Psychostimulants, and Hallucinogens

PART 14 Poisoning, Drug Overdose, and Envenomation

458 Heavy Metal Poisoning

459 Poisoning and Drug Overdose

460 Disorders Caused by Venomous Snakebites and Marine Animal Exposures

461 Ectoparasite Infestations and Arthropod Injuries

PART 15 Disorders Associated with Environmental Exposures

462 Altitude Illness

463 Hyperbaric and Diving Medicine

464 Hypothermia and Peripheral Cold Injuries

465 Heat-Related Illnesses

PART 16 Genes, the Environment, and Disease

466 Principles of Human Genetics

467 The Practice of Genetics in Clinical Medicine

468 Mitochondrial DNA and Heritable Traits and Diseases

469 Telomere Disease

470 Gene- and Cell-Based Therapy in Clinical Medicine

471 The Human Microbiome

PART 17 Global Medicine

472 Global Issues in Medicine

473 Emerging and Reemerging Infectious Diseases

474 Primary Care and Global Health

475 Health Effects of Climate Change

PART 18 Aging

476 Biology of Aging

477 Caring for the Geriatric Patient

PART 19 Consultative Medicine

478 Approach to Medical Consultation

479 Medical Disorders During Pregnancy

480 Medical Evaluation of the Surgical Patient

PART 20 Frontiers

481 Behavioral Economics and Health

482 Complementary and Integrative Therapies and Practices

483 The Role of Epigenetics in Disease and Treatment

484 Applications of Stem Cell Biology in Clinical Medicine

485 The Role of Circadian Biology in Health and Disease

486 Network Medicine: Systems Biology in Health and Disease

487 Emerging Neurotherapeutic Technologies

488 Machine Learning and Augmented Intelligence in Clinical Medicine

489 Metabolomics

490 Circulating Nucleic Acids as Liquid Biopsies and Noninvasive Disease Biomarkers

491 Protein Folding Disorders

492 Novel Approaches to Diseases of Unknown Etiology

Index

 

 

 

An aparitie	3 Jun. 2022
Autor	Joseph Loscalzo, Anthony Fauci, Dennis Kasper, Stephen Hauser, Dan Longo, J. Larry Jameson
Dimensiuni	22.61 x 11.94 x 29.72 cm
Editura	McGraw-Hill
Format	Hardcover
ISBN	9781264285846
Limba	Engleza
Nr pag	4384