Goldfrank’s Clinical Manual of Toxicologic Emergencies, Second Edition

 

Derived from the definitive guide to medical toxicology, this hands-on companion provides accurate information for diagnosing and treating poisoned patients on the spot
After more than a decade on the market, Goldfrank’s Toxicologic Emergencies has established itself as the go-to reference for medical toxicology—and this companion manual distills the most important information into a portable, easy-to-navigate resource.
Goldfrank’s Manual of Toxicologic Emergencies distills critical information into short summaries and synopses, so you can use it to treat patients in clinical settings or for quick review of critical topics. Fully updated to ensure all information is completely current, this new edition is filled with tables, figures, images, and other visuals to make finding the right answers quick and easy. Each chapter is a direct distillation of the corresponding chapter in Goldfrank’s Toxicologic Emergencies.
Whether you’re a medical toxicologist, pharmacist, physician, nurse practitioner, or student, Goldfrank’s Manual of Toxicologic Emergencies provides all the right answers where and when you need them.
Covers the full range of xenobiotics:

Includes pharmaceuticals, recreational drugs, and substances of abuse; food and plant toxins; envenomations; household toxins; pesticides and herbicides; rodenticides; metals; poison gases; and environmental toxins

Systematically reviews toxicokinetics, pathophysiology, clinical manifestations, diagnostic testing, and management for each xenobiotic

Provides "Antidotes in Brief"—at-a-glance guides to specific antidotes and their primary applications

Authoritative answers at your fingertips:

How to manage the poisoned or overdosed patient

What techniques effectively eliminate toxins

Which imaging modalities yield the best results

 

Table of Contents:

 

Table of Contents

The table of contents (below) will mirror the main text, both for completeness and ease of cross-referencing.

Historical Principles and Perspectives

Toxicologic Misfortunes and Catastrophes in History

PART A

THE GENERAL APPROACH TO THE PATIENT

Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes

Principles of Managing the Acutely Poisoned or Overdosed Patient

SC1. Principles of Antidote Stocking

Decontamination Principles: Prevention of Gastrointestinal Absorption

SC2. Decontamination Principles: Prevention of Dermal, ophthalmic and inhalational Absorption

A1. Activated Charcoal

A2. Whole-Bowel Irrigation and Other Intestinal Evacuants

Principles and Techniques Applied to Enhance Elimination

Laboratory Principles

Principles of Diagnostic Imaging

Pharmacokinetic and Toxicokinetic Principles

PART B

THE FUNDAMENTAL PRINCIPLES OF MEDICALTOXICOLOGY

SECTION I

BIOCHEMICAL AND MOLECULAR CONCEPTS

Chemical Principles

Biochemical and Metabolic Principles

Fluid, Electrolyte, and Acid–Base Principles

Neurotransmitters and Neuromodulators

Withdrawal Principles

SECTION II

PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS

Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles

Cardiologic Principles II: Hemodynamics

Dermatologic Principles

SC3. Transdermal Toxicology

Gastrointestinal Principles

Genitourinary Principles

Hematologic Principles

Hepatic Principles

Neurologic Principles

Oncologic Principles

Ophthalmic Principles

Otolaryngologic Principles

Psychiatric Principles

SC4. patient violence

Respiratory Principles

Thermoregulatory Principles

SECTION III

SPECIAL POPULATIONS

Reproductive and Perinatal Principles

Pediatric Principles

Geriatric Principles

PART C

THE CLINICAL BASIS OF MEDICAL TOXICOLOGY

SECTION I

A. ANALGESICS AND ANTIINFLAMMATORY MEDICATIONS

Acetaminophen

A3. N-Acetylcysteine

Colchicine, Podophyllin, and the Vinca Alkaloids

Nonsteroidal Antiinflammatory Drugs

Opioids

A4. Opioid antagonists

SC5. Internal Concealment of Xenobiotics

SC6. Harm Reduction for Opioid Overdose

Salicylates

A5. Sodium bicarbonate

B. Food, Diet, and Nutrition

Botulism

A6. botulinum antitoxin

Food Poisoning

Dieting Xenobiotics and Regimens

Athletic Performance Enhancers

Essential Oils

Plantand Animal-Derived Dietary Supplements

Vitamins

Iron

A7. deferoxamine

C. pharmaceuticals

Pharmaceutical Additives

Antidiabetics and Hypoglycemics/Antiglycemics

A8. Dextrose(d-Glucose)

A9. octreotide

Antiepileptics

A10. l-carnitine

Antihistamines and Decongestants

A11. physostigmine salicylate

Chemotherapeutics

Methotrexate,5-Flourouracil, and Capecitabine

A12. folates :leucovorin (Folinic acid) and Folic Acid

A13. glucarpidase(carboxypeptidase g2)

A14. uridine triacetate

SC7. Inadvertent Intrathecal Administration of Xenobiotics

SC8. Extravasation of Chemotherapeutics

Antimigraine Medications

Thyroidand Antithyroid Medications

D. Antimicrobials

Antibacterials, Antifungals, and Antivirals

Antimalarials

Antituberculous Medications

A15. pyridoxine

E. Cardiopulmonary Medications

CASE STUDY 4

Antidysrhythmics

A16. Magnesium Sulfate

Antithrombotics

A17. Protein Complex Concentrate and Novel Antithrombotic Antidotes

A18. Vitamin k1

A19. protamine

A20. Glucagon

Calcium Channel Blockers

A21. High-dose insulin (HDI)

Miscellaneous Antihypertensives and Pharmacologically Related Agents

Cardioactive Steroids

A22. digoxin-specific antibody fragments

Methylxanthines and Selective 

F.ANESTHETICS AND RELATED MEDICATIONS

Local Anesthetics

A23. lipid emulsion

Inhalational Anesthetics

Neuromuscular Blockers

A24. dantrolene sodium

G. Psychotropics

Antipsychotics

Cyclic Antidepressants

Serotonin Reuptake Inhibitors and Atypical Antidepressants

Lithium

Monoamine Oxidase Inhibitors

Sedative-Hypnotics

A25. flumazenil

H. SUBSTANCES OF ABUSE

Amphetamines

Cannabinoids

Cocaine

A26. Benzodiazepines

Ethanol

A27. Thiamine hydrochloride

Ethanol Withdrawal

Disulfiram and Disulfiram-like Reactions

Hallucinogens

Inhalants

Nicotine

Phencyclidine and Ketamine

I. Metals

Aluminum

Antimony

Arsenic

A28. Dimercaprol (british anti-lewisite or bal)

Bismuth

Cadmium

Cesium

Chromium

Cobalt

Copper

Lead

A29. succimer (2,3-dimercaptosuccinic acid)

A30. edetate calcium disodium (CaNa2EDTA)

Manganese

Mercury

Nickel

Selenium

Silver

Thallium

A31. Prussian blue

Zinc

J. HOUSEHOLD PRODUCTS

Antiseptics, Disinfectants, and Sterilants

Camphorand Moth Repellents

Caustics

Hydrofluoric Acid and Fluorides

A32. Calcium

Hydrocarbons

Toxic Alcohols

A33. fomepizole

A34. ethanol

SC9. Diethylene Glycol

K. PESTICIDES

Barium

Fumigants

Herbicides

Insecticides: Organic Phosphorus Compounds and Carbamates

A35. Atropine

A36. Pralidoxime

Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, Neonicitinoids and Insect Repellents

Phosphorus

Sodium Monofluoroacetate and Fluoroacetamide

Strychnine

L. Natural Toxins and Envenomations

Arthropod

A37. antivenom: spider

A38. antivenom: scorpion

Marine Envenomations

Mushrooms

Plants

Native(US) Venomous Snakes and Lizards

A39. antivenom: snakes (native [US] venomous [crotaline and elapid])

SC10. Exotic Nonnative Snake Envenomations

M. OCCUPATIONAL AND ENVIRONMENTAL TOXINS

CASE STUDY 11

Smoke Inhalation

Simple Asphyxiants and Pulmonary Irritants

Carbon Monoxide

A40. hyperbaric oxygen

Cyanide and Hydrogen Sulfide

A41. hydroxocobalamin

A42. nitrites(sodium amyl) and sodium thiosulfate

Methemoglobin Inducers

A43. methyleneblue

Nanotoxicology

N. DISASTER PREPAREDNESS

Chemical Weapons

Biological Weapons

Radiation

A44. Potassium iodide

A45. Pentetic acid or pentetate (zinc or calcium) trisodium (dtpa)

part D

POPULATION HEALTH

section 1

POISON CENTERS, HEALTH SYSTEMS, AND EPIDEMIOLOGY

Poison Prevention and Education

Poison Centers and Poison Epidemiology

Principles of Occupational Toxicology: Diagnosis and Control

Hazardous Materials Incident Response

Risk Assessment and Risk Communication

Medication Safety and Adverse Drug Events

Drug Development, Adverse Drug Events, and Post-marketing Surveillance

International Perspectives on Medical Toxicology

Principles of Epidemiology and Research Design

Section II

LEGAL ASPECTS OF TOXICOLOGY

Risk Management and Legal Principles

Medicolegal Interpretive Toxicology

SC11. Assessment of Ethanol-Induced Impairment

Postmortem Toxicology

SC12. Organ Procurement from Poisoned Patients

 

An aparitie	15 dec 2023
Autor	Robert Hoffman, Sophie Gosselin, Lewis Nelson, Neal Lewin, Mary Howland, Silas W. Smith, Lewis Goldfrank
Editura	McGraw-Hill
Format	Paperback
ISBN	9781260474992
Limba	Engleza