Cancer: Prevention, Early Detection, Treatment and Recovery, 2nd Edition

 

Description:

A guide to recent insights into the genetic and epigenetic parameters of cancer biology and pathology and emerging clinical applications

The thoroughly updated second edition of The Biology and Treatment of Cancer, now titled Cancer: Prevention, Early Detection, Treatment and Recovery, goes beyond reviewing the fundamental properties of cancer biology and the relevant issues associated with treatment of the disease. The new edition contains coverage of additional "patient centric" topics and presents cancer biology with selection of topics, facts, and perspectives written in easy-to-understand terms.

With contributions from noted experts, the book explores recent advances in the understanding of cancer including breakthroughs in the molecular and cellular basis of cancer and provides strategies for approaching cancer prevention, early detection, and treatment. The authors incorporate recent information on the genetic and epigenetic parameters of cancer biology and pathology with indications of emerging clinical applications. The text offers a unique guide to cancer prevention, early detection, treatment, and recovery for students, caregivers, and most importantly cancer patients. This significant book:

Incorporates current insight into the genetic and epigenetic parameters of cancer biology and pathology and information on emerging clinical applications

Contains contributions from leaders in cancer research, care, and clinical trials

Offers an accessible guide to an accurate and balanced understanding of cancer and the cancer patient

Focuses on the importance of cancer prevention, early detection, treatment, and survivorship

Written for medical students, students of cancer biology, and caregivers and cancer patients, Cancer: Prevention, Early Detection, Treatment and Recovery offers an authoritative overview of the challenges and opportunities associated with cancer biology, cancer research, and the spectrum of clinical considerations.

 

 

Table of contents:

 

 

 

I: CANCER AND THE CANCER EXPERIENCE

 

1 CANCER AND THE CANCER EXPERIENCE

ENCOUNTERING CANCER

CHALLENGES, OPPORTUNITIES AND COMMITMENTS

WHAT IS CANCER?

CANCER AND THE PATIENT

PATHWAYS TO DISCOVERY

EMPHASIS ON CANCER PREVENTION AND SURVIVORSHIP

LESSONS LEARNED AND ENCOURAGING PROSPECTS

II: CURRENT UNDERSTANDING OF CANCER BIOLOGY

2 CANCER BIOLOGY AND PATHOLOGY

INTRODUCTION

BASIC CONCEPTS IN CANCER

TYPES OF CANCER

THE CAUSES OF CANCERS

CHEMICAL CARCINOGENS

BIOLOGICAL CARCINOGENS

PHYSICAL CARCINOGENS

GENETIC PREDISPOSITION

CANCER DEVELOPS IN MULTIPLE STEPS OF GENETIC AND EPIGENETIC CHANGES

SUMMARY

REFERENCES

3 CAUSES OF CANCER: GENETIC, EPIGENETIC, VIRAL, MICROENVIRONMENTAL, AND ENVIRONMENTAL CONTRIBUTIONS TO CANCER

INTRODUCTION

TUMOR GENETICS AND MUTATIONAL LANDSCAPE

EPIGENETIC DRIVERS OF CANCER

VIRAL

ENVIRONMENTAL STIMULI

MICROENVIRONMENT‐DRIVEN ONCOGENESIS

TUMOR HETEROGENEITY AND CLONALITY

CAUSES OF DISEASE PROGRESSION

MICROENVIRONMENT HIJACKING FOR CANCER PROGRESSION

CONCLUSIONS

REFERENCES

III: A CANCER DIAGNOSIS

4 EARLY WARNING SIGNS

INTRODUCTION

EARLY DETECTION: TECHNIQUES

GENERAL SIGNS AND SYMPTOMS

ORGAN‐SPECIFIC SIGNS AND SYMPTOMS

SUMMARY

REFERENCES

5 IMPORTANCE OF IMAGING FOR DIAGNOSIS AND TREATMENT OF CANCER

INTERVENTIONAL RADIOLOGY

IMAGING SCREENING, DIAGNOSIS AND STAGING, AND FOLLOW‐UP

BREAST CANCER SCREENING, DIAGNOSIS AND STAGING

DIAGNOSIS, STAGING, AND FOLLOW‐UP

ONCOLOGIC APPLICATIONS OF NUCLEAR MEDICINE

6 CANCER BIOMARKERS

WHAT IS A CANCER BIOMARKER?

HOW ARE CANCER BIOMARKERS BEING USED?

TYPES OF CANCER BIOMARKERS

CHALLENGES IN THE IMPLEMENTATION OF CANCER BIOMARKERS

EXAMPLES OF MAJOR CANCER BIOMARKERS BY TUMOR TYPE

CONCLUSIONS

ACKNOWLEDGMENTS

REFERENCES

7 MOLECULAR DIAGNOSIS

CLINICAL DIAGNOSTICS

MOLECULAR DIAGNOSTIC TESTS

MOLECULAR TECHNIQUES AND THEIR APPLICATIONS

PRECISION DIAGNOSTICS AND OVERDIAGNOSIS

REFERENCES

IV: NAVIGATING THE CANCER EXPERIENCE

8 NAVIGATING THE CANCER EXPERIENCE

INTRODUCTION

THE COMPLEXITY OF CANCER CARE

PATIENT NAVIGATION IN CANCER CARE

THE CURRENT NEED FOR PATIENT NAVIGATION (CONCLUSION)

REFERENCES

V: CLINICAL DIMENSIONS TO CANCER

9 CLASSIFICATION OF TUMORS, THEIR FREQUENCY AND PROGRESSION

TUMOR CLASSIFICATION

METASTATIC CANCER

TUMOR FREQUENCY

TUMOR PROGNOSIS

COMMON CANCER TYPES

REFERENCES

10 CANCER EPIDEMIOLOGY: IDENTIFYING CANCER RISK

INTRODUCTION

PRIMARY AND SECONDARY PREVENTION

CONFOUNDING AND BIAS

STATISTICAL ANALYSIS

COHORT AND CASE‐CONTROL STUDIES

CLINICAL TRIALS

CASE STUDY: CLINICAL TRIAL OF ASPIRIN TO PREVENT COLORECTAL ADENOMAS

CASE STUDY: CANCER SURVIVORSHIP AND RACIAL DISPARITIES

CASE STUDY: DIESEL MOTOR EXHAUST EXPOSURE AND LUNG CANCER RISK

CONCLUSION

REFERENCES

VI: TUMOR TYPES

11 BREAST CANCER: UNIQUE CHARACTERISTICS AS TARGETS FOR THERAPY

OVERVIEW

RISK FACTORS

RISK ASSESSMENT

SCREENING

PREVENTION

DETECTION

TYPES OF BREAST CANCER

CLINICAL CHARACTERISTICS, HISTOLOGY AND PROGNOSTIC MARKERS

STAGING

TREATMENT

SURVIVORSHIP

REFERENCES

12 PROSTATE CANCER

WHAT IS A PROSTATE?

HOW COMMON IS PROSTATE CANCER AND ARE THERE ANY RISK FACTORS?

CAN IT BE PREVENTED?

WHAT TESTS EXIST TO TRY TO SCREEN FOR IT?

HOW IS IT DIAGNOSED?

WHAT TREATMENTS ARE AVAILABLE FOR CLINICALLY LOCALIZED DISEASE?

WHAT IF THE CANCER RECURS AFTER TREATMENT?

WHAT ARE THE TREATMENTS FOR LOCALLY ADVANCED AND METASTATIC DISEASE?

REFERENCES

13 GASTROINTESTINAL CANCER

INTRODUCTION

ESOPHAGEAL CANCER

GASTRIC CANCER

COLORECTAL CANCER

CONCLUSION

14 LUNG CANCER

LUNG CANCER OVERVIEW

EPIDEMIOLOGY AND RISK FACTORS

PREVENTION AND SCREENING

SYMPTOMS

DIAGNOSIS

STAGING

TYPES OF LUNG CANCER

TREATMENT

IMPORTANT ADDITIONAL TREATMENTS IN NON‐SMALL AND SMALL CELL LUNG CANCERS

SURVIVORSHIP AND SURVEILLANCE

CONFLICTS OF INTEREST

REFERENCES

15 PEDIATRIC ONCOLOGY

WHY DO KIDS GET CANCER?

WHAT KINDS OF CANCER IMPACT CHILDREN?

TREATMENTS FOR CHILDHOOD CANCER

WHAT IS THE IMPACT OF A CANCER DIAGNOSIS ON A CHILD?

HOW DOES A CHILDHOOD CANCER DIAGNOSIS AFFECT THE FAMILY?

ADOLESCENTS AND YOUNG ADULTS: A SPECIAL POPULATION

WHERE DO WE GO FROM HERE?

16 LEUKEMIA, LYMPHOMA, AND MYELOMA

INTRODUCTION

LEUKEMIAS

ACUTE MYELOGENOUS LEUKEMIA (AML)

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

CHRONIC MYELOGENOUS LEUKEMIA (CML)

CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)

LYMPHOMAS

HODGKIN LYMPHOMA

NON‐HODGKIN LYMPHOMA

MYELOMA

CONCLUSION

17 GU ONCOLOGY: KIDNEY, UROTHELIAL, AND PENILE CANCER

INTRODUCTION

KIDNEY CANCER

UROTHELIAL CANCER

PENILE CANCER

REFERENCES

18 LIVER CANCER: HEPATOCELLULAR CARCINOMA

GENERAL CONSIDERATIONS

DEMOGRAPHICS

RISK FACTORS

PREVENTION

SCREENING

CLINICAL PRESENTATION

DIAGNOSTIC WORKUP

STAGING AND PROGNOSIS

TREATMENT

REFERENCES

19 GYN ONCOLOGY: UNIQUE CHARACTERISTIC TARGETS FOR THERAPY IN GYNECOLOGIC CANCERS

CERVIX CANCER

SQUAMOUS CARCINOMAS AND HUMAN PAPILLOMA VIRUS INFECTION

IMMUNOSUPPRESSION

PREVENTION, SCREENING, AND TREATMENT

CANCER OF THE VULVA

ENDOMETRIAL CANCER

PIK3CA/AKT/mTOR PATHWAY

METFORMIN IN EAC

OVARIAN CANCER

LOW GRADE AND BORDERLINE EOC

CURRENT THERAPY

IMMUNE THERAPY

CONCLUSION

REFERENCES

20 TESTICULAR CANCER

INTRODUCTION

HISTOLOGIC SUBTYPES

RISK FACTORS

SCREENING

SIGNS AND SYMPTOMS

DIAGNOSTIC WORKUP AND STAGING

MANAGEMENT OF TESTICULAR TUMORS

SUMMARY

REFERENCES

21 HEAD AND NECK CANCER

INTRODUCTION

ANATOMY

EPIDEMIOLOGY AND RISK FACTORS

PREVENTION

CLINICAL PRESENTATION

EXAMINATION

ADDITIONAL WORKUP

TISSUE BIOPSY/EXAMINATION UNDER ANESTHESIA

STAGING

MULTIDISCIPLINARY APPROACH TO HEAD AND NECK CANCER CARE

MANAGEMENT

SURGICAL MANAGEMENT OF THE PRIMARY TUMOR

SURGICAL MANAGEMENT OF CERVICAL LYMPHATICS

NONSURGICAL THERAPY

ADJUVANT THERAPY

IMMUNOTHERAPY

SURVIVORSHIP AND SURVEILLANCE

SUMMARY

REFERENCES

22 BRAIN AND SPINAL CORD TUMORS

INTRODUCTION

AN ONCOLOGIC PRIMER ON THE CNS

THE NEURO‐ONCOLOGIC DIAGNOSTIC AND TREATMENT TOOLKIT

A SURVEY OF PRIMARY AND METASTATIC CNS TUMORS

REFERENCES

23 THYROID CANCER

OVERVIEW

INTRODUCTION

GENERAL INFORMATION

TYPES OF THYROID CANCER

RISK FACTORS

DIAGNOSIS AND CLASSIFICATION OF THYROID CANCER

STAGING OF THYROID CANCER

TREATMENT OPTIONS

INNOVATIONS

REFERENCES

VII: TREATMENT OPTIONS

24 RADIATION THERAPY

HISTORY

RADIATION BIOLOGY AND SENSITIZATION

MODERN RADIATION THERAPY

BRACHYTHERAPY

RADIOSURGERY AND STEREOTACTIC RADIATION THERAPY

FUTURE DIRECTIONS

REFERENCES

25 RADIATION THERAPY – THE PATIENT EXPERIENCE

THE RADIATION TEAM

THE EQUIPMENT

THE EXPERIENCE

SIDE EFFECTS

RESEARCH IN RADIATION ONCOLOGY

REFERENCES

26 PAIN MANAGEMENT IN CANCER

INTRODUCTION

PRINCIPLES OF PHARMACOTHERAPY

SYMPTOMATIC CANCER PAIN MANAGEMENT

INTERVENTIONAL PAIN THERAPIES

REFERENCES

27 COMPLEMENTARY AND ALTERNATIVE MEDICINE

THE COMPLEMENTARY AND INTEGRATIVE APPROACH

THE INTEGRATIVE ONCOLOGY ENCOUNTER

PARTNERSHIP, COMMUNICATION, DECISION‐MAKING

OVERVIEW OF COMMONLY USED COMPLEMENTARY AND INTEGRATIVE THERAPIES

MANUAL/MOVEMENT THERAPIES

EXAMPLES OF POTENTIAL INTERACTIONS

COMMON PATIENT USES OF DIETARY SUPPLEMENTS IN CANCER CARE

PROMISING BIOLOGICALLY BASED ADJUVANT THERAPIES

THE CRITICAL IMPORTANCE OF NUTRITION

CONCLUSION

REFERENCES

28 GENE THERAPY

CANCER GENE THERAPY

VECTOR‐MEDIATED IMMUNOTHERAPY

TUMOR DESTRUCTION

ANTI‐ANGIOGENIC GENE THERAPY

SUMMARY AND FUTURE DIRECTIONS

REFERENCES

VIII: PATIENT RESOURCES

29 CANCER‐CENTER‐BASED CARE

CONCLUSIONS

REFERENCES

30 SUPPORTIVE CARE

WHAT DOES SUPPORT REALLY MEAN?

INDIVIDUAL THERAPY

EMOTIONAL AND SOCIAL SUPPORTS

PRACTICAL SUPPORT

MEDICAL SUPPORT

WHEN DO WE NEED SUPPORT?

WHO CAN PROVIDE SUPPORT?

HOW DOES CANCER DIFFER FROM OTHER DIAGNOSES?

WHAT DOES IT FEEL LIKE TO GIVE BACK?

REFERENCES

31 INVESTIGATING CANCER SENTIMENTS ACROSS SOCIAL MEDIA

INTRODUCTION

NAVIGATING TWITTER DATA

CLEANING YOUR DATASET: (SAMPLING RESULTS)

DATA VISUALIZATION: SAMPLE PRELIMINARY ANALYSES

ANALYSIS OF GEO‐TAGGED TWEETS MENTIONING CANCER

FUTURE SOCIETAL IMPLICATIONS

REFERENCES

IX: THE PATH TO REDUCING THE CANCER BURDEN: PREVENTION, EARLY DETECTION, RECOVERY, SURVIVORSHIP

32 CANCER GENETICS: RISK ASSESSMENT

INTRODUCTION

REFERRAL – WHO IS A GOOD CANDIDATE FOR CANCER RISK ASSESSMENT?

COLLECTION OF FAMILY HISTORY INFORMATION

GENETIC COUNSELING AND TESTING – DISCUSSION OF RISKS/BENEFITS/LIMITATIONS OF GENETIC TECHNOLOGIES

PROTECTIONS AGAINST GENETIC DISCRIMINATION

NEW TECHNOLOGIES

MEDICAL MANAGEMENT

PSYCHOSOCIAL ISSUES

REPRODUCTIVE OPTIONS

ROLE OF LIFESTYLE AND ENVIRONMENT IN CANCER RISK

SUMMARY

REFERENCES

33 CANCER PREVENTION: DIET, NUTRITION, AND LIFESTYLE

INTRODUCTION

HOW DO WE KNOW THIS?

PHYSICAL ACTIVITY: HOW MUCH WE MOVE

DIET: WHAT WE EAT

SUMMARY

REFERENCES

34 CANCER SURVIVORSHIP

DIAGNOSIS

GETTING INFORMATION

YOUR TREATMENT HAS ENDED – NOW WHAT?

SURVIVORSHIP CARE PLANS

CAREGIVERS

REFERENCE

35 THE TOOLS OF ADVOCACY IN CANCER PREVENTION, EARLY DETECTION, RECOVERY, AND TREATMENT

THE ACA: ADVOCACY AT WORK

THE POWER OF COALITION

PUBLIC HEALTH AND ADVOCACY

SURGEON GENERAL'S REPORT: CASE IN “LONG‐VIEW” PUBLIC POLICY

THE PRIMARY TOOLS OF ADVOCACY

RESEARCH AND POLICY: HAND IN HAND FOR PUBLIC HEALTH

HOW COALITIONS AND GRASSROOTS CAPACITY INFLUENCE

MASS MEDIA, MEDIA ADVOCACY, AND CANCER PREVENTION

OUR STORIES ARE UNDEBATABLE TRUTHS

CONNECTION AS THE ROOT OF ACTION

BREAKING DOWN THE STIGMA

TURNING STIGMA INTO AWARENESS AND AWARENESS INTO ADVOCACY

WHAT IS THE FUTURE OF CANCER ADVOCACY?

REFERENCES

INDEX

End User License Agreement

 

An aparitie	2019
Autor	Gary S. Stein (Editor), Kimberly P. Luebbers (Editor)
Dimensiuni	17.78 x 3.05 x 25.15 cm
Editura	Wiley
Format	Softcover
ISBN	9781118962886
Limba	Engleza
Nr pag	680