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  • 7000lei 50.00 lei

    Numerous designers have pioneered cutting-edge garments and collections throughout the evolution of fashion. But all too often a lack of obvious fit or purpose has been mistaken for a lack of design sophistication. In an informed defence of innovative fashion, Why You Can Go Out Dressed Like That champions the improbable, the provocative, the uncomfortable and the seemingly ridiculous. Inspired by diverse sources, theories and concepts, as well as futuristic textiles and techniques, the book explores the groundbreaking work of designers who strive to extend the boundaries of their creativity. There are no fixed elements to the 100 designs featured in this book, which range from the cerebral conceptions of Comme des Garçons, to the augmented anatomies of Thierry Mugler and the exaggerated physicality of Thom Brownes broad-shouldered men. The garments do not have to fulfil a function, keep you warm, or increase sexual attraction, nor do they have to beguile or disarm. They do need to have impact at the time of creation and to prove influential in the longer term. Many original designs elicit the response: You cant go out dressed like that!. Marnie Fogg proves decisively that modern fashion is not as outrageous and unwearable as it may seem.

  • 10000lei 70.00 lei

    Great, well-illustrated, resource for ideas for urban dwellings by leading architects.

  • 10000lei 75.00 lei

    These are some of the ground rules if you work at Netflix. They are part of a unique cultural experiment that explains how the company has transformed itself at lightning speed from a DVD mail order service into a streaming superpower - with 190 million fervent subscribers and a market capitalisation that rivals the likes of Disney. Finally Reed Hastings, Netflix Chairman and CEO, is sharing the secrets that have revolutionised the entertainment and tech industries. With INSEAD business school professor Erin Meyer, he will explore his leadership philosophy - which begins by rejecting the accepted beliefs under which most companies operate - and how it plays out in practice at Netflix. From unlimited holidays to abolishing approvals, Netflix offers a fundamentally different way to run any organisation, one far more in tune with an ever-changing fast-paced world. For anyone interested in creativity, productivity and innovation, the Netflix culture is something close to a holy grail. This book will make it, and its creator, fully accessible for the first time.

  • More Minimal
    by Loft
    In stoc
    16000lei 80.00 lei

    Minimalism continues to be among the most popular themes in interior design. This volume explains minimalist concepts and concentrates on private interiors. This guide includes dozens of sophisticated photographs and introductions to each chapter written by leaders of this extraordinary, contemporary design movement. All the examples featured in the book have one thing in common: they feature the essential, but use the minimal.

  • Paediatric Clinical Examination Made Easy
    La comanda in aproximativ 4 saptamani
    14200lei 115.00 lei

     Description:

    Fully revised, this is an updated new edition of a much-loved book which has built a reputation for pithy, entertaining good sense over the course of six editions. ‘Children are different. Paediatrics is much more than medicine miniaturised.’

    From reviews of the previous edition:

    ‘All in all a very handy book for the student, the resident or other professionals working with children. I had a lot of fun reading it.’

    ‘The book is full of wonderful illustrations, and funny and profound advice with quotations, like the words of Sir Dominic Corrigan (1853): "The trouble with many doctors is not that they do not know enough but that they do not see enough", or the advice to teach thy tongue to say" "I do not know" (Rabbi Moses Maimonides or Rambam, 1135-1204). I have used this book for my final medical year paediatrics exams, the DCH and the MRCP and it has been a great help. It reminds us of the most important and basic things - history and examination, and of course a friendly demeanour.’

    • Short, manageable chapters
    • Clinical examples of examination techniques
    • Very helpful tips and topics section
    • Clinical checklists
    • Simply illustrated
    • Updated throughout
    • New section of ‘questions of fives’ questions
    • Short glossary of Latin terms

     

    Contents

     

    ·  1: Introduction

    ·  CHILDREN AND DOCTORS

    ·  ‘VETERINARY’ PAEDIATRICS

    ·  AIMS AND OBJECTIVES IN PAEDIATRICS

    ·  THE SEVEN AGES OF CHILDREN

    ·  CHILDREN IN HOSPITAL

    ·  THREE PILLARS OF DIAGNOSIS

    ·  2: History taking

    ·  LISTENING TO MOTHERS

    ·  CUE WORDS

    ·  A SAMPLE HISTORY

    ·  LET THE CHILDREN SPEAK

    ·  TALKING TO PARENTS

    ·  BREAKING BAD NEWS TO PARENTS

    ·  3: Approaching children

    ·  THE APPROACH CODE

    ·  THINGS NOT TO DO

    ·  POINT TO THE PART WHICH HURTS

    ·  PUTTING IT TOGETHER

    ·  I DON’T KNOW

    ·  DIAGNOSTIC LOGIC

    ·  SYNDROME RECOGNITION

    ·  4: Examination at different ages

    ·  NEWBORN

    ·  SIX-WEEK EXAMINATION

    ·  THE ACUTELY ILL INFANT

    ·  THE TERRIFIED TODDLER

    ·  5: Systems examination

    ·  THE CHEST

    ·  THE CARDIOVASCULAR SYSTEM

    ·  THE ABDOMEN

    ·  EXAMINING THE GLANDS

    ·  CLINICAL EVALUATION OF THE IMMUNE SYSTEM

    ·  EAR, NOSE, MOUTH AND THROAT

    ·  SKIN, HAIR AND NAILS

    ·  NEUROLOGICAL EXAMINATION

    ·  MUSCULO-SKELETAL SYSTEM

    ·  THE EYES

    ·  SURGERY

    ·  6: A measure of progress

    ·  7: Hydration and nutrition

    ·  DETECTING AND DETERMINING DEHYDRATION

    ·  NUTRITION

    ·  8: Developmental assessment

    ·  3 MONTHS

    ·  4–5 MONTHS

    ·  6–8 MONTHS: VERY IMPORTANT EXAMINATION

    ·  9–10 MONTHS

    ·  12 MONTHS

    ·  18 MONTHS

    ·  3 YEARS

    ·  4 YEARS

    ·  9: Examining excreta

    ·  THE STOOL MEDICAL INSPECTION

    ·  CAST YOUR EYE ON THE URINE

    ·  10: Using your senses

    ·  A CACOPHONY OF CRIES

    ·  A SENSE OF DIAGNOSIS

    ·  THE DIAGNOSTIC TOUCH

    ·  THE LAST WORD

    ·  11: Paediatric tips and topics

    ·  NORMAL FINDINGS

    ·  TOOLS OF THE TRADE

    ·  TRICKS OF THE TRADE

    ·  BIOLOGICAL WARNING SIGNS

    ·  CLINICAL CURIOS

    ·  RULES OF THUMB

    ·  MATERNAL MYTHS

    ·  ACRIMONIOUS ACRONYMS

    ·  A–Z OF EPONYMS

    ·  ALARM SIGNALS: ? NON-ACCIDENTAL INJURIES

    ·  MEMORABLE MNEMONICS

    ·  GENETIC GRAPHICS

    ·  ‘GROWING OUT’ OF DISORDERS/ILLNESSES

    ·  ‘THE CHILD IS FATHER OF THE MAN’

    ·  TIPS FOR THE PAEDIATRIC EXAMINATION

    ·  ESSENTIAL CLINICAL SKILLS

    ·  THINGS TO BE SEEN AND UNDERSTOOD BY UNDERGRADUATE STUDENTS

    ·  CLINIQUIZ

    ·  CHILDREN’S ‘WISDOMISMS’

    ·  PAEDIATRIC SYNONYMS AND SLANG

    ·  Synonyms Slang

    ·  CHILDREN ARE DIFFERENT

    ·  PHYSIOLOGICAL FACTS: DID YOU KNOW THAT . . .

    ·  AT WHAT AGE CAN A CHILD . . .

    ·  SOME LATIN TRANSLATIONS

    ·  A QUESTION OF FIVES

    ·  MULTIPLE CHOICE QUESTIONS (MCQS) – BEST OF FIVE

    ·  Answers

    ·  MULTIPLE CHOICE QUESTIONS (MCQS) – TRUE/FALSE

    ·  Answers

  • 19000lei 133.00 lei

     

    Pierre-Auguste Renoir (1841–1919) is so closely associated with Impressionist painting that the surprising diversity of his early work is frequently forgotten. His most important model during these early years was the artist’s mistress, Lise Tréhot, with whom he had a relationship between 1865 and 1872. After posing for a large group of prominent early works, including Woman in a Garden and En été (both 1868), Lise turned her back on the Bohemian lifestyle in favor of a bourgeois marriage. The paintings created between 1864 and the end of the following decade show the broad spectrum of Renoir’s art and the development of his artistic vocabulary, including the Impressionist phase. This is the first extensive examination of the painter’s early oeuvre and the strong influence of his close friendships with other artists, such as Éd0uard Manet, Claude Monet, Frédéric Bazille, and Alfred Sisley.

  • 25000lei 200.00 lei

     

    Description:

     

    The leading introductory radiology text for medical students and others who are required to read and interpret common radiologic images, Learning Radiology, 4th Edition, stresses an easy-to-follow pattern recognition approach that teaches how to differentiate normal and abnormal images. Dr. William Herring’s clear, conversational writing style employs a touch of humor to explain what you need to know to effectively interpret medical images of all modalities. From the basics of patient safety, dose reduction, and radiation protection to the latest information on ultrasound, MRI, and CT, this concise, user-friendly text provides a complete, up-to-date introduction to radiology needed by today’s students.

    Related Ancillary Titles:

     

    Table Of Contents:

     

    1 Recognizing Anything: An Introduction to Imaging Modalities

    Many Shades of Gray
    Conventional Radiography (Plain Films)
    The Five Basic Densities
    Computed Tomography
    Ultrasound
    Magnetic Resonance Imaging
    Fluoroscopy
    Nuclear Medicine
    Conventions Used in This Book

    2 Recognizing a Technically Adequate Chest Radiograph

    Evaluating the Chest Radiograph for Technical Adequacy
    Penetration
    Inspiration
    Rotation
    Magnification
    Angulation

    3 Recognizing Normal Pulmonary Anatomy

    The Normal Frontal Chest Radiograph
    The Normal Lateral Chest Radiograph
    Normal CT Anatomy of the Chest

    4 Recognizing Normal Cardiac Anatomy

    Evaluating the Heart on Chest Radiographs
    General Principles
    Evaluating the Heart on Cardiac CT
    Uses of Cardiac CT
    Cardiac MRI

    5 Recognizing Airspace Versus Interstitial Lung Disease

    Classifying Parenchymal Lung Disease
    Characteristics of Airspace Disease
    Some Causes of Airspace Disease
    Characteristics of Interstitial Lung Disease
    Some Causes of Interstitial Lung Disease

    6 Recognizing the Causes of an Opacified Hemithorax

    Atelectasis of the Entire Lung
    Massive Pleural Effusion
    Pneumonia of an Entire Lung
    Postpneumonectomy

    7 Recognizing Atelectasis

    What Is Atelectasis?
    Signs of Atelectasis
    Types of Atelectasis
    How Atelectasis Resolves

    8 Recognizing a Pleural Effusion

    Normal Anatomy and Physiology of the Pleural Space
    Modalities for Detecting Pleural Effusions
    Causes of Pleural Effusions
    Types of Pleural Effusions
    Side-Specificity of Pleural Effusions
    Recognizing the Different Appearances of Pleural Effusions

    9 Recognizing Pneumonia

    General Considerations
    General Characteristics of Pneumonia
    Patterns of Pneumonia
    Lobar Pneumonia
    Segmental Pneumonia (Bronchopneumonia)
    Interstitial Pneumonia
    Round Pneumonia
    Cavitary Pneumonia
    Aspiration
    Localizing Pneumonia
    How Pneumonia Resolves

    10 Recognizing the Correct Placement of Lines and Tubes and Their Potential Complications: Critical Care Radiology

    Endotracheal and Tracheostomy Tubes
    Intravascular Catheters
    Peripherally Inserted Central Catheters: PICC
    Multiple Lumen Catheters: “Quinton Catheters,” Hemodialysis Catheters
    Pleural Drainage Tubes (Chest Tubes, Thoracotomy Tubes)
    Cardiac Devices: Pacemaker, Automatic Implantable Cardiac Defibrillator (AICD), Intra-aortic Balloon Pump (IABP)
    Automatic Implantable Cardiac Defibrillators (AICD)
    Intra-aortic Counterpulsation Balloon Pump (IABP or IACB)
    GI Tubes and Lines: Nasogastric Tubes, Feeding Tubes

    11 Recognizing Other Diseases of the Chest

    Mediastinal Masses
    Anterior Mediastinum
    Middle Mediastinal Masses
    Posterior Mediastinal Masses
    Solitary Nodule/Mass in the Lung
    Bronchogenic Carcinoma
    Metastatic Neoplasms in the Lung
    Pulmonary Thromboembolic Disease (PE)
    Chronic Obstructive Pulmonary Disease
    Bullae, Cysts, and Cavities
    Bronchiectasis

    12 Recognizing Adult Heart Disease

    Recognizing an Enlarged Cardiac Silhouette
    Recognizing Common Cardiac Diseases

    13 Recognizing the Normal Abdomen and Pelvis: Conventional Radiographs

    Recognizing the Normal Abdomen: What to Look For
    Acute Abdominal Series: The Views and What They Show
    Recognizing the Normal Abdomen: Extraluminal Air
    Recognizing the Normal Abdomen: Calcifi cations
    Recognizing the Normal Abdomen: Organomegaly

    14 Recognizing the Normal Abdomen and Pelvis on Computed Tomography

    Introduction to Abdominal and Pelvic CT
    Intravenous Contrast in CT Scanning
    Oral Contrast in CT Scanning
    Abdominal CT: General Considerations
    Abdominal CT: By Organ

    15 Recognizing Bowel Obstruction and Ileus

    Abnormal Gas Patterns
    Laws of the Gut
    Functional Ileus: Localized-Sentinel Loops
    Functional Ileus: Generalized Adynamic Ileus
    Mechanical Obstruction: Small Bowel Obstruction
    Mechanical Obstruction: Large Bowel Obstruction (LBO)
    Volvulus of the Colon
    Intestinal Pseudoobstruction (Ogilvie Syndrome)

    16 Recognizing Extraluminal Gas in the Abdomen

    Signs of Free Intraperitoneal Air
    Signs of Extraperitoneal Air (Retroperitoneal Air)
    Signs of Air in the Bowel Wall
    Signs of Air in the Biliary System

    17 Recognizing Abnormal Calcifications and Their Causes

    Patterns of Calcification
    Location of Calcification

    18 Recognizing Gastrointestinal, Hepatobiliary, and Urinary Tract Abnormalities

    Barium Studies of the Gastrointestinal Tract
    Esophagus
    Stomach and Duodenum
    Small and Large Bowel
    Large Bowel
    Pancreas
    Hepatobiliary Abnormalities
    Biliary System
    Urinary Tract
    Pelvis
    Urinary Bladder
    Adenopathy

    19 Ultrasonography: Understanding the Principles and Its Uses in Abdominal and Pelvic Imaging

    How it Works
    Types of Ultrasound
    Adverse Effects or Safety Issues
    Medical Uses of Ultrasonography
    Female Pelvic Organs
    Pregnancy
    Abdominal Hernias
    Appendicitis
    Ascites
    Musculoskeletal System
    Contrast-Enhanced Ultrasound

    20 Vascular, Pediatric, and Point-of-Care Ultrasound

    Vascular Ultrasound
    Arterial Stenosis
    Pseudoaneurysm
    Deep Vein Thrombosis (DVT)
    Pediatrics
    Point-of-Care Ultrasound

    21 Magnetic Resonance Imaging: Understanding the Principles and Recognizing the Basics

    How MRI Works
    Hardware That Makes Up an MRI Scanner
    What Happens Once Scanning Begins
    How Can You Identify a T1-Weighted or T2-Weighted Image?
    MRI Contrast: General Considerations
    MRI Safety Issues
    Diagnostic Applications of MRI

    22 Recognizing Nontraumatic Abnormalities of the Appendicular Skeleton Including Arthritis

    Conventional Radiography, CT, and MRI in Bone Imaging
    Normal Bone and Joint Anatomy
    Diseases That Affect Bone Density
    Diseases That Increase Bone Density
    Diseases That Decrease Bone Density
    Diseases of the Joints: An Approach to Arthritis

    23 Recognizing Nontraumatic Abnormalities of the Spine

    The Normal Spine
    Normal MRI Appearance of the Spine
    Back Pain

    24 Recognizing Trauma to the Bony Skeleton

    Recognizing an Acute Fracture
    Recognizing Dislocations and Subluxations
    Describing Fractures
    Avulsion Fractures
    Salter-Harris Fractures: Epiphyseal Plate Fractures in Children
    Child Abuse
    Stress Fractures
    Common Fracture Eponyms
    Some Subtle Fractures or Dislocations
    Fracture Healing
    Spinal Trauma
    Pathologic Fractures

    25 Recognizing the Imaging Findings of Trauma to the Chest

    Chest Trauma
    Chest Wall Trauma
    Pleural Abnormalities: Pneumothorax
    Imaging Modalities Used to Diagnose a Pneumothorax
    Trauma-Related Parenchymal Lung Abnormalities
    Aortic Trauma

    26 Recognizing the Imaging Findings of Trauma to the Abdomen and Pelvis

    Abdominal Trauma
    Pelvic Trauma
    Less Common Abdominal Injuries

    27 Recognizing Some Common Causes of Intracranial Pathology

    Normal Anatomy
    MRI and the Brain
    Head Trauma
    Intracranial Hemorrhage
    Diffuse Axonal Injury
    Increased Intracranial Pressure
    Stroke
    Ruptured Aneurysms
    Hydrocephalus
    Cerebral Atrophy
    Brain Tumors
    Other Diseases
    Terminology

    28 Recognizing Pediatric Diseases

    Diseases Discussed in This Chapter
    Newborn Respiratory Distress
    Childhood Lung Disease
    Soft Tissues of the Neck
    Ingested Foreign Bodies
    Other Diseases
    Salter-Harris Fractures: Epiphyseal Plate Fractures in Children
    Child Abuse
    Necrotizing Enterocolitis (NEC)
    Esophageal Atresia With/Without Tracheoesophageal Fistula (TEF)

    29 Using Image-Guided Interventions in Diagnosis and Treatment: Interventional Radiology

    Arterial Access and Arteriography
    Central Venous Access: Image-Guided Venous Access
    Pulmonary Embolism: Thrombolysis
    Pulmonary Embolism: Inferior Vena Caval (IVC) Filter Placement
    Pulmonary Nodule: Image-Guided Biopsy
    Hepatic/Renal/Pulmonary Tumor: Thermal Ablation
    Portal Hypertension: Transjugular Intrahepatic Portosystemic Shunt (TIPS)
    Abscess: Percutaneous Abscess Aspiration and Drain Placement
    Gastrointestinal (GI) Bleeding: Arteriography and Embolization
    Obstructive Uropathy: Percutaneous Nephrostomy (PCN)/Nephroureterostomy (PCNU)
    Aortic Aneurysm: Endovascular Aneurysm Repair (EVAR)
    Uterine Fibroids: Uterine Fibroid Embolization (UFE)
    Acute Ischemic Stroke: Mechanical Thrombectomy

    30 Recognizing the Findings in Breast Imaging

    Breast Imaging Modalities: Overview
    Mammography: Screening Versus Diagnostic
    Fundamental Mammography Findings
    Ultrasound
    Magnetic Resonance Imaging
    Management of Breast Abnormalities
    Special Considerations

    Bibliography

    Chapter 1 Quiz Answers

    Online-Only Appendixes

    A. Self-Assessment Quizzes
    B. Normal Imaging Anatomy Quizzes
    C. Unknown Cases
    D. The ABCs of Heart Disease
    E. Radiation Dose and Safety
    F. What to Order When
    G. Chapters 1 and 18 Glossaries (General Terminology and GI Imaging Terminology)
    H. Nuclear Medicine: Understanding the Principles and Recognizing the Basics

       

     

  • Practical Interventional Cardiology: Third Edition
    La comanda in aproximativ 4 saptamani
    26000lei 210.00 lei

     

    Description:

     

    This new and comprehensively revised third edition of Practical Interventional Cardiology, led by an eminent UK Cardiologist and supported by contributing authors from around the world, discusses the different interventional procedures by context and addresses current guidelines and ongoing trials, including European experience with non-FDA approved devices. It represents an extended practical reference for the Interventional Cardiologist, Fellows in training, catheter laboratory Nursing and Technical staff as well as the non-invasive Cardiologist and General Physician. Rather than providing detailed and exhaustive reviews – a criticism of many Interventional Cardiology texts – the purpose of this book is to present practical information regarding Interventional procedures and important topics in Cardiology. An emphasis on clarity, clinical relevance and up-to-date information has been favoured as well as discussion of points of controversy so frequently overlooked."

     

     

    Table of Contents:

     

    PART 1: CORONARY ARTERY DISEASE

    1 Epidemiology and pathophysiology of coronary artery disease

    2 Radiation protection, image archiving and communication systems

    3 Non-invasive cardiac imaging for the interventionist

    4 Coronary intravascular ultrasound (IVUS)

    5 New intravascular imaging techniques (optical coherence tomography”OCT” and optical frequency domain imaging”OFDI”)

    6 Fractional flow reserve: Invasive and non-invasive assessment to guide percutaneous coronary interventions

    7 New concepts in coronary physiological assessment

    8 Overview of randomised trials of percutaneous coronary intervention: Comparison with medical and surgical therapy

    9 Adjunctive pharmacotherapy and coronary intervention

    10 Percutaneous transluminal coronary intervention: History, techniques, indications and complications

    11 Percutaneous coronary intervention of single- or multi-vessel disease

    12 Coronary stenting I: Intracoronary stents – Form and function

    13 Coronary stenting II: New developments

    14 Stent thrombosis and restenosis

    15 A practical approach to percutaneous interventions in chronic total occlusions

    16 PCI for bifurcation lesions

    17 Percutaneous coronary intervention for left main stem disease

    18 Haemodynamic support for high-risk percutaneous intervention

    19 Acute coronary syndrome: PCI for unstable angina and non-ST elevation myocardial infarction

    20 Acute coronary syndrome: Acute ST-segment elevation myocardial infarction

    21 Percutaneous treatment of cardiogenic shock after myocardial infarction

    22 Rotational coronary atherectomy

    23 Excimer laser coronary angioplasty

    24 Advantages and disadvantages in radial and femoral arterial access

    25 Devices for femoral and radial haemostasis

    26 Percutaneous removal of retained intravascular foreign bodies

    27 PCI and the cardiac surgeon: A hybrid approach

    28 PCI in centres without on-site cardiac surgery

    29 Interventions after coronary artery bypass surgery

    PART 2: STRUCTURAL HEART DISEASE

    30 Alcohol septal ablation in hypertrophic obstructive cardiomyopathy: Techniques and results

    31 Percutaneous transvenous mitral commissurotomy

    32 Percutaneous mitral valve repair and replacement

    33 Trans-catheter closure of left atrial appendage

    34 Trans-catheter aortic valve implantation

    35 Coronary intervention in patients with aortic valve disease

    36 Interventional cardiac catheterisation in adults with congenital heart disease

    PART 3: ELECTROPHYSIOLOGY

    37 Fundamentals of cardiac electrophysiology

    38 Investigations for abnormal cardiac electrophysiology

    39 Catheter ablation of supraventricular tachycardia

    40 Ablation of ventricular arrhythmias

    41 Pacemakers for the treatment of bradyarrhythmias

    42 Cardiac resynchronisation therapy (CRT)

    43 Implantable cardioverter defibrillators

    PART 4: MISCELLANY

    44 The role of the interventionalist in peripheral vascular interventions

    45 Training programs and certification in interventional cardiology in European countries

    46 Training in interventional cardiology in the United States: Program accreditation and physician certification

    47 The principles and practice of audit in coronary intervention

    48 What’s on the horizon?

    Index

     

  • 30500lei 244.00 lei

    Description:

    Get instant access to the critical data you need to make accurate diagnoses and effectively plan treatment. Small Animal Medical Differential Diagnosis, 3rd Edition combines over 400 expert resources and boils them down into one easy-to-use reference covering the differential diagnosis, etiology, clinical signs, and relevant laboratory abnormalities of the most common conditions you will encounter in dogs and cats. And because of its pocket size and intuitive organization, you can have it on hand as a quick consultative device throughout the day to make reliable on-the-scene decisions.

    Features:

    More than 400 lists bring the most important medical diagnostic information from multiple resources into a single quick reference.

    Easy identification of the likeliest diagnosis is attributed by the possibilities being listed in order of incidence.

    Intuitive organization presents differential diagnosis by sign, symptom, and disorder to facilitate quick access to information.

    Alphabetical listing of all relevant laboratory tests makes information easy to find.

    Pocket size makes this guide portable, practical, and simple to use.

    New To This Edition:

    NEW! Coverage of FAST ultrasound examinations is found in the section on Focused Assessment with Sonography for Trauma, Triage, and Tracking.

    NEW! Overall content update includes substantial revisions to the disorders, syndromes, and diagnostic and laboratory tests that are listed in this guide.

    Table Of Contents:

    Part One - Clinical Signs Approach to Differential Diagnosis


    Part Two - Systemic Approach to Differential Diagnosis


    1. Cardiopulmonary Disorders
    2. Dermatologic Disorders
    3. Endocrinologic and Metabolic Disorders
    4. Gastroenterologic Disorders
    5. Hematologic Disorders
    6. Immunologic and Immune-Mediated Disorders
    7. Infectious Disease
    8. Joint and Bone Disorders
    9. Liver and Exocrine Pancreatic Disorders
    10. Neoplasia
    11. Neurologic and Neuromuscular Disorders
    12. Ocular Disorders
    13. Toxicology
    14. Urogenital Disorder
    15. Pain Diagnosis
    Part Three - Laboratory Values and Interpretation of Results

       

     

  • Braddom's Rehabilitation Care: A Clinical Handbook
    La comanda in aproximativ 4 saptamani
    31000lei 248.00 lei

    Description:

    Concise and portable, Braddom’s Clinical Handbook of Physical Medicine and Rehabilitation, by Drs. David X. Cifu and Henry L. Lew, gives you dependable, up-to-date content in a handbook format ideally suited for use at the bedside or in outpatient clinics. This quick reference covers the everyday topics you need - assistive devices and orthoses, spasticity, pediatric, adult, and geriatric care, pain management, outcome measures, and much more - all derived from the most trusted name in the field of PM&R.

    Features:

    • Reader-friendly format with succinct, templated chapters for ease of use.
    • Authoritative content derived from the #1 comprehensive reference in the field: Braddom’s Physical Medicine and Rehabilitation.
    • An ideal resource for the entire rehabilitation team as a quick reference or study guide.
    • Highlights key concepts spanning the full spectrum of rehabilitation medicine to help optimize outcomes for patients with a range of chronic diseases, impairments, and disabilities.
    • Online videos provide guidance on essential techniques including Muscle Energy Technique; Paraffin Bath; Monophasic Arterial Doppler Waveform; Feeding Training with Putty; Lachman Test; and Carbidopa- and Levodopa-Induced Dyskinesia.
    • Includes eSlides complied by internationally renowned experts to summarize key teaching points and clinical pearls.
    • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures and references from the book on a variety of devices.

    Table Of Contents:

    SECTION 1 Evaluation

    1. The Physiatric History and Physical Examination

    2. History and Examination of the Pediatric Patient

    3. Adult Neurogenic Communication and Swallowing Disorders

    4. Psychological Assessment and Intervention in Rehabilitation

    5. Practical Aspects Of Impairment Rating And Disability Determination

    6. Employment of People with Disabilities

    7. Quality and Outcome Measures for Medical Rehabilitation

    8. Electrodiagnostic Medicine

    SECTION 2 Treatment Techniques and Special Equipment

    9. Rehabilitation and Prosthetic Restoration in Upper Limb Amputation

    10. Lower Limb Amputation and Gait

    11. Upper Limb Orthoses

    12. Lower Limb Orthoses

    13. Spinal Orthoses

    14. Wheelchairs and Seating Systems

    15. Therapeutic Exercise

    16. Manipulation, Traction, and Massage

    17. Physical Agent Modalities

    18. Integrative Medicine in Rehabilitation

    19. Computer Assistive Devices and Environmental Controls

    SECTION 3 Common Clinical Problems

    20. Bladder Dysfunction

    21. Neurogenic Bowel: Dysfunction and Rehabilitation

    22. Sexual Dysfunction and Disability

    23. Spasticity

    24. Chronic Wounds

    25. Vascular Diseases

    26. Burns

    27. Acute Medical Conditions

    28. Chronic Medical Conditions: Pulmonary Disease, Organ Transplantation, and Diabetes

    29. Cancer Rehabilitation

    30. The Geriatric Patient

    31. Rheumatologic Rehabilitation

    SECTION 4 Issues in Specific Diagnoses

    32. Common Neck Problems

    33. Low Back Pain

    34. Osteoporosis

    35. Upper Limb Pain and Dysfunction

    36. Musculoskeletal Disorders of the Lower Limb

    37. Chronic Pain

    38. Pelvic Floor Disorders

    39. Sports Medicine and Adaptive Sports

    40. Motor Neuron Diseases

    41. Rehabilitation of Patients with Neuropathies

    42. Myopathy

    43. Traumatic Brain Injury

    44. Stroke Syndromes

    45. Degenerative Movement Disorders of the Central Nervous System

    46. Multiple Sclerosis

    47. Cerebral Palsy

    48. Myelomeningocele and Other Spinal Dysraphisms

    49. Spinal Cord Injury

    50. Auditory, Vestibular, and Visual Impairments

  • 34000lei 272.00 lei

    Description:

    Designed to help you learn and retain key information in pharmacology, this foundational text takes you from course exams and the USMLE Step 1 right through to clinical practice. Brenner and Stevens’ Pharmacology, 5th Edition, focuses on the essential principles you need to know, in a concise yet comprehensive manner that’s easy to understand. Highly illustrated and formatted for quick reference, it’s your go-to text for the must-know aspects of pharmacology you’ll need for clinical problem solving and decision making.

    Features:

    • Teaches the fundamental aspects of pharmacology using full-color illustrations, detailed explanations, and a consistent format to present classification of drugs for each system/disease.
    • Features useful tables, drug classifications boxes, case studies, and self-assessments in each chapter to help you review and prepare for course exams and Step 1.
    • Student Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and animations, designed to produce a more rounded learning experience. You’ll also find an additional glossary, chapter-by-chapter summaries and case studies, a full list of featured drugs, 150 USMLE-style questions, and more.

    New To This Edition:

    • Includes the latest pharmacologic mechanisms and applications with new and updated drug information throughout.

    Table Of Contents:

    Brenner and Stevens’ Pharmacology
    Fifth Edition

    Section I: Principles of Pharmacology
    Chapter 1 Introduction to Pharmacology
    Chapter 2 Pharmacokinetics
    Chapter 3 Pharmacodynamics
    Chapter 4 Drug Development and Safety
    Chapter 5 Toxicology and the Treatment of Poisoning

    Section II: Autonomic and Neuromuscular Pharmacology
    Chapter 6 Peripheral Neuropharmacology and Acetylcholine Agonists
    Chapter 7 Acetylcholine Receptor Antagonists
    Chapter 8 Sympathetic Neurotransmission and Adrenoceptor Agonists
    Chapter 9 Adrenoceptor Antagonists

    Section III: Cardiovascular, Renal, and Hematologic Pharmacology
    Chapter 10 Antihypertensive Drugs
    Chapter 11 Antianginal Drugs
    Chapter 12 Drugs for Heart Failure
    Chapter 13 Diuretics
    Chapter 14 Drugs for Cardiac Dysrhythmia
    Chapter 15 Drugs for Hyperlipidemia
    Chapter 16 Antithrombotic and Thrombolytic Drugs
    Chapter 17 Hematopoietic Drugs

    Section IV: Central Nervous System Pharmacology
    Chapter 18 Introduction to Central Nervous System Pharmacology
    Chapter 19 Sedative-Hypnotic and Anxiolytic Drugs
    Chapter 20 Antiepileptic Drugs
    Chapter 21 Local and General Anesthetics
    Chapter 22 Psychotherapeutic Drugs
    Chapter 23 Opioid Analgesics and Antagonists
    Chapter 24 Drugs for Neurodegenerative Diseases
    Chapter 25 Drugs of Abuse

    Section V: Pharmacology of Respiratory and Other Systems
    Chapter 26 Autacoid Drugs
    Chapter 27 Respiratory Pharmacology
    Chapter 28 Gastrointestinal Pharmacology
    Chapter 29 Drugs for Headache Disorders
    Chapter 30 Drugs for Pain, Inflammation, and Arthritic Disorders

    Section VI: Endocrine Pharmacology
    Chapter 31 Hypothalamic and Pituitary Drugs
    Chapter 32 Thyroid Drugs
    Chapter 33 Adrenal Steroids and Related Drugs
    Chapter 34 Drugs Affecting Fertility and Reproduction
    Chapter 35 Drugs for Diabetes
    Chapter 36 Drugs Affecting Calcium and Bone

    Section VII: Chemotherapy
    Chapter 37 Principles of Antimicrobial Chemotherapy
    Chapter 38 Inhibitors of Bacterial Cell Wall Synthesis
    Chapter 39 Inhibitors of Bacterial Protein Synthesis
    Chapter 40 Quinolones, Antifolate Drugs, and Other Antimicrobial Agents
    Chapter 41 Antimycobacterial Drugs
    Chapter 42 Antifungal Drugs
    Chapter 43 Antiviral Drugs
    Chapter 44 Antiparasitic Drugs
    Chapter 45 Antineoplastic and Immunomodulating Drugs

    Answers and Explanations to Review Questions

    Index

       

  • 34700lei 278.00 lei

     


    Description:

    Get a solid foundation in the language of movement! Essentials of Kinesiology for the Physical Therapist Assistant 3rd Edition builds on previous editions by delivering a rich and varied learning experience that is needed to succeed in today’s fast-paced PTA education programs. Clear, concise explanations of anatomy and function, full-color illustrations and unique atlas-style chapters make even the most complex concepts easy to master. In addition, a robust lineup of on- and off-line resources, featuring a companion Evolve website, give students the tools they need to succeed in both the classroom and the clinical setting!



    Features:


    • UNIQUE! Author team of Paul Mansfield and Don Neumann represent a rich blend of their experiences and expertise.
    • Outstanding artwork with more than 600 full-color photos and drawings help you understand key concepts.
    • UNIQUE! Atlas-style muscle presentations clearly link specific muscles or muscle groups with relevant information.
    • Clinical Insight and Considerations boxes link the concepts of kinesiology with their clinical applications.
    • Summary boxes and tables pull content together into concise, reader-friendly format.
    • Study questions and key terminology serves as a valuable study tool for exam preparation.
    • Learning Objectives serve as an overview of each chapter as well as a handy checklist for review.



    New To This Edition:

    • NEW! UNIQUE! Goniometry boxes added at the end of each joint-specific chapter illustrate principles of goniometry as they relate to kinesiology.
    • NEW! UNIQUE! Art from Neumann added where appropriate to help illustrate material.
    • NEW! Thoroughly revised content reflects the very latest in Kinesiology.



    Table Of Contents:

    1. Basic Principles of Kinesiology
    2. Structure and Function of Joints
    3. Structure and Function of Skeletal Muscle
    4. Structure and Function of the Shoulder Complex
    5. Structure and Function of the Elbow and Forearm Complex
    6. Structure and Function of the Wrist
    7. Structure and Function of the Hand
    8. Structure and Function of the Vertebral Column
    9. Structure and Function of the Hip
    10. Structure and Function of the Knee
    11. Structure and Function of the Ankle and Foot
    12. Fundamentals of Human Gait
    13. Kinesiology of Mastication and Ventilation

       

  • 35700lei 286.00 lei

     

    Description:

     

    Well organized and easy to read, Clinical Procedures in Primary Eye Care, 5th Edition, takes an accessible, step-by-step approach to describing the commonly used primary care procedures that facilitate accurate diagnosis and effective patient management. This practical, clinically-focused text offers succinct descriptions of today's most frequently encountered optometric techniques supported by research-based evidence. You’ll find essential instructions for mastering the procedures you need to know, including recent technical advances in the field.

    Discusses technical advances that are dramatically altering optometry: Optical Coherence Tomography (OCT) and ultra-wide field imaging (optomaps).

    Presents outstanding new digital images of OCT cases and optomaps for a wide variety of conditions of the central and peripheral retina.

    Focuses on evidence-based optometry; all procedures include a section that reviews when and how the procedure should be measured and uses clinical wisdom in addition to research-based evidence.

    Presents new digital images of normal variations of the eye – crucial visual support for understanding what is normal and what is disease.

    Helps you clearly visualize procedures and eye disorders through full-color photographs, diagrams, and video clips.

    Provides fully revised print on dry eye assessment based on the latest international Dry Eye Workshop (DEWS) guidelines.

    Features coverage of changes in the eye due to high myopia, and expounds the need for myopia control techniques.

    Offers extensive material online to enhance learning: video clips, interactive testing sections, additional photographs, and more.

     

    Table of Contents:

     

    1.  Evidence-based eye examinations

    1.1 Several tests are widely used because of tradition and not evidence

    1.2 Tips on reviewing the evidence base for clinical tests

    1.3 “Screen everybody, don’t miss disease” vs. “what about false positives?”

    1.4 Should I perform a database, system, and/or problem-oriented eye examination?

    1.5 The evidence to support routine dilated fundus examinations is limited

    1.6 Lessons to learn from the Honey Rose case

    References

    2.  Communication skills

    2.1 Turning anxious patients into satisfied ones

    2.2 The importance of recording

    2.3 Case history-taking

    2.4 The 5 Rs: Providing diagnoses and management plan information

    2.5 Giving bad news

    2.6 What should a good referral letter include?

    References

    3.  Assessment of visual function

    3.1 Distance visual acuity

    3.2 Reading (or near) acuity

    3.3 Contrast sensitivity

    3.4 Congenital colour vision deficiency

    3.5 Acquired colour vision deficiency

    3.6 Central visual field (24°) testing

    3.7 Central visual field (10°), including Amsler

    3.8 Peripheral visual field (30° to 60°)

    3.9 Visual field assessment for drivers

    3.10 Simple visual field assessments

    3.11 Stereopsis

    References

    4.  Refraction and prescribing

    4.1 Focimetry (vertometry or lensometry)

    4.2 Interpupillary distance

    4.3 Phoropters are standard, but when are trial frames better?

    4.4 Objective refraction

    4.5 Monocular subjective refraction

    4.6 Best vision sphere (maximum plus to maximum visual acuity)

    4.7 Best vision sphere (plus/minus technique)

    4.8 Duochrome (or bichromatic) test

    4.9 Assessment of astigmatism

    4.10 Binocular balancing of accommodation

    4.11 Binocular subjective refraction

    4.12 Cycloplegic refraction

    4.13 The reading addition

    4.14 Myopia control

    4.15 Guidelines for prescribing glasses

    References

    5.  Contact lens assessment

    5.1 Contact lens fitting

    5.2 Pre-fitting case history

    5.3 Determining contact lens diameter

    5.4 Corneal topography

    5.5 Assessment of ocular physiology

    5.6 Soft contact lens fitting

    5.7 Selecting a soft trial lens

    5.8 Assessment of the soft lens fit

    5.9 Toric soft lens fitting

    5.10 Presbyopic soft lens fitting

    5.11 Fitting corneal RGP contact lenses

    5.12 Scleral RGP lenses

    5.13 Management of myopia progression

    5.14 Patient instruction for contact lens care

    5.15 Contact lens aftercare

    References

    6.  Assessment of binocular vision and accommodation

    6.1 Adaptations when testing younger patients

    6.2 The cover test: Detection and assessment of strabismus and heterophoria

    6.3 Other tests for the detection and measurement of strabismus

    6.4 Motility test: Detection and assessment of incomitant strabismus

    6.5 Convergence assessment: Near point of convergence

    6.6 Suppression testing: Worth 4-dot and mallett test

    6.7 Stereopsis

    6.8 Accommodation assessment

    6.9 Further assessment of binocular vision and accommodation (‘Functional tests’)

    6.10 Further assessment of binocular status in strabismus

    6.11 Further assessment of heterophoria

    6.12 Fusional reserves

    6.13 Fixation disparity

    6.14 The accommodative convergence to accommodation relationship

    6.15 Further assessment of the relationship between convergence and accommodation

    6.16 Further evaluation of incomitant strabismus

    6.17 Assessment of eye movements

    6.18 Making a final diagnosis and management plan

    References

    7.  Ocular health assessment

    7.1 Examination of the anterior segment and ocular adnexa

    7.2 Tear film and ocular surface assessment

    7.3 Assessment of the lacrimal drainage system

    7.4 Anterior chamber angle depth estimation

    7.5 Examination of the anterior chamber angle by gonioscopy

    7.6 Pachymetry

    7.7 Tonometry

    7.8 Instillation of diagnostic drugs

    7.9 Pupil light reflexes

    7.10 Fundus examination, particularly the posterior pole

    7.11 Optical coherence tomography

    7.12 Fundus examination of the peripheral retina

    References

    8.  Variations in appearance of the normal eye

    8.1 Anterior eye variations

    8.2 Anterior eye changes in older patients

    8.3 Lens and vitreous variations

    8.4 Lens and vitreous changes in older patients

    8.5 Optic nerve head variations

    8.6 Fundus variations

    8.7 Fundus changes in older patients

    8.8 Peripheral fundus variations

    8.9 Peripheral fundus changes in older patients

    8.10 Myopic eyes

    References

    9.  Physical examination procedures

    9.1 Blood pressure measurement

    9.2 Carotid artery assessment

    9.3 Lymphadenopathy in the head–neck region

    References

    Subject index

     

  • Current Diagnosis and Treatment Surgery, 15th
    Pe comanda in aproximativ 4 saptamani
    43000lei 290.00 lei

     

    Evidence-based, point-of-care information on the full scope of surgical diseases
    CURRENT Diagnosis& Treatment Surgery delivers to-the-point information on more than 1,000 diseases and
    disorders that surgeons are most often required to treat. Concise yet thorough,the book covers both general surgery and the surgical subspecialties, including neurosurgery, otolaryngology, plastic and reconstructive surgery, gynecology, orthopedic surgery, urology, and pediatric surgery. This Fifteenth Edition has been updated throughout to reflect the latest research and discoveries. The consistent presentation, headings, and accessible text makes it easy to find answers quickly. 


    • An outstanding review for the USMLE and shelf examinations
    • The best introductory text to the field of surgery
    • More than 600 photographs and illustrations
    • Detailed treatment algorithms
    • Updated throughout with the latest research and discoveries
    • Intuitively organized to help you find answers quickly and easily
    • More than 200 chapter review multiple choice questions

     



    Table of Contents:

    1. Approach to the Surgical Patient

    2. Training, Communication, Professionalism, & Systems-Based Practice

    3. Preoperative Preparation

    4. Postoperative Care

    5. Postoperative Complications

    6. Wound Healing

    7. Power Sources in Surgery

    8. Inflammation, Infection, & Antimicrobial Therapy in Surgery

    9. Fluid, Electrolyte, & Acid–Base Disorders

    10. Surgical Metabolism & Nutrition

    11. Anesthesia

    12. Shock in Surgical Patients

    13. Acute Pulmonary Failure in Surgical Patients

    14. Management of the Injured Patient

    15. Burns & Other Thermal Injuries

    16. Otolaryngology: Head and Neck Surgery

    17. Thyroid & Parathyroid

    18. Breast Disorders

    19. Thoracic Wall, Pleura, Mediastinum, & Lung

    20. Acquired Cardiac Disease

    21. Congenital Heart Disease

    22. Esophagus & Diaphragm

    23. The Acute Abdomen

    24. Peritoneal Cavity

    25. Stomach & Duodenum

    26. Liver & Portal Venous System

    27. Biliary Tract

    28. Pancreas

    29. Spleen

    30. Appendix

    31. Small Intestine

    32. Large Intestine

    33. Anorectum

    34. Abdominal Wall Hernias

    35. Adrenals

    36. Arteries

    37. Veins & Lymphatics

    38. Neurosurgery

    39. The Eye & Ocular Adnexa

    40. Urology

    41. Gynecology

    42. Orthopedic Surgery

    43. Plastic & Reconstructive Surgery

    44. Hand Surgery

    45. Pediatric Surgery

    46. Surgical Weight Management

    47. Oncology

    48. Abdominal Organ Transplantation

    Appendix: Answers to Multiple Choice Questions

    Index

     

     

     

     

  • 40000lei 300.00 lei

     

    Entrepreneurship, 5th Edition helps aspiring entrepreneurs understand the process of starting a new venture and appreciate the vital role of entrepreneurship in the economy. This accessible textbook explains the steps involved in starting a new company, and offers insights on engaging with startups as investors, bankers, accountants, lawyers, vendors, customers, and employees. Delving into the real-world trials and tribulations of entrepreneurship, the text covers every stage of the entrepreneurial process, from searching for an opportunity and molding it into an attractive product or service, to launching, growing, and eventually harvesting the new venture. 

    The fully revised and updated fifth edition integrates core concepts of entrepreneurship and practical case studies—enabling students to develop an inclusive perspective on how businesses are born, grow, and succeed or fail. The authors explore the entrepreneurial competitiveness of nations throughout the world, describe the critical factors for starting a new enterprise and building it into a successful business, and demonstrate how to build a workable business model. Clear, straightforward chapters cover each essential area of entrepreneurship, including marketing, strategy, team building, financial projections, business planning, and more.

     

  • 40900lei 327.00 lei

    The Johns Hopkins High-Yield Review for Orthopaedic Surgery is a compact, concise study tool to help residents prepare for Part 1 of the American Board of Orthopaedic Surgery (ABOS) examination and the Orthopaedic In-Training Examination (OITE). The book is also ideal for seasoned clinicians studying for the ABOS recertification exams and motivated medical students preparing for orthopaedic surgery rotations. With its numerous illustrations, streamlined structure and heavily bulleted text, the book is designed as a 'memory-jogger' to supplement basic knowledge of fundamental orthopaedic surgery principles and procedures. Covers the most important, core exam material in a single, easy-to-use resource. Content is structured in a bulleted format throughout for rapid recall and effective absorption of information. Written by expert educators in the field of orthopaedic surgery. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

    ·  Cover Page

    ·  Title Page

    ·  Copyright Page

    ·  CONTRIBUTORS

    ·  FOREWORD

    ·  PREFACE

    ·  CONTENTS

    ·  1 Basic Science

    ·  2 Adult Reconstruction

    ·  3 Pediatrics

    ·  4 Hand and Wrist

    ·  5 Trauma

    ·  6 Sports Medicine

    ·  7 Shoulder and Elbow

    ·  8 Foot and Ankle

    ·  9 Spine

    ·  10 Oncology and Pathology

    ·  Appendix: Test-Taking Strategies

    ·  Index


  • 52000lei 416.00 lei

     

    Description:

    Successfully learn to apply dental anatomy to the practice of dentistry with Wheeler’s Dental Anatomy, Physiology, and Occlusion, 11th Edition. Updated and visually enhanced, the eleventh edition of this market-leading dental text expands its focus on clinical applications and includes dozens of online 360-degree and 3-D tooth animations to give you an unparalleled view of dentitions, pulp formation, the sequence of eruptions, and countless clinical considerations.

    ·  Table of Contents

    ·  Copyright

    ·  Dedication

    ·  Preface

    ·  1. Introduction to Dental Anatomy

    ·  Pretest Questions

    ·  Formation of the Dentitions (Overview)

    ·  Nomenclature

    ·  Formulae for Mammalian Teeth

    ·  Tooth Numbering Systems

    ·  Division Into Thirds, Line Angles, and Point Angles

    ·  Tooth Drawing and Carving

    ·  Measurement of Teeth

    ·  Summary

    ·  Pretest Answers

    ·  2. Development and Eruption of the Teeth

    ·  Pretest Questions

    ·  Clinical Considerations

    ·  Variability

    ·  Malformations

    ·  Chronology of Primary Dentition

    ·  Development and Eruption/Emergence of the Teeth

    ·  Dentitions

    ·  Neuromuscular Development

    ·  Transitional (Mixed) Dentition Period

    ·  Loss of Primary Teeth

    ·  Permanent Dentition

    ·  Size of Teeth

    ·  Dental Pulp

    ·  Cementoenamel Junction

    ·  Dental Age

    ·  Tooth Formation Standards

    ·  Chronologies of Human Dentition

    ·  Types of Chronologies

    ·  Stages of Tooth Formation

    ·  Age of Attainment

    ·  Age Prediction

    ·  Maturity Assessment

    ·  Duration of Root and Crown Formation

    ·  Summary of Chronologies

    ·  Sequence of Eruption

    ·  Estimating Time of Enamel Hypoplasia

    ·  Pretest Answers

    ·  3. The Primary (Deciduous) Teeth

    ·  Pretest Questions

    ·  Life Cycle

    ·  Importance of Primary Teeth

    ·  Nomenclature

    ·  Major Contrasts Between Primary and Permanent Teeth

    ·  Pulp Chambers and Pulp Canals

    ·  Detailed Description of Each Primary Tooth

    ·  Pretest Answers

    ·  4. Forensics, Comparative Anatomy, Geometries, and Form and Function

    ·  Pretest Questions

    ·  Forensic Dentistry

    ·  Comparative Dental Anatomy

    ·  Facial and Lingual Aspects of All Teeth

    ·  Summary of Schematic Outlines

    ·  Form and Function of the Permanent Dentition

    ·  Alignment, Contacts, and Occlusion

    ·  Pretest Answers

    ·  5. Orofacial Complex: Form and Function

    ·  Pretest Questions

    ·  Form and Function

    ·  Form Follows Function

    ·  Articulation of Teeth

    ·  Physiologic Form of the Teeth and Periodontium

    ·  Fundamental Curvatures

    ·  Proximal Contact Areas

    ·  Interproximal Spaces (Formed by Proximal Surfaces in Contact)

    ·  Embrasures (Spillways)

    ·  Contact Areas and Incisal and Occlusal Embrasures From the Labial and Buccal Aspect

    ·  Contact Areas and Labial, Buccal, and Lingual Embrasures From the Incisal and Occlusal Aspects

    ·  Facial and Lingual Contours at the Cervical Thirds (Cervical Ridges) and Lingual Contours at the Middle Thirds of Crowns

    ·  Height of Epithelial Attachment: Curvatures of the Cervical Lines (Cementoenamel Junction) Mesially and Distally

    ·  Pretest Answers

    ·  6. The Permanent Maxillary Incisors

    ·  Pretest Questions

    ·  Maxillary Central Incisor

    ·  Maxillary Lateral Incisor

    ·  Pretest Answers

    ·  7. The Permanent Mandibular Incisors

    ·  Pretest Questions

    ·  Mandibular Central Incisor

    ·  Mandibular Lateral Incisor

    ·  Pretest Answers

    ·  8. The Permanent Canines: Maxillary and Mandibular

    ·  Pretest Questions

    ·  Maxillary Canine

    ·  Mandibular Canine

    ·  Pretest Answers

    ·  9. The Permanent Maxillary Premolars

    ·  Pretest Questions

    ·  Maxillary First Premolar

    ·  Maxillary Second Premolar

    ·  Pretest Answers

    ·  10. The Permanent Mandibular Premolars

    ·  Pretest Questions

    ·  Mandibular First Premolar

    ·  Mandibular Second Premolar

    ·  Pretest Answers

    ·  11. The Permanent Maxillary Molars

    ·  Pretest Questions

    ·  Maxillary First Molar

    ·  Maxillary Second Molar

    ·  Maxillary Third Molar

    ·  Pretest Answers

    ·  12. The Permanent Mandibular Molars

    ·  Pretest Questions

    ·  Mandibular First Molar

    ·  Mandibular Second Molar

    ·  Mandibular Third Molar

    ·  Pretest Answers

    ·  13. Pulp Chambers and Canals

    ·  Pretest Questions

    ·  Pulp, Chamber, and Canals

    ·  Radiographs

    ·  Foramen

    ·  Demarcation of Pulp Cavity and Canal

    ·  Pulp Horns

    ·  Clinical Applications

    ·  Pulp Cavities of the Maxillary Teeth

    ·  Pulp Cavities of the Mandibular Teeth

    ·  Radiographs: Pulp Chamber and Canals

    ·  Crown and Root Fractures

    ·  Pretest Answers

    ·  14. Dento-Osseous Structures, Blood Vessels, and Nerves

    ·  Pretest Questions

    ·  The Maxillae

    ·  The Mandible

    ·  Arterial Supply to the Teeth

    ·  Nerve Supply to the Jaws and Teeth

    ·  Pretest Answers

    ·  15. The Temporomandibular Joints, Teeth, and Muscles and Their Functions

    ·  Pretest Questions

    ·  Temporomandibular Articulation

    ·  Muscles

    ·  Mandibular Movements and Muscle Activity

    ·  Pretest Answers

    ·  16. Occlusion

    ·  Pretest Questions

    ·  Concepts of Occlusion

    ·  Development of the Dentitions

    ·  Primary Dentition

    ·  Mixed (Transitional) Dentition

    ·  Permanent Dentition

    ·  Cusp, Fossa, and Marginal Ridge Relations

    ·  Lateral Occlusal Relations

    ·  Biomechanics of Chewing Function

    ·  Neurobehavioral Aspects of Occlusion

    ·  Oral Motor Behavior

    ·  Swallowing

    ·  Summary

    ·  Pretest Answers

    ·  17. Clinical Application of Dental Anatomy, Physiology, and Occlusion

    ·  Pretest Questions

    ·  Instrument Design/Usage Relating to Dental Anatomy

    ·  Oral Surgery

    ·  Periodontics

    ·  Endodontics

    ·  Restorative Dentistry

    ·  Esthetics

    ·  Variant Anatomy

    ·  Occlusion

    ·  Pretest Answers

  • 58900lei 471.00 lei

     

    DESCRIPTION:

    MICRONEEDLING

    A complete guide to microneedling and its varied roles in modern aesthetic medicine

    Microneedling is an increasingly common procedure in the day-to-day practice of dermatologists across the globe. Minimally invasive and requiring minimal downtime, the process can be used to address a range of cosmetic and dermatologic concerns, including rejuvenation of the skin, transdermal delivery of drugs, skin textural irregularities, luminosity, and treatment of dyschromia, m­elasma, and scarring. Treatment is administered with pens, rollers, and, stamps that have been designed to stimulate the release of growth factors and induce collagen production, working to enhance the appearance of patients of all ages and skin types.

    Edited by leading dermatologist Dr. Elizabeth Bahar Houshmand, Microneedling brings together practical instruction, top tips, and exciting new research to provide all those working in aesthetic medicine with an essential guide to this multifaceted procedure. The book includes a global approach and insightful discussion of topics including:

      The therapeutic benefit of microneedling when skin injury, disease, or aging causes aesthetic changes in the skin

      The advantages of microneedling, including its decreased risk of pigmentation changes or scarring compared with other procedures

      The practical skills and technology used in the implementation of different microneedling techniques

      Tips for applying microneedling to a wide range of skin types

      The use of microneedling to inject platelet-rich plasma

    Based upon the latest research and industry practices, Microneedling is an invaluable tool for all dermatologists, dermatologic surgeons, and other aesthetic medicine practitioners looking to provide their patients with the best possible care.

    TABLE OF CONTENTS:

    List of Editors and Contributors vi

    Preface ix

    1 Introduction to Microneedling 1
    Elizabeth Bahar Houshmand

    2 A Short History of Skin Needling 10
    Desmond Fernandes

    3 The Value of Medical Needling in Burn Scars 22
    Matthias Aust

    4 Skin Care Used with Microneedling 41
    Chytra V. Anand and Parinitha Rao

    5 Treatment of Hyperpigmentation with Microneedling 52
    Atchima Suwanchinda

    6 Treatment of Acne and Acne Scars with Microneedling 81
    Stuti Khare Shukla and Michael H. Gold

    7 Microneedling and Platelet-Rich Plasma (PRP) 98
    Elizabeth Bahar Houshmand


     

  • 59700lei 480.00 lei

     

    Description:

    The quintessential guide to state-of-the-art cosmetic injection approaches, from two renowned experts!

    This revised and updated second edition of Cosmetic Injection Techniques: A Text and Video Guide to Neurotoxins and Fillers by esteemed facial plastic surgeons Theda Kontis and Victor Lacombe builds on their bestselling first edition. Content is designed to augment knowledge of beginner injectors and train veteran injectors on how to finesse facial fillers and muscle-relaxing injections. Since publication of the first edition, understanding of the aging face has increased, while the number of non-surgical facial enhancements has continued to skyrocket. The book's primary focus is the improvement of minor facial irregularities and asymmetries using the latest injection procedures.

    Divided into six sections and four appendices, the book starts with the patient consultation and concludes with a new section on fat-dissolving techniques using Kybella. The fillers section features new chapters on choosing the right filler, fine lines and skin boosters, the de Maio technique, the mandibular angle, poly-l-lactic acid for the décolleté, and gender-specific injections. All chapters follow a reader-friendly, consistent format with succinct paragraphs covering indications, injection techniques, anatomic considerations, precautions, risks, pearls, illustrations or photos, and additional reading. Select chapters reflect North American techniques utilized by the authors that vary from East Coast to West Coast.

    Key Highlights

    • Precise, full-color illustrations by Sarah Faris afford a detailed look at underlying anatomy
    • 75 superb short video clips narrated by Dr. Kontis provide procedural guidance
    • A section dedicated to neurotoxin injections details the use of neuromodulators such as Botox and Dysport, with new chapters on neurotoxins for the décolleté and profusely sweating forehead
    • A full spectrum of facial augmentation, rejuvenation, and volumization techniques are described, using hyaluronic acid fillers, hyaluronidase, Sculptra, Radiesse, BellaFill, and others
    • Appendix A lists chapters by degree of difficulty, enabling injectors to safely advance to more challenging injection techniques

    This is the essential quick-reference guide on injection techniques. Plastic surgeons, cosmetic surgeons, dermatologists, nurse injectors, and physician assistant/nurse practitioner injectors who wish to increase their knowledge of injection methods and refine skills will greatly benefit from this outstanding, easy-to-use manual.

     

    1.    Table of Contents

    2.    Foreword

    3.    Preface

    4.    Acknowledgments

    5.    Menu of Accompanying Videos

    6.    Section I Introduction to Injectables

    7.    1 The Consultation

    8.    2 The Physicians Aesthetic Coalition for Injectable Safety

    9.    Section II Introduction to Neurotoxins

    10. 3 Neurotoxins Overview

    11. 4 Neurotoxin Preparation

    12. 5 Instrumentation for Neurotoxin Injections

    13. Section III Neurotoxin Injection Techniques

    14. 6 Neurotoxin Injection for Glabellar Frown Lines

    15. 7 Neurotoxin Injection for Forehead Wrinkles

    16. 8 Neurotoxin Injection for Smile Lines and Crow’s Feet

    17. 9 Neurotoxin Injection for Lateral Brow Lift

    18. 10 Neurotoxin Injection for Chemical Brow Lift

    19. 11 Neurotoxin Injection for Lower Eyelid Roll

    20. 12 Neurotoxin Injection for Bunny Lines

    21. 13 Neurotoxin Injection for Nasal Tip Lift

    22. 14 Neurotoxin Injection for Nasal Flare

    23. 15 Neurotoxin Injection for Elevating the Oral Commissures

    24. 16 Neurotoxin Injection for Lip Lift

    25. 17 Neurotoxin Injection for Smoker’s Lines

    26. 18 Neurotoxin Injection for Gummy Smile

    27. 19 Neurotoxin Injection for Dimpled Chin

    28. 20 Neurotoxin Injection for Platysmal Banding

    29. 21 Neurotoxin Injection for Necklace Lines

    30. 22 Neurotoxin Injection for the Décolleté

    31. 23 Neurotoxin Injection for Nefertiti Neck Lift

    32. 24 Neurotoxin Injection for Masseter Hypertrophy

    33. 25 Neurotoxin Injection for Parotid Gland Hypertrophy

    34. 26 Neurotoxin Injection for Submandibular Gland Hypertrophy

    35. 27 Neurotoxin Injection for Gustatory Sweating (Frey Syndrome)

    36. 28 Neurotoxin Injection for Profusely Sweating Underarms

    37. 29 Neurotoxin Injection for Profusely Sweating Scalp and Forehead

    38. 30 Neurotoxin Injection for Profusely Sweating Hands

    39. 31 Neurotoxin Injection for Profusely Sweating Feet

    40. 32 Neurotoxin Injection for Chronic Migraines

    41. 33 Management of Neurotoxin Injection Complications

    42. Section IV Introduction to Fillers

    43. 34 Fillers Overview

    44. 35 Anesthesia Techniques

    45. 36 Filler Injection Methods

    46. 37 Choosing the Right Filler

    47. Section V Filler Injection Techniques

    48. 38 Filler Injection for Nasolabial Folds

    49. 39 Filler Injection with Polymethyl Methacrylate (Bellafill)

    50. 40 Fine Line Fillers and Skin Boosters

    51. 41 Filler Injection for Marionette Lines

    52. 42 Filler Injection for Lip Augmentation

    53. 43 Filler Injection for Elevating the Oral Commissures

    54. 44 Filler Injection for Vertical Lip Lines

    55. 45 Filler Injection for Glabellar Frown Lines

    56. 46 Filler Injection for Forehead Wrinkles

    57. 47 Filler Injection for Tear Trough Deformity

    58. 48 Filler Injection for Sunken Upper Eyelids

    59. 49 Filler Injection for Lateral Brow Lift

    60. 50 Filler Injection for Sunken Temples

    61. 51 Filler Injection for Nonsurgical Rhinoplasty

    62. 52 Filler Injection for Nasal Valve Stenting

    63. 53 Filler Injection for Medial Midface Hollowing

    64. 54 Filler Injection for Cheekbone Augmentation

    65. 55 Filler Injection for Sunken Cheeks

    66. 56 Filler Injection for Cheek Lift: de Maio Technique

    67. 57 Filler Injection for Chin Augmentation

    68. 58 Filler Injection for the Mental Crease

    69. 59 Filler Injection for Jawline Rejuvenation

    70. 60 Filler Injection for Mandibular Angle Augmentation

    71. 61 Filler Injection for Earlobe Rejuvenation

    72. 62 Filler Injection for Acne Scars

    73. 63 Filler Injection for Aging Hands

    74. 64 Filler Injection with Poly-L-Lactic Acid for Facial Volumizing (Sculptra)

    75. 65 Filler Injection with Poly-L-Lactic Acid for the Décolleté

    76. 66 The “Liquid Facelift”

    77. 67 Gender-Specific Injections

    78. 68 Management of Filler Injection Complications

    79. Section VI Fat-Dissolving Injections

    80. 69 Submental Fat Reduction

    81. Section VII Appendices

    82. Appendix A: Neurotoxin/Filler Injection Techniques by Advancing Difficulty and Injector’s Experience

    83. Appendix B: Sample Informed Consent Form for Neurotoxin Injections

    84. Appendix C: Sample Informed Consent Form for Filler Injections

    85. Appendix D: Sample Informed Consent Form for Kybella Treatment

    86. Index

    87. Additional MedOne Information

     

  • 80500lei 645.00 lei

     

    DESCRIPTION:

    An illustrated guide to best practices when performing and assessing biopsies for GI conditions of all kinds

    Accurate diagnosis of GI conditions necessarily entails both the careful taking of biopsies and the informed analysis of tissue material. With that being so, gastroenterologists and GI pathologists alike must have a solid understanding of the techniques, handling requirements, and diagnostic characteristics involved if they are to collaborate effectively. Gastrointestinal Pathology has been designed to provide a clinically focussed and richly illustrated guide to real-world scenarios faced by practicing GI specialists, offering step-by-step instruction and professional advice on the correct diagnosis of all major GI conditions. This essential new book includes:

    ·         Full-color illustrations throughout

    ·         Complete details of biopsy samples required to diagnose specific conditions

    ·         Reviews of differential diagnoses

    ·         Clinical management clues based on pathologic findings

    Featuring information to improve the practice of all gastroenterologists and GI pathologists, Gastrointestinal Pathology is a practical and every-day resource for the precise diagnosis of a wide range of GI conditions.


    TABLE OF CONTENTS:

     

    Chapter 1 -PRINCIPAL of BIOSPYDIAGNOSI

    Chapter 2-ESOPHAGUS-Inflammatory Conditions

    Chapter 3-ESOPHAGUS-Neopastic Conditions

    Chapter 4-STOMACH- Inflammatory Conditions

    Chapter 5-STOMACH-Polypoid Lesions

    Chapter 6-STOMACH- Neoplastic Conditions

    Chapter 7-DUODENUM-  Inflammatory Conditions

    Chapter 8-SMALL INTESTINE-Inflammatory Conditions

    Chapter 9-SMALL INTESTINE- Neoplastic Conditions

    Chapter 10- COLON Inflammatory Conditions

    Chapter 11 COLON-Polypoid Lesions

    Chapter 12-COLON-Neoplastic Conditions

    Chapter 13-ANUS Inflammatory Conditions

    Chapter 14 ANUS- Neoplastic Conditions

     

  • 93500lei 750.00 lei

     

    DESCRIPTION:

     

    A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY

    Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made.

    Topics covered include:

    ·         Biologically-guided radiation therapy

    ·         Informatics for precision medicine

    ·         Molecular imaging

    ·         Biomarkers for treatment assessment

    ·         Big data

    ·         Nanoplatforms

    Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

     

    TABLE OF CONTENTS:

    List of Contributors xiii

    Preface xv

    List of Abbreviations xvii

    1 Genomic Strategies for Personalized Cancer Therapy
    Arkadiusz Z. Dudek, Kate Baxstrom, Sushma Bharadwaj, Anne Blaes, Amit Kulkarni, Emil Lou, Vijeyaluxmy Nehru, Emma Rabinovich, Ardaman Shergill, and Maya Viner

    1.1 Introduction 1

    1.1.1 Definition of Precision Medicine in Oncology 1

    1.1.2 DNA and RNA Sequencing Techniques 2

    1.2 Precision Medicine in Specific Tumors 3

    1.2.1 Lung Cancer 3

    1.2.1.1 Adenocarcinoma 4

    1.2.1.2 Squamous Cell Carcinoma 4

    1.2.1.3 Small-Cell Lung Carcinoma (SCLC) 4

    1.2.1.4 Epidermal Growth Factor Receptor (EGFR) Mutations 4

    1.2.1.5 Anaplastic Lymphoma Kinase (ALK) 5

    1.2.1.6 BRAF, ROS1, MET 5

    1.2.1.7 KRAS 6

    1.2.1.8 Other: RET, NTRK 6

    1.2.2 Head and Neck Cancers 6

    1.2.2.1 HPV-Positive Cancers 7

    1.2.2.2 HPV-Negative Cancers 8

    1.2.2.3 Targeting the Epidermal Growth Factor Receptor (EGFR) Pathway 8

    1.2.2.4 Thyroid Cancers 8

    1.2.2.5 Other Targets 8

    1.2.3 Hematological Malignancies 9

    1.2.3.1 Lymphoma 9

    1.2.3.2 Leukemia 10

    1.2.3.3 Myelodysplastic Syndrome 11

    1.2.4 Gynecologic Malignancies 11

    1.2.4.1 Cervical 11

    1.2.4.2 Uterine 11

    1.2.4.3 Ovarian 12

    1.2.5 Melanoma 13

    1.2.6 Gastrointestinal Malignancies 16

    1.2.6.1 Gastroesophageal Cancers 17

    1.2.6.2 Colorectal Cancers 17

    1.2.7 Breast Cancer 19

    1.2.7.1 Basal-Like, or Triple Negative Breast Cancer 19

    1.2.7.2 Luminal A/B, or Hormone Positive 20

    1.2.7.3 HER2 Positive Breast Cancer 20

    1.2.7.4 Immunotherapy 20

    1.2.7.5 Germline Testing in Breast Cancer 21

    1.2.7.6 Conclusion 21

    1.2.8 Genitourinary Malignancies 21

    1.2.8.1 Prostate Cancer 21

    1.2.8.2 Renal Cell Cancer (RCC) 23

    1.2.8.3 Urothelial Cancers 23

    1.2.9 Pediatric Cancers 24

    1.2.9.1 Introduction 24

    1.2.9.2 Leukemia and Lymphoma 24

    1.2.9.3 Central and Peripheral Nervous System Tumors 25

    1.2.9.4 Bone and Soft Tissue Sarcomas 26

    1.2.9.5 Other Embryonal Tumors 26

    1.2.9.6 Conclusion 27

    1.2.10 Cancers of Unknown Primary Origin 27

    1.2.10.1 Diagnosis 27

    1.2.10.2 Gene Expression Profiling 28

    1.2.10.3 Mutational Testing with Next-Generation Sequencing (NGS) 28

    1.2.10.4 Treatment 28

    1.3 Biomarkers for Immunotherapy of Cancer 28

    1.3.1 PD-L1 29

    1.3.2 Soluble PD-L1 (sPD-L1) 29

    1.3.3 Combined Positive Score (CPS) 30

    1.3.4 Tumor Microenvironment 30

    1.3.5 Tumor Mutational Burden (TMB) 30

    1.3.6 Microsatellite Instability (MSI) 31

    1.3.7 MMR Deficiency 31

    1.3.8 Peripheral Blood Absolute Neutrophil Count/Absolute Lymphocyte Count 31

    1.3.9 Microbiome 31

    1.4 Clinical Trial Design in the Era of Precision Oncology 32

    1.5 Ethical, Legal, and Social Issues of Precision Oncology 33

    1.5.1 Ethical Issues 33

    1.5.2 Legal Issues 34

    1.5.3 Social Issues 35

    1.6 Databases, Data Sharing, and Challenges of Precision Oncology 36

    References 37

    2 Blood-Based Biomarkers for the Diagnosis and Prognosis of Cancer 61
    Shreetama Bandyopadhayaya and Chandi C. Mandal

    2.1 Introduction 61

    2.2 Importance of Blood-Based Biomarkers 61

    2.3 Circulating Proteins as Biomarkers 62

    2.4 Circulating Long Non-coding RNAs as Biomarkers 64

    2.5 Circulating miRNAs as Biomarkers 65

    2.6 Circulating Autoantibodies as Biomarkers 67

    2.7 Circulating Tumor DNA as Biomarkers 69

    2.8 Metabolites as Biomarkers 70

    2.9 Lipids as Biomarkers 72

    2.10 Exosomes as Biomarkers 74

    2.11 Conclusion 77

    References 77

    3 Application of Circulating Cell-free DNA for Personalized Cancer Therapy 83
    Indranil Chattopadhyay

    3.1 Introduction 83

    3.2 Drawbacks and Challenges of Invasive Tumor Tissue in Treatment and Diagnosis of Cancer 84

    3.3 Importance of Noninvasive Biomarkers in Treatment and Diagnosis of Cancer 84

    3.4 Liquid Biopsy: cfDNA and ctDNA 85

    3.4.1 Biogenesis of ctDNA: Mechanisms of Release, Characteristics, Quantity, and Quality 85

    3.4.2 Role of Preanalytical Factors that Affect cfDNA Measurements 86

    3.5 Practical Approach to Estimate ctDNA in Liquid Biopsy 86

    3.5.1 Isolation of cfDNA and ctDNA 86

    3.5.2 Analysis of ctDNA by Real-Time Quantitative PCR 86

    3.5.3 Analysis of ctDNA by Digital PCR (dPCR) 87

    3.5.4 Analysis of ctDNA by Beads, Emulsion, Amplification, and Magnetics (BEAMing) 87

    3.5.5 Analysis of ctDNA by Next-Generation Sequencing (NGS) 87

    3.6 Clinical Application of ctDNA Detection in Various Cancers 88

    3.6.1 Clinical Applications of ctDNA in Lung Cancer 88

    3.6.2 Clinical Application of ctDNA in Head and Neck Cancer 89

    3.6.3 Clinical Utility of Circulating Tumor DNA in Pancreatic Cancer 90

    3.6.4 Clinical Utility of Circulating Tumor DNA in Early and Metastatic Breast Cancer 90

    3.6.5 Clinical Utility of Circulating Tumor DNA in Colorectal Cancer 91

    3.6.6 Clinical Utility of Circulating Tumor DNA in Melanoma 91

    3.7 Clinical Utility of Methylation in ctDNA in Personalized Oncology 92

    3.8 Conclusion 92

    References 93

    4 Prognostic Implications of EGFR, p53, p16, Cyclin D1, and Bcl-2 in Head and Neck Squamous Cell Carcinoma (HNSCC) 99
    Zane Deliu, Ardaman Shergill, Anne Meier, Phyo Thazin Myint, Sarah Khan, Paramjeet Khosla, and Lawrence Feldman

    4.1 Introduction 99

    4.2 Epidermal Growth Factor Receptor (EGFR) 99

    4.2.1 EGFR Structure and Ligands 99

    4.2.2 Physiology 100

    4.2.3 EGFR Expression and Genetic Changes 100

    4.2.3.1 EGFR Expression in HNSCC 100

    4.2.3.2 Normal Adjacent Oral Mucosa and Pre-malignant Lesions 101

    4.2.4 EGFR Genetic Changes: Gene Copy Numbers, Amplifications, and Mutations in HNSCC 101

    4.2.4.1 Association of EGFR Expression or Genetic Changes with HPV Infection 101

    4.2.5 EGFR as a Prognostic and Predictive Marker 102

    4.2.5.1 EGFR as a Prognostic Marker 102

    4.2.5.2 EGFR as a Predictive Marker 102

    4.2.6 Future Perspectives 103

    4.2.6.1 EGFR in Immuno-SPECT or PET Imaging 103

    4.2.6.2 Molecular Profiling for Precision Medicine 104

    4.3 TP53 Mutations in Head and Neck Cancer 104

    4.3.1 Pathogenesis and Prevalence 104

    4.3.2 Risk Factors 104

    4.3.3 TP53 Structure and Physiology 105

    4.3.3.1 TP53 Structure 105

    4.3.3.2 TP53 as a Tumor Suppressor Gene 105

    4.3.4 TP53 Gain of Function Properties 105

    4.3.5 TP53 as a Prognostic and Predictive Marker 106

    4.3.6 Therapeutic Strategies Targeting TP53 106

    4.4 P16 and Cyclin D1 Mutations in Head and Neck Cancer 107

    4.4.1 Cyclin D1 107

    4.4.2 P16 108

    4.5 Bcl-2 Mutations in Head and Neck Cancer 109

    4.5.1 Bcl-2 109

    4.5.1.1 Physiological Role of Bcl-2 109

    4.5.2 Bcl-2 Family of Proteins 109

    4.5.3 Significance of Bcl-2 Overexpression 110

    4.5.4 Association with Chemoresistance and Radioresistance 111

    4.5.5 Role of Bcl-2 as a Marker of Prognosis 111

    4.5.6 Chemotherapeutics Targeting Bcl-2 112

    4.5.7 Bcl-2 Summary 113

    4.6 Conclusion 113

    References 114

    5 Immunotherapy and Cancer 133
    Maaly Bassiony, Adedoyin Victoria Aluko, and James A. Radosevich

    5.1 Introduction 133

    5.2 What Is Cancer Immunotherapy? 134

    5.3 How Does Immunotherapy Work? 135

    5.4 Timing of Immunotherapy 135

    5.5 Combination Immunotherapy 136

    5.6 Side Effects of Immunotherapy 137

    5.7 Types of Cancer Immunotherapy Treatments 137

    5.7.1 Immune Checkpoint Inhibitors 137

    5.7.2 Monoclonal Antibodies and Tumor-Agnostic Therapies 138

    5.7.3 Adoptive T Cell Therapy 138

    5.8 Cancer Vaccines 139

    5.9 Oncolytic Viral Immunotherapy (OVIs) 140

    5.10 Non-specific Immunotherapies 141

    5.11 Immunotherapy by Cancer Type 141

    5.11.1 Skin Cancer 141

    5.11.2 Lung Cancer 142

    5.11.3 Breast Cancer 142

    5.11.4 Kidney and Prostate Cancers 143

    5.11.5 Brain Cancer 145

    5.11.6 Colorectal Cancer 146

    5.11.7 Bladder Cancer 147

    5.11.8 Cervical Cancer 147

    5.11.9 Leukemia 147

    5.11.10 Liver Cancer 148

    5.12 Proven Studies 150

    5.13 Cancer Immunity Pathway 150

    5.14 Recent Developments in Immunotherapy 150

    5.15 Neoantigens for Cancer Immunotherapy 151

    5.16 Discussion 152

    References 153

    6 Predictive and Prognostic Markers for Cancer Medicine 157
    Elif Zeynep Yilmaz and Ebru Esin Yoruker

    6.1 Introduction 157

    6.2 Historical Development of Cancer Markers 157

    6.3 Characteristics of the Ideal Cancer Markers 158

    6.3.1 Ideal Source of Cancer Markers 159

    6.3.2 Kinetics of Cancer Markers 162

    6.3.3 Sensitivity and Specificity for Evaluation of Cancer Markers 163

    6.4 Utilization of Cancer Markers in Most Common Cancers 163

    6.4.1 Colorectal Cancer 166

    6.4.1.1 CEA 166

    6.4.1.2 KRAS/NRAS 167

    6.4.1.3 MSI 168

    6.4.1.4 PD-1/PD – L1 168

    6.4.1.5 BRAF 169

    6.4.1.6 Oncotype DX Colon Cancer Test 169

    6.4.1.7 ColoPrint 169

    6.4.1.8 CTC 169

    6.4.2 Breast Cancer 169

    6.4.2.1 ER/PR 170

    6.4.2.2 HER2 171

    6.4.2.3 Oncotype DX 171

    6.4.2.4 MammaPrint 171

    6.4.2.5 uPA/PAI-1 172

    6.4.3 Ovarian Cancer 172

    6.4.4 Lung Cancer 172

    6.4.4.1 EGFR 173

    6.4.4.2 ALK Rearrangements 173

    6.4.4.3 ROS1 Rearragements 174

    6.4.5 Urological Cancers 174

    6.4.5.1 Prostate Cancer 174

    6.4.5.2 Renal Cancer 175

    6.5 Classification and Techniques for Studying of Cancer Markers 176

    6.5.1 Circulating Tumor Cells as Cancer Markers 176

    6.5.2 DNA-Based Cancer Markers 177

    6.5.2.1 Microsatellite Alterations 177

    6.5.2.2 cfDNA Integrıty 177

    6.5.2.3 DNA Methylation 178

    6.5.2.4 Mutations and Single Nucleotide Polymorphisms (SNPs) 178

    6.5.3 RNA-Based Tumor Markers 180

    6.5.3.1 mRNAs 180

    6.5.3.2 Noncoding RNAs 180

    6.5.4 Protein-Based Tumor Markers 181

    6.6 Clinical Validation of Cancer Markers 185

    6.7 Conclusions and Future Perspectives 186

    References 187

    7 Dual Energy Imaging in Precision Radiation Therapy 203
    John C. Roeske, Maksat Haytmyradov, Roberto Cassetta, and Murat Surucu

    7.1 Introduction and Overview 203

    7.2 Historical Perspective 203

    7.2.1 X-Ray Production 204

    7.2.2 X-Ray Interactions in Matter 205

    7.2.3 Planar Image Formation 205

    7.2.4 Computed Tomography 206

    7.2.5 X-Ray Imaging in Radiation Oncology 207

    7.2.6 Dual Energy Imaging in Radiation Therapy 207

    7.3 Planar Dual Energy Imaging 208

    7.3.1 Theory 209

    7.3.2 Planar Dual Energy Imaging Methods 210

    7.3.3 Applications in Radiation Therapy 210

    7.3.3.1 Image-Guided Radiation Therapy 211

    7.3.3.2 Markerless Tumor Tracking 211

    7.3.3.3 Megavoltage Dual Energy Imaging 214

    7.4 Dual Energy Computed Tomography 214

    7.4.1 Theory 215

    7.4.2 Dual Energy Scanning Methods 216

    7.4.3 Applications in Radiation Therapy 218

    7.4.3.1 Brachytherapy Planning 218

    7.4.3.2 Proton Planning 218

    7.4.3.3 Normal Tissue Segmentation 220

    7.4.3.4 Assessment of Therapy Response 221

    7.4.3.5 Dual Energy Cone Beam Computed Tomography 222

    7.5 Summary and Future Directions 222

    Acknowledgement 223

    References 224

    8 The Role of Big Data in Personalized Medicine 229
    Jean-Emmanuel Bibault and Lei Xing

    8.1 Introduction 229

    8.2 The Concept of Big Data and the Specificities of Healthcare 230

    8.2.1 Volume: How Big Is Big Data? 230

    8.2.2 Variety: Where Does Big Data Come from? 231

    8.2.3 Velocity: How Fast Is Big Data Generated and Interpreted? 232

    8.2.4 Variability: How Does Big Data Change? 232

    8.2.5 Veracity: How Accurate Is Big Data? 232

    8.2.6 Value: Why Is Big Data Important? 232

    8.3 Sources of Data 233

    8.3.1 Genomics, Epigenomics, and Transcriptomics 233

    8.3.2 Proteomics and Metabolomics 234

    8.3.3 Medical Imaging and Radiomics 235

    8.3.4 Clinical Informatics 236

    8.4 Big Data Analytical Techniques 236

    8.4.1 Machine Learning 236

    8.4.2 Deep Learning 237

    8.4.3 Natural Language Processing 238

    8.5 Challenges in Big Data Analytics 239

    8.5.1 Implementing a Big Data Approach 239

    8.5.2 Developing an Information-Sharing Culture 239

    8.5.3 Security Measures 240

    8.5.4 Ethics in Big Data Analysis 240

    8.5.4.1 Consent in the Era of Big Data 240

    8.5.4.2 Privacy 240

    8.5.4.3 Anonymization 241

    8.5.4.4 Ownership 241

    References 241

    Index 249

     

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