Basic and Clinical Pharmacology 15e

Description:

Master key pharmacological concepts and practices with the most comprehensive, authoritative guide available
Presented in full-color and packed with hundreds of illustrations, Basic and Clinical Pharmacology is the wide-ranging, engaging guide students have counted on for decades.
Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, the guide covers the important concepts students need to know about the science of pharmacology and its application to clinical practice.
This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!.
Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters
New chapter on the increasingly relevant topic of cannabis pharmacology
Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information
Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019
New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters

Table of Contents:

Section I Basic Principles

1. Introduction: The Nature of Drugs & Drug Development & Regulation

2. Drug Receptors & Pharmacodynamics

3. Pharmacokinetics & Pharmacodynamics: Rational Dosing & the time Course of Drug Action

4. Drug Biotransformation

5. Pharmacogenomics

Section II Autonomic Drugs

6. Introduction to Autonomic Pharmacology

7. Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs

8. Cholinoceptor-Blocking Drugs

9. Adrenoceptor Agonists & Sympathomimetic Drugs

10. Adrenoceptor Antagonist Drugs

Section III Cardiovascular-Renal Drugs

11. Antihypertensive Agents

12. Vasodilators & the Treatment of Angina Pectoris

13. Drugs Used in Heart Failure

14. Agents Used in Cardiac Arrhythmias

15. Diuretic Agents

Section IV Drugs with Important Actions on Smooth Muscle

16. Histamine, Serotonin, & the Ergot Alkaloids

17. Vasoactive Peptides

18. The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds

19. Nitric Oxide

20. Drugs Used in Asthma & Chronic Obstructive Pulmonary Disease

Section V Drugs That Act in the Central Nervous System

21. Introduction to the Pharmacology of CNS Drugs

22. Sedative-Hypnotic Drugs

23. The Alcohols

24. Antiseizure Drugs

25. General Anesthetics

26. Local Anesthetics

27. Skeletal Muscle Relaxants

28. Pharmacologic Management of Parkinsonism & Other Movement Disorders

29. Antipsychotic Agents & Lithium

30. Antidepressant Agents

31. Opioid Agonists & Antagonists

32. Drugs of Abuse

Section VI Drugs Used to Treat Diseases of the Blood, Inflammation, & Gout

33. Agents Used in Cytopenias; Hematopoietic Growth Factors

34. Drugs Used in Disorders of Coagulation

35. Agents Used in Dyslipidemia

36. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout

Section VII Endocrine Drugs

37. Hypothalamic & Pituitary Hormones

38. Thyroid & Antithyroid Drugs

39. Adrenocorticosteroids & Adrenocortical Antagonists

40. The Gonadal Hormones & Inhibitors

41. Pancreatic Hormones & Glucose-Lowering Drugs

42. Agents That Affect Bone Mineral Homeostasis

Section VIII Chemotherapeutic Drugs

43. Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics

44. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, Oxazolidinones, & Pleuromutilins

45. Aminoglycosides & Spectinomycin

46. Sulfonamides, Trimethoprim, & Quinolones

47. Antimycobacterial Drugs

48. Antifungal Agents

49. Antiviral Agents

50. Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, & Sterilants

51. Clinical Use of Antimicrobial Agents

52. Antiprotozoal Drugs

53. Pharmacology of the Antihelminthic Drugs

54. Cancer Chemotherapy

55. Immunopharmacology

Section IX Toxicology

56. Introduction to Toxicology: Occupational & Environmental

57. Heavy Metal Intoxication & Chelators

58. Management of the Poisoned Patient

Section X Special Topics

59. Special Aspects of Perinatal & Pediatric Pharmacology

60. Special Aspects of Geriatric Pharmacology

61. Dermatologic Pharmacology

62. Drugs Used in the Treatment of Gastrointestinal Diseases

63. Cannabinoid Drugs

64. Therapeutic & Toxic Potential of Over-the-Counter Agents

65. Dietary Supplements & Herbal Medications

66. Rational Prescribing & Prescription Writing

67. Important Drug Interactions & Their Mechanisms

Appendix: Vaccines, Immune Globulins, & Other Complex Biologic Products

Index