Pulmonary Circulation: Diseases and Their Treatment, Fourth Edition

Description:

Pulmonary Circulation provides physicians with a better understanding of the structure, function and pathophysiology of the pulmonary circulation. It provides comprehensive coverage from diagnosis and clinical evaluation of patients with pulmonary hypertension to imaging techniques, disorders and treatment. This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders. In particular, it provides greater emphasis on the role of the right ventricle in pulmonary vascular disease, updated knowledge on pathobiology and genetics, and includes new material related to imaging and other diagnostic modalities. This edition also reflects new classifications and all the recommendations from the 2013 World Conference on Pulmonary Circulation as well as current guidelines from the European Society of Cardiology and the European Respiratory Society. Thoroughly updated to keep up with the brisk pace of discovery and emerging therapies, the book remains an essential resource by providing a balance between scientific review and clinically relevant guidelines for the busy practicing physician.

Table of contents:

Part 1: Physiology and Pathophysiology of Pulmonary Circulation and Right Heart

1. Evolution of the pulmonary circulation and the right heart

2. Pulmonary vascular function

3. Gas exchange

4. Right ventricular function

5. Heart-lung interactions

Part 2: Pathobiology of Pulmonary Vascular Disease and Right Ventricular Failure

6. Pathology of pulmonary vascular diseases

7. Pathobiology of pulmonary hypertension

8. Pathobiology of right ventricular failure

Part 3: Clinical Assessment of Pulmonary Hypertension

9. Clinical features

10. Echocardiography

11. Imaging and pulmonary hypertension: chest radiography, ventilation-perfusion scintigraphy, and c

12. Imaging: emerging modalities (magnetic resonance and nuclear imaging)

13. Exercise testing in pulmonary hypertension

14. Clinical assessment of PH: biomarkers

15. Cardiac catheterization

16. Classification of pulmonary hypertension

Part 4: Group 1: Pulmonary Arterial Hypertension

17. Idiopathic pulmonary arterial hypertension

18. Heritable pulmonary hypertension

19. Pulmonary arterial hypertension associated with drugs and toxins

20. Pulmonary arterial hypertension associated with connective tissue diseases

21. Portopulmonary hypertension

22. Pulmonary arterial hypertension associated with HIV infection

23. Pulmonary hypertension related to congenital systemic-to-pulmonary shunts

24. Schistosomiasis

25. Pulmonary hypertension in pregnancy

26. Pulmonary venoocclusive disease and pulmonary capillary hemangiomatosis

27. Pulmonary arterial hypertension registries

Part 5: Drug and Nondrug Treatment of Group 1 Pulmonary Arterial Hypertension

28. Conventional medical therapies: supportive therapies and general clinical care measures

29. Calcium channel blockers in the treatment of pulmonary arterial hypertension

30. Prostacyclins

31. Endothelin receptor antagonists

32. Phosphodiesterase type-5 inhibitors

33. Soluble guanylate cyclase stimulators and activators

34. Rehabilitation

35. Combination therapy for pulmonary arterial hypertension

36. Atrial septostomy and Potts procedure

37. Lung transplantation for pulmonary arterial hypertension including bridging to transplantation

38. Future of pulmonary arterial hypertension therapy

Part 6: Group 2: Pulmonary Hypertension Associated with Left Heart Conditions

39. World Health Organization pulmonary hypertension group 2: pulmonary hypertension due to left hea

40. Diagnosis and clinical relevance of pulmonary hypertension secondary to mitral or aortic valve d

41. Treatment of pulmonary hypertension in left heart disease

Part 7: Group 3: Pulmonary HypertensIon Associated with Hypoxia, Hypoventilation, and Lung Disease

42. Chronic high-altitude exposure

43. Hypoventilation and sleep apnea syndromes

44. Chronic obstructive pulmonary disease (COPD)

45. Interstitial lung disease and pulmonary hypertension

46. Combined pulmonary fibrosis and emphysema syndrome

Part 8: Group 4: Chronic Thromboembolic Pulmonary Hypertension

47. Diagnosis of chronic thromboembolic pulmonary hypertension

48. Medical therapy for chronic thromboembolic pulmonary hypertension

49. Balloon pulmonary angioplasty

50. Pulmonary thromboendarterectomy

Part 9: Pulmonary Hypertension with Unclear and/or Multifactorial Mechanisms

51. “Group 5” pulmonary hypertension with unclear and/or multifactorial mechanisms

52. Pulmonary hypertension in sickle cell disease and thalassemia

Part 10: Acute Pulmonary Embolism

53. Diagnosis of acute pulmonary thromboembolism

54. Treatment of acute pulmonary embolism

Part 11: Pediatric Pulmonary Hypertension

55. Pulmonary hypertension in children: a global perspective

56. Idiopathic pulmonary arterial hypertension in children

57. Persistent pulmonary hypertension of the newborn: pathophysiology and treatment

Part 12: Pulmonary Circulation in Critical Care

58. Acute lung injury and acute respiratory distress syndrome

59. Severe right ventricular failure

Part 13: Pulmonary Circulation in Environmental Stress

60. Exercise

61. Pulmonary circulation at high altitude

Part 14: Pulmonary Arteriovenous Malformations and Shunts

62. Pulmonary circulation after palliative cavopulmonary connections

63. The hepatopulmonary syndrome

64. Pulmonary arteriovenous malformations

Part 15: Pulmonary Vascular Tumors and Pulmonary Vasculitis

65. Pulmonary vascular tumors

66. Pulmonary vasculitis

Back Cover