Kaplan and Sadock’s Pocket Handbook of Psychiatric Drug Treatment

 

Description:

Now in vibrant full color, Kaplan and Sadock’s Pocket Handbook of Psychiatric Drug Treatment, 8th Edition, remains your reference of choice for easy-to-find information on the full spectrum of psychiatric drug therapies. Written by Dr. Samoon Ahmad, this trusted resource provides a wealth of data for each drug, presenting information in a clear, concise manner for quick, efficient retrieval. This edition brings you fully up to date in the field, with new information on cannabis, psychedelics, psychotropic medicines and medical comorbidities, genetics and pharmacogenomics testing, and more. 

 

Table of Contents:

 

Index to Book by Generic Name of Drug

Chapter 1: General Principles of Psychopharmacology

Introduction

Classification

Pharmacologic Actions

Pharmacokinetics

Pharmacodynamics

Drug Interactions

Drug Selection

Therapeutic Indications

Drug Approval Process in the United States

Off-Label Uses

Precautions and Adverse Effects

Precautions

Adverse Effects

Dosage and Clinical Guidelines

Diagnosis and the Identification of Target Symptoms

Explaining Rationale, Risks, Benefits, and Treatment Alternatives

Choice of Drug

Assessment of Outcome

Possible Reasons for Therapeutic Failures

Strategies for Increasing Efficacy

Combined Psychotherapy and Pharmacotherapy

Duration of Treatment

Special Populations

Children

Geriatric Patients

Pregnant and Nursing Women

Persons with Hepatic or Renal Insufficiency

Persons with Other Medical Illnesses

Laboratory Monitoring

Chapter 2: α-Adrenergic Receptor Ligands

Introduction

α2-Adrenergic Receptor Agonists

CLONIDINE AND GUANFACINE

Pharmacologic Actions

Therapeutic Indications

Withdrawal from Opioids, Alcohol, or Nicotine

Tourette Disorder

Other Tic Disorders

Hyperactivity and Aggression in Children

Posttraumatic Stress Disorder

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Overdose

Withdrawal

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

DEXMEDETOMIDINE

Pharmacokinetics

Indications

Precautions and Adverse Effects

Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

α2-Adrenergic Receptor Antagonists

YOHIMBINE

Precautions

Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Other α2-Adrenergic Receptor Antagonists

α1-Adrenergic Receptor Antagonists

PRAZOSIN

Pharmacologic Actions

Therapeutic Action

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 3: β-Adrenergic Receptor Antagonists

Introduction

Pharmacologic Actions

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Anxiety Disorders, Obsessive-Compulsive Disorder, and PTSD

Lithium-Induced Postural Tremor

Neuroleptic-Induced Acute Akathisia

Aggression and Violent Behavior

Alcohol Withdrawal

Antidepressant Augmentation

Other Disorders

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 4: Anticholinergic Agents

Introduction

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Treatment of Akathisia

Biperiden

Scopolamine

Trihexyphenidyl

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Neuroleptic-Induced Parkinsonism

Neuroleptic-Induced Acute Dystonia

Akathisia

Chapter 5: Anticonvulsants

Introduction

GABAPENTIN

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosages and Clinical Guidelines

TOPIRAMATE

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosages and Clinical Guidelines

TIAGABINE

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Laboratory Tests

Dosage and Administration

LEVETIRACETAM

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosages and Clinical Guidelines

ZONISAMIDE

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosages and Clinical Guidelines

PREGABALIN

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

PHENYTOIN

Pharmacologic Action

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 6: Antihistamines

Introduction

Pharmacologic Actions

Indications

Off-Label Psychiatric Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 7: Barbiturates and Similarly Acting Drugs

Introduction

Pharmacologic Actions

Therapeutic Indications

Electroconvulsive Therapy

Seizures

Sleep

Anxiety

Narcoanalysis

Withdrawal from Sedative-Hypnotics

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dose and Clinical Guidelines

Other Similarly Acting Drugs

PARALDEHYDE

Pharmacologic Actions

Therapeutic Indications

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosing and Clinical Guidelines

MEPROBAMATE

Pharmacologic Actions

Therapeutic Indications

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosing and Clinical Guidelines

CHLORAL HYDRATE

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosing and Clinical Guidelines

PROPOFOL

ETOMIDATE

Chapter 8: Benzodiazepines and Drugs Acting on GABA Receptors

Introduction

Pharmacologic Actions

Therapeutic Indications

Insomnia

Anxiety Disorders

Spasticity and Seizures

Alcohol Withdrawal Syndrome

Off-Label Uses

Bipolar I and II Disorders

Akathisia

Catatonia

Parkinson Disease

Posttraumatic Stress Disorder

Other Psychiatric Indications

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Tolerance, Dependence, and Withdrawal

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

FLUMAZENIL

Benzodiazepine Overdosage

Flumazenil Off-Label Uses

OREXIN ANTAGONISTS—SUVOREXANT (BELSOMRA) AND LEMBOREXANT (DAYVIGO)

BREXANOLONE

Pharmacologic Actions

Therapeutic Indications

Precautions and Adverse Events

Use in Pregnancy and Lactation

Drug Interactions

Dosage and Clinical Guidelines

Chapter 9: Bupropion

Introduction

Pharmacologic Actions

Therapeutic Indications

Depression

Smoking Cessation

Off-Label Uses

Attention-Deficit/Hyperactivity Disorder

Bipolar Disorders

Cocaine Detoxification

Hypoactive Sexual Desire Disorder

Neuropathic Pain

Weight Loss

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 10: Buspirone

Introduction

Pharmacologic Actions

Therapeutic Indications

Generalized Anxiety Disorder

Off-Label Uses

Depression

Obsessive-Compulsive Disorder

Posttraumatic Stress Disorder

Other

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Switching from a Benzodiazepine to Buspirone

Chapter 11: Calcium Channel Inhibitors

Introduction

Pharmacologic Actions

Indications

Off-Label Psychiatric Uses

Bipolar Disorder

Other Psychiatric Indications

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 12: Cannabis

Introduction

Cannabis—The Plant

Phytocannabinoids

Hemp and Marijuana

Regulatory History—20th Century

Regulatory History—21st Century

Sativa and Indica

The Endocannabinoid System

Endocannabinoid System Signaling

Cannabis and the ECS

Conclusion

Chapter 13: Marijuana

Introduction

MEDICAL MARIJUANA

Pharmacokinetics

Distribution

Elimination and Excretion

Pharmacodynamics

Mechanism of Action

Therapeutic Index

Tolerance, Dependence, and Withdrawal

Therapeutic Indications

State Approved Indications

Potential Indications and Ongoing Research

Precautions and Adverse Events

Psychiatric Adverse Reactions

Hazardous Activities

Risk of Overdose or Abuse

Use in Pregnancy and Lactation

Drug Interactions

DRONABINOL

Pharmacokinetics

Absorption

Distribution and Bioavailability

Elimination

Metabolism

Excretion

Pharmacodynamics

Mechanism of Action

Dose-Response Curve

Tolerance, Dependence, and Withdrawal

Therapeutic Indications

Precautions and Adverse Events

Psychiatric Adverse Reactions

Hazardous Activities

Risk of Abuse and Dependence

Use in Pregnancy and Lactation

Drug Interactions

Dosing and Clinical Guidelines

Geriatric Use

NABILONE

Pharmacokinetics

Absorption

Distribution

Bioavailability

Metabolism

Elimination

Excretion

Pharmacodynamics

Mechanism of Action

Dose-Response Curve

Tolerance, Dependence, and Withdrawal

Therapeutic Indications

Precautions and Adverse Reactions

Psychiatric Adverse Reactions

Hazardous Activities

Risk of Abuse and Dependence

Pregnant and Nursing Women

Drug Interactions

Dosage and Clinical Guidelines

Geriatric Use

Chapter 14: Cannabidiol (CBD)

Introduction

Pharmacology

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Precautions and Adverse Events

Risk of Overdose and Abuse

Hepatocellular Injury

Baseline Measurement and Monitoring

Use in Pregnancy and Lactation

Drug Interactions

Dosage and Clinical Guidelines

Guidance on Quality Assurance of CBD

Pediatric Use

Chapter 15: Carbamazepine and Oxcarbazepine

Introduction

CARBAMAZEPINE

Pharmacologic Actions

Therapeutic Indications

Bipolar Disorder

Off-Label Uses

Acute Depression

Other Disorders

Precautions and Adverse Reactions

Blood Dyscrasias

Hepatitis and Cholestasis

Dermatologic Effects

Renal Effects

Other Adverse Effects

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosing and Administration

Routine Laboratory Monitoring

OXCARBAZEPINE

Pharmacologic Actions

Off-Label Psychiatric Uses

Precautions and Adverse Effects

Use in Pregnancy and Lactation

Drug Interactions

Dosing and Administration

Chapter 16: Cholinesterase Inhibitors, Memantine, and Aducanumab

Introduction

Cholinesterase Inhibitors

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

MEMANTINE

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

ADUCANUMAB

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 17: Disulfiram and Acamprosate

Introduction

DISULFIRAM

Pharmacologic Actions

Blood Concentrations in Relation to Action

Therapeutic Indications

Precautions and Adverse Reactions

With Alcohol Consumption

Without Alcohol Consumption

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

ACAMPROSATE

Pharmacologic Actions

Indications

Off-Label Uses

Precautions and Adverse Effects

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 18: Dopamine Receptor Agonists and Precursors

Introduction

Pharmacologic Actions

Therapeutic Indications

Parkinson Disease

Medication-Induced Movement Disorders

Restless Leg Syndrome

Type II Diabetes Mellitus

Off-Label Uses

Mood Disorders

Restless Leg Syndrome

Neuroleptic Malignant Syndrome

Sexual Dysfunction

Other Medical Conditions

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

AMANTADINE

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Effects

Use in Pregnancy and Lactation

Drug Interactions

Dosage and Clinical Guidelines

Chapter 19: Dopamine Receptor Antagonists (First-Generation Antipsychotics)

Introduction

Pharmacologic Actions

Therapeutic Indications

Schizophrenia and Schizoaffective Disorder

Acute Mania

Tourette Syndrome

Severe Agitation and Violent Behavior

Bipolar Disorder

Generalized Anxiety Disorder

Behavioral Problems in Children

Miscellaneous Medical Conditions

Off-Label Uses

Depression with Psychotic Symptoms

Delusional Disorder

Chronic Pruritus and Delusional Parasitosis

Dementia and Delirium

Substance-Induced Psychotic Disorder

Childhood Schizophrenia

Irritability or Aggression Associated with Autism Spectrum Disorder

Borderline Personality Disorder

Other Psychiatric and Nonpsychiatric Indications

Precautions and Adverse Reactions

Neuroleptic Malignant Syndrome

Seizure Threshold

Sedation

Central Anticholinergic Effects

Cardiac Effects

Sudden Death

Orthostatic (Postural) Hypotension

Hematologic Effects

Tardive Dyskinesia

Peripheral Anticholinergic Effects

Endocrine Effects

Sexual Adverse Effects

Skin and Eye Effects

Jaundice

Overdoses

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Short-Term Treatment

Rapid Neuroleptization

Early Treatment

Intermittent Medications

Maintenance Treatment

Long-Acting Depot Medications

Plasma Concentrations

Treatment-Resistant Persons

Adjunctive Medications

Choice of Drug

Chapter 20: Lamotrigine

Introduction

Pharmacologic Actions

Psychiatric Indications

Bipolar Disorder

Off-Label Indications

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Testing

Laboratory Interferences

Dosage and Administration

Chapter 21: Ketamine

Introduction

Pharmacology

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Effects

Precautions

Adverse Effects

Risk of Overdose or Abuse

Pregnant and Nursing Women

Drug Interactions

Dosage and Clinical Guidelines

Special Populations

Risk Evaluation and Mitigation Strategy

Chapter 22: Lithium

Introduction

Pharmacologic Actions

Therapeutic Indications

Bipolar I Disorder

Off-Label Uses

Bipolar Depression

Major Depressive Disorder

Schizoaffective Disorder and Schizophrenia

Suicide Prevention

Neuroprotective Agent

Other Off-Label Uses

Precautions and Adverse Effects

Cardiac Effects

Gastrointestinal Effects

Weight Gain

Neurologic Effects

Renal Effect

Thyroid Effects

Cardiac Effects

Dermatologic Effects

Lithium Toxicity and Overdoses

Adolescents

Elderly Persons

Use in Pregnancy and Lactation

Miscellaneous Effects

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Initial Medical Workup

Dosage Recommendations

Laboratory Monitoring

Patient Education

Chapter 23: Agents for Insomnia and Excessive Daytime Sleepiness

Introduction

Agents for Insomnia

MELATONIN

Pharmacologic Actions

Therapeutic Indications

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interference

Dosage and Administration

RAMELTEON

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Events

Use in Pregnancy and Lactation

Drug Interactions

Dosing and Clinical Guidelines

TASIMELTEON

Pharmacologic Action

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Events

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interference

Dosage and Administration

AGOMELATINE

DUAL OREXIN RECEPTOR ANTAGONISTS

Pharmacologic Actions

Therapeutic Indications

Precautions and Adverse Events

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interference

Dosage and Clinical Guidelines

Suvorexant

Lemborexant

Daridorexant

Agents for Excessive Daytime Sleepiness

MODAFINIL AND ARMODAFINIL

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Attention Deficit Hyperactivity Disorder

Acute Unipolar and Bipolar Depressive Episodes

Cocaine Dependence

Fatigue

Precautions and Adverse Events

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interference

Dosage and Clinical Guidelines

PITOLISANT

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Cataplexy

Pediatric Uses

Precautions and Adverse Events

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interference

Dosage and Clinical Guidelines

SOLRIAMFETOL

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Events

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interference

Dosage and Clinical Guidelines

CALCIUM, MAGNESIUM, POTASSIUM, AND SODIUM OXYBATES

Pharmacologic Actions

Therapeutic Indications

Precautions and Adverse Events

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interference

Dosing and Clinical Guidelines

Chapter 24: Methylenedioxymethamphetamine

Introduction

Description and Route of Administration

Pharmacokinetics

Absorption and Distribution

Metabolism

Elimination and Excretion

Pharmacodynamics

Mechanism of Action

Therapeutic Index

Tolerance, Dependence, and Withdrawal

Therapeutic Indications

Precautions and Adverse Effects

Risk of Overdose

Drug Interactions

Dosage and Clinical Guidelines

Conclusion

Chapter 25: Mirtazapine

Introduction

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Chemotherapy (as Appetite Stimulant and Sedative)

Anti–Depressant-Induced Side Effects

Posttraumatic Stress Disorder

Insomnia

Anxiety Disorders

Other Off-Label Uses

Precautions and Adverse Reactions

Suicide Warning

Side Effects

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Administration

Chapter 26: Monoamine Oxidase Inhibitors

Introduction

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Suicide Warning

Use in Pregnancy and Lactation

Tyramine-Induced Hypertensive Crisis

Withdrawal

Overdose

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 27: Nefazodone and Trazodone

Introduction

NEFAZODONE

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Liver Failure

Suicide Warning

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

TRAZODONE

Pharmacologic Actions

Therapeutic Indications

Off-Label Uses

Insomnia

Erectile Disorder

Other Indications

Precautions and Adverse Reactions

Trazodone Intoxication

Suicide Warning

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 28: Opioid Receptor Agonists: Methadone, Buprenorphine, and Tramadol

Introduction

Pharmacologic Actions

Therapeutic Indications

METHADONE

BUPRENORPHINE

TRAMADOL

Off-Label Use

Precautions and Adverse Reactions

Overdosage

Withdrawal Symptoms

Use in Pregnancy and Lactation

Neonatal Opioid Withdrawal Symptoms

Drug–Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Methadone

Buprenorphine

Tramadol

Chapter 29: Opioid Receptor Antagonists: Naltrexone, Nalmefene, and Naloxone

Introduction

Pharmacologic Actions

Therapeutic Indications

Opioid Dependence

Rapid Detoxification

Alcohol Dependence

Off-Label Uses

Substance Use Disorders

Smoking Cessation

Compulsive Behaviors

Chronic Pain

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Overdose

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Rapid Detoxification

Emergency Administration

Chapter 30: Medications for Sexual Dysfunction

Introduction

Pharmacologic Actions

Therapeutic Indications

Erectile Dysfunction

Benign Prostatic Hyperplasia

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Treatment of Priapism

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 31: Psychedelics

Introduction

PSILOCYBIN

Pharmacokinetics

Absorption, Bioavailability, and Distribution

Metabolism

Elimination and Excretion

Pharmacodynamics

Mechanism of Action

Therapeutic Index

LYSERGIC ACID DIETHYLAMIDE

Pharmacokinetics

Absorption, Bioavailability, and Distribution

Metabolism

Elimination and Excretion

Pharmacodynamics

Mechanism of Action

Therapeutic Index

Shared Characteristics of Psilocybin and LSD

Therapeutic Indications and Off-Label Uses

Tolerance, Dependence, and Withdrawal

Precautions and Adverse Effects

Drug Interactions

Dosage and Clinical Guidelines

Conclusion

Chapter 32: Selective Serotonin–Norepinephrine Reuptake Inhibitors

Introduction

Pharmacodynamics

VENLAFAXINE AND DESVENLAFAXINE

Pharmacokinetics

Therapeutic Indications

Depression

Generalized Anxiety Disorder

Social Anxiety Disorder

Panic Disorder

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Administration

DULOXETINE

Pharmacologic Actions

Therapeutic Indications

Depression

Generalized Anxiety Disorder

Neuropathic Pain Associated with Diabetes and Stress Urinary Incontinence

Other Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Administration

MILNACIPRAN AND LEVOMILNACIPRAN

Levomilnacipran (Fetzima)

Pharmacokinetics

Therapeutic Indications

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Administration

VILOXAZINE

Pharmacokinetics

Therapeutic Indications

Off-Label Uses

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Administration

Chapter 33: Selective Serotonin Reuptake Inhibitors

Introduction

Pharmacologic Actions

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Depression

Anxiety Disorders

Posttraumatic Stress Disorder

Bulimia Nervosa and Other Eating Disorders

Premenstrual Dysphoric Disorder

Acute Depressive Episodes in Bipolar I Disorder

Treatment-Resistant Depression

Off-Label Uses

Premature Ejaculation

Paraphilias

Autism Spectrum Disorder

Alcohol Use Disorder

Precautions and Adverse Reactions

Suicide

Sexual Dysfunction

Gastrointestinal Adverse Effects

Cardiovascular Effects

Headaches

Central Nervous System or Psychiatric Adverse Effects

Anticholinergic Effects

Hematologic Adverse Effects

Electrolyte and Glucose Disturbances

Endocrine and Allergic Reactions

Serotonin Syndrome

Sweating

Overdose

SSRI Withdrawal

Loss of Efficacy

Pregnancy and Breastfeeding

SSRI Use During Pregnancy (Excluding Paroxetine)

Paroxetine Use During Pregnancy

SSRI Use While Nursing

Drug Interactions

Fluoxetine

Sertraline

Paroxetine

Fluvoxamine

Citalopram

Escitalopram

Vilazodone

Laboratory Interferences

Dosage and Clinical Guidelines

Fluoxetine

Sertraline

Paroxetine

Fluvoxamine

Citalopram

Escitalopram

Vilazodone

VORTIOXETINE

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Precautions and Adverse Reactions

Warnings

Pregnancy and Nursing

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 34: Second-Generation or Atypical Antipsychotics (Serotonin–Dopamine Antagonists, Modulators, and Similarly Acting Drugs)

Introduction

General Overview of SGAs

Pharmacodynamics

Warnings, Precautions, and Adverse Events

Use in Pregnancy and Lactation

Clinical Guidelines for SGAs

ARIPIPRAZOLE

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Off-Label Uses

Adverse Events

Drug Interactions

Dosage and Clinical Guidelines—Schizophrenia

ASENAPINE

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Off-Label Uses

Adverse Events

Drug Interactions

Dosage and Guidelines

BREXPIPRAZOLE

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Off-Label Uses

Adverse Events

Drug Interactions

Dosage and Guidelines

CARIPRAZINE

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Off-Label Uses

Adverse Events

Drug Interactions

Dosage and Guidelines

ILOPERIDONE

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Adverse Events

Drug Interactions

Dosage and Guidelines

LUMATEPERONE

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Off-Label Uses

Adverse Events

Drug Interactions

Dosage and Guidelines

LURASIDONE

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Off-Label Uses

Adverse Events

Drug Interactions

Dosage and Guidelines

OLANZAPINE

Pharmacokinetics

Pharmacodynamics

Indications

Adverse Events

Drug Interactions

Dosages

Combined Formulations

PALIPERIDONE

Pharmacokinetics

Pharmacodynamics

Indications

Adverse Events

Drug Interactions

Dosage and Clinical Guidelines

Long-Acting Formulations

PIMAVANSERIN

Pharmacokinetics

Pharmacodynamics

Indications

Off-Label Uses

Adverse Events

Drug Interactions

Dosage and Guidelines

QUETIAPINE

Pharmacokinetics

Pharmacodynamics

Indications

Off-Label Uses

Adverse Events

Drug Interactions

Dosage and Guidelines

RISPERIDONE

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Off-Label Uses

Adverse Events

Drug Interactions

Dosage and Clinical Guidelines

ZIPRASIDONE

Pharmacokinetics

Pharmacodynamics

Indications

Adverse Events

Drug Interactions

Dosage and Guidelines

CLOZAPINE

Pharmacokinetics

Pharmacodynamics

Therapeutic Indications

Off-Label Uses

Adverse Events

Drug Interactions

Dosage and Guidelines

Risk Evaluation and Management Strategy for Clozapine

Chapter 35: Sympathomimetic Drugs and Atomoxetine

Introduction

Pharmacologic Actions

Therapeutic Indications

Attention Deficit Hyperactivity Disorder

Narcolepsy and Hypersomnolence

Binge Eating Disorder

Off-Label Uses

Depressive Disorders

Encephalopathy Caused by Brain Injury

Obesity

Fatigue

Apathy in Alzheimer Disease

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Administration

ATOMOXETINE

Pharmacologic Actions

Therapeutic Indications

Precautions and Adverse Reactions

Dosage and Clinical Guidelines

Chapter 36: Thyroid Hormones

Introduction

Pharmacologic Actions

Therapeutic Indications

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Thyroid Function Tests

Thyrotropin-Releasing Hormone Stimulation Test

Dosage and Clinical Guidelines

Chapter 37: Tricyclics and Tetracyclics

Introduction

Pharmacologic Actions

Therapeutic Indications

Major Depressive Disorder

Generalized Anxiety Disorder

Obsessive-Compulsive Disorder

Childhood Enuresis

Off-Label Uses

Panic Disorder with Agoraphobia

Pain

Other Disorders

Precautions and Adverse Reactions

Psychiatric Effects

Anticholinergic Effects

Cardiac Effects

Other Autonomic Effects

Sedation

Neurologic Effects

Allergic and Hematologic Effects

Hepatic Effects

Other Adverse Effects

Use in Pregnancy and Lactation

Drug Interactions

Monoamine Oxidase Inhibitors

Antihypertensives

Antiarrhythmic Drugs

Dopamine Receptor Antagonists

Central Nervous System Depressants

Sympathomimetics

Oral Contraceptives

Other Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Plasma Concentrations and Therapeutic Drug Monitoring

Overdose Attempts

Chapter 38: Valproate

Introduction

Pharmacologic Actions

Therapeutic Indications

Bipolar I Disorder

Off-Label Uses

Bipolar I Disorder

Schizophrenia and Schizoaffective Disorder

Other Mental Disorders

Other Medical Conditions

Precautions and Adverse Reactions

Use in Pregnancy and Lactation

Drug Interactions

Laboratory Interferences

Dosage and Clinical Guidelines

Chapter 39: Nutritional Supplements and Medical Foods

Introduction

Nutritional Supplements

Medical Foods

Phytomedicinals

Adverse Effects

Chapter 40: Assessment and Treatment of Obesity and Metabolic Syndrome

Introduction

Definitions

Obesity

Body Mass Index

Metabolic Syndrome

Epidemiology

Etiology

Tobacco Cessation

Medications

Effects on Health—Metabolic Syndrome and Beyond

Assessment and Interventions When Prescribing Psychotropic Medications

Diet

Lifestyle Changes

Exercise

Stress Management

Psychotherapy

Pharmacotherapy

Surgery

Conclusion

Chapter 41: Weight Loss Drugs

Introduction

Drugs with FDA Approval for Weight Loss

PHENTERMINE

PHENTERMINE/TOPIRAMATE EXTENDED RELEASE (QSYMIA)

PHENTERMINE RESIN (IONAMIN)

PHENDIMETRAZINE (BONTRIL PDM, ADIPOST, PHENDIET, STATOBEX)

DIETHYLPROPION (TENUATE)

ORLISTAT (XENICAL, ALLI)

BENZPHETAMINE (DIDREX)

LIRAGLUTIDE INJECTION (SAXENDA)

NALTREXONE/BUPROPION (CONTRAVE)

SEMAGLUTIDE (WEGOVY, OZEMPIC)

AMPHETAMINE (EVEKEO)

Drugs without FDA Approval for Weight Loss

TOPIRAMATE (TOPAMAX)

ZONISAMIDE (ZONEGRAN)

METFORMIN (GLUCOPHAGE)

AMPHETAMINE AND DEXTROAMPHETAMINE (ADDERALL)

NALTREXONE (VIVITROL, REVIVA)

AMANTADINE (GOCOVRI)

TIRZEPATIDE (MOUNJARO)

Chapter 42: Medication-Induced Movement Disorders

Introduction

Neuroleptic-Induced Parkinsonism and Other Medication-Induced Parkinsonism

Diagnosis, Signs, and Symptoms

Epidemiology

Etiology

Differential Diagnosis

Treatment

Neuroleptic Malignant Syndrome

Diagnosis, Signs, and Symptoms

Epidemiology

Course and Prognosis

Treatment

Medication-Induced Acute Dystonia

Diagnosis, Signs, and Symptoms

Epidemiology

Etiology

Differential Diagnosis

Course and Prognosis

Treatment

Medication-Induced Acute Akathisia

Diagnosis, Signs, and Symptoms

Epidemiology

Treatment

Tardive Dyskinesia

Diagnosis, Signs, and Symptoms

Epidemiology

Course and Prognosis

Treatment

Tardive Dystonia and Tardive Akathisia

Medication-Induced Postural Tremor

Diagnosis, Signs, and Symptoms

Epidemiology

Etiology

Treatment

Other Medication-Induced Movement Disorders

Periodic Limb Movement Disorder

Restless Legs Syndrome

Hyperthermic Syndromes

Chapter 43: Pharmacogenomic Testing

Introduction

Effect of SNPs on Drug Metabolism

Effect of SNPs on Pharmacodynamics

Conclusion

Chapter 44: Brain Stimulation or Neuromodulation Procedures

Introduction

Pretreatment Evaluation

Mechanism of Action

Pregnancy

Electroconvulsive Therapy

Therapeutic Indications and Uses

Procedure

Warnings

Adverse Events

Transcranial Magnetic Stimulation

Therapeutic Indications and Uses

Procedure

Warnings

Adverse Events

Cranial Electrotherapy Stimulation

Therapeutic Indications and Uses

Procedure

Contraindications

Adverse Events

Transcranial Direct Current Stimulation

Therapeutic Indications and Uses

Procedure

Contraindications

Adverse Events

Vagus Nerve Stimulation

Psychiatric Indications

Procedure

Adverse Events

Deep Brain Stimulation

Therapeutic Indications and Uses

Procedure

Contraindications

Adverse Events

Experimental Treatments

Magnetic Seizure Therapy

Low Field Magnetic Stimulation

Conclusion

Index

About the Author

 

An aparitie	03 Jun 2023
Autor	Samoon Ahmad M.D.
Dimensiuni	127 x 203 mm
Editura	LWW
Format	Paperback
ISBN	9781975168995
Limba	Engleza
Nr pag	552
Versiune digitala	DA