Colorectal Liver Metastasis

Description:

This book provides a practically applicable guide to the management of liver metastases in cases of colorectal cancer. It features detailed reviews of the latest diagnostic and therapeutic options. Instruction on how to appropriately apply surgical techniques including two stage hepatectomy as well as both laprascopic and open resection in a variety of scenarios is covered. The use of systemic therapies involving oxaliplatin, immunotherapy and infusional therapy are also described along with a range of surveillance strategies.  Vauthey and Adam Colorectal Liver Metastasis comprehensively covers the latest advances in how to successfully diagnose and treat colorectal liver metastases and is an indispensable resource for all trainee and practicing medical professionals who encounter these patients within their clinical practice.    

Table of Contents:

Part I. Introduction

1. History of Treatment of Colorectal Liver Metastases

Part II. Surgery

2. Liver Anatomy

3. Exposure for Hepatectomy

4. Parenchymal Preservation in the Operative Management of Colorectal Liver Metastases

5. Simulation and Navigation

6. Advanced Techniques in Multiple Metastases: Fiduciary Markers and Completion Ablation

7. Two-Stage Hepatectomy for Bilateral Colorectal Liver Metastases: Experience of MD Anderson Cancer Center

8. Two-Stage Hepatectomy for Bilobar Colorectal Liver Metastases: Experience of Hôpital Paul-Brousse

9. One-Stage Hepatectomy for Bilateral Colorectal Liver Metastases: Experience of the University of Tokyo

10. Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) for Colorectal Liver Metastasis

11. Open Resection Technique

12. Laparoscopic Liver Resection Technique: The Norwegian Experience

13. Laparoscopic Liver Resection Technique: French Experience

14. Laparoscopic Anatomical Liver Resection Technique: The Japanese Experience

15. Is There a Place for Robotic Resection?

16. Advanced Resection Technique with Vascular Reconstruction

17. Resection Margins

18. R1 Vascular Surgery

19. Prevention and Treatment of Perihepatic Fluid Collection Including Two-Step Air Leak Test

20. Synchronous Presentation of Primary and Colorectal Liver Metastasis: Classic, Reverse, and Combined

21. Approach to Synchronous Lung and Liver Metastases and Single-Incision Combined Resection

22. Perioperative Chemotherapy: Review of Randomized Trials and Recommended Approach

23. Disappearing Liver Metastasis

24. Downsizing Chemotherapy for Liver Metastases from Colorectal Cancer

25. Is There a Place for Debulking?

26. Liver Transplantation

27. Prognostic Models for Colorectal Liver Metastases

28. Personalized Prognostic Model (Contour Prognostic Model)

29. Conditional Recurrence-Free Survival

30. Repeat Hepatectomy for Colorectal Liver Metastases

Part III. Systemic and Regional Therapy

31. Initial Systemic Chemotherapy for Metastatic Colorectal Cancer

32. Treatment Refractory Metastatic Colorectal Cancer

33. Targeted Therapy with Anti-EGFR and Anti-VEGF Therapy and Beyond

34. Adjuvant Systemic Chemotherapy

35. Immunotherapy

36. Hepatic Artery Infusion Therapy: The European Experience

37. Infusional Therapy: American Experience

Part IV. Radiology, Interventional Radiology and Radiation

38. Optimal Diagnostic Imaging of CLM for Surgical Candidates

39. Prevention of Postoperative Hepatic Insufficiency

40. Portal Vein Embolization with and without Hepatic Vein Occlusion

41. Radiofrequency Ablation, Electroporation, and Microwave Ablation

42. Radiation Therapy

43. Yttrium-90 Radioembolization for Metastatic Colorectal Cancer

Part V. Surgical Pathology and Molecular Pathology

44. Hepatic Injury from Chemotherapy

45. Imaging Response Evaluation

46. Pathological Response Criteria

47. Histopathological Patterns of Progression and Vessel Co-option

48. Colorectal Liver Micrometastases

49. Liquid Biopsy

Part VI. Genetic Sequencing and Clinical Implication

50. Multigene Testing for Prognostication and Therapeutic Actionability

51. Cancer-Related Signaling Pathway and Prognosis

Part VII. Ultrasound and Operating Room Settings

52. Intraoperative Ultrasound

53. Hybrid Room for Combined Procedures

Part VIII. Role of Multidisciplinary Team and Recovery and Surveillance Strategy

54. Multidisciplinary Liver Tumour Board

55. Role of Advanced Practice Providers in Enhancing Perioperative and Intraoperative Patient Care

56. Enhanced Recovery in Liver Surgery

57. Improved Survival After CLM Resection over 20 Years

58. The LiverMetSurvey Registry

59. Circulating Tumour DNA and Risk-Stratified Surveillance Strategies for Patients with Colorectal Liver Metastases

Back Matter