Cardiovascular Pathology

Description:

Cardiovascular Pathology, Fourth Edition, provides users with a comprehensive overview that encompasses its examination, cardiac structure, both normal and physiologically altered, and a multitude of abnormalities. This updated edition offers current views on interventions, both medical and surgical, and the pathology related to them.

Congenital heart disease and its pathobiology are covered in some depth, as are vasculitis and neoplasias. Each section has been revised to reflect new discoveries in clinical and molecular pathology, with new chapters updated and written with a practical approach, especially with regards to the discussion of pathophysiology. New chapters reflect recent technological advances with cardiac devices, transplants, genetics, and immunology. Each chapter is highly illustrated and covers contemporary aspects of the disease processes, including a section on the role of molecular diagnostics and cytogenetics as specifically related to cardiovascular pathology.

Customers buy the Print + Electronic product together!

• Serves as a contemporary, all-inclusive guide to cardiovascular pathology for clinicians and researchers, as well as clinical residents and fellows of pathology, cardiology, cardiac surgery, and internal medicine
• Offers new organization of each chapter to enable uniformity for learning and reference: Definition, Epidemiology, Clinical Presentation, Pathogenesis/Genetics, Light and Electron Microscopy/Immunohistochemistry, Differential Diagnosis, Treatment and Potential Complications
• Features six new chapters and expanded coverage of the normal heart and blood vessels, cardiovascular devices, congenital heart disease, tropical and infectious cardiac disease, and forensic pathology of the cardiovascular system
• Contains 400+ full color illustrations and an online image collection facilitate research, study, and lecture slide creation

1.    Table of Contents

2.    Copyright

3.    Dedication

4.    Contributors

5.    Preface

6.    Acknowledgments

7.    Chapter 1: Anatomic Considerations and Examination of Cardiovascular Specimens (Excluding Devices)

8.    Abstract

9.    Gross Examination of the Heart

10. Examination of Surgical Cardiovascular Specimens

11. Microscopic Examination of the Blood Vessels and Heart

12. Chapter 2: Age-related Cardiovascular Changes and Diseases

13. Abstract

14. Nonspecific Cardiovascular Changes of Aging

15. Changes in the Conduction System

16. Changes in Arteries

17. Age-related Diseases

18. Disorders of Premature Aging

19. Telomere

20. Chapter 3: Vascular Pathobiology: Atherosclerosis and Large Vessel Disease

21. Abstract

22. Introduction to Atherosclerosis

23. Epidemiology and Risk Factors

24. Gross and Microscopic Morphology of the Fibroinflammatory Lipid Plaque

25. Steps in Atherosclerotic Plaque Formation and Complications

26. Cellular Function and Pathways in Atherogenesis

27. Nonatherosclerotic Diseases of the Aorta

28. Chapter 4: Diseases of Small and Medium-sized Blood Vessels

29. Abstract

30. Introduction

31. Vascular Activation and Common Vascular Pathologic Changes

32. Congenital Vascular Diseases

33. Genetic Vascular Disorders

34. Endocrine/Metabolic Vascular Disorders

35. Vasculitis

36. Infection

37. Toxic Vasculopathies

38. Coagulopathic Disorders

39. Hypertension

40. Vascular Deposition Disorders

41. Intimal Proliferative Diseases

42. Arterial Dissections

43. Miscellaneous Conditions

44. Disorders of Veins

45. Chapter 5: Aneurysms of the Aorta: Ascending, Thoracic and Abdominal and Their Management

46. Abstract

47. Introduction

48. Normal Anatomy and Histology of the Aorta

49. Aging Changes of the Aorta

50. Thoracic Aortic Aneurysms

51. Etiology and Pathologic Findings

52. Clinical Presentation and Natural History

53. Abdominal Aortic Aneurysm

54. Aortic Dissection

55. Management

56. Chapter 6: Fundamental Principles in Cardiovascular Genetics

57. Abstract

58. Genetic Variation

59. Modern Molecular Diagnostics

60. Identifying the Genetic Basis of Cardiovascular Disease

61. Representative Genetic Cardiovascular Conditions

62. Molecular Diagnostics in Cardiovascular Pathology Practice

63. Chapter 7: Myocardial Ischemia and Its Complications

64. Abstract

65. Definition and History

66. Clinical Manifestations

67. Epidemiology

68. Biochemical Changes with Ischemia and Biochemical Markers

69. Ultrastructural Evolution of Acute Ischemic Injury

70. Cellular and Subcellular Mechanisms of Myocardial Injury

71. Microscopic Evolution of Acute Ischemic Injury

72. Morphology of Coronary Arteries and Plaques

73. Tako-Tsubo Cardiomyopathy

74. Gross Evolution of Acute Ischemic Injury

75. Patterns of MI

76. Phenomena Associated with Ischemic Injury

77. Reperfusion of Ischemic Myocardium

78. Complications of MI

79. Recognition and Quantification of Acute Ischemic Injury

80. Pathology of Interventions

81. Pathophysiological and Pharmacological Interventions

82. Molecular Biology of Myocardial Ischemia

83. Chapter 8: Pathophysiology of Heart Failure and an Overview of Therapies

84. Abstract

85. Overview of Heart Failure

86. Pathophysiology of HF

87. Neurohormonal Alterations in HF

88. Signaling Responses to Various Stimuli During HF

89. HF-related Alterations in Cellular Function and Biochemical Pathways

90. Metabolic Remodeling in HF

91. Summary of HF

92. Therapeutic Management of HF

93. Chapter 9: Myocarditis

94. Abstract

95. Definition of Myocarditis

96. Diagnosis of Myocarditis

97. Histopathologic Patterns of Myocarditis

98. Etiologies of Myocarditis

99. Treatment of Myocarditis

100.              Chapter 10: Pathology of Sudden Death, Cardiac Arrhythmias and Conduction System

101.              Abstract

102.              Acknowledgments

103.              Sudden Death

104.              Cardiac Conduction System

105.              Atrial Fibrillation

106.              Appendix Guidelines for Postmortem Study of Sudden Death

107.              Chapter 11: Cardiomyopathies

108.              Abstract

109.              Definition and Classification of Cardiomyopathies

110.              Dilated Cardiomyopathy

111.              Hypertrophic Cardiomyopathy

112.              Arrhythmogenic Cardiomyopathy

113.              Restrictive Cardiomyopathy

114.              Others

115.              Chapter 12: Valvular Heart Disease

116.              Abstract

117.              Introduction

118.              Functional Anatomy

119.              Types of Valvular Dysfunction

120.              Chapter 13: Cardiac Valve Replacement and Related Interventions

121.              Abstract

122.              General Considerations

123.              Valve-related Complications: Clinical Importance, Morphology, Secondary Effects, and Pathogenesis

124.              Other Tissue Valve Substitutes

125.              Catheter-based Valve Implantation

126.              Valve Repair and Valve Sparing Procedures

127.              New Developments and Future Considerations

128.              Pathologic Considerations in Analysis of Heart Valve Substitutes

129.              Disclosure

130.              Appendix

131.              Chapter 14: The Pathology of Cardiovascular Interventions and Devices for Coronary Artery Disease, Vascular Disease, Heart Failure, and Arrhythmias

132.              Abstract

133.              Endovascular Therapies and Myocardial Revascularization

134.              Aortic and Peripheral Vascular Replacement and Reconstruction

135.              Cardiac Assist and Replacement

136.              Arrhythmia Control

137.              Chapter 15: Congenital Heart Disease: Pathology, Natural History, and Interventions

138.              Abstract

139.              Introduction

140.              Epidemiology and Etiology

141.              Embryology of the Cardiovascular System

142.              Clinical Features and Consequences

143.              Specific Forms of CHD

144.              Surgical and Nonsurgical Interventions for Treatment of CHD

145.              CHD in the Adult

146.              Natural History of CHD Without and with Interventions

147.              Chapter 16: The Pericardium and Its Diseases

148.              Abstract

149.              Anatomy

150.              Physiology

151.              Histology

152.              Echocardiography

153.              Pericardiocentesis and Biopsy

154.              Congenital Abnormalities

155.              Pericardial Effusion After Cardiac Surgery

156.              Pneumopericardium

157.              Early Postmyocardial Infarction Pericarditis and Dressler Syndrome

158.              Iatrogenic and Traumatic Pericarditis

159.              Chapter 17: Pathology of Cardiac Transplantation

160.              Abstract

161.              General Clinicopathologic Considerations

162.              Pathology of the Explanted Recipient Heart

163.              Pathology of the Donor Heart

164.              Pathology of the Allograft

165.              Heart Transplantation in Combination with Other Organs

166.              Pathological Review of an EMB

167.              Approach to the Examination of a Failed Allograft

168.              Future Considerations

169.              Chapter 18: Toxins and the Heart

170.              Abstract

171.              Introduction

172.              Endocardium

173.              Myocardium

174.              Pericarditis

175.              Primary Conduction System Abnormalities

176.              Coronary Artery Lesions

177.              Cocaine-Other Drug Interactions

178.              Drugs to Treat Attention Deficit-Hyperactivity Disorders

179.              Antipsychotic Medications

180.              Nonsteroidal Anti-inflammatory Drugs

181.              Myocardial Toxins as a Cause of Death

182.              Chapter 19: Tumors of the Cardiovascular System: Heart and Blood Vessels

183.              Abstract

184.              Incidence and Classification

185.              Clinical Symptoms

186.              Reactive Cardiac Masses and Pseudotumors

187.              Ectopias

188.              Hamartomas and Benign Neoplasms

189.              Hamartomas of Cardiac Muscle

190.              Benign Fatty Tumors

191.              Benign Tumors of Myofibroblastic Tissue

192.              Miscellaneous Benign Fibrous Tumors

193.              Cardiac Myxoma

194.              Benign Neural Neoplasms

195.              Malignant Tumors

196.              Metastatic Tumors

197.              Sarcomas of the Great Vessels

198.              Chapter 20: Forensic Aspects of Cardiovascular Pathology

199.              Abstract

200.              Investigative Information

201.              General Changes

202.              Primary Diseases/Injuries of the Heart

203.              Cardiomyopathies, Myocarditis, and Genetic Causes of SCD

204.              Anomalies and Diseases of the Aorta and Coronary Arteries

205.              Diseases of the Cardiac Valves

206.              Ancillary Studies

207.              Sudden Death Following Surgery and Medical Procedures

208.              Organ and Tissue Harvesting

209.              Cardiovascular Pathology Consultation

210.              Summary

211.              Index